CN108783015A - Application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets - Google Patents

Application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets Download PDF

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Publication number
CN108783015A
CN108783015A CN201810747819.2A CN201810747819A CN108783015A CN 108783015 A CN108783015 A CN 108783015A CN 201810747819 A CN201810747819 A CN 201810747819A CN 108783015 A CN108783015 A CN 108783015A
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CN
China
Prior art keywords
bile acid
growth performance
additive
bile
preparing
Prior art date
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Pending
Application number
CN201810747819.2A
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Chinese (zh)
Inventor
曹爱智
李金宝
娄倩倩
孙志亮
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Shandong Long Chang Animal Health-Care Product Co Ltd
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Shandong Long Chang Animal Health-Care Product Co Ltd
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Priority to CN201810747819.2A priority Critical patent/CN108783015A/en
Publication of CN108783015A publication Critical patent/CN108783015A/en
Priority to PCT/CN2019/095091 priority patent/WO2020011128A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/168Steroids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/30Feeding-stuffs specially adapted for particular animals for swines
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/60Feeding-stuffs specially adapted for particular animals for weanlings

Abstract

The present invention provides application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets, and the bile acid includes hyocholic acid, hyodesoxycholic acid and chenodeoxycholic acid.The present invention, which is experimentally confirmed, is added to bile acid in weanling pig daily ration, growth performance can be improved, improve the especially fatty digestibility of nutriment, reduce the anti-nutritional factors of vegetable protein, to improve piglet growth performance comprehensively, efficiency of feed utilization and the end weight uniformity are improved, meat cost is made in reduction, return of increasing economic efficiency.

Description

Application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets
Technical field
The invention belongs to animal feed additive fields, and in particular to bile acid is being prepared for improving weanling pig growth Application in the additive of performance.
Background technology
In modern production system, the linear fast lifting of inhereditary feature of pig causes the continuous variation of nutritional need, needs Feed formula and processing technology are improved to meet nutritional need.The gastrointestinal tract of newborn piglet is immature, be in germ-free condition, one Denier piglet starts to eat breast milk and feed, and gastrointestinal tract just plays a role, and generates microorganism species.Daily ration energy can be improved in addition fat Amount level and efficiency of feed utilization.However, it is necessary to recognize that the absorptivity of fat increases with age in days, 1-2 weeks after wean Piglet to fat absorption have physiological limitation.Piglet can be made to overcome physiology gastricism using endogenous or exogenous measure, Best is reached to digesting and assimilating for feed.It is in recent years to add synthetic emulsifier relative to other additives, in piglet diet Convention.Emulsifier is the auxiliary substances to be formed with stable emulsion, and emulsification is exactly not miscible under normal conditions two kinds of liquid It is dissolved in one.Emulsifier has special construction, and hydrophilic, oleophilic substance can be made to be combined together.The mechanism of action of emulsifier is energy Fat surface activity is enough improved, activates lipase, triglyceride hydrolysis is aliphatic acid and monoglyceride by lipase, and is formed Include the micelle of steatolysis object.This is the key that one step of fat absorption, because it generates diffusion gradient, young animal can be improved to fat The absorption of fat.
It is well known that the gastrointestinal development of growth early stage is not perfect.Research shows that:It cannot divide in the piglet stomach of growth early stage Secrete sufficient hydrochloric acid, pH high in stomach cannot activate propepsin, lead to harmful bacteria intrusion enteron aisle epimere.If piglet is unexpected Grain ration is changed to by breast milk, since enteron aisle digestion power is insufficient, grain ration enters big intestinal fermentation.Large intestine germ grows, Volatile fatty acid and other electrolyte are built up, and are led to osmotic imbalances, are caused grice diarrhoea.Therefore, when piglet diet changes, Acidulant appropriate must be added to keep normal digestive function.However, it is necessary to recognize that the absorptivity of fat is with day Age and increase, piglet to fat absorption have physiological limitation.
Invention content
The object of the present invention is to provide bile acids in preparing the additive for improving Growth Performance of Weaning Piglets Using bile acid of the present invention is added in weanling pig daily ration, the growth performance of piglet is significantly improved.
For achieving the above object, the present invention is achieved using following technical proposals:
The present invention provides application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets.
Further:The bile acid includes following component:It counts in mass ratio, hyocholic acid 5%-20%, hyodesoxycholic acid 55%-75% and chenodeoxycholic acid 10%-20%.
Further:The preparation method of the bile acid includes the following steps:
(1) saponification
It weighs the bile paste of crushing, is added in reaction kettle, sodium hydroxide solution is added, heat up and keep fluidized state 6-24h, Saponification liquor is cooled to solid-liquid layering, supernatant is removed, solid is bile paste saponification product;
(2) it decolourizes
Add water into bile paste saponification product and heating makes bile paste saponification product be completely dissolved, hydrogen peroxide is then added, stirs evenly After react, after completion of the reaction, reaction solution is filtered to get filtrate;
(3) it is acidified
The filtrate is cooled to room temperature, is slowly added to hydrochloric acid solution, and stir, when solution ph is in 3-4, stops adding Acid obtains white form of solid object at this time;
(4) it purifies
By the white form of solid object filter after, add water to rinse, it is to be filtered go out water detection be in neutrality for washing terminate;Incited somebody to action White form of solid object after filter is placed in oven and dried to moisture and is not higher than 10%, obtains bile acid crude;
(5) it recrystallizes
Obtained bile acid crude is put into extractor, ethyl acetate stirring and dissolving is added, waits for that bile acid crude is basic Dissolving is added anhydrous sodium sulfate dehydration, collects solution, solution is concentrated under reduced pressure, concentrate press filtration is obtained bile acid;
(6) dry
Obtained bile acid is put into baking oven, logical steam is dried in vacuo, and waits for that bile acid moisture is no more than 1%, then To the bile acid.
Further:The piglet that the weanling pig is 1-2 weeks after wean.
Further:The bile acid is added in the daily ration containing rice bran oil and/or full-cream dregs of beans.
Further:The additive amount of the bile acid is the 0.03%~0.1% of daily ration gross mass.
Further:The rice bran oil dosage account for daily ration total amount mass ratio be 0.7%, weanling pig daily gain highest and Feedstuff-meat ratio is minimum.
Further:The bile acid is added in the daily ration of weanling pig, hence it is evident that improves piglet growth performance, improves it Body weight gains, survival rate and the end weight uniformity, reduce feedstuff-meat ratio and make meat cost.
Compared with prior art, it advantages of the present invention and has the technical effect that:The present invention, which is experimentally confirmed, adds bile acid It is added in weanling pig daily ration, growth performance can be improved, improve the especially fatty digestibility of nutriment, reduce plant egg White anti-nutritional factors improves efficiency of feed utilization and the end weight uniformity to improve piglet growth performance comprehensively, reduction make meat at This, return of increasing economic efficiency.
Specific implementation mode
Further detailed description is done to technical scheme of the present invention with reference to specific embodiment.
Embodiment 1
Compared with the livestock and poultry that grow up, young age livestock and poultry are relatively low to the digestibility of fat.The present invention is in order to improve the life of weanling pig Long performance has carried out following tests.The objective that the present invention tests is to assess to be mixed containing rice bran oil, full-cream dregs of beans and the two Influence of the bile acid to piglet growth performance is added in the daily ration of object.
Bile acid of the present invention is made by five saponification, decoloration, acidification, purifying and recrystallization steps, in detail Steps are as follows:
1, saponification
The bile paste 200kg of crushing is weighed, is added in R201 reaction kettles, 10% sodium hydroxide is added according to solid-to-liquid ratio 1: 10 Solution 2000L.Start timing when the solution in R201 reaction kettles is warming up to 100 DEG C, keeps fluidized state 12h.By saponification liquor It is cooled to solid-liquid layering, is turned in supernatant to storage tank with Piping Centrifugal Pumps, the remaining solid in reaction kettle is bile paste saponification Product.
2, it decolourizes
Into reaction kettle plus 1200kg tap water heatings are to 80 DEG C, so that bile paste saponification product is completely dissolved and (add water volume:Bile paste Quality=6: 1).Then 60L hydrogen peroxide is added, after stirring evenly, reacts 2h at 80 DEG C.After completion of the reaction, by solution through pipe Filter screen device in road is filtered into souring tank.Filter screen in pipeline can fall the cotton-shaped contaminant filter generated after saponification.
3, it is acidified
After being beaten into souring tank by Piping Centrifugal Pumps, solution is cooled to room temperature by logical condensed water in tank body interlayer. By sour measuring tank toward the hydrochloric acid solution for being slowly added to 5% in slot is acidified, it is stirred continuously.When solution ph is 3 or so, stop Acid adding obtains white form of solid object at this time.
4, it purifies
Flame filter press is connected on souring tank.White form of solid object is filtered with flame filter press.After filtering, Jia Shuichong Wash, it is to be filtered go out water detection be in neutrality for washing terminate.The purpose of washing is will to be attached to the water on bile acid solid content surface Solubility impurity removes.Filtered white form of solid object is put into baking oven, is dried to moisture at 100 DEG C and is not higher than 10%, obtained Bile acid crude.
5, it recrystallizes
Obtained bile acid crude is put into extractor, ethyl acetate is added and (volume and bile of ethyl acetate is added Acid crude mass ratio is 10: 1), stirring and dissolving waits for that bile acid crude dissolves substantially, and anhydrous sodium sulfate dehydration is added, collects molten Liquid.Solution is squeezed into concentration tank and is concentrated under reduced pressure, ethyl acetate is recycled.Concentrate is obtained into bile with filter press press filtration Acid.
6, dry
Obtained bile acid is laid in stainless steel drying tray, baking oven is put into, logical steam is dried in vacuo, dry temperature Degree is 100 DEG C.When bile acid becomes white powder, sample detection is then considered as drying and finishes if moisture is no more than 1%.
Embodiment 2
1. materials and methods
It tests and respects commercial pig farm (the Reang Sifi Farm) progress of a management regulation of province in Thailand hole.480 28 Age in days wean three way cross (Duroc × Yorkshire × length is white) piglet (counterpoise 8.62-8.65kg) is divided into 4 processing, each to locate 4 repetitions are managed, each to repeat 30, male and female is fifty-fifty.In the sprayable nursery house for adjusting temperature, experimental period is feeding piglet 28-62 ages in days, free choice feeding and free water.Often house has the feeder and 4 nipple drinking devices in 3 10 holes.It is young to weigh experiment Pig starting weight and end weight record feed intake and the death rate to off-test daily.The piglet uniformity is based on average last weight standard deviation 2 Percentage again.Test group 1 (T1) contains rice bran oil and full-fat bean, does not add bile acid.The other three test group is added 0.04% bile acid (mass ratio that bile acid accounts for feed total amount is 0.04%), rice bran oil dosage accounts for the quality score of feed total amount Not Wei 0.7%, 1.0% and 1.3%, and with crack rice supplement (referring to table 1).Daily ration is fed with paste.
2. statistical analysis
All response variable data use the one-way analysis of variance of general linear model in SAS softwares, group difference to adopt It is handled with Duncan Multiple range test.Significance analysis is based on 0.05 probability.
3. experimental result
Influence test result of the bile acid to piglet growth performance is shown in Table 2, during entire experiment, the addition of test group daily ration 0.04% bile acid, rice bran oil dosage are 0.70%, 1.00% and 1.3%, and 34 days experimental periods added the piglet body of bile acid group Weight (BW), body weight gains (BWG, last weight-initial weight), feed intake (FI), feedstuff-meat ratio (FCR feed intakes/end weight-initial weight), survival rate (SR, work son number/experimental group head number), end weigh the uniformity (UBWT, number of individuals/total sample number of average weight ± 10%) and make meat Cost (FCG, feeding cost/(last weight-initial weight)) is superior to or close to control group.Compared with the control group, it is added in piglet diet 0.04% bile acid can obviously improve growth performance, significantly reduce FCR (P < 0.05);Improve FI (P > 0.05);Improve UBWT (P > 0.05);Significantly reduce FCG (P < 0.05).Bile acid is added in piglet diet, net profit can be improved, wherein adding 0.7% Rate of return on investment (ROI) highest of rice bran oil.
Conclusion accordingly:Piglet growth can be improved by adding 0.04% bile acid in piglet diet and adding 0.7% rice bran oil Can, BWG, SR and UBWT are improved, FCR and FCG is reduced, improves ROI.
Compared with the control group, 3 test groups of rice bran oil dosage (0.70%, 1.00%, 1.30%), add 0.04% Weight and body weight gains can be improved in bile acid, but difference is not notable (P > 0.05) between different rice bran oil dosage groups.It significantly reduces Feedstuff-meat ratio improves survival rate, improves the end weight uniformity, but difference is not notable between different rice bran oil dosage groups, significant decrease is made Meat cost.
The present invention the experimental results showed that:Addition bile acid can make piglet reach best to digesting and assimilating for feed, wherein dropping The test group daily gain highest of low 0.7% rice bran oil, feedstuff-meat ratio is minimum, and economic benefit returns highest.As a result also show:Add courage 3 test group economic benefits return of juice acid is above control group, and reduces the investment repayment of the test group of 0.7% rice bran oil Highest.
Table 1 is for examination weanling pig daily ration composition
Contain in per kilogram daily ration used in weanling pig in the present invention:Vitamin A:2500IU.;Vitamin D3: 250IU;Vitamin E:20IU;Vitamin B12:0.2mg;Pantothenic acid:12mg;Niacin:20mg;Riboflavin:4mg;Thiamine:2mg; Choline chloride 1g;Vitamin B6:2mg;Biotin:0.3mg;Vitamin K3:0.5mg;Folic acid:0.3mg;Ethoxyquinoline: 12.5mg;Copper:250mg;Iodine:0.4mg;Iron:100mg;Manganese:40mg;Selenium:0.3mg;Zinc:100mg;Cobalt:0.14mg; Trimulin (a kind of anti-diarrhea antibiotic):100mg;Amoxicillin:300mg;Colistin:200mg;Aureomycin:400mg.
Bile acid:Shandong Long Chang animal health-care products Co., Ltd provides;
Feed cost (Thai Baht/kg):T1=22.256;T2=22.236;T3=22.182;T4=22.128.
Influence (28-62 age in days) of the bile acid to Growth Performance of Weaning Piglets is added in 2 daily ration of table
Note:The average value Superscript letters difference person that goes together indicates significant difference (p < 0.05)
Average every net profit=body weight gains × unit price (82 Thai Bahts/kg) feed cost (Thai Baht/head)
The present invention is shown by test result:Compared with the control group for not adding bile acid, in experimental period (34d), wean Growth performance can be improved in piglet diet whole process addition bile acid, wherein the test group daily gain of the rice bran oil of addition 0.7% is most Height, feedstuff-meat ratio is minimum, and economic benefit returns highest.The present invention adds bile acid in weanling pig daily ration whole process, can improve battalion The especially fatty digestibility of foster substance, reduces the anti-nutritional factors of vegetable protein, to improve piglet growth performance comprehensively, carries Meat cost is made in high efficiency of feed utilization and the end weight uniformity, reduction, return of increasing economic efficiency.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than is limited;Although with reference to aforementioned reality Applying example, invention is explained in detail, for those of ordinary skill in the art, still can be to aforementioned implementation Technical solution recorded in example is modified or equivalent replacement of some of the technical features;And these are changed or replace It changes, the spirit and scope for claimed technical solution of the invention that it does not separate the essence of the corresponding technical solution.

Claims (8)

1. application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets.
2. bile acid according to claim 1 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The bile acid includes following component:It counts in mass ratio, hyocholic acid 5%-20%, hyodesoxycholic acid 55%- 75% and chenodeoxycholic acid 10%-20%.
3. bile acid according to claim 1 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The preparation method of the bile acid includes the following steps:
(1)Saponification
The bile paste of crushing is weighed, is added in reaction kettle, sodium hydroxide solution is added, heats up and keeps fluidized state 6-24h, by soap Change liquid and be cooled to solid-liquid layering, supernatant is removed, solid is bile paste saponification product;
(2)Decoloration
Add water into bile paste saponification product and heating makes bile paste saponification product be completely dissolved, hydrogen peroxide is then added, it is anti-after stirring evenly It answers, after completion of the reaction, reaction solution is filtered to get filtrate;
(3)Acidification
The filtrate is cooled to room temperature, is slowly added to hydrochloric acid solution, and stir, when solution ph is in 3-4, stops acid adding, White form of solid object is obtained at this time;
(4)Purifying
By the white form of solid object filter after, add water to rinse, it is to be filtered go out water detection be in neutrality for washing terminate;After filtering White form of solid object be placed in oven and dried to moisture be not higher than 10%, obtain bile acid crude;
(5)Recrystallization
Obtained bile acid crude is put into extractor, ethyl acetate stirring and dissolving is added, waits for that bile acid crude dissolves substantially, Anhydrous sodium sulfate dehydration is added, collects solution, solution is concentrated under reduced pressure, concentrate press filtration is obtained into bile acid;
(6)It is dry
Obtained bile acid is put into baking oven, logical steam is dried in vacuo, and waits for that bile acid moisture is no more than 1%, then is obtained described Bile acid.
4. bile acid according to claim 1 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The piglet that the weanling pig is 1-2 weeks after wean.
5. bile acid according to claim 1 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The bile acid is added in the daily ration containing rice bran oil and/or full-cream dregs of beans.
6. bile acid according to claim 5 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The additive amount of the bile acid is the 0.03% ~ 0.1% of daily ration gross mass.
7. bile acid according to claim 5 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The mass ratio that the rice bran oil dosage accounts for daily ration total amount is 0.7%, weanling pig daily gain highest and material meat Than minimum.
8. bile acid according to claim 1 answering in preparing the additive for improving Growth Performance of Weaning Piglets With, it is characterised in that:The bile acid is added in the daily ration of weanling pig, hence it is evident that improves piglet growth performance, improves its body Weightening, survival rate and the end weight uniformity, reduce feedstuff-meat ratio and make meat cost.
CN201810747819.2A 2018-07-09 2018-07-09 Application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets Pending CN108783015A (en)

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CN201810747819.2A CN108783015A (en) 2018-07-09 2018-07-09 Application of the bile acid in preparing the additive for improving Growth Performance of Weaning Piglets
PCT/CN2019/095091 WO2020011128A1 (en) 2018-07-09 2019-07-08 Bile acid, preparation method thereof, and application of same in preparing animal feed additive

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Cited By (3)

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CN110150487A (en) * 2019-05-09 2019-08-23 淮安市澳华农牧有限公司 Alleviate the LCA feed and feeding method of weanling pig stress reaction
WO2020011128A1 (en) * 2018-07-09 2020-01-16 山东龙昌动物保健品有限公司 Bile acid, preparation method thereof, and application of same in preparing animal feed additive
CN113827601A (en) * 2021-09-16 2021-12-24 中国农业大学 Application of ursodeoxycholic acid in relieving growth inhibition of low-birth-weight piglets caused by intrauterine growth restriction

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WO2020011128A1 (en) * 2018-07-09 2020-01-16 山东龙昌动物保健品有限公司 Bile acid, preparation method thereof, and application of same in preparing animal feed additive
CN110150487A (en) * 2019-05-09 2019-08-23 淮安市澳华农牧有限公司 Alleviate the LCA feed and feeding method of weanling pig stress reaction
CN113827601A (en) * 2021-09-16 2021-12-24 中国农业大学 Application of ursodeoxycholic acid in relieving growth inhibition of low-birth-weight piglets caused by intrauterine growth restriction

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