CN108836553B - Trigeminal ganglion injection guide plate, preparation method and application thereof - Google Patents
Trigeminal ganglion injection guide plate, preparation method and application thereof Download PDFInfo
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- CN108836553B CN108836553B CN201810737320.3A CN201810737320A CN108836553B CN 108836553 B CN108836553 B CN 108836553B CN 201810737320 A CN201810737320 A CN 201810737320A CN 108836553 B CN108836553 B CN 108836553B
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D1/00—Surgical instruments for veterinary use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Surgical Instruments (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a trigeminal ganglion injection guide plate, comprising: a fitting portion to be fitted to the maxillofacial tissue; the hollow part exposes soft tissues and nasal cavities in the range of the bilateral nasal wings; a support part positioned at the upper end of the hollow part and supporting hard tissues at the forehead part; the fixing part is positioned at the lower end of the hollow part and is provided with a groove fixed on the upper front teeth; and two injection channels are respectively positioned at the left side and the right side of the fixing part, and each injection channel is provided with an access direction reaching the foramen ovale at the skull base and is used for leading an injection needle to reach the trigeminal ganglion through the guide puncture of the injection channel. The injection guide plate for the trigeminal ganglion can simply, rapidly, accurately and little-traumatically realize the approach of the trigeminal ganglion, has simple preparation process and good repeatability, and has important significance for in-vivo study of maxillofacial sensation and pain sense.
Description
Technical Field
The invention relates to a medical model, in particular to a trigeminal ganglion injection guide plate, a preparation method and application thereof.
Background
The trigeminal ganglion (TRIGEMINAL GANGLION) consists of a pseudo-single-stage neuronal cell body in which the axons concentrate into the coarse trigeminal sensory root, which is the first site for maxillofacial sensory afferent, and is a very important structure in maxillofacial sensory and pain studies, with great research implications. In various animal experiments, it is desirable to obtain access closest to the trigeminal ganglion in a manner that minimizes trauma under conditions that ensure animal survival in order to facilitate reagent injection and electrophysiological studies.
In the body study, there are two ways to obtain access to the trigeminal ganglion, one is by craniotomy with the aid of a brain stereotactic instrument, via penetration of brain tissue to the base of the skull to access the trigeminal ganglion. However, the method is complex to operate, and the animals need deep anesthesia and are greatly damaged. Another is by way of reference to the extra-oral approach of the human trigeminal ganglion from the facial approach to the base foramen ovale to access the trigeminal ganglion. The method is relatively simple, but the requirement on the experience of an operator is high due to the fact that the method is completely dependent on manual injection, important tissues are extremely vulnerable to improper operation, and operability and practicability are not achieved in a practical application scene.
Therefore, providing a simple, rapid, accurate, and less damaging approach to the trigeminal ganglion is a problem to be solved in the art.
It is noted that the information disclosed in the foregoing background section is only for enhancement of understanding of the background of the invention and therefore it may contain information that does not form the prior art that is already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide a trigeminal ganglion injection guide plate, a preparation method and application thereof, wherein the guide plate can obtain an access closest to the trigeminal ganglion in a mode of minimizing damage under the condition of ensuring that animals survive and are close to a good physiological state, has high success rate and accuracy of puncture of a foramen ovale at the base of a cranium, and can avoid unnecessary damage caused by repeated puncture. The trigeminal ganglion injection guide plate has simple preparation process and good repeatability, and has important significance for in-vivo study of maxillofacial sensation and pain sense.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
the invention provides a trigeminal ganglion injection guide plate, comprising:
A fitting portion to be fitted to the maxillofacial tissue;
the hollow part exposes soft tissues and nasal cavities in the range of the bilateral nasal wings;
a support part positioned at the upper end of the hollow part and supporting hard tissues at the forehead part;
the fixing part is positioned at the lower end of the hollow part and is provided with a groove fixed on the upper front teeth; and
The two injection channels are respectively positioned at the left side and the right side of the fixing part, and each injection channel is provided with an access direction reaching the foramen ovale at the skull base and is used for leading the injection needle to reach the trigeminal ganglion through the guide puncture of the injection channel.
According to one embodiment of the invention, the injection channel is internally provided with a trocar.
According to one embodiment of the invention, the trocar is a detachable trocar.
According to one embodiment of the invention, the depth of the injection channel is 8-10 mm.
The invention also provides a preparation method of the trigeminal ganglion injection guide plate, which comprises the following steps:
inserting a puncture needle into the cranium part exposing the trigeminal ganglion, so that the puncture needle enters from the oval foramen of the cranium of the trigeminal ganglion and penetrates out from the surface layer of the face of the cranium part, and determining the needle insertion point and the access direction of the face;
retaining the puncture needle to make an impression and casting a mold having a hollow injection channel along the access direction;
Scanning the model by a computer to obtain a three-dimensional model image, and carrying out digital processing on the three-dimensional model image to obtain digital guide plate data;
And importing the digital guide plate data into 3D printing equipment to prepare the trigeminal ganglion injection guide plate.
The invention also provides a preparation method of the trigeminal ganglion injection guide plate, which comprises the following steps:
inserting a puncture needle into the cranium part exposing the trigeminal ganglion, so that the puncture needle enters from the oval foramen of the cranium of the trigeminal ganglion and penetrates out from the surface layer of the face of the cranium part, and determining the needle insertion point and the access direction of the face;
retaining the puncture needle to make an impression and casting a mold having a hollow injection channel along the access direction;
and (3) preparing a pre-cured template in the shape of the model by using a photo-cured prepolymer, and carrying out light treatment on the pre-cured template to obtain the trigeminal ganglion injection guide plate.
The invention also provides application of the trigeminal ganglion injection guide plate in the puncture of the foramen ovale.
The invention has the beneficial effects that:
The trigeminal ganglion injection guide plate provided by the invention is provided with an injection channel reaching the entrance direction of the foramen ovale at the skull base, has good directional positioning function, can accurately realize the directional puncture of an injection needle, and further approaches to the trigeminal ganglion for reagent injection and electrophysiological research. The trigeminal ganglion injection guide plate can simply, rapidly, accurately and little-traumatically realize the approach of the trigeminal ganglion, has high success rate and accuracy, can avoid unnecessary damage caused by repeated puncture, has simple preparation process and good repeatability, and has important significance for in-vivo study of maxillofacial sensation and pain sense.
Drawings
FIG. 1 is a schematic front view of a trigeminal ganglion injection guide plate according to one embodiment of the present invention;
FIG. 2 is a schematic side view of a trigeminal ganglion injection guide plate according to one embodiment of the present invention;
FIG. 3 is a schematic view of a trigeminal ganglion injection guide plate according to one embodiment of the present invention applied to the cranium of a rat;
FIG. 4 is a schematic view of the insertion of a needle into a rat cranium specimen exposing a trigeminal ganglion in example 1;
FIG. 5 is a schematic diagram of the casting model in example 1;
Fig. 6 and 7 are three-dimensional model images obtained after the computer scans the model in example 1, respectively;
FIG. 8 is a three-dimensional model image of the guide plate obtained by digitizing in example 1.
Wherein reference numerals are as follows:
1: bonding part
2: Hollow part
3: Support part
4: Fixing part
51. 52: Injection channel
Detailed Description
The following provides many different embodiments, or examples, for implementing different features of embodiments of the invention. Specific examples of components and arrangements are described below to simplify the present disclosure. These are, of course, merely examples and are not intended to limit embodiments of the present invention. Embodiments of the present invention may repeat reference numerals and/or letters in the various examples. This repetition is for the purpose of simplicity and clarity and does not in itself dictate a relationship between the various embodiments and/or configurations discussed. In addition, in the following description, descriptions of well-known structures and techniques are omitted so as not to unnecessarily obscure the present invention.
Forming one element on, connecting to, and/or coupling another element in embodiments of the present invention may include forming embodiments in which such element directly contacts another element, and may also include forming embodiments in which additional elements are interposed between such elements such that such elements are not directly in contact. Moreover, for ease of describing the relationship between one component and another component of embodiments of the present invention, spatially relative terms such as "lower," "upper," "horizontal," "vertical," "above …," "above," "below …," "below …," "upward," "downward," "top," "bottom," and the like may be used herein. These spatially relative terms are intended to encompass different orientations of the device in which the component is incorporated.
FIG. 1 is a schematic front view of a trigeminal ganglion injection guide plate according to one embodiment of the present invention; FIG. 2 is a schematic side view of a trigeminal ganglion injection guide plate according to one embodiment of the present invention; referring to fig. 1 and 2, the trigeminal ganglion injection guide plate of the present invention comprises: a fitting part 1 to be fitted to a maxillofacial tissue; the hollow part 2 exposes soft tissues and nasal cavities in the range of the nasal wings at two sides, so that a user can breathe normally during the use process of the injection guide plate; a support part 3 positioned at the upper end of the hollow part 2 and supporting hard tissue at the forehead; a fixing part 4 positioned at the lower end of the hollow part 2 and provided with a groove fixed on the upper front teeth; and two injection channels 51, 52, respectively located at the left and right sides of the fixing part, having an access direction reaching the base foramen ovale, for leading the injection needle to reach the trigeminal ganglion through the guided penetration of the injection channels.
Specifically, for example, as shown in fig. 3, when the mouse is used, the fixing portion 4 of the trigeminal ganglion injection guide plate is fixed to the upper front teeth of the rat, and the supporting portion 3 is supported by the hard tissue of the forehead of the rat, so as to be positioned and fixed on the face of the rat. When the injection is ready for trigeminal ganglion injection, the injection needles are only required to be respectively inserted into the two injection channels 51 and 52, the directional puncture of the injection needles can be realized through the guidance of the two injection channels 51 and 52, and the injection needles are the positions of the trigeminal ganglion when reaching the skull base bone plate. Proved by verification, the injection guide plate can be used for carrying out trigeminal ganglion injection, so that the injection guide plate can be used for positioning and avoiding damaging important structures.
In some embodiments, a trocar is provided inside the injection channel. The trocar is favorable for guiding the position of the puncture needle, and is preferably a detachable trocar which can be taken out from an injection channel and replaced, so that the sterilization operation can be conveniently carried out when the trigeminal ganglion injection guide plate is applied to different rats in experiments.
In some embodiments, the injection channel has a depth of 8-10 mm. The purpose of accurate positioning can be achieved by controlling the depth of the injection channel. The diameter of the injection channel can be designed and matched according to the thickness of the injection needle, and the puncture needle or the injection needle can pass through the injection channel.
In some embodiments, the material of the trigeminal ganglion injection guide plate is 3D printing material or photo-curing resin, including but not limited to epoxy acrylate, polyurethane acrylate, polyester acrylate, polyether acrylate, acrylic resin, unsaturated polyester, polyene/thiol system, aqueous acrylate, epoxy resin, ethynyl ether, etc.
The invention also provides a preparation method of the trigeminal ganglion injection guide plate, which comprises the following steps:
inserting a puncture needle into the cranium part exposing the trigeminal ganglion, so that the puncture needle enters from the oval foramen of the cranium of the trigeminal ganglion and penetrates out from the surface layer of the face of the cranium part so as to find a passage, and determining the needle inlet point and the passage inlet direction of the face in the opposite direction;
retaining the puncture needle to make an impression and casting a mold having a hollow injection channel along the access direction;
Scanning the model by a computer to obtain a three-dimensional model image, and carrying out digital processing on the three-dimensional model image to obtain digital guide plate data;
And importing the digital guide plate data into 3D printing equipment to prepare the trigeminal ganglion injection guide plate.
The specific methods of "making the stamp" and "casting the mold" are well known in the art, wherein the material from which the stamp is made is a conventional stamp material, such as silicone rubber, alginate, and the like. Materials used for the casting model include, but are not limited to, gypsum.
The invention also provides a preparation method of the trigeminal ganglion injection guide plate, which comprises the following steps:
inserting a puncture needle into the cranium part exposing the trigeminal ganglion, so that the puncture needle enters from the oval foramen of the cranium of the trigeminal ganglion and penetrates out from the surface layer of the face of the cranium part, and determining the needle insertion point and the access direction of the face;
retaining the puncture needle to make an impression and casting a mold having a hollow injection channel along the access direction;
and (3) preparing a pre-cured template in the shape of the model by using a photo-cured prepolymer, and carrying out light treatment on the pre-cured template to obtain the trigeminal ganglion injection guide plate.
In some embodiments, the manner in which the pre-cured template is made includes pre-coating the mold with a release agent, including but not limited to petrolatum or the like. The photo-curing prepolymer (i.e., the moldable photo-curing material) is laid on the mold surface to adhere to the mold and the injection channel is maintained. The specific method of photo-curing is to use the method known in the art to cure and shape the prepared trigeminal ganglion guide plate.
The trigeminal ganglion injection guide plate prepared by the method has good repeatability, and can be used for preparing different guide plates according to rats with different weights, for example, 250g,300g,350g and 400g of rats can be used for preparing a series of trigeminal ganglion injection guide plates respectively so as to be better applied to rats with different weights. It was verified that rats of similar body weight can use the same guide plate, so the trigeminal ganglion injection guide plate of the present invention has industrial applicability.
The following is further illustrated by the specific examples:
Example 1
Dead rat carcasses were taken, their heads were separated, brain tissue was removed, and the cranio-basal trigeminal ganglion was exposed. As shown in fig. 4, two long needles are taken as puncture needles to enter from the oval foramen of the cranium of the trigeminal ganglion and penetrate out of the skin from the facial surface layer of the cranium specimen, so that after a passage is found, the facial needle insertion point and the direction of the passage are reversely determined.
A trocar was placed over the puncture needle and both were left, a layer of 2mm dental wax was applied to the rat face, and individual trays of the rat face were made from a photo-curable material. Taking off dental wax, placing the impression material into individual trays, positioning the impression material on the face of the rat, taking off the impression material after the impression material is hard, and finishing the preparation of the impression. Mixing dental superhard gypsum material, injecting into the impression, and casting into gypsum model. As shown in FIG. 5, the prepared model has a needle and trocar reaching the approach direction of the foramen ovale at the base of the cranium; the resulting model is computer scanned to obtain a three-dimensional model image, as shown in fig. 6 and 7. Performing digital processing on the obtained three-dimensional model image to obtain a guide plate three-dimensional model image (shown in figure 8) and digital guide plate data, wherein the digital processing is performed on the Geomagic Studio 2013 (3D Systems, germany); the digitized guide plate data is led into a 3D printing device DLP (DIGITAL LIGHT processing), and the trigeminal ganglion injection guide plate is prepared by adopting an acrylic resin e shell 600 (ENVISIONTEC, germany) and processing.
Example 2
The steps of "producing a stamp" and "casting a mold" and the steps before are the same as in example 1, a plaster mold was coated with a release agent, a moldable photo-setting material (methacrylic acid salt, a main component of Shandong Shanghai pigeon oral stock Co., ltd.) was spread on the surface of the plaster mold so as to be adhered to the mold, and an adhering portion, a supporting portion, a hollow portion, and a fixing portion were formed in this order, and the photo-setting material was thickened around a puncture needle and a catheter penetrating the skin surface to form an injection passage. And (5) curing by using a light curing lamp after molding. And taking down the three-fork ganglion injection guide plate after solidification.
It will be appreciated by persons skilled in the art that the embodiments described herein are merely exemplary and that various other alternatives, modifications and improvements may be made within the scope of the invention. For example, the above embodiments all use "rat" as animal model, but the trigeminal ganglion injection guide plate of the present invention includes but is not limited to injection guide plate suitable for rat, and other animals needing trigeminal ganglion reagent injection, electrophysiological study, etc., such as small experimental animals including rabbit, mouse, guinea pig, etc., can be prepared by the preparation method of the present invention, and the applicable trigeminal ganglion injection guide plate can be used correspondingly. That is, the scope of the present invention is not limited to the above embodiments, but is only limited by the claims, and the trigeminal ganglion injection guide obtained by changing only the animal model should be included in the scope of the present invention.
Claims (5)
1. A trigeminal ganglion injection guide plate comprising:
A fitting portion to be fitted to the maxillofacial tissue;
the hollow part exposes soft tissues and nasal cavities in the range of the bilateral nasal wings;
a support part positioned at the upper end of the hollow part and supporting hard tissues at the forehead part;
the fixing part is positioned at the lower end of the hollow part and is provided with a groove fixed on the upper front teeth; and
The two injection channels are respectively positioned at the left side and the right side of the fixing part, and each injection channel is provided with an access direction reaching the foramen ovale at the skull base and is used for leading an injection needle to reach the trigeminal ganglion through the guide puncture of the injection channel;
Wherein, the injection channel is internally provided with a trocar, and the depth of the injection channel is 8-10 mm.
2. The trigeminal ganglion injection guide plate according to claim 1, wherein the trocar is a detachable trocar.
3. A method of preparing the trigeminal ganglion injection guide plate according to any one of claims 1-2, comprising:
taking an impression of the needle and casting a model having a hollow injection channel along the access direction;
Scanning the model by a computer to obtain a three-dimensional model image, and carrying out digital processing on the three-dimensional model image to obtain digital guide plate data;
And importing the digital guide plate data into 3D printing equipment to prepare the trigeminal ganglion injection guide plate.
4. A method of preparing the trigeminal ganglion injection guide plate according to any one of claims 1-2, comprising:
taking an impression of the needle and casting a model having a hollow injection channel along the access direction;
and (3) preparing a pre-cured template in the shape of the model by using a photo-cured prepolymer, and carrying out light treatment on the pre-cured template to obtain the trigeminal ganglion injection guide plate.
5. Use of the trigeminal ganglion injection guide plate according to any one of claims 1-2 in the penetration of a base foramen ovale.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810737320.3A CN108836553B (en) | 2018-07-06 | 2018-07-06 | Trigeminal ganglion injection guide plate, preparation method and application thereof |
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| CN201810737320.3A CN108836553B (en) | 2018-07-06 | 2018-07-06 | Trigeminal ganglion injection guide plate, preparation method and application thereof |
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| CN110141323A (en) * | 2019-05-30 | 2019-08-20 | 江门市中心医院 | For treating the mask of trigeminal neuralgia |
| CN110236672B (en) * | 2019-06-03 | 2020-05-05 | 福建省立医院 | Brain tumor operation board and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104287840A (en) * | 2014-10-28 | 2015-01-21 | 江苏舟可医疗器械科技有限公司 | Navigation template used for trigeminal nerve navigation puncture and navigation puncture method |
| CN209808618U (en) * | 2018-07-06 | 2019-12-20 | 北京大学口腔医学院 | Trigeminal ganglion injection guide plate |
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| CN204033534U (en) * | 2014-08-21 | 2014-12-24 | 浙江中医药大学附属第三医院 | A kind of flexible retainer for Conscious Rat |
| US20180000553A1 (en) * | 2014-12-18 | 2018-01-04 | Norwegian University Of Science And Technology | Intervention guidance device |
| CN107198592A (en) * | 2017-05-16 | 2017-09-26 | 于生元 | Rat inflammation soup stimulates model and method for building up |
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| US4620540A (en) * | 1985-10-17 | 1986-11-04 | Micromedical Research And Development Company | Mold for rapid stereotaxic injections into mouse striatum |
| CN104287840A (en) * | 2014-10-28 | 2015-01-21 | 江苏舟可医疗器械科技有限公司 | Navigation template used for trigeminal nerve navigation puncture and navigation puncture method |
| CN209808618U (en) * | 2018-07-06 | 2019-12-20 | 北京大学口腔医学院 | Trigeminal ganglion injection guide plate |
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