CN108815527B - Chinese medicinal preparation for treating hepatitis B and preparation method thereof - Google Patents
Chinese medicinal preparation for treating hepatitis B and preparation method thereof Download PDFInfo
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- CN108815527B CN108815527B CN201810905569.0A CN201810905569A CN108815527B CN 108815527 B CN108815527 B CN 108815527B CN 201810905569 A CN201810905569 A CN 201810905569A CN 108815527 B CN108815527 B CN 108815527B
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating hepatitis B, which is prepared from the following raw materials in parts by weight: 4-15 parts of astragalus membranaceus, 1-6 parts of salvia miltiorrhiza, 5-13 parts of elecampane, 1-4 parts of lucid ganoderma, 1-4 parts of oriental wormwood, 1-5 parts of abrus cantoniensis hance, 4-9 parts of dayflower, 1-6 parts of polygonum cuspidatum, 1-6 parts of Chinese date, 1-3 parts of purple eggplant, 0.1-2 parts of liquorice, 1-4 parts of pumpkin, 15-40 parts of amino acid raw pulp, 10-28 parts of pearl concentrated solution, 10-18 parts of cane sugar and 0.02-0.05 part of sodium benzoate. The Chinese medicinal preparation can improve the immunity of organisms, inhibit viruses, nourish the liver and the kidney, clear away heat and toxic materials, and has good effect of treating acute and chronic hepatitis B and surface antigenicity health-related toxicants.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine preparation for treating hepatitis B and a preparation method thereof.
Background
Hepatitis B is one of the diseases which have the greatest harm to human health in the middle of the twentieth century, and viral hepatitis B has stronger infectivity, so that patients have higher morbidity throughout the world, particularly in tropical regions, the harm to human bodies is great, the universal cooperation research of the world medical field considers that the pathogenic cause of hepatitis B is caused by hepatitis B virus, the traditional treatment method firstly implements the main prevention policy and controls the spread of the disease source, secondly adopts the immunopotentiator, the antiviral drug and the liver protection drug, the controlled treatment is carried out on the hepatitis B patients, so that the morbidity and the mortality of the hepatitis B are greatly reduced, however, the traditional Chinese medicine composition has unsatisfactory curative effect and large toxic and side effect, leads to the previous disease not to be cured and the subsequent disease to be developed, leads the patient to be suffered from long spirit and suffering of the body, and has no ideal healing treatment medicine and method at home and abroad up to now.
The pathogenesis of hepatitis B is considered by the traditional Chinese medical science in China to be as follows: or deficiency of the body, deficiency of healthy qi, or improper diet, invasion of damp-heat evil toxin by chance, heat stagnation and phlegm stasis, damp-phlegm obstruction, stagnation of toxin, qi movement disorder, blood disorder, difficulty in transportation and transformation of the spleen and stomach, failure in distribution of kidney water, prolonged course of disease, frequent consumption of pathogenic factors, decline of healthy qi, mild debility, and serious life threatening. It treats deficiency syndrome mainly by treating liver, spleen and kidney, nourishes liver and strengthens body resistance, and clears liver heat and promotes diuresis to remove pathogenic toxin. Because the traditional Chinese medicine focuses on treatment based on syndrome differentiation, one syndrome or one party is rather restless, and the disease is usually prolonged for a long time, pathogenic factors are spread throughout the whole body, the head is difficult to manage, and some patients often lose the excess and are not sufficiently nourished along with the aging and the physical weakness, so that the liver disease is more difficult to recover. Therefore, the traditional Chinese medicine has the advantages of no obvious curative effect, long treatment course and difficult acceptance by patients. At present, hepatitis B has become a hot topic of research in the middle-school medical field, and various comprehensive treatment formulas appear in succession, and the comprehensive treatment formulas comprise a liver soothing and stomach harmonizing method, a liver and spleen nourishing and tonifying method, a blood activating and stasis removing method, a liver and kidney nourishing method, a spleen and kidney stabilizing and tonifying method and the like. But also has the problems of long treatment time, high cost, poor curative effect and the like.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provides a traditional Chinese medicine preparation for treating hepatitis B and a preparation method thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the traditional Chinese medicine preparation for treating hepatitis B is prepared from the following raw materials in parts by weight: 4-15 parts of astragalus membranaceus, 1-6 parts of salvia miltiorrhiza, 5-13 parts of elecampane, 1-4 parts of lucid ganoderma, 1-4 parts of oriental wormwood, 1-5 parts of abrus cantoniensis hance, 4-9 parts of dayflower, 1-6 parts of polygonum cuspidatum, 1-6 parts of Chinese date, 1-3 parts of purple eggplant, 0.1-2 parts of liquorice, 1-4 parts of pumpkin, 15-40 parts of amino acid raw pulp, 10-28 parts of pearl concentrated solution, 10-18 parts of cane sugar and 0.02-0.05 part of sodium benzoate.
Preferably, the feed is prepared from the following raw materials in parts by weight: 6-10 parts of astragalus membranaceus, 2-4 parts of salvia miltiorrhiza, 7-10 parts of elecampane, 2-3 parts of lucid ganoderma, 2-3 parts of oriental wormwood, 2-4 parts of abrus cantoniensis hance, 5-8 parts of dayflower, 3-5 parts of polygonum cuspidatum, 3-5 parts of Chinese date, 2-3 parts of purple eggplant, 0.5-1.5 parts of liquorice, 2-3 parts of pumpkin, 20-30 parts of amino acid raw pulp, 15-22 parts of pearl concentrated solution, 12-15 parts of cane sugar and 0.03-0.04 part of sodium benzoate.
The following medicinal material sources of the traditional Chinese medicine composition are as follows:
astragalus membranaceus, Latin is Leguminosae, is also called Astragalus membranaceus and Astragalus membranaceus, and is the dry root of Astragalus membranaceus bge. Warm in nature, sweet in taste and slightly sweet. Has effects in invigorating qi, consolidating superficial resistance, promoting urination, expelling pus, healing sore, and promoting granulation.
Salvia miltiorrhiza, is the dried root and rhizome of Salvia miltiorrhiza bge. Collected in spring and autumn, removed of silt and dried. Has the effects of activating blood circulation to dissipate blood stasis, stimulating the menstrual flow to relieve pain, clearing away the heart-fire and relieving restlessness, cooling blood and eliminating carbuncle. Can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.
Radix Kadsurae Longipedunculata Finet Gagn, root or root bark of Kadsura longipedunculata Kadsura longeppendula of Schisandraceae. Is distributed in places in the south of Yangtze river basin. Has the effects of regulating qi, relieving pain, dispelling pathogenic wind, dredging collaterals, promoting blood circulation and relieving swelling. It is commonly used for stomachache, abdominal pain, rheumatic arthralgia, dysmenorrhea, irregular menstruation, postpartum abdominal pain, sore throat, hemorrhoid, innominate toxic swelling, and traumatic injury.
Ganoderma is fruiting body of Ganoderma lucidum of Polyporaceae. Has effects of invigorating qi, tranquilizing mind, relieving cough and asthma, and prolonging life. Can be used for treating vertigo, insomnia, palpitation, short breath, neurasthenia, and cough with asthma due to asthenia.
Artemisia capillaris Thunb, Latin Wen name Artemisia apiacea, Compositae, Oregano, is not dead in winter, while spring is due to old root, so it is named Chen or Artemisia capillaris Thunb. Herba Artemisiae Scopariae clears away heat and promotes diuresis; and (4) removing the yellow color. The main treatment is as follows: jaundice, dysuria, eczema, pruritus, infectious icterohepatitis, etc. The pharmacological research has the functions of benefiting gallbladder, protecting liver function, relieving fever, resisting inflammation, reducing blood fat, reducing blood pressure, expanding crown and the like.
Abrus cantoniensis is dried whole plant of Abrus cantoniensis of Leguminosae. Sweet, slightly bitter and cool. Has the functions of eliminating dampness and jaundice, clearing away heat and toxic material, soothing liver and relieving pain. It is commonly indicated for damp-heat yellow abscess, uncomfortable hypochondriac region, distending pain in stomach, and mammary abscess with swelling pain. The abrus herb can also be used for cooking soup for dietotherapy in wet spring and summer.
Dayflower, latin scientific name: (Commelina communis), Bizhu, Cuiyan, Lophatherum gracile et al. Belonging to the order of floury endosperm, the family Commelinaceae, the genus Commelina, and the genus annual mantle of the plant. Move water, clear heat, cool blood and remove toxicity. It can be used for treating edema, tinea pedis, dysuria, common cold, erysipelas, parotitis, icterohepatitis, dysentery, malaria, epistaxis, hematuria, metrorrhagia, leucorrhea, sore throat, carbuncle, cellulitis, and furuncle.
Rhizoma Polygoni Cuspidati is dried rhizome and root of Polygonum cuspidatum Sieb. Collected in spring and autumn, removed fibrous root, cleaned, cut into short segments or thick slices, and dried in the sun. Distributed in northwest, east, center, south and southwest regions. Has effects of promoting diuresis, eliminating jaundice, clearing heat, removing toxic substance, removing blood stasis, relieving pain, relieving cough, and eliminating phlegm. Can be used for treating jaundice due to damp-heat pathogen, stranguria with turbid discharge, leukorrhagia, rheumatalgia, carbuncle, swelling, sore, scald due to water and fire, amenorrhea, abdominal mass, contusion injury, and cough due to lung heat.
Fructus Jujubae is the mature fruit of Zizyphi fructus of Rhamnaceae family. Mainly used for reinforcing the spleen and harmonizing the stomach, tonifying qi and promoting the production of body fluid, regulating ying and wei and relieving drug toxicity. It is indicated for deficiency of stomach and food, spleen weakness, loose stool, qi, blood and body fluids deficiency, disharmony between ying and wei, palpitation.
Solanum torvum Linne is a plant of Solanaceae, Solanum. The eggplant branches vertically and is herbaceous to subshrubular, contains vitamin A, B1, B2, C and P, and further contains protein and calcium. Has effects in dispelling blood stasis, relieving pain, relieving swelling, relaxing bowels, preventing blood vessel rupture, lowering blood pressure, and stopping hemoptysis.
Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L, which is a dried root of Glycyrrhiza uralensis Fisch. Sweet in flavor, tonify spleen and qi, clear heat and remove toxicity, dispel phlegm and stop cough, relieve spasm and alleviate pain, and harmonize the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Pumpkin, the name: cucurbita moschata (duch. ex Lam.) duch. ex Poiret) a species of cucurbitaceae family Cucurbita, an annual vine herbaceous plant. Has warm nature and sweet taste, has cancer preventing effect, helps to recover liver and kidney functions, and enhances regeneration capability of liver and kidney cells.
The invention also aims to provide a preparation method of the traditional Chinese medicine preparation, which is prepared by adopting water extraction. The preparation method comprises the following steps: weighing astragalus, salvia miltiorrhiza, rosa banksiae, lucid ganoderma, virgate wormwood herb, abrus cantoniensis hance, dayflower, polygonum cuspidatum, Chinese date, aubergine, liquorice and pumpkin according to a certain weight part, grinding into powder, adding clear water for immersing, soaking for 1-2 h, heating for primary decoction for 2-3 h, pouring out primary decoction, squeezing dregs to remove water, adding clear water for immersing again, soaking for 10-25 min, heating for secondary decoction for 1-2 h, mixing the obtained secondary decoction and the primary decoction, standing for 12-24 h, taking supernatant, heating and concentrating to half, stirring while adding amino acid protoplasm, cane sugar and sodium benzoate in sequence, boiling for 5-15 min, adding pearl concentrated solution, fully and uniformly mixing, filtering, adding water for dilution, and sterilizing to obtain the finished traditional Chinese medicine preparation.
Preferably, the amino acid primary pulp comprises the following raw materials in percentage by mass: 30-40% of silkworm chrysalis amino acid powder, 30-40% of soybean amino acid powder, 10-15% of composite amino acid powder and 20-50% of water.
Preferably, the preparation method of the amino acid primary pulp comprises the steps of sequentially adding the silkworm chrysalis amino acid powder, the soybean amino acid powder and the composite amino acid powder in corresponding parts by weight into water, carrying out ultrasonic treatment for 5-10 min, heating to 30-50 ℃, and stirring for 10-15 min to obtain the amino acid primary pulp.
Preferably, the pearl concentrated solution is prepared by grinding pearls into superfine pearl powder, adding water, uniformly stirring and heating for 10-35 min, wherein the content of the pearl powder in the pearl concentrated solution is 60-85%.
Preferably, the water is added for dilution to 8-15 times of the volume of the added concentrated pearl liquid.
The applicant combines the traditional Chinese medicine dialectical treatment and modern pharmacological research results, and obtains a traditional Chinese medicine preparation capable of effectively treating acute and chronic hepatitis B and surface antigen positive healthy carriers by comparing various formulas through years of research and tests. In the formula, the lucid ganoderma has the effects of tonifying qi and soothing nerves, is suitable for dizziness and insomnia, palpitation and shortness of breath, has a strong immune effect, is an important mechanism for preventing and treating liver diseases, the oriental wormwood has the effects of clearing away damp-heat, soothing the liver and benefiting the gallbladder, and has the effects of treating jaundice due to cold dampness and relieving liver depression, the abrus cantoniensis is sweet in taste and cool in nature, and has the effects of helping dampness and removing jaundice, damp-heat in liver and gallbladder, soothing the liver and relieving pain, and the three are monarch drugs; the salvia miltiorrhiza has the effects of expanding and improving microcirculation, activating blood and cooling blood, the elecampane can regulate qi and relieve pain, the polygonum cuspidatum can clear away heat and toxic materials, promote diuresis and remove jaundice, dissipate blood stasis and relieve pain, the amino acid protoplasm can supplement energy for a human body and greatly improve immunity, and the salvia miltiorrhiza is a ministerial drug; the astragalus is sweet and mild in nature, is an essential drug for tonifying qi, is used for tonifying middle-jiao and qi, consolidating superficial resistance, strengthening spleen, drowsiness, weakness and short breath, and improving immunity, the dayflower can induce diuresis to alleviate edema, and the liquorice tonifies spleen and qi, is helpful for the lucid ganoderma and the oriental wormwood to be used as adjuvant drugs; the jujube is rich in protein and fat, the purple eggplant has the effects of calming blood and relieving pain, the pumpkin assists in recovering liver function, and the pearl concentrated solution can nourish liver and improve eyesight and enhance human body resistance, and is a messenger drug.
Due to the adoption of the technical scheme, the invention has the following beneficial effects:
(1) the traditional Chinese medicine preparation is prepared from various traditional Chinese medicinal materials and plant extracts, is safe and mild, has little side effect on human bodies, has the effects of enriching blood and tonifying qi, and effectively treating hepatitis B and surface antigen positive healthy carriers, and in addition, can improve the immune function of organisms, inhibit viruses, nourish liver and tonify kidney, and clear heat and remove toxicity.
(2) Clinical tests prove that the traditional Chinese medicine preparation has a cure rate of 13-17% for hepatitis B and a total effective rate of 95.7%, so that the traditional Chinese medicine preparation can effectively treat the hepatitis B, clinical observations prove that the traditional Chinese medicine preparation has a remarkable curative effect on the hepatitis B, has a quick curative effect, can obviously relieve or disappear after being generally taken for 1 treatment course by a patient, does not have abnormal changes and adverse reactions on the renal function and the hematopoietic system of the patient, does not cause disease rebound after stopping taking the medicine, and is safe and reliable for clinical administration.
(3) The traditional Chinese medicine composition and the preparation thereof have the advantages of scientific and reasonable formula, small side effect, simple preparation method and low preparation cost, can greatly reduce the physical and economic burden of patients, and have great popularization value.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below with reference to preferred embodiments. It should be noted, however, that the numerous details set forth in the description are merely for the purpose of providing the reader with a thorough understanding of one or more aspects of the present invention, which may be practiced without these specific details.
Example 1
Weighing 4 parts of astragalus membranaceus, 1 part of salvia miltiorrhiza, 5 parts of costus root, 1 part of lucid ganoderma, 1 part of oriental wormwood, 1 part of abrus cantoniensis hance, 4 parts of dayflower, 1 part of polygonum cuspidatum, 1 part of Chinese date, 1 part of eggplant, 0.1 part of liquorice, 1 part of pumpkin, 15 parts of amino acid raw pulp, 10 parts of pearl concentrated solution, 10 parts of sucrose and 0.02 part of sodium benzoate.
The preparation method comprises the following steps: weighing radix astragali, radix salviae miltiorrhizae, radix rosae rubra, lucid ganoderma, herba artemisiae capillaris, herba abri, dayflower, polygonum cuspidatum, Chinese date, purple eggplant, liquorice and pumpkin according to a certain weight part, grinding the materials into powder, adding clear water for immersing, soaking for 1h, heating for primary decoction for 2h, pouring out primary decoction, squeezing the residues to remove water, adding clear water for immersing again, soaking for 10min, heating for secondary decoction for 1h, mixing the obtained secondary decoction and the primary decoction, standing for 12h, taking supernatant, heating and concentrating to half, sequentially adding amino acid protoplasm, cane sugar and sodium benzoate while stirring, boiling for 5min, adding pearl concentrate, fully and uniformly mixing, filtering, adding water for dilution, and sterilizing to obtain the finished traditional Chinese medicine preparation.
Example 2
Weighing 15 parts of astragalus membranaceus, 6 parts of salvia miltiorrhiza, 13 parts of costus root, 4 parts of lucid ganoderma, 4 parts of oriental wormwood, 5 parts of abrus cantoniensis hance, 9 parts of dayflower, 6 parts of polygonum cuspidatum, 6 parts of Chinese date, 3 parts of eggplant, 0.1-2 parts of liquorice, 4 parts of pumpkin, 40 parts of amino acid raw pulp, 28 parts of pearl concentrated solution, 18 parts of sucrose and 0.05 part of sodium benzoate.
The preparation method comprises the following steps: weighing radix astragali, radix salviae miltiorrhizae, radix rosae rubra, lucid ganoderma, herba artemisiae capillaris, herba abri, dayflower, polygonum cuspidatum, Chinese date, purple eggplant, liquorice and pumpkin according to a certain weight part, grinding into powder, adding clear water to immerse the powder, soaking the powder for 2 hours, heating the powder to decoct for 3 hours, pouring out primary decoction liquid, adding clear water to immerse the residues again after squeezing the residues to remove water, soaking the residues for 25 minutes, heating the decoction for 2 hours, mixing the obtained secondary decoction liquid and the primary decoction liquid, standing the mixture for 24 hours, taking supernatant liquid to heat and concentrate to half, sequentially adding amino acid protoplasm, cane sugar and sodium benzoate while stirring, boiling the mixture for 15 minutes, adding pearl concentrate, fully mixing the mixture, filtering the mixture, adding water to dilute the mixture, and sterilizing the finished product of the traditional Chinese medicine preparation.
Example 3
Weighing 6 parts of astragalus membranaceus, 2 parts of salvia miltiorrhiza, 7 parts of costus root, 2 parts of lucid ganoderma, 2 parts of oriental wormwood, 2 parts of abrus cantoniensis hance, 5 parts of dayflower, 3 parts of polygonum cuspidatum, 3 parts of Chinese date, 2 parts of purple eggplant, 0.5 part of liquorice, 2 parts of pumpkin, 20 parts of amino acid raw pulp, 15 parts of pearl concentrated solution, 12 parts of sucrose and 0.03 part of sodium benzoate.
The preparation method comprises the following steps: weighing radix astragali, radix salviae miltiorrhizae, radix rosae rubra, lucid ganoderma, herba artemisiae capillaris, herba abri, dayflower, polygonum cuspidatum, Chinese date, purple eggplant, liquorice and pumpkin according to a certain weight part, grinding the materials into powder, adding clear water for immersing, soaking for 1h, heating for primary decoction for 2h, pouring out primary decoction, squeezing the residues to remove water, adding clear water for immersing again, soaking for 10min, heating for secondary decoction for 1h, mixing the obtained secondary decoction and the primary decoction, standing for 12h, taking supernatant, heating and concentrating to half, sequentially adding amino acid protoplasm, cane sugar and sodium benzoate while stirring, boiling for 5min, adding pearl concentrate, fully and uniformly mixing, filtering, adding water for dilution, and sterilizing to obtain the finished traditional Chinese medicine preparation.
Example 4
Weighing 10 parts of astragalus membranaceus, 4 parts of salvia miltiorrhiza, 10 parts of costus root, 3 parts of lucid ganoderma, 3 parts of oriental wormwood, 4 parts of abrus cantoniensis hance, 8 parts of dayflower, 5 parts of polygonum cuspidatum, 5 parts of Chinese date, 3 parts of eggplant, 0.5-1.5 parts of liquorice, 3 parts of pumpkin, 30 parts of amino acid raw pulp, 22 parts of pearl concentrate, 15 parts of sucrose and 0.04 part of sodium benzoate.
The preparation method comprises the following steps: weighing radix astragali, radix salviae miltiorrhizae, radix rosae rubra, lucid ganoderma, herba artemisiae capillaris, herba abri, dayflower, polygonum cuspidatum, Chinese date, purple eggplant, liquorice and pumpkin according to a certain weight part, grinding into powder, adding clear water to immerse the powder, soaking the powder for 2 hours, heating the powder to decoct for 3 hours, pouring out primary decoction liquid, adding clear water to immerse the residues again after squeezing the residues to remove water, soaking the residues for 15 minutes, heating the decoction for 2 hours, mixing the obtained secondary decoction liquid and the primary decoction liquid, standing the mixture for 24 hours, taking supernatant liquid to heat and concentrate to half, sequentially adding amino acid protoplasm, cane sugar and sodium benzoate while stirring, boiling the mixture for 15 minutes, adding pearl concentrate, fully mixing the mixture, filtering the mixture, adding water to dilute the mixture, and sterilizing the finished product of the traditional Chinese medicine preparation.
Example 5
Weighing 8 parts of astragalus membranaceus, 3 parts of salvia miltiorrhiza, 8 parts of costus root, 2.5 parts of lucid ganoderma, 2.5 parts of oriental wormwood, 3 parts of abrus cantoniensis hance, 6 parts of dayflower, 4 parts of polygonum cuspidatum, 4 parts of Chinese date, 2.5 parts of purple eggplant, 1 part of liquorice, 3 parts of pumpkin, 25 parts of amino acid raw pulp, 48 parts of pearl concentrated solution, 14 parts of sucrose and 0.03 part of sodium benzoate.
The preparation method comprises the following steps: weighing radix astragali, radix salviae miltiorrhizae, radix rosae rubra, lucid ganoderma, herba artemisiae capillaris, herba abri, dayflower, polygonum cuspidatum, Chinese date, purple eggplant, liquorice and pumpkin according to a certain weight part, grinding into powder, adding clear water to immerse the powder, soaking the powder for 2 hours, heating the powder to decoct for 3 hours, pouring out primary decoction liquid, adding clear water to immerse the residues again after squeezing the residues to remove water, soaking the residues for 20 minutes, heating the decoction for 2 hours, mixing the obtained secondary decoction liquid and the primary decoction liquid, standing the mixture for 18 hours, taking supernatant liquid to heat and concentrate to half, sequentially adding amino acid protoplasm, cane sugar and sodium benzoate while stirring, boiling the mixture for 10 minutes, adding pearl concentrate, fully mixing the mixture, filtering the mixture, adding water to dilute the mixture, and sterilizing the finished product of the traditional Chinese medicine preparation.
Summary of clinical trials
1. Basic data
189 patients diagnosed with hepatitis B were selected, wherein 98 patients with chronic hepatitis B, 91 patients with acute hepatitis B, 70 patients with the largest age, 24 patients with the smallest age and 39.6 years of average age were selected; the course of the disease is 1-15 years. Eliminating pregnant and lactating women, patients allergic to the medicine, severe cardiopulmonary dysfunction, kidney disease, hypertension, and stomach diseases.
2. Diagnostic criteria
The diagnosis was carried out with reference to the national published diagnostic standard for viral hepatitis B (WS 299-2008).
3. Method of treatment
The preparation of the embodiment 5 of the invention is used for oral treatment, 3 times a day, 10-20 ml each time, one course of treatment is 30 days for acute hepatitis B patients, and one course of treatment is 90 days for chronic hepatitis B patients.
4. Criteria for judging therapeutic effects
And (3) curing: the clinical symptoms of liver distension, yellow urine, hypodynamia, chest distress, anorexia, insomnia, dreaminess and the like disappear.
The effect is shown: the clinical symptoms such as liver distension, yellow urine, hypodynamia, chest distress, anorexia, insomnia, dreaminess and the like are relieved and obviously improved.
The method has the following advantages: the clinical symptoms such as liver distension, yellow urine, hypodynamia, chest distress, anorexia, insomnia, dreaminess and the like are relieved and are slightly improved.
And (4) invalidation: there was no improvement in symptoms, essentially the same as before treatment, or an increase in the number, extent and duration of pain episodes.
5. Results
After 5 courses of treatment, the clinical efficacy is shown in table 1.
TABLE 1 therapeutic Effect
| Disorders of the disease | Cure/example | Significant effects/examples | Effective/example | Invalid/example | Percent cure rate/%) | Total effective rate/%) |
| Acute hepatitis B | 12 | 51 | 21 | 7 | 13.2 | 92.3 |
| Chronic hepatitis B | 19 | 50 | 23 | 6 | 19.4 | 93.9 |
| Total number of | 31 | 101 | 44 | 13 | 16.4 | 95.7 |
As can be seen from the table 1, after 1 course of treatment, the cure rate of the traditional Chinese medicine preparation of the invention to hepatitis B reaches 16.4%, the total effective rate is 95.7%, thus the traditional Chinese medicine preparation of the invention can effectively treat hepatitis B, clinical observation shows that the traditional Chinese medicine preparation of the invention has obvious curative effect to hepatitis B, and the curative effect is rapid, the treatment speed to symptoms such as liver swelling, yellow urine, hypodynamia, chest distress, poor appetite, insomnia and dreaminess is rapid, patients can feel obviously relieved or disappear after taking the traditional Chinese medicine preparation for 1 course of treatment, abnormal changes and adverse reactions are not found to the renal function and hematopoietic system of the patients, the disease condition does not appear to rebound after stopping taking the traditional Chinese medicine preparation, and the clinical administration is safe and reliable.
Typical cases
First, chronic hepatitis B
Case 1: zhang XX, female, 38 years old.
The main complaints are: the chronic hepatitis B is not cured for two years, and symptoms are manifested by fatigue, weakness, liver pain, loose stool, drowsiness, abdominal pain, deep and thready pulse, and the like. Patients take a plurality of western medicines, but stop taking the medicines due to nausea and stomach discomfort reaction during taking. After the traditional Chinese medicine preparation is taken for one month, all symptoms are reduced, and no adverse reaction is caused during the taking. After taking for three months, the liver function is basically recovered to normal.
Case 2: what X, male, 50 years old.
The main complaints are: the liver function of patients with chronic hepatitis B is not recovered all the time through the treatment of the combination of Chinese and Western medicines. The clinical symptoms comprise mental fatigue, slight abdominal distension, dry and bitter mouth, deep and thready pulse and the like, and after the traditional Chinese medicine preparation disclosed by the invention is taken for 2 months, all symptoms are reduced, and no adverse reaction exists during the taking. After the administration for three months, the liver function is recovered to normal.
Acute hepatitis B
Case 3: old XX, male, 65 years old.
The main complaints are: due to fever, general weakness, cachexia, appetite reduction and bitter taste, the inspection shows that: two-half quantitative HBsAg: 138, HBeAg: 5.1. anti-HBe: 1.55. anti-HBc: 4.49, 1.5g of cefonicid, 1 part of energy mixture and 5-20mg of dexamethasone are given for intravenous drip, and after the traditional Chinese medicine preparation is taken for 1 month, all indexes of liver function are checked to be normal, and big three positive turns negative; DNA (-), reaching the national standards for cure.
Case 4: chen XX, female, 36 years old.
The main complaints are: fever, general debilitation, mental deficiency, loss of appetite, bitter taste, yellow tongue coating, distending sensation or discomfort in the upper abdomen, yellow urine, signs: the sclera is not yellow, and the liver is swollen with dull pain; laboratory examination: three minor positive with abnormal liver function ALT: 672 units, AST: 596 units, Y-GT: 256 units of DNA (-) are taken, and after one treatment course, each index of liver function is checked to be normal.
In conclusion, the traditional Chinese medicine preparation for treating hepatitis B has the advantages of good treatment effect, safety, reliability and no side effect.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be construed as the protection scope of the present invention.
Claims (7)
1. A Chinese medicinal preparation for treating hepatitis B is characterized in that: the composition is prepared from the following raw materials in parts by weight: 4-15 parts of astragalus membranaceus, 1-6 parts of salvia miltiorrhiza, 5-13 parts of elecampane, 1-4 parts of lucid ganoderma, 1-4 parts of oriental wormwood, 1-5 parts of abrus cantoniensis hance, 4-9 parts of dayflower, 1-6 parts of polygonum cuspidatum, 1-6 parts of Chinese date, 1-3 parts of purple eggplant, 0.1-2 parts of liquorice, 1-4 parts of pumpkin, 15-40 parts of amino acid raw pulp, 10-28 parts of pearl concentrated solution, 10-18 parts of sucrose and 0.02-0.05 part of sodium benzoate;
the amino acid raw pulp comprises the following raw materials in percentage by mass: 30-40% of silkworm chrysalis amino acid powder, 30-40% of soybean amino acid powder, 10-15% of composite amino acid powder and 20-50% of water.
2. The traditional Chinese medicine preparation for treating hepatitis B according to claim 1, which is characterized in that: the composition is prepared from the following raw materials in parts by weight: 6-10 parts of astragalus membranaceus, 2-4 parts of salvia miltiorrhiza, 7-10 parts of elecampane, 2-3 parts of lucid ganoderma, 2-3 parts of oriental wormwood, 2-4 parts of abrus cantoniensis hance, 5-8 parts of dayflower, 3-5 parts of polygonum cuspidatum, 3-5 parts of Chinese date, 2-3 parts of purple eggplant, 0.5-1.5 parts of liquorice, 2-3 parts of pumpkin, 20-30 parts of amino acid raw pulp, 15-22 parts of pearl concentrated solution, 12-15 parts of cane sugar and 0.03-0.04 part of sodium benzoate.
3. The Chinese medicinal preparation for treating hepatitis B according to claim 1 or 2, which is characterized in that: the active ingredients of the Chinese medicinal preparation are prepared by water extraction.
4. The traditional Chinese medicine preparation for treating hepatitis B according to claim 3, which is characterized in that: the preparation method of the traditional Chinese medicine preparation comprises the following steps: weighing astragalus, salvia miltiorrhiza, rosa banksiae, lucid ganoderma, virgate wormwood herb, abrus cantoniensis hance, dayflower, polygonum cuspidatum, Chinese date, aubergine, liquorice and pumpkin according to a certain weight part, grinding into powder, adding clear water for immersing, soaking for 1-2 h, heating for primary decoction for 2-3 h, pouring out primary decoction, squeezing dregs to remove water, adding clear water for immersing again, soaking for 10-25 min, heating for secondary decoction for 1-2 h, mixing the obtained secondary decoction and the primary decoction, standing for 12-24 h, taking supernatant, heating and concentrating to half, stirring while adding amino acid protoplasm, cane sugar and sodium benzoate in sequence, boiling for 5-15 min, adding pearl concentrated solution, fully and uniformly mixing, filtering, adding water for dilution, and sterilizing to obtain the finished traditional Chinese medicine preparation.
5. The traditional Chinese medicine preparation for treating hepatitis B according to claim 1, which is characterized in that: the preparation method of the amino acid raw pulp comprises the steps of sequentially adding the silkworm chrysalis amino acid powder, the soybean amino acid powder and the composite amino acid powder in corresponding mass parts into water, carrying out ultrasonic treatment for 5-10 min, heating to 30-50 ℃, and stirring for 10-15 min to obtain the amino acid raw pulp.
6. The traditional Chinese medicine preparation for treating hepatitis B according to claim 1, which is characterized in that: the pearl concentrated solution is prepared by grinding pearls into superfine pearl powder, adding water, uniformly stirring, and heating for 10-35 min, wherein the content of the pearl powder in the pearl concentrated solution is 60-85%.
7. The Chinese materia medica preparation for treating hepatitis B according to claim 6, which is characterized in that: the water is added for dilution until the volume of the added concentrated pearl liquid is 8-15 times of the volume of the added concentrated pearl liquid.
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| CN1943658B (en) * | 2005-10-08 | 2010-11-10 | 周小明 | A Chinese traditional medicinal composition for treating acute, chronic hepatitis and preparing method |
| CN102048998A (en) * | 2009-10-28 | 2011-05-11 | 江西三琦药业有限公司 | Medicine prepared by taking termites as main raw material and used for treating hepatitis B |
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