CN108784632A - A kind of bleeding detection capsule system - Google Patents

A kind of bleeding detection capsule system Download PDF

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Publication number
CN108784632A
CN108784632A CN201810523783.XA CN201810523783A CN108784632A CN 108784632 A CN108784632 A CN 108784632A CN 201810523783 A CN201810523783 A CN 201810523783A CN 108784632 A CN108784632 A CN 108784632A
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CN
China
Prior art keywords
bleeding
cabin
color
capsule
led light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810523783.XA
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Chinese (zh)
Inventor
皮喜田
乔盼盼
刘洪英
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing University
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Chongqing University
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Publication date
Application filed by Chongqing University filed Critical Chongqing University
Priority to CN201810523783.XA priority Critical patent/CN108784632A/en
Publication of CN108784632A publication Critical patent/CN108784632A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/041Capsule endoscopes for imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02042Determining blood loss or bleeding, e.g. during a surgical procedure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/1032Determining colour for diagnostic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/42Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4261Evaluating exocrine secretion production
    • A61B5/4283Evaluating exocrine secretion production gastrointestinal secretions, e.g. bile production
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/746Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms

Abstract

The present invention provides a kind of bleedings to detect capsule system, and whether have bleeding, and testing result is transferred in vitro if detecting in enteron aisle, alarms.The bleeding detection capsule system of the present invention includes bleeding detection capsule and external alarm;Bleeding detection capsule includes main cabin and secondary cabin, and main cabin includes main shell, wireless transmitter module, minicell, energy supply control module, color acquisition module out of my cabin;The color acquisition module includes color sensor, LED light group, microcontroller and black darkening ring;Secondary cabin includes secondary shell, Color-sensitive film and enteric film out of my cabin.There is the baffle of waterproof to be isolated between the main cabin and secondary cabin of bleeding detection capsule provided by the present invention, the enteric film in secondary cabin dissolves in small intestine, intestinal juice enters capsule from through-hole later, has detected whether bleeding, and according to whether the number of bleeding and amount of bleeding carries out different alarms in vitro;Bleeding detects capsule system automatic alarm, greatly reduces the workload of doctor, and noninvasive convenient, at low cost.

Description

A kind of bleeding detection capsule system
Technical field
The present invention relates to medicinal detection device, specifically a kind of bleeding detects capsule system, by capsule of eating, detects intestines Gastrointestinal hemorrhage.
Background technology
Intestinal bleeding is clinical common disease of digestive tract, and serious intestinal bleeding can cause acute anemia and hemorrhagic to be stopped Gram, or even jeopardizing patient vitals, the major way of the intestinal bleeding detection used in clinic has at present:Colonoscopy detection, radioisotope scanning, Angiography, capsule endoscope etc..Enteroscopy is most widely used means during hemorrhage of digestive tract checks, colonoscopy can generally go deep into At the 50cm to 80cm of proximal jejunum and terminal ileum, the hemorrhagic focus of intestinal segment part is detected, but enteroscopy is one The high invasiving inspection method of kind, operation difficulty is high, and the intervention of colonoscopy is easy to make patient by wound in checking process, together When bear the pain brought by inspection;Enteroscopy also adds the complication generated by inspection, improves the death rate;Nucleic Scanning also can cause wound to patient with angiography and cost is relatively high.Capsule endoscope for hemorrhage of digestive tract inspection there is also Deficiency, it is bad to the Checking on effect of alimentary canal fold and knee, in addition, Capsule Endoscopy is by image transmitting to body Outside, it needs doctor to read a large amount of image and rule of thumb judges intestinal bleeding situation, cause the workload of doctor very big.
Invention content
For overcome the deficiencies in the prior art, the present invention provides a kind of bleedings to detect capsule system, and whether detection enteron aisle There is bleeding, and according to whether there is the number of bleeding and amount of bleeding to carry out different alarms in vitro;Bleeding detects capsule system Automatic alarm greatly reduces the workload of doctor, and noninvasive convenient, at low cost.
Technical scheme of the present invention:
Bleeding detects capsule system, including bleeding detection capsule and external alarm;Bleeding detection capsule include main cabin and Secondary cabin, wherein main cabin includes main shell, color acquisition module, wireless transmitter module, energy supply control module and minicell out of my cabin, it is secondary Cabin includes secondary shell, Color-sensitive film and enteric film out of my cabin.
The color acquisition module includes LED light group, color sensor, microcontroller and black darkening ring;Black shading Circle is between LED light group and color sensor, it is therefore an objective to stop that LED light group enters the direct light of color sensor, make color Sensor preferably receives the reflected light from Color-sensitive film, is lifted out the accuracy of blood examination survey;The height of black darkening ring Degree is more than color sensor;Color sensor uses the TCS3200 sensors of AMS-TAOS companies of the U.S., acquisition Color-sensitive thin Then the colouring information of film carries out signal processing by microcontroller.
Color acquisition module has detected whether bleeding and amount of bleeding, and then bleeding information is transmitted to by wireless transmitter module In vitro.
External alarm includes three red LED lamps and a buzzer, is received from the signal sent out in vivo, according to whether There are bleeding and how much different alarms of carry out of amount of bleeding;When detecting a small amount of bleeding of enteron aisle, the buzzing of external alarm Device sounding and only there are one LED light shine, when measuring blood in detecting, the buzzer sounding of external alarm and there are two LED light shines, when detect bleed profusely when, the buzzer sounding of external alarm and there are three LED light to shine, when not going out When the electricity of blood and minicell is less than lowest threshold, external alarm only has buzzer sounding.
The outer layer of the Color-sensitive film is white medical non-woven fabrics, and centre is embedded with 330 anion exchange resin, sets Hemoglobin can be adsorbed onto on resin by the hydrophobic forces between fat and hemoglobin, when bleeding occurs in enteron aisle, because inhaling The presence of attached property resin, blood are easier to enter in capsule, and by Color-sensitive dyeing films.
The one kind of the enteric membrane material in following substance:Eudragit, EudragitⅡ, propylene Acid resin III, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, shellac;Enteric film is insoluble It in gastric juice, can be dissolved in small intestine, after bleeding detection capsule is swallowed to, small intestine is reached by esophagus and stomach, enteric film dissolves, Intestinal juice enters capsule from through-hole.
It is 2-6 that, which there are through-hole, number in one end of the secondary shell out of my cabin, and shape is round or oval.
There are one transparent isolation baffle plates, blocking intestinal juice to enter master between the main cabin and secondary cabin of the bleeding detection capsule Cabin.
The course of work of the present invention:
The bleeding detection capsule is by oral administration by esophagus and stomach, and into small intestine, enteric film disintegration, intestinal juice is entered by through-hole Secondary cabin, by Color-sensitive dyeing films, the colouring information of color acquisition module acquisition Color-sensitive film has simultaneously analysed whether out Blood and amount of bleeding, bleeding information are transferred in vitro by wireless transmitter module;External alarm reception goes out from what is transmitted in vivo Blood information, and according to how much different alarms of carry out of amount of bleeding, if detecting a small amount of bleeding of enteron aisle, the bee of external alarm Ring device sounding and only there are one LED light to shine, and measures blood if it is in, the buzzer sounding of external alarm and there are two LED Lamp shines, if it is bleeding profusely, the buzzer sounding of external alarm and there are three LED light to shine, if without bleeding and The electricity of minicell is less than lowest threshold, and external alarm only has buzzer sounding.
Description of the drawings:
Fig. 1 is the structural schematic diagram that bleeding of the present invention detects capsule system;
Fig. 2 is black darkening ring schematic diagram;
Fig. 3 is Color-sensitive dyeing films result schematic diagram.
In Fig. 1 to Fig. 3:
The main cabins 1 -, 2 - pairs cabins, 3 - Color-sensitives films, 4 - enteric films, 5 - through-holes, 6 - baffles, 7 - LED light groups, 8 - color sensors, 9 - black darkening rings, 10 - microcontrollers, 11 - wireless transmitter modules, 12 - energy supply control modules, 13 - minicells, the external alarms of 14 -, 15 - LED light, 15a - LED light, 15b - LED light, 16 - buzzers, the main cabins 17 - Shell, 19 - bleedings detect the Color-sensitive that capsule, 20 - color acquisition modules, 21 - detect bleeding out of my cabin for shell, 18 - pairs Film.
Specific implementation mode
Embodiment:
As shown in Figure 1, a kind of bleeding detects capsule system, including bleeding detection capsule 19 and external alarm 14;Bleeding It includes main cabin 1 and secondary cabin 2 to detect capsule 19, wherein main cabin 1 includes main shell 17, color acquisition module 20, wireless transmission mould out of my cabin Block 11, energy supply control module 12 and minicell 13, secondary cabin 2 include secondary shell 18, Color-sensitive film 3 and enteric film 4 out of my cabin.
Color acquisition module 20 includes LED light group 7, color sensor 8, microcontroller 10 and black darkening ring 9;Black hides Aperture 9 is between LED light group 7 and color sensor 8, it is therefore an objective to stop that LED light group 7 enters the direct light of color sensor 8, So that color sensor 8 is preferably received the reflected light from Color-sensitive film 3, be lifted out the accuracy of blood examination survey, black hides The height of aperture 9 is more than color sensor 8;Color sensor 8 is adopted using the TCS3200 sensors of AMS-TAOS companies of the U.S. Collect the colouring information of Color-sensitive film 3, signal processing is then carried out by microcontroller 10, bleeding information is by wireless transmission mould Block 11 is transmitted in vitro.3 outer layer of Color-sensitive film is white medical non-woven fabrics, and centre is embedded with 330 anion exchange resin, Hemoglobin can be adsorbed onto on resin by the hydrophobic forces between resin and hemoglobin, when bleeding occurs in enteron aisle, because The presence of adsorptive resin, blood are easier to enter in capsule, and Color-sensitive film 3 is dyed;The material of enteric film 4 selects Use cellulose acetate-phthalate;There are 6 circular through holes 5 in one end of secondary shell 18 out of my cabin;Bleeding detects 1 He of main cabin of capsule 19 There are one transparent isolation baffle plates 6, blocking intestinal juice to enter main cabin 1 between secondary cabin 2.
External alarm 14 includes three red LED lamps 15,15a, 15b and a buzzer 16, and reception is sent out from vivo Signal, according to whether having bleeding and how much different alarms of carry out of amount of bleeding;When detecting a small amount of bleeding of enteron aisle, body 16 sounding of buzzer of outer alarm 14 and only there are one LED light 15 shine, when measuring blood in detecting, external alarm 14 16 sounding of buzzer and there are two LED light 15,15a shine, when detect bleed profusely when, the buzzer of external alarm 14 16 sounding and there are three LED light 15,15a, 15b shine, when do not have the electricity of bleeding and minicell 13 be less than lowest threshold when, External alarm 14 only has 16 sounding of buzzer.
The course of work of the present embodiment is as follows:Bleeding detection capsule 19 is by oral administration by esophagus and stomach, into small intestine, Enteric film 4 is disintegrated, and intestinal juice enters secondary cabin 2 by through-hole 5, and Color-sensitive film 3 is dyed, and it is quick that color acquisition module 20 acquires color Feel the colouring information of film 3 and analysed whether bleeding and amount of bleeding, bleeding information is transferred to by wireless transmitter module 11 In vitro;External alarm 14 is received from the bleeding information transmitted in vivo, and according to whether have bleeding and amount of bleeding number into The different alarm of row, if detecting a small amount of bleeding of enteron aisle, 16 sounding of buzzer of external alarm 14 and only there are one LED light 15 shine, if in measure blood, 16 sounding of buzzer of external alarm 14 and there are two LED light 15,15a to shine, if greatly Measure blood, 16 sounding of buzzer of external alarm 14 and there are three LED light 15,15a, 15b to shine, if without bleeding and micro- The electricity of type battery 13 is less than lowest threshold, and external alarm 14 only has 16 sounding of buzzer.
The present invention is not limited to above-mentioned specific implementation mode, according to the above, according to the ordinary technical knowledge of this field And customary means, under the premise of not departing from above-mentioned basic fundamental thought of the invention, the present invention can also make other diversified forms Equivalent modifications, replacement or change, all fall among protection scope of the present invention.

Claims (3)

1. a kind of bleeding detects capsule system, which is characterized in that the system comprises bleeding detection capsules (19) and external alarm Device (14), bleeding detection capsule (19) includes main cabin (1) and secondary cabin (2), wherein main cabin includes main shell (17), color acquisition out of my cabin Module (20), wireless transmitter module (11), energy supply control module (12) and minicell (13), secondary cabin include secondary shell out of my cabin (18), Color-sensitive film (3) and enteric film (4);The color acquisition module (20) includes LED light group (7), color sensor (8), microcontroller (10) and black darkening ring (9);External alarm (14) include three red LED lamps (15,15a, 15b) and Buzzer (16);Color-sensitive film (3) outer layer is white medical non-woven fabrics, and centre is embedded with 330 anion exchange trees Hemoglobin can be adsorbed onto on resin by fat, the hydrophobic forces between resin and hemoglobin, when bleeding occurs in enteron aisle, Because of the presence of adsorptive resin, blood is easier to enter in capsule, and Color-sensitive film (3) are dyed;The black hides Aperture (9) is located between LED light group (7) and color sensor (8), and blocking LED light group (7) enters the straight of color sensor (8) Light is penetrated, so that color sensor (8) is preferably received the reflected light from Color-sensitive film (3), is lifted out blood accuracy in detection; The one kind of enteric film (4) material in following substance:Eudragit, EudragitⅡ, acrylic resin No. III, cellulose acetate-phthalate, hydroxypropyl methylcellulose phthalate, shellac;Enteric film (4) does not dissolve in stomach Liquid can dissolve in small intestine, after bleeding detection capsule (19) is swallowed to, reach small intestine by esophagus and stomach, enteric film (4) is molten Solution, intestinal juice enter capsule from through-hole (5), and Color-sensitive film (3) are dyed, and color acquisition module (20) has detected whether bleeding And amount of bleeding, bleeding information are transmitted in vitro by wireless transmitter module (11), the information in external alarm (14) receiving body, According to how much different alarms of carry out of amount of bleeding;When detecting a small amount of bleeding of enteron aisle, the buzzer of external alarm (14) (16) sounding and only there are one LED light (15) shine, when measuring blood in detecting, the buzzer (16) of external alarm (14) Sounding and there are two LED light (15,15a) shine, when detect bleed profusely when, external alarm (14) buzzer (16) hair Sound and there are three LED light (15,15a, 15b) shine, when do not have the electricity of bleeding and minicell (13) be less than lowest threshold when, External alarm (14) only has buzzer (16) can sounding.
2. bleeding according to claim 1 detects capsule system, which is characterized in that one end of the secondary shell (18) out of my cabin has Through-hole (5), number are 2-6, and shape is round or oval.
3. bleeding according to claim 1 detects capsule system, which is characterized in that the height of the black darkening ring (9) More than color sensor (8).
CN201810523783.XA 2018-05-28 2018-05-28 A kind of bleeding detection capsule system Pending CN108784632A (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
CN201810523783.XA CN108784632A (en) 2018-05-28 2018-05-28 A kind of bleeding detection capsule system

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109621169A (en) * 2019-01-09 2019-04-16 李红岩 A kind of obstetrics' observing and treating instrument
CN110151110A (en) * 2019-06-05 2019-08-23 上海长海医院 Fixable type gastrorrhagia monitors capsule endoscope and gastrorrhagia real-time monitoring system
CN110151110B (en) * 2019-06-05 2024-04-23 上海长海医院 Fixable capsule endoscope for monitoring gastrorrhagia and real-time monitoring system for gastrorrhagia

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CN101511257A (en) * 2006-09-07 2009-08-19 奥林巴斯医疗株式会社 Encapsulated endoscope
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109621169A (en) * 2019-01-09 2019-04-16 李红岩 A kind of obstetrics' observing and treating instrument
CN109621169B (en) * 2019-01-09 2021-06-08 李红岩 Observation therapeutic instrument for obstetrical department
CN110151110A (en) * 2019-06-05 2019-08-23 上海长海医院 Fixable type gastrorrhagia monitors capsule endoscope and gastrorrhagia real-time monitoring system
CN110151110B (en) * 2019-06-05 2024-04-23 上海长海医院 Fixable capsule endoscope for monitoring gastrorrhagia and real-time monitoring system for gastrorrhagia

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Application publication date: 20181113