CN108785484A - A kind of composition and its preparation method for toxin elimination and clot absorbing - Google Patents
A kind of composition and its preparation method for toxin elimination and clot absorbing Download PDFInfo
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention provides a kind of composition and its preparation method for toxin elimination and clot absorbing, the composition is mainly made of oyster, santal, Inula britannica chinensis, silk floss Bi , the dried immature fruit of citron orange, Chu Shizi, aster, rhizoma menispermi and the root of bidentate achyranthes according to certain parts by weight, and the composition has extraordinary therapeutic effect to breast cancer.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of compositions and its preparation method for toxin elimination and clot absorbing.
Background technology
For breast cancer mainly caused by troubled thoughts pent-up, the liver and spleen circulation of vital energy in the wrong direction, qi depression to blood stasis, qi depression to blood stasis refers to the operation because of gas
Stasis is unsmooth, leads to blood operation obstacle, the pathological state of blood stasis occurs；Qi depression to blood stasis is mostly because of feelings will internal injury, depressed unsuccessful, gas
Machine blocks, liver controlling conveyance and dispersion and store blood, and the catharsis of irritability, which acts in QI movement being in harmonious way, plays key effect, thus qi depression to blood stasis mostly with
Liver dysfunction is closely related, clinically the diseases such as poly-, disease product of common fullness in chest and hypochondrium pain, lump in the abdomen.
Currently, operation is the most important method of Current therapeutic breast cancer, but operation is the tangible product of removal breast, and residual poison
Still exist, chemotherapeutic category heat toxin, radiotherapy category fire-evil, heat evil, these perverse trends are to the internal organs damage of human body it is clear that being therefore badly in need of one
The toxin elimination and clot absorbing product for treating breast cancer that kind toxic side effect is small, curative effect is high.
Invention content
In order to solve the above technical problem, the present invention provides a kind of composition and its preparation method for toxin elimination and clot absorbing, the use
Have the function of toxin elimination and clot absorbing in the composition of toxin elimination and clot absorbing, especially there is good therapeutic effect to breast cancer.
Specific technical solution of the present invention is as follows：
The present invention provides a kind of composition for toxin elimination and clot absorbing, this is used for the composition of toxin elimination and clot absorbing mainly by following heavy
The raw material of amount part is prepared：
Further to improve, which is prepared by the raw material of following parts by weight：
The present invention is obtained by lot of experiments, using oyster, santal, Inula britannica chinensis, silk floss Bi ?, the dried immature fruit of citron orange, Chu Shizi, purple
The composition for toxin elimination and clot absorbing of aster, rhizoma menispermi and root of bidentate achyranthes composition, mutual compatibility between each traditional Chinese medicine ingredients, synergy, energy
Enough play the role of toxin elimination and clot absorbing, effectively treat breast cancer, has no toxic side effect.
Further to improve, the composition for toxin elimination and clot absorbing is prepared via a method which to obtain：
A. it takes the oyster of formula ratio to be positioned in refiner, the distilled water of 0.1 times of oyster weight is added, with 12000-
The speed of 16000rpm handles 8-10min, and taking-up homogenate, which is positioned in 80 DEG C of distilled water, to be extracted twice, extracts 2- every time
The volume ratio of 4h, homogenate and water is 1:10-20 collects each secondary leaching liquor, and 20- is centrifuged with the speed of 2000-4000rpm
30min takes supernatant, and oyster leaching liquor is made；
B. the santal of formula ratio, the dried immature fruit of citron orange, rhizoma menispermi, aster and the root of bidentate achyranthes are positioned in volatile oil extractor and are extracted with water four
Secondary, santal, the dried immature fruit of citron orange, rhizoma menispermi and the total weight of aster and the solid-to-liquid ratio of water are 1:12-16, each extraction conditions are extraction temperature
80-90 DEG C of degree, extraction time 4-8h；Volatile oil is removed, each secondary filtrate is merged and is filtered, the 1/4-1/6 of original volume is concentrated into, is made
Obtain mixed extract；
c：The Inula britannica chinensis of formula ratio, silk floss Bi ?and Chu Shizi are extracted with the ethanol solution of a concentration of 40%-60%,
The solid-to-liquid ratio of Inula britannica chinensis, the total weight of silk floss Bi ?and Chu Shizi and ethanol solution is 1:15-20, each extraction conditions are to extract
65-75 DEG C of temperature, extraction time 6-10h, three times, filtering, merging filtrate is concentrated into the 1/2 of original volume for extraction, is added and concentrates
The ethyl acetate of liquid phase same volume extracts 3-4min, detaches ester layer, is concentrated under reduced pressure, evaporates into dried powder, and mixed-powder is made；
d：Mixed extract made from oyster leaching liquor made from step a and step b is merged, is uniformly mixed, is concentrated, is done
It is dry to be uniformly mixed with mixed-powder made from step c to powder, then by the powder, composition is made.
Wherein, solid-to-liquid ratio refers to the ratio of the weight g of something and the volume mL of liquid.
In order to convenient to take, pill will be made for the composition of toxin elimination and clot absorbing and auxiliary material in the present invention, wherein composition with
The weight part ratio of auxiliary material is 1-2:0.2-0.5.
Further to improve, auxiliary material includes 0.1-0.3 parts of arginine and 0.5-0.7 parts of hydroxypropyl methylcellulose K100M.
The present invention can significantly improve the stability of pill by the way that arginine and hydroxypropyl methylcellulose K100M is added, and extend it and guarantee the quality
Phase.
Further to improve, auxiliary material further includes 1-1.5 parts of leucine and 0.2-0.6 parts of gallic acid ester.The present invention passes through
The mixture of leucine and gallic acid ester is added in auxiliary material, can play the role of oxidation resistant.
Further to improve, auxiliary material further includes 1.2-2 parts of Sorbitan Trioleate and 0.5-0.7 parts of polyoxyethylene stearate
(40) ester.It is provided by the invention by the way that Sorbitan Trioleate and polyoxyethylene stearate (40) ester are added in auxiliary material, can play
Shorten the purpose for leaching the time limit.
Another aspect of the present invention provides a kind of composition for toxin elimination and clot absorbing in the product for preparing treatment breast cancer
Using.
The present invention is using oyster and santal as monarch drug in a prescription, using Inula britannica chinensis, silk floss Bi ?as ministerial drug, with aster, the dried immature fruit of citron orange, Chu Shizi, north
Beans root is adjutant, is that medicine, monarch mutual reinforcement between is made mutually to make with the root of bidentate achyranthes, reasonable compatibility, Synergy and attenuation；Wherein, oyster has soothing the liver
The effect of checking exuberance of yang, transquilization with heavy material, softening and resolving hard mass, convergence astringent method；Santal has effects that promoting qi circulation and relieving pain, warm stomach preventing or arresting vomiting；Inula britannica chinensis
Have effects that sending down abnormally ascending, dissolving phlegm；Mian Bi ?have effects that dampness removing removes turbid, wind expelling stagnation removing；There is aster moistening lung to lower qi, dissolving phlegm to stop
The effect of cough；The dried immature fruit of citron orange has effects that relieving stagnant Qi disperse accumulation, resolving sputum dissipate ruffian；Chu Shizi has effects that kidney tonifying clearing liver, improving eyesight, diuresis；
Rhizoma menispermi has effects that clearing heat and detoxicating, wind-expelling pain-stopping；The root of bidentate achyranthes has the effect of dispelling stasis of blood and stimulating the menstrual flow, filling liver kidney, strengthening the bones and muscles；It is above each
The effect of acting synergistically between ingredient, toxin elimination and clot absorbing is improved after compatible use has good therapeutic effect to breast cancer.
Beneficial effects of the present invention：The present invention provides a kind of composition and its preparation method for toxin elimination and clot absorbing, the row of being used for
The composition for poisoning the stasis of blood has the function of toxin elimination and clot absorbing, while having good therapeutic effect to breast cancer.
Specific implementation mode
A kind of 1 composition of embodiment
The composition is prepared by the raw material of following parts by weight：
A kind of 2 composition of embodiment
The composition is prepared by the raw material of following parts by weight：
A kind of 3 composition of embodiment
The composition is prepared by the raw material of following parts by weight：
A kind of 4 composition of embodiment
The composition is prepared by the raw material of following parts by weight：
The preparation method of the composition is as follows：
A. it takes the oyster of formula ratio to be positioned in refiner, the distilled water of 0.1 times of oyster weight is added, with 12000rpm's
Speed handles 8min, and taking-up homogenate, which is positioned in 80 DEG C of distilled water, to be extracted twice, extracts 2h, the body of homogenate and water every time
Product is than being 1:10, each secondary leaching liquor is collected, 20min is centrifuged with the speed of 2000rpm, takes supernatant, oyster leaching liquor is made；
B. the santal of formula ratio, the dried immature fruit of citron orange, rhizoma menispermi, aster and the root of bidentate achyranthes are positioned in volatile oil extractor and are extracted with water four
Secondary, santal, the dried immature fruit of citron orange, rhizoma menispermi and the total weight of aster and the solid-to-liquid ratio of water are 1:12, each extraction conditions are Extracting temperature 80
DEG C, extraction time 4h；Volatile oil is removed, each secondary filtrate is merged and is filtered, the 1/4 of original volume is concentrated into, mixed extract is made；
c：The Inula britannica chinensis of formula ratio, silk floss Bi ?and Chu Shizi are extracted with a concentration of 40% ethanol solution, it is sheathed
The solid-to-liquid ratio of flower, the total weight of silk floss Bi ?and Chu Shizi and ethanol solution is 1:15, each extraction conditions are Extracting temperature 65
DEG C, extraction time 6h, three times, filtering, merging filtrate is concentrated into the 1/2 of original volume for extraction, is added and concentrate same volume
Ethyl acetate extracts 3min, detaches ester layer, is concentrated under reduced pressure, evaporates into dried powder, and mixed-powder is made；
d：Mixed extract made from oyster leaching liquor made from step a and step b is merged, is uniformly mixed, is concentrated, is done
It is dry to be uniformly mixed with mixed-powder made from step c to powder, then by the powder, composition is made.
A kind of 5 composition of embodiment
The composition is prepared by the raw material of following parts by weight：
The preparation method of the composition is as follows：
A. it takes the oyster of formula ratio to be positioned in refiner, the distilled water of 0.1 times of oyster weight is added, with 14000rpm's
Speed handles 9min, and taking-up homogenate, which is positioned in 80 DEG C of distilled water, to be extracted twice, extracts 3h, the body of homogenate and water every time
Product is than being 1:15, each secondary leaching liquor is collected, 25min is centrifuged with the speed of 3000rpm, takes supernatant, oyster leaching liquor is made；
B. the santal of formula ratio, the dried immature fruit of citron orange, rhizoma menispermi, aster and the root of bidentate achyranthes are positioned in volatile oil extractor and are extracted with water four
Secondary, santal, the dried immature fruit of citron orange, rhizoma menispermi and the total weight of aster and the solid-to-liquid ratio of water are 1:14, each extraction conditions are Extracting temperature 85
DEG C, extraction time 6h；Volatile oil is removed, each secondary filtrate is merged and is filtered, the 1/5 of original volume is concentrated into, mixed extract is made；
c：The Inula britannica chinensis of formula ratio, silk floss Bi ?and Chu Shizi are extracted with a concentration of 50% ethanol solution, it is sheathed
The solid-to-liquid ratio of flower, the total weight of silk floss Bi ?and Chu Shizi and ethanol solution is 1:18, each extraction conditions are Extracting temperature 70
DEG C, extraction time 8h, three times, filtering, merging filtrate is concentrated into the 1/2 of original volume for extraction, is added and concentrate same volume
Ethyl acetate extracts 3.5min, detaches ester layer, is concentrated under reduced pressure, evaporates into dried powder, and mixed-powder is made；
d：Mixed extract made from oyster leaching liquor made from step a and step b is merged, is uniformly mixed, is concentrated, is done
It is dry to be uniformly mixed with mixed-powder made from step c to powder, then by the powder, composition is made.
A kind of 6 composition of embodiment
The composition is prepared by the raw material of following parts by weight：
The preparation method of the composition is as follows：
A. it takes the oyster of formula ratio to be positioned in refiner, the distilled water of 0.1 times of oyster weight is added, with 16000rpm's
Speed handles 10min, takes out homogenate and is positioned in 80 DEG C of distilled water and extracts twice, extracts 4h every time, homogenate and water
Volume ratio is 1:20, each secondary leaching liquor is collected, 30min is centrifuged with the speed of 4000rpm, takes supernatant, oyster leaching liquor is made；
B. the santal of formula ratio, the dried immature fruit of citron orange, rhizoma menispermi, aster and the root of bidentate achyranthes are positioned in volatile oil extractor and are extracted with water four
Secondary, santal, the dried immature fruit of citron orange, rhizoma menispermi and the total weight of aster and the solid-to-liquid ratio of water are 1:16, each extraction conditions are Extracting temperature 90
DEG C, extraction time 8h；Volatile oil is removed, each secondary filtrate is merged and is filtered, the 1/6 of original volume is concentrated into, mixed extract is made；
c：The Inula britannica chinensis of formula ratio, silk floss Bi ?and Chu Shizi are extracted with a concentration of 60% ethanol solution, it is sheathed
The solid-to-liquid ratio of flower, the total weight of silk floss Bi ?and Chu Shizi and ethanol solution is 1:20, each extraction conditions are Extracting temperature 75
DEG C, extraction time 10h, three times, filtering, merging filtrate is concentrated into the 1/2 of original volume, is added and concentrate same volume for extraction
Ethyl acetate extract 4min, detach ester layer, be concentrated under reduced pressure, evaporate into dried powder, be made mixed-powder；
d：Mixed extract made from oyster leaching liquor made from step a and step b is merged, is uniformly mixed, is concentrated, is done
It is dry to be uniformly mixed with mixed-powder made from step c to powder, then by the powder, composition is made.
A kind of 7 pill of embodiment
The pill includes each ingredient of following parts by weight：
The composition 10 of embodiment 2
Arginine 0.34
Hydroxypropyl methylcellulose K100M 1.66.
A kind of 8 pill of embodiment
The pill includes each ingredient of following parts by weight：
The composition 15 of embodiment 2
Arginine 0.75
Hydroxypropyl methylcellulose K100M 1.75.
A kind of 9 pill of embodiment
The pill includes each ingredient of following parts by weight：
A kind of 10 pill of embodiment
The pill includes each ingredient of following parts by weight：
A kind of 11 pill of embodiment
The pill includes each ingredient of following parts by weight：
A kind of 12 pill of embodiment
The pill includes each ingredient of following parts by weight：
A kind of 1 composition of reference examples
The composition is prepared by the raw material of following parts by weight：
The composition is prepared using the method for embodiment 5.
A kind of 2 composition of reference examples
The composition is prepared by the raw material of following parts by weight：
The composition is prepared using the method for embodiment 5.
A kind of 3 composition of reference examples
The composition is prepared by the raw material of following parts by weight：
The composition is prepared using the method for embodiment 5.
A kind of 4 composition of reference examples
The composition is prepared using the method for embodiment 5.
The composition is prepared using the method for embodiment 5.
A kind of 5 pill of reference examples
The pill includes each ingredient of following parts by weight：
A kind of 6 pill of reference examples
The pill includes each ingredient of following parts by weight：
A kind of 7 pill of reference examples
The pill includes each ingredient of following parts by weight：
A kind of 8 pill of reference examples
The pill includes each ingredient of following parts by weight：
1 each group composition of experimental example tests the therapeutic effect of breast cancer
1 grouping
By 190 SPF grades of BALB/c mouses (6-8 week old, female) be randomly divided into blank group, model group, positive drug group,
Test 1-3 groups, control 1-4 groups, oyster group, santal group, Inula britannica chinensis group, Mian Bi ?group, dried immature fruit of citron orange group, Chu's reality subgroup, aster group, north
Beans root and root of bidentate achyranthes group, every group 10, wherein blank group and model group give the distilled water of equivalent, and positive drug group gives equivalent
Vinorelbine, experiment 1-3 groups give the composition of test example 2-4, and control 1-4 groups give the composition of reference examples 1-4, oyster
Group gives the dried powder of the oyster aqueous extract of equivalent, and santal group gives the dried powder of the santal aqueous extract of equivalent, rotation
Cover the dried powder for the Inula britannica chinensis ethanol extract that colored group is given equivalent, Mian Bi ?group give equivalent Mian Bi ?ethanol extract
Dried powder, dried immature fruit of citron orange group gives the dried powder of the dried immature fruit of citron orange aqueous extract of equivalent, and Chu's reality subgroup gives Chu of equivalent sub- second in fact
The dried powder of alcohol extract, aster group give the dried powder of the aster aqueous extract of equivalent, and rhizoma menispermi group gives equivalent
The dried powder of rhizoma menispermi aqueous extract, root of bidentate achyranthes group give the dried powder of the root of bidentate achyranthes aqueous extract of equivalent；Dosage is
120mg/kg, administering mode are gastric infusion, are administered 8 weeks altogether.
Note：Santal, the dried immature fruit of citron orange, rhizoma menispermi, aster and the root of bidentate achyranthes aqueous extract be the aqueous extract for removing volatile oil, it is sheathed
Flower, silk floss Bi ?and Chu Shizi are extracted with ethyl acetate after being extracted with ethyl alcohol, and specific method is by the Inula britannica chinensis of formula ratio, silk floss Bi ?
Or Chu Shizi is extracted with the ethanol solution of a concentration of 40%-60%, Inula britannica chinensis, silk floss Bi ?or Chu Shizi weight and ethyl alcohol
The solid-to-liquid ratio of solution is 1:15-20, each extraction conditions are 65-75 DEG C of Extracting temperature, extraction time 6-10h, are extracted three times,
Filtering, merging filtrate are concentrated into the 1/2 of original volume, are added and extract 3-4min, separation with the ethyl acetate of concentrate same volume
Ester layer, be concentrated under reduced pressure, evaporate into dried powder to get.
2 modelings
In addition to blank group, remaining each group mouse is all made of iodophor disinfection inoculation position, and 4T1 cells are drawn with 1mL syringes
Suspension 0.2mL (contains 0.8 × 105A cell) to be inoculated in the right armpit of mouse subcutaneous, when tumor size is 2mm × 2mm, it is judged as
Model foundation success.
3 test indexs
The longest diameter and each 2 times of most wide diameter of lotus knurl are measured using vernier caliper (precision 0.02mm), and 1 is measured before execution mouse
Secondary longest diameter and most wide diameter, according to formula V=0.52 × a × b2(a is lotus knurl longest diameter, and b is the most wide diameter vertical with a) calculates
Knurl ratio after administration, puts to death mouse, removes knurl, carefully removes the connective tissues such as proliferating vessels, the envelope on knurl surface
Afterwards, it and weighs (g), the results are shown in Table 1.
Treatment results of the table 1 to breast cancer
As it can be seen from table 1 composition provided by the invention can significantly reduce the knurl weight and knurl ratio of model mice,
When changing the certain ingredients or exclusive use single component in the present composition, it can reduce the treatment to mouse tumor and make
With.
Experimental example 2 leaches time-limit test
According to《Chinese Pharmacopoeia》Method is detected specified in versions the 4th in 2015；By hanging basket, (mesh size is about
It 2mm) is hung on metallic support by the stainless steel shaft of upper end, into 1000mL beakers, and adjusts hanging basket position and make under it
Sieve fills the water that temperature is 37 ± 1 DEG C away from beaker bottom 25mm when drop in beaker, and regulating liquid surface height is sieved when hanging basket being made to increase
Net at 15mm, takes the composition of the composition and reference examples 5-8 of the embodiment of the present invention 11, is respectively placed in above-mentioned hanging basket under liquid level
Glass tube in, often manage respectively plus 1 ball, add baffle, start disintegration tester immediately and checked, observe the state of pill in glass tube,
Until all stopping timing, every group is done 6 Duplicate Samples, the results are shown in Table 2 by sieve.
2 each pill of table leaches the test result in time limit
As can be seen from Table 2, for the present invention by adding auxiliary material, can greatly shorten pill leaches the time limit.
Claims (8)
1. a kind of composition for toxin elimination and clot absorbing, which is characterized in that the composition is mainly by the raw material system of following parts by weight
It is standby to form：
2. being used for the composition of toxin elimination and clot absorbing as described in claim 1, which is characterized in that the composition is by following parts by weight
Raw material be prepared：
3. being used for the composition of toxin elimination and clot absorbing as described in claim 1, which is characterized in that the composition is by such as lower section
What method was prepared：
A. it takes the oyster of formula ratio to be positioned in refiner, the distilled water of 0.1 times of oyster weight is added, with 12000-16000rpm
Speed handle 8-10min, take out homogenate and be positioned in 80 DEG C of distilled water and extract twice, extract 2-4h, homogenate every time
Volume ratio with water is 1:10-20 collects each secondary leaching liquor, centrifuges 20-30min with the speed of 2000-4000rpm, takes supernatant
Oyster leaching liquor is made in liquid；
B. the santal of formula ratio, the dried immature fruit of citron orange, rhizoma menispermi, aster and the root of bidentate achyranthes are positioned in volatile oil extractor and are extracted with water four times,
Santal, the dried immature fruit of citron orange, rhizoma menispermi and the total weight of aster and the solid-to-liquid ratio of water are 1:12-16, each extraction conditions are Extracting temperature
80-90 DEG C, extraction time 4-8h；Volatile oil is removed, each secondary filtrate is merged and is filtered, the 1/4-1/6 of original volume is concentrated into, is made
Mixed extract；
c：The Inula britannica chinensis of formula ratio, silk floss Bi ?and Chu Shizi are extracted with the ethanol solution of a concentration of 40%-60%, it is sheathed
The solid-to-liquid ratio of flower, the total weight of silk floss Bi ?and Chu Shizi and ethanol solution is 1:15-20, each extraction conditions are Extracting temperature
65-75 DEG C, extraction time 6-10h, three times, filtering, merging filtrate is concentrated into the 1/2 of original volume for extraction, is added and concentration liquid phase
The ethyl acetate of same volume extracts 3-4min, detaches ester layer, is concentrated under reduced pressure, evaporates into dried powder, and mixed-powder is made；
d：Mixed extract made from oyster leaching liquor made from step a and step b is merged, is uniformly mixed, concentration, drying is extremely
Powder, then the powder is uniformly mixed with mixed-powder made from step c, composition is made.
4. a kind of pill is made of the composition and auxiliary material for toxin elimination and clot absorbing described in claim 1-3, which is characterized in that
The weight part ratio of the composition and auxiliary material is 1-2:0.2-0.5.
5. pill as claimed in claim 4, which is characterized in that the auxiliary material includes 0.1-0.3 parts of arginine and 0.5-0.7
The hydroxypropyl methylcellulose K100M of part.
6. pill as claimed in claim 5, which is characterized in that the auxiliary material further includes 1-1.5 parts of leucine and 0.2-0.6
The gallic acid ester of part.
7. pill as claimed in claim 6, which is characterized in that the auxiliary material further include 1.2-2 parts Sorbitan Trioleate and
0.5-0.7 parts polyoxyethylene stearate (40) ester.
8. a kind of application of claim 1-3 any one of them composition in the product for preparing treatment breast cancer.
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| CN1943771A (en) * | 2005-10-08 | 2007-04-11 | 河北以岭医药研究院有限公司 | The pharmaceutical for treatment of vascular lesion through actions on the NEI network |
| CN103520360A (en) * | 2013-10-16 | 2014-01-22 | 中国海洋大学 | Chinese herbal compound preparation, and preparation method and application of Chinese herbal compound preparation |
| CN107308436A (en) * | 2017-05-23 | 2017-11-03 | 辽宁阿里郎生物工程股份有限公司 | A kind of alleviation physical fatigue, the biological products of anti-oxidation function and preparation method |
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