CN108785446A - A kind of preparation method reducing cholesterol matrimony vine sustained release tablets - Google Patents
A kind of preparation method reducing cholesterol matrimony vine sustained release tablets Download PDFInfo
- Publication number
- CN108785446A CN108785446A CN201710281538.8A CN201710281538A CN108785446A CN 108785446 A CN108785446 A CN 108785446A CN 201710281538 A CN201710281538 A CN 201710281538A CN 108785446 A CN108785446 A CN 108785446A
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- auxiliary material
- sustained release
- release tablets
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007939 sustained release tablet Substances 0.000 title claims abstract description 25
- 244000241838 Lycium barbarum Species 0.000 title claims abstract description 21
- 235000015459 Lycium barbarum Nutrition 0.000 title claims abstract description 21
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 235000012000 cholesterol Nutrition 0.000 title claims abstract description 7
- 239000000843 powder Substances 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 22
- 239000011122 softwood Substances 0.000 claims abstract description 22
- 239000003826 tablet Substances 0.000 claims abstract description 15
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 235000020717 hawthorn extract Nutrition 0.000 claims abstract description 13
- 238000012797 qualification Methods 0.000 claims abstract description 11
- 239000002245 particle Substances 0.000 claims abstract description 10
- 238000003556 assay Methods 0.000 claims abstract description 9
- 239000011812 mixed powder Substances 0.000 claims abstract description 9
- 238000007873 sieving Methods 0.000 claims abstract description 9
- 239000000080 wetting agent Substances 0.000 claims abstract description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 15
- 239000008101 lactose Substances 0.000 claims description 15
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 14
- 229930195725 Mannitol Natural products 0.000 claims description 14
- 239000000594 mannitol Substances 0.000 claims description 14
- 235000010355 mannitol Nutrition 0.000 claims description 14
- 210000003022 colostrum Anatomy 0.000 claims description 12
- 235000021277 colostrum Nutrition 0.000 claims description 12
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 11
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 claims description 11
- 239000008213 purified water Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims 1
- 241001092040 Crataegus Species 0.000 claims 1
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims 1
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims 1
- 235000009685 Crataegus X maligna Nutrition 0.000 claims 1
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims 1
- 235000009486 Crataegus bullatus Nutrition 0.000 claims 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims 1
- 235000009682 Crataegus limnophila Nutrition 0.000 claims 1
- 235000004423 Crataegus monogyna Nutrition 0.000 claims 1
- 235000002313 Crataegus paludosa Nutrition 0.000 claims 1
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims 1
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 235000014103 egg white Nutrition 0.000 claims 1
- 210000000969 egg white Anatomy 0.000 claims 1
- 238000001035 drying Methods 0.000 abstract description 16
- 239000003814 drug Substances 0.000 description 9
- 239000002994 raw material Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 235000019605 sweet taste sensations Nutrition 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- KSDSYIXRWHRPMN-UHFFFAOYSA-N 4'-O-beta-D-Galactopyranoside-6''-p-Coumaroylprunin-4',5,7-Trihydroxyflavanone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC(O)=C3C(=O)C2)C=C1 KSDSYIXRWHRPMN-UHFFFAOYSA-N 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- DEMKZLAVQYISIA-ONJCETCRSA-N Liquiritin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)c1ccc([C@@H]2Oc3c(C(=O)C2)ccc(O)c3)cc1 DEMKZLAVQYISIA-ONJCETCRSA-N 0.000 description 1
- DEMKZLAVQYISIA-UHFFFAOYSA-N Liquirtin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000020426 cherry syrup Nutrition 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000374 eutectic mixture Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- DEMKZLAVQYISIA-ZRWXNEIDSA-N liquiritin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C([C@H]2OC3=CC(O)=CC=C3C(=O)C2)C=C1 DEMKZLAVQYISIA-ZRWXNEIDSA-N 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000012858 packaging process Methods 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000014860 sensory perception of taste Effects 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- -1 through compounding Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000020985 whole grains Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/19—Dairy proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The preparation method of the present invention for reducing cholesterol matrimony vine sustained release tablets, carries out as follows：Haw thorn extract, wolfberry fruit extract and auxiliary material are crushed after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder, after above-mentioned medicinal powder is mixed 30~35 minutes, wetting agent softwood is added into mixed powder, it obtains sieving wet granular processed with 20 mesh after softwood, wet granular is dried, drying temperature is 50~55 DEG C, it is dry qualified to moisture, after particle after dry qualification crosses 20 mesh sieves, tabletting is carried out on tablet press machine, obtains the sustained release tablets.
Description
Technical field
The invention belongs to technical field of health care food, and in particular to a kind of preparation side reducing cholesterol matrimony vine sustained release tablets
Method.
Background technology
Sustained release tablets mean the tablet swallowed after chewing in oral cavity.Sustained release tablets size is generally identical as conventional tablet, can root
According to needing that Special-shaped sheet of different shapes is made.
Sustained release tablets good mouthfeel is just easily accepted by patients, and most drug ingedient especially traditional Chinese medicine ingredients mouthfeels are all poor.
Bland corrigent should be selected in the sustained release tablets of buccal absorption, to reduce the secretion of saliva.It is gulped down caused by salivary secretion
Pharynx can reduce the buccal absorption of drug, this is appropriate to the occasion to save corrigent.Not in the sustained release tablets of buccal absorption, it is typically chosen sweet taste or summary
Acidulated corrigent should give nice and cool feeling after chewing, and chance saliva can dissolve rapidly.Generally using sucrose, lactose,
Glucose, citric acid, tartaric acid etc. carry out compatibility mechanism respectively, screen suitable corrigent proportioning.Simple syrup (such as orange peel sugar
Slurry, cherry syrup, glycyrrhiza syrup etc.) to make corrigent also more common, and it not only can flavoring, moreover it is possible to cover bad smell.Mannitol and
Without grit sense when sorbierite is chewed, being dissolved in mouth can absorb heat, and have cooling feeling, be also commonly used for the corrigent of sustained release tablets, also may be used
It is used cooperatively, mutual tonifying for the deficiency.Mannitol is with good stability, no hygroscopicity, is chiefly used in the drugs such as vitamins, relieving haperacidity class
Sustained release tablets, to mitigate in mouth the uncomfortable sense of taste；And eutectic mixture can be formed with other carbohydrates (such as sucrose, lactose), have
Good mobility and compressibility, can be with direct tablet compressing.If drug taste is more bitter, the stronger aspartame of sweet taste can be used,
Sweetness ratio sucrose is 150~200 times high, and without rear bitter taste, does not easily lead to saprodontia, can also effectively reduce heat, therefore be relatively applicable in
In diabetes and obesity patient.Diabetic is also an option that stevioside, liquiritin, protein sugar, maltitol, xylose
The corrigents such as alcohol, lactose, sorbierite.
The preparation process of sustained release tablets, without too big difference, mostly uses wet granulation with conventional tablet.General technological process is：
Drug pre-treatment, softwood processed, granulation, whole grain and mix, tabletting, analysis detection, finished product.Chemicals can be directly mixed with auxiliary material
It closes, adds certain wetting agent or binder softwood.When preparing Chinese medicine sustained release tablets, generally first by medicinal material extract, isolated leaching
Then cream adds auxiliary material softwood.The active ingredient of some drugs may be impacted because of wet granulation, and powder can be used and directly press
The method of piece can improve medicine stability, such as aspirin sustained release tablet.
Invention content
Goal of the invention：Aiming at the deficiencies in the prior art, the present invention provides a kind of reduction cholesterol matrimony vine sustained releases
The preparation method of piece.
Technical solution：The preparation method of the present invention for reducing cholesterol matrimony vine sustained release tablets, carries out as follows：
Haw thorn extract, wolfberry fruit extract and auxiliary material are crushed after the assay was approved, 80 mesh is crossed and sieves to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 1~2 hour, wetting agent softwood is added into mixed powder；It obtains sieving wet granular processed with 40 mesh after softwood, it will be wet
Particle drying, drying temperature are 80~85 DEG C, dry to moisture qualification；After particle after dry qualification crosses 20 mesh sieves,
Tabletting is carried out on tablet press machine, obtains the sustained release tablets.
The proportioning of the haw thorn extract, wolfberry fruit extract and auxiliary material is：40~50 parts of haw thorn extract, matrimony vine extraction
30~35 parts of object, 10~20 parts of auxiliary material.
The auxiliary material includes following components：Colostrum basic protein fraction powder, mannitol and lactose.
The proportioning of the auxiliary material is：2~5 parts of colostrum basic protein fraction powder, 5~10 parts of mannitol, 3~5 parts of lactose.
The proportioning of the auxiliary material is：2 parts of colostrum basic protein fraction powder, 5 parts of mannitol, 3 parts of lactose.
The wetting agent is purified water.
The tabletting, piece weight 1.5g/ pieces, tablet weight variation control are weighed once ± 5% per half an hour.
Advantageous effect：The present invention using haw thorn extract, wolfberry fruit extract as primary raw material, through compounding, softwood processed, granulation,
Drying, tabletting, sterilizing and packaging process are made smooth appearance, fresh and crisp, are convenient for carrying, have good market prospects.
Specific implementation mode：
Embodiment 1
Formula：40 parts of haw thorn extract, 30 parts of wolfberry fruit extract, 2 parts of colostrum basic protein fraction powder, 5 parts of mannitol, lactose 3
Part.
Above-mentioned raw materials and auxiliary material are weighed by formula, crushes after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 30~35 minutes, purified water softwood is added into mixed powder, obtains sieving wet granular processed, general with 20 mesh after softwood
Wet granular is dried, and drying temperature is 50 DEG C, dry to be pressed after the particle after drying is qualified crosses 20 mesh sieves to moisture qualification
Tabletting, piece weight 1.5g/ pieces are carried out on piece machine, tablet weight variation control weighs once per half an hour ± 5%, obtains sustained release tablets.
Embodiment 2
Formula：50 parts of haw thorn extract, 35 parts of wolfberry fruit extract, 5 parts of colostrum basic protein fraction powder, 10 parts of mannitol, lactose 5
Part.
Above-mentioned raw materials and auxiliary material are weighed by formula, crushes after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 30~35 minutes, purified water softwood is added into mixed powder, obtains sieving wet granular processed, general with 20 mesh after softwood
Wet granular is dried, and drying temperature is 50 DEG C, dry to be pressed after the particle after drying is qualified crosses 20 mesh sieves to moisture qualification
Tabletting, piece weight 1.5g/ pieces are carried out on piece machine, tablet weight variation control weighs once per half an hour ± 5%, obtains sustained release tablets.
Embodiment 3
Formula：40 parts of haw thorn extract, 35 parts of wolfberry fruit extract, 5 parts of colostrum basic protein fraction powder, 0 part of mannitol, lactose 5
Part.
Above-mentioned raw materials and auxiliary material are weighed by formula, crushes after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 30~35 minutes, purified water softwood is added into mixed powder, obtains sieving wet granular processed, general with 20 mesh after softwood
Wet granular is dried, and drying temperature is 50 DEG C, dry to be pressed after the particle after drying is qualified crosses 20 mesh sieves to moisture qualification
Tabletting, piece weight 1.5g/ pieces are carried out on piece machine, tablet weight variation control weighs once per half an hour ± 5%, obtains sustained release tablets.
Embodiment 4
Formula：50 parts of haw thorn extract, 30 parts of wolfberry fruit extract, 5 parts of colostrum basic protein fraction powder, 5 parts of mannitol, lactose 5
Part.
Above-mentioned raw materials and auxiliary material are weighed by formula, crushes after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 30~35 minutes, purified water softwood is added into mixed powder, obtains sieving wet granular processed, general with 20 mesh after softwood
Wet granular is dried, and drying temperature is 50 DEG C, dry to be pressed after the particle after drying is qualified crosses 20 mesh sieves to moisture qualification
Tabletting, piece weight 1.5g/ pieces are carried out on piece machine, tablet weight variation control weighs once per half an hour ± 5%, obtains sustained release tablets.
Embodiment 5
Formula：50 parts of haw thorn extract, 30 parts of wolfberry fruit extract, 5 parts of colostrum basic protein fraction powder, 10 parts of mannitol, lactose 5
Part.
Above-mentioned raw materials and auxiliary material are weighed by formula, crushes after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 30~35 minutes, purified water softwood is added into mixed powder, obtains sieving wet granular processed, general with 20 mesh after softwood
Wet granular is dried, and drying temperature is 50 DEG C, dry to be pressed after the particle after drying is qualified crosses 20 mesh sieves to moisture qualification
Tabletting, piece weight 1.5g/ pieces are carried out on piece machine, tablet weight variation control weighs once per half an hour ± 5%, obtains sustained release tablets.
Embodiment 6
Formula：50 parts of haw thorn extract, 30 parts of wolfberry fruit extract, 5 parts of colostrum basic protein fraction powder, 10 parts of mannitol, lactose 5
Part.
Above-mentioned raw materials and auxiliary material are weighed by formula, crushes after the assay was approved, sieve with 100 mesh sieve to obtain medicinal powder；It will be above-mentioned
After medicinal powder mixes 30~35 minutes, purified water softwood is added into mixed powder, obtains sieving wet granular processed, general with 20 mesh after softwood
Wet granular is dried, and drying temperature is 50 DEG C, dry to be pressed after the particle after drying is qualified crosses 20 mesh sieves to moisture qualification
Tabletting, piece weight 1.5g/ pieces are carried out on piece machine, tablet weight variation control weighs once per half an hour ± 5%, obtains sustained release tablets.
Claims (7)
1. a kind of preparation method reducing cholesterol matrimony vine sustained release tablets, it is characterised in that carry out as follows：Hawthorn is extracted
Object, wolfberry fruit extract and auxiliary material crush after the assay was approved, cross 80 mesh and sieve to obtain medicinal powder；Above-mentioned medicinal powder is mixed 1~2 hour
Afterwards, wetting agent softwood is added into mixed powder；It obtains sieving wet granular processed with 40 mesh after softwood, wet granular is dried, dry temperature
Degree is 80~85 DEG C, dry to moisture qualification；After particle after dry qualification crosses 20 mesh sieves, pressed on tablet press machine
Piece obtains the sustained release tablets.
2. preparation method according to claim 1, it is characterised in that haw thorn extract, wolfberry fruit extract and the auxiliary material
Proportioning be：40~50 parts of haw thorn extract, 30~35 parts of wolfberry fruit extract, 10~20 parts of auxiliary material.
3. preparation method according to claim 1, it is characterised in that the auxiliary material includes following components：Colostrum alkalinity egg
White powder, mannitol and lactose.
4. preparation method according to claim 1, it is characterised in that the proportioning of the auxiliary material is：Colostrum basic protein fraction powder
2~5 parts, 5~10 parts of mannitol, 3~5 parts of lactose.
5. preparation method according to claim 1, it is characterised in that the proportioning of the auxiliary material is：Colostrum basic protein fraction powder
2 parts, 5 parts of mannitol, 3 parts of lactose.
6. preparation method according to claim 1, it is characterised in that the wetting agent is purified water.
7. preparation method according to claim 1, it is characterised in that the tabletting, piece weight 1.5g/ pieces, tablet weight variation control
System is weighed once ± 5% per half an hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710281538.8A CN108785446A (en) | 2017-04-26 | 2017-04-26 | A kind of preparation method reducing cholesterol matrimony vine sustained release tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710281538.8A CN108785446A (en) | 2017-04-26 | 2017-04-26 | A kind of preparation method reducing cholesterol matrimony vine sustained release tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108785446A true CN108785446A (en) | 2018-11-13 |
Family
ID=64068866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710281538.8A Pending CN108785446A (en) | 2017-04-26 | 2017-04-26 | A kind of preparation method reducing cholesterol matrimony vine sustained release tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108785446A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700888A (en) * | 2019-02-01 | 2019-05-03 | 泸州岷宏科技有限公司 | A kind of penthorum chinense pursh tablet and preparation method thereof |
-
2017
- 2017-04-26 CN CN201710281538.8A patent/CN108785446A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700888A (en) * | 2019-02-01 | 2019-05-03 | 泸州岷宏科技有限公司 | A kind of penthorum chinense pursh tablet and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101341949B (en) | Various grains chewing slice and preparation method thereof | |
| WO2018077276A1 (en) | Immunity-enhancing composition and preparation method therefor | |
| CN101617800A (en) | Fructus phyllanthi buccal tablet and preparation method thereof | |
| CN107875393B (en) | Buccal tablet flavoring agent and preparation method thereof | |
| CN101601827A (en) | A kind of Chinese medicine preparation that prevents and/or treats dry syndrome, slow down aging | |
| CN112057485B (en) | American ginseng royal jelly double-layer buccal tablet and preparation method thereof | |
| CN111149910A (en) | Double ginseng chewing gum and preparation method thereof | |
| CN106723029A (en) | A kind of health food and its preparation technology with auxiliary hyperglycemic function | |
| CN101669641B (en) | Fruit flavored sweet tea chewable tablets and preparation method thereof | |
| CN108785446A (en) | A kind of preparation method reducing cholesterol matrimony vine sustained release tablets | |
| CN109418806A (en) | A kind of preparation method of date-wolfberry fruit composite chewable tablet | |
| CN108567044A (en) | A kind of blue or green money willow pressed candy and preparation method thereof | |
| CN108785369A (en) | A kind of preparation method of pure natural chewable tablets | |
| CN108936420A (en) | The preparation method of antiallergy fruit sustained release tablets | |
| CN108938575A (en) | A kind of preparation method of glucosamine chewable tablet | |
| CN109275895A (en) | A kind of preparation method of sweet orange chewable tablets | |
| CN108925852A (en) | A kind of preparation method of more tastes containing Biocal | |
| CN109419776A (en) | A kind of preparation method of antifatigue chewable tablets | |
| CN109394717A (en) | A kind of preparation method of Radix Isatidis honeysuckle sustained release tablets | |
| CN109275854A (en) | A kind of is suitable for the preparation method for storing chewable tablets | |
| CN108936591A (en) | A kind of preparation method of antiviral draft disintegrated tablet | |
| CN109380660A (en) | A kind of preparation method of the calcium tablet of strawberry taste | |
| CN107361281B (en) | Momordica grosvenori effervescent tablet and preparation method thereof | |
| KR101979351B1 (en) | Ginseng chewing extracts and manufacturing method thereof | |
| KR20170130756A (en) | The method of functional korea traditional cracker using the jujube |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181113 |
|
| WD01 | Invention patent application deemed withdrawn after publication |