CN1088105A - Treatment chronic viral hepatitis B medicine - Google Patents
Treatment chronic viral hepatitis B medicine Download PDFInfo
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- CN1088105A CN1088105A CN 92114542 CN92114542A CN1088105A CN 1088105 A CN1088105 A CN 1088105A CN 92114542 CN92114542 CN 92114542 CN 92114542 A CN92114542 A CN 92114542A CN 1088105 A CN1088105 A CN 1088105A
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- extract
- viral hepatitis
- chronic viral
- medicine
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Abstract
The invention discloses a kind of treatment chronic viral hepatitis B medicine, the methanolic extract and the macroporous resin extract that belong to (Phyllanttuis) Cacumen Securinegae Suffruticosae (P.urirnaria.L), close Citrus chachiensis Hort. grass (P.matsumarae.H) or Ye Houzhu (P.simplet.R) for the plant phyllanthus emblica, can effectively suppress duplicating of chronic viral hepatitis B virus, clinical trial reaches 62.5% to e antigen positive negative conversion rate, abnormal liver function improvement rate 100%, and curative effect is lasting, side effect is little, raw material resources are abundant, technology is simple, with low cost, the remarkable benefit of exploiting natural resources.
Description
The present invention is relevant with the treatment chronic viral hepatitis B, provides a kind of medicine for the treatment of hepatitis B, particularly a kind of medicine that can effectively suppress its virus replication.
Hepatitis B is that the whole world comprises the very popular infectious disease of China.At present both at home and abroad medicine probably is divided three classes: 1. hepatinica, 2. regulate the medicine of immune function, and 3. suppress the medicine that hepatitis virus is duplicated.Be used for clinical curative human blood interferon abroad, HBV is suppressed effect only 25～32%, and virus replication will recover after the drug withdrawal, and toxic and side effects costs an arm and a leg greatly; State's giving drugs into nose glycyrrhizin clinical effectiveness is undesirable.Patent documentation report: benzene, ethane, the methanolic extract of Phyllanttuis nirari.L all can suppress WoodckuekhepatisVivs(WHV during the plant phyllanthus emblica belonged to) effect of archaeal dna polymerase, and can suppress the activity of WHV surface antigen, can suppress the activity of HBV-DNA polymerase and suppress the HBsAg activity in vitro tests.
The objective of the invention is to utilize China's phyllanthus emblica platymiscium resources advantage, opened up new medicament sources, thereby obtain cheap treatment chronic viral hepatitis B medicine.
The present invention is that the plant phyllanthus emblica belongs to pure eluting part and preparation series thereof in methanolic extract, Diluted Alcohol extract or the macroporous resin extract of Cacumen Securinegae Suffruticosae (P.urirnaria.L), close Citrus chachiensis Hort. grass (P.matsumarae.H) or Ye Houzhu (P.simplet.R).
Production extraction process of the present invention is to adopt well-established law to extract.
Embodiment: Fig. 1 is the technological process that methanol of the present invention (Diluted Alcohol) extracts, and Fig. 2 is the technological process of macroporous resin extraction of the present invention.Methanol of the present invention (Diluted Alcohol) extraction and preparation technique such as accompanying drawing 1 are pulverized crude drug in whole, and methanol or Diluted Alcohol soaked after one day, cold oozing to the color light green, to original volume 1/3, add precipitant at 80 ℃～90 ℃ decompression recycling ethanols, filter, filtrate is concentrated into the extractum shape, must measure at the per kilogram crude drug is 31g～80g, and (recovery rate 3%～8%) adds adjuvant and make the 0.5g/ sheet, dose is each 2, every day three times.Macroporous resin extraction preparation technology of the present invention such as accompanying drawing 2, crude drug in whole is soaked, and temperature maintenance is at 60 ℃～80 ℃, boiled after two hours one hour, and then add water boil three times, the decocting liquid cooling is but filtered, macroporous resin adsorption, washing is with 50%～95% ethanol elution, at 80 ℃～90 ℃ decompression recycling ethanols, to the extractum shape, add adjuvant and make the 0.5g/ sheet, dose is each 2, every day three times.
Embodiment: Lee *, the man, 18 years old, at the beginning of 1991, be diagnosed as the chronic virus b active hepatitis, oral medication chronic viral hepatitis B medicine (tablet), every day three times, each 2, through two months courses of treatment, its virus marker quality testing is surveyed the result for e antigen is turned out cloudy, the cloudy sun that changes of e antibody, follow up a case by regular visits to the e antigen negative half a year, therapeutic effect is good.Two months courses of treatment, do not see toxicity.
The present invention has obvious protective effect through pharmacological evaluation to rats'liver damage due to the ccl, and toxic and side effects is minimum; Clinical trial 30 examples reach 62.5%, abnormal liver function improvement rate 100% to chronic viral hepatitis B e antigen positive negative conversion rate.Raw material resources required for the present invention are abundant, and technology is simple, and is with low cost, the remarkable benefit of exploiting natural resources.
Claims (2)
1, a kind of medicine for the treatment of chronic viral hepatitis B, derive from the extract that phyllanthus emblica belongs to (Phyllanttis) plant Cacumen Securinegae Suffruticosae (P.urlrnarla.L), close Citrus chachiensis Hort. grass (P.matsumarae.H) or Ye Houzhu (P.simplrt.R), it is characterized in that extract is a pure eluting part in methanolic extract, Diluted Alcohol extract or the macroporous resin extract.
2, treatment chronic viral hepatitis B medicine according to claim 1 is characterized in that component is to remove the material of water-soluble solution behind the impurity in ethanol extract with precipitant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114542 CN1088105A (en) | 1992-12-17 | 1992-12-17 | Treatment chronic viral hepatitis B medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92114542 CN1088105A (en) | 1992-12-17 | 1992-12-17 | Treatment chronic viral hepatitis B medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1088105A true CN1088105A (en) | 1994-06-22 |
Family
ID=4946991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92114542 Pending CN1088105A (en) | 1992-12-17 | 1992-12-17 | Treatment chronic viral hepatitis B medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1088105A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079258C (en) * | 1999-01-21 | 2002-02-20 | 云南西电肝病防治所 | Yexiazhu tablet for treating hepatism |
| CN1112198C (en) * | 2000-04-26 | 2003-06-25 | 中国科学院昆明植物研究所 | Thrombolytic medicine and its preparation and use |
| CN108164545A (en) * | 2018-02-27 | 2018-06-15 | 昆明理工大学 | A kind of sesquiterpenoids derivative and its application in treatment hepatitis B diseases drug is prepared |
-
1992
- 1992-12-17 CN CN 92114542 patent/CN1088105A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1079258C (en) * | 1999-01-21 | 2002-02-20 | 云南西电肝病防治所 | Yexiazhu tablet for treating hepatism |
| CN1112198C (en) * | 2000-04-26 | 2003-06-25 | 中国科学院昆明植物研究所 | Thrombolytic medicine and its preparation and use |
| CN108164545A (en) * | 2018-02-27 | 2018-06-15 | 昆明理工大学 | A kind of sesquiterpenoids derivative and its application in treatment hepatitis B diseases drug is prepared |
| CN108164545B (en) * | 2018-02-27 | 2020-10-02 | 昆明理工大学 | Sesquiterpenoids derivative and application thereof in preparing medicament for treating hepatitis B disease |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |