CN108823081A - A kind of device of quick obtaining concentration nanometer fat - Google Patents

A kind of device of quick obtaining concentration nanometer fat Download PDF

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Publication number
CN108823081A
CN108823081A CN201810967265.7A CN201810967265A CN108823081A CN 108823081 A CN108823081 A CN 108823081A CN 201810967265 A CN201810967265 A CN 201810967265A CN 108823081 A CN108823081 A CN 108823081A
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CN
China
Prior art keywords
filter
quick obtaining
obtaining concentration
converter
cup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810967265.7A
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Chinese (zh)
Inventor
吴引弟
刘宏伟
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Jinan University
University of Jinan
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Jinan University
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Publication date
Application filed by Jinan University filed Critical Jinan University
Priority to CN201810967265.7A priority Critical patent/CN108823081A/en
Publication of CN108823081A publication Critical patent/CN108823081A/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/04Cell isolation or sorting

Abstract

The invention discloses a kind of devices of quick obtaining concentration nanometer fat, including converter and filter device, the both ends of the converter to connect respectively with spiral syringe, and multiple apertures are provided in the converter;The filter device includes filter bag and filter cup, and clip is provided in the filter cup, and one end of the clip is fixed on the wall of cup of the filter cup.The device is using porous converter and the filter device of energy high efficiency filter fat, shorten the Production Time of production concentration nanometer fat, the volume increase of total concentration nanometer fat of single production, to retain the activity for the active material for including inside adipose tissue to a greater extent.

Description

A kind of device of quick obtaining concentration nanometer fat
Technical field
The present invention relates to fat extraction technique field, in particular to a kind of device of quick obtaining concentration nanometer fat.
Background technique
In recent years, many scholars propose various methods to improve the survival rate of fat transfer, and some scholars pass through a type Collagenase digesting fat-extraction goes out fat stem cell, and then with fatty co-injection in vivo, but this method is related to enzyme Use problem, be difficult to be verified and promote in the short time.Nanometer is proposed early in Tonnald (Donald) doctor in 2013 The concept of fat, nanometer fat because of its good tissue repair and regeneration function and more balanced small particle, and in the surface of a wound and Reconstructive surgery has obtained extensive utilization.Lu Feng team of the country proposes the method for SVF-Gel (fatty glue) within 2017, will be fatty It is concentrated.But the device is complicated for this method needs, troublesome in poeration.
Contain a large amount of fat stem cell, extracellular matrix isoreactivity ingredient in adipose tissue, and nanometer fat skill is concentrated Art removes extra grease and moisture by pure broken physical method, and the effective component of nanometer fat is carried out in certain proportion Concentration.However at this stage concentration nanometer fat prepare it is pure broken manual by manpower, by time, fat volume and human body energy Limitation, cannot largely prepare.This has not only delayed the progress of clinical position, since the time elapses, the activity inside adipose tissue The activity of ingredient such as fat stem cell also will be greatly reduced.
Summary of the invention
It is an object of the invention to overcome the deficiencies of existing technologies and insufficient, a kind of quick obtaining concentration nanometer rouge is provided The device of fat, the device make production concentration nanometer fat using porous converter and the filter device of energy high efficiency filter fat Production Time shorten, single production total concentration nanometer fat volume increase, to retain adipose tissue to a greater extent The activity for the active material that inside includes.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of device of quick obtaining concentration nanometer fat, including converter and filter device, the both ends of the converter It is connect respectively with spiral syringe, multiple apertures is provided in the converter;The filter device includes filter bag and filtering Glass, it is provided with clip in the filter cup, one end of the clip is fixed on the wall of cup of the filter cup.
The clip includes two cylindric idler wheels as a preferred technical solution, and the wall of cup of the filter cup is equipped with Protrusion;One end of two idler wheels passes through steel wire winding in the protrusion respectively, the steel wire connecting with one of idler wheel On be provided with small hook;The other end of two idler wheels is connected with each other by steel wire.
The material of the idler wheel is stainless steel, length 65mm as a preferred technical solution,.
The bag body diameter of the filter bag is 500um, a length of 160mm of bag as a preferred technical solution, and bag diameter is 60mm。
The rim of a cup diameter of the filter cup is 90mm as a preferred technical solution, is highly 125mm.
10 apertures are equipped in the converter as a preferred technical solution,.
The aperture of the aperture is 1.2mm or 2.4mm as a preferred technical solution,.
The both ends of the converter are provided with external screw thread, the lower end of the spiral syringe as a preferred technical solution, It is provided with internal screw thread, the specification of the external screw thread and internal screw thread is M12X1.5-6g.
The spiral syringe is 50ml or 100ml as a preferred technical solution,.
The lower end exit diameter of the spiral syringe is 12mm as a preferred technical solution,.
Compared with prior art, the present invention having the following advantages that and beneficial effect:
1, converter inside of the invention is provided with multiple apertures, can effectively cut fat, improves concentration nanometer rouge Fat obtains efficiency.
2, the form that filter device of the invention is combined using filter bag and filter cup utilizes the fixed filter bag of clip, energy Most of fat is enough allowed to be collected, to reduce fat loss.Fat in filter bag can come into full contact with filter bag, mention High filtration effect.
3, the diameter in the lower end exit of spiral syringe of the invention is bigger than ordinary syringe, can make more multicapacity Fat cut by converter, improve concentration nanometer fat acquisition efficiency.
4, the device provided by the invention for obtaining concentration nanometer fat can disposably obtain the concentration nanometer fat of 100ml, Traditional equipment disposably at most makes 10ml, obtains efficiency and is obviously improved.
Detailed description of the invention
Fig. 1 is the connection schematic diagram of converter and spiral syringe in the embodiment of the present invention
Fig. 2 is the front view for the converter that aperture is 1.2mm in the embodiment of the present invention
Fig. 3 is the top view of Fig. 2
Fig. 4 is the top view for the converter that aperture is 2.4mm in the embodiment of the present invention
Fig. 5 is the structural schematic diagram of spiral syringe in the embodiment of the present invention
Fig. 6 is the structural schematic diagram of filter bag in the embodiment of the present invention
Fig. 7 is the structural schematic diagram of filter cup under clip opening state in the embodiment of the present invention
Fig. 8 is the structural schematic diagram of filter cup under clip closed state in the embodiment of the present invention
Fig. 9 is the detail view that clip is connect with filter cup in the embodiment of the present invention
Detailed description of the invention:1:Converter, 2:Spiral syringe, 3:Aperture, 4:Lower part plug, 5:Filter bag, 6:Filter cup, 7:Idler wheel, 8:Small hook, 9:Upper part plug
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited In this.
A kind of device of quick obtaining concentration nanometer fat is provided as shown in Fig. 1,2,6,7, in the embodiment of the present invention, it should Device includes converter 1 and filter device.Converter 1 and filter device are matching used, are to obtain concentration nanometer fat not Tool to be used is respectively required in biconditional operation step.
The both ends of converter 1 are connect with spiral syringe 2 respectively.The both ends of converter 1 are provided with external screw thread, screw injection The lower end of device 2 is provided with internal screw thread, and external screw thread and internal screw thread match, and screw thread specification is M12X1.5-6g.As shown in Figure 3,4, 10 apertures 3 are equipped in converter 1, according to the acquisition needs of concentration nanometer fat, the aperture of settable aperture 3 for 1.2mm or 2.4mm.When aperture is 1.2mm, aperture 3 can be evenly arranged in inside converter 1.When aperture is 2.4mm, paracentral position is leaned on For 7 complete circular holes, 6 semicircle orifices are distributed in periphery, are equivalent to 10 complete circular holes.The total length of converter 1 is 35mm, material are 304 stainless steels.
As shown in figure 5, the capacity of two spiral syringes 2 is 100ml and 50ml respectively.Each spiral syringe includes Upper part plug 9 and lower part plug 4, upper part plug 9 can allow spiral syringe 2 and air exclusion.The spiral of 100ml is infused Emitter 2, length 130mm, diameter 36mm, material are macromolecule polypropylene.It fills in the upper part of the spiral syringe 2 of 100ml The diameter of son 9 is 36mm, and material is 304 stainless steels.The screw thread specification of the lower part plug 4 of the spiral syringe 2 of 100ml is M12X1.5-6g, material are 304 stainless steels.The spiral syringe 2 of 50ml, length 120mm, diameter 30mm, material are height Molecular polypropylene.The diameter of the upper part plug 9 of the spiral syringe 2 of 50ml is 30mm, and material is 304 stainless steels.50ml's The screw thread specification of the lower part plug 4 of spiral syringe 2 is M12X1.5-6g, and material is 304 stainless steels.Two spiral syringes The diameter of 2 lower ends exit is 12mm, bigger than general syringe diameter, facilitates the fat for obtaining more multicapacity.
When obtaining concentration nanometer fat, converter connects two spiral syringes, alternately pushes two spiral syringes, Make the aperture in fatty multipass converter, to play the role of cutting fat.Turning for two kinds of apertures can be used Parallel operation carries out aforesaid operations respectively, and fat is made to cut more evenly.
Fat after cutting, which needs to be placed into filter device, to be filtered.Filter device includes 5 He of filter bag Filter cup 6.Clip is provided in filter cup 6, clip includes two cylindric idler wheels 7, and the wall of cup of filter cup 6 is equipped with protrusion. As shown in figure 9, one end of two idler wheels 7 passes through steel wire winding in protrusion respectively, on the steel wire connecting with one of idler wheel 7 It is provided with small hook 8.The other end of two idler wheels 7 is connected with each other by steel wire.As shown in fig. 7, when under clip opening state, filtering Bag 5 can be put between two idler wheels 7.When small hook 8 is caught on the other side steel wire connecting with filter cup, closed form is presented in clip State, as shown in Figure 8.Clip can clamp the filter bag 5 equipped with fat when being closed, lift filter bag 5 at this time, fatty from filter bag 5 Mesh in flow into filter cup 6 in.
The bag body diameter of filter bag 5 is 500um, bag a length of 160mm, bag diameter 60mm.The mesh quantity of filter bag 5 For 500 mesh.The rim of a cup diameter of filter cup 6 is 90mm, a height of 125mm.The length of idler wheel 7 is 65mm, and material is 304 stainless steels.
A kind of working principle of the device of quick obtaining concentration nanometer fat provided by the invention is:Fat is packed into spiral In syringe, by spiral syringe and another spiral syringe of the converter connection equipped with fat.Alternately push two spiral shells Syringe is revolved, cuts fat for several times in the converter.Fat after cutting is packed into filter bag, and filter bag was placed in In the clip of filter bowl, grip clamp extracts filter bag out, and fat is filtered.Filtered fat is by that can obtain after centrifugal treating Nanometer fat must be concentrated.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (10)

1. a kind of device of quick obtaining concentration nanometer fat, which is characterized in that including converter and filter device, the conversion The both ends of device are connect with spiral syringe respectively, and multiple apertures are provided in the converter;The filter device includes filtering Bag and filter cup are provided with clip in the filter cup, and one end of the clip is fixed on the wall of cup of the filter cup.
2. a kind of device of quick obtaining concentration nanometer fat according to claim 1, which is characterized in that the clip packet Two cylindric idler wheels are included, the wall of cup of the filter cup is equipped with protrusion;One end of two idler wheels is twined by steel wire respectively It is wound in the protrusion, is provided with small hook on the steel wire connecting with one of idler wheel;The other end of two idler wheels passes through Steel wire is connected with each other.
3. a kind of device of quick obtaining concentration nanometer fat according to claim 2, which is characterized in that the idler wheel Material is stainless steel, length 65mm.
4. a kind of device of quick obtaining concentration nanometer fat according to claim 1, which is characterized in that the filter bag Bag body diameter be 500um, bag a length of 160mm, bag diameter 60mm.
5. a kind of device of quick obtaining concentration nanometer fat according to claim 1, which is characterized in that the filter cup Rim of a cup diameter be 90mm, be highly 125mm.
6. a kind of device of quick obtaining concentration nanometer fat according to claim 1, which is characterized in that the converter Inside it is equipped with 10 apertures.
7. a kind of device of quick obtaining concentration nanometer fat according to claim 6, which is characterized in that the aperture Aperture is 1.2mm or 2.4mm.
8. a kind of according to claim 1, device of quick obtaining concentration nanometer fat described in 6 or 7, which is characterized in that described The both ends of converter are provided with external screw thread, and the lower end of the spiral syringe is provided with internal screw thread, the external screw thread and internal screw thread Specification be M12X1.5-6g.
9. a kind of device of quick obtaining concentration nanometer fat according to claim 1, which is characterized in that the spiral note Emitter is 50ml or 100ml.
10. a kind of device of quick obtaining concentration nanometer fat according to claim 1 or described in 9, which is characterized in that the spiral shell The lower end exit diameter for revolving syringe is 12mm.
CN201810967265.7A 2018-08-23 2018-08-23 A kind of device of quick obtaining concentration nanometer fat Pending CN108823081A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109731498A (en) * 2019-02-25 2019-05-10 乔爱军 A kind of nanometer of fat or fatty glue boost motor
CN115554478A (en) * 2021-07-01 2023-01-03 高山艳 Autologous living cell preparation for biological tissue repair and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120156177A1 (en) * 2010-10-07 2012-06-21 Scarpone Michael A Methods and devices for harvesting and processing connective tissue precursor cells from autologous fat
CN103028281A (en) * 2012-11-12 2013-04-10 大连太平洋电子有限公司 Copper removal technique for tin immersion bath solution of chemical tin immersion line
CN106178134A (en) * 2016-07-14 2016-12-07 鲁峰 A kind of adipose-derived stem cells containing high enrichment and the fat transplantation material of extracellular matrix and pure physical preparation method thereof and application
CN207290236U (en) * 2017-08-15 2018-05-01 中国人民解放军第二军医大学第二附属医院 Arthroscope fat cutting emulsifier unit
CN108355170A (en) * 2018-01-17 2018-08-03 暨南大学 A kind of concentration nanometer fat and preparation method thereof, application

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120156177A1 (en) * 2010-10-07 2012-06-21 Scarpone Michael A Methods and devices for harvesting and processing connective tissue precursor cells from autologous fat
CN103028281A (en) * 2012-11-12 2013-04-10 大连太平洋电子有限公司 Copper removal technique for tin immersion bath solution of chemical tin immersion line
CN106178134A (en) * 2016-07-14 2016-12-07 鲁峰 A kind of adipose-derived stem cells containing high enrichment and the fat transplantation material of extracellular matrix and pure physical preparation method thereof and application
CN207290236U (en) * 2017-08-15 2018-05-01 中国人民解放军第二军医大学第二附属医院 Arthroscope fat cutting emulsifier unit
CN108355170A (en) * 2018-01-17 2018-08-03 暨南大学 A kind of concentration nanometer fat and preparation method thereof, application

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* Cited by examiner, † Cited by third party
Title
李国学, 北京:中国环境科学出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109731498A (en) * 2019-02-25 2019-05-10 乔爱军 A kind of nanometer of fat or fatty glue boost motor
CN115554478A (en) * 2021-07-01 2023-01-03 高山艳 Autologous living cell preparation for biological tissue repair and preparation method and application thereof

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