CN108779110B - 磷脂酰肌醇3-激酶γ的新颖抑制剂 - Google Patents

磷脂酰肌醇3-激酶γ的新颖抑制剂 Download PDF

Info

Publication number
CN108779110B
CN108779110B CN201780014898.XA CN201780014898A CN108779110B CN 108779110 B CN108779110 B CN 108779110B CN 201780014898 A CN201780014898 A CN 201780014898A CN 108779110 B CN108779110 B CN 108779110B
Authority
CN
China
Prior art keywords
dihydro
oxo
isoindol
methyl
thiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201780014898.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN108779110A (zh
Inventor
M.莫格马克
N.佩姆伯顿
J.彼得森
M.佩里
K.卡拉贝拉斯
P.兹拉托伊斯基
R.科克斯
C.泰尔钱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN108779110A publication Critical patent/CN108779110A/zh
Application granted granted Critical
Publication of CN108779110B publication Critical patent/CN108779110B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201780014898.XA 2016-03-10 2017-03-09 磷脂酰肌醇3-激酶γ的新颖抑制剂 Expired - Fee Related CN108779110B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306328P 2016-03-10 2016-03-10
US62/306328 2016-03-10
PCT/EP2017/055552 WO2017153527A1 (en) 2016-03-10 2017-03-09 Novel inhibitors of phosphatidylinositol 3-kinase gamma

Publications (2)

Publication Number Publication Date
CN108779110A CN108779110A (zh) 2018-11-09
CN108779110B true CN108779110B (zh) 2021-10-29

Family

ID=58264542

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780014898.XA Expired - Fee Related CN108779110B (zh) 2016-03-10 2017-03-09 磷脂酰肌醇3-激酶γ的新颖抑制剂

Country Status (13)

Country Link
US (2) US10858355B2 (https=)
EP (1) EP3426652B1 (https=)
JP (1) JP6893520B2 (https=)
KR (1) KR20180117693A (https=)
CN (1) CN108779110B (https=)
AR (1) AR107840A1 (https=)
AU (1) AU2017229445B2 (https=)
BR (1) BR112018068075A2 (https=)
CA (1) CA3015893C (https=)
EA (1) EA036388B1 (https=)
MX (1) MX387125B (https=)
TW (1) TWI746525B (https=)
WO (1) WO2017153527A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
WO2020102216A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Substituted heterocyclic derivatives as pi3k inhibitors
US11078204B2 (en) 2018-11-13 2021-08-03 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
EP3952870B1 (en) * 2019-04-10 2025-09-24 Nanjing Zenshine Pharmaceuticals Co., Ltd. Phosphatidylinositol 3-kinase inhibitors
KR20220047247A (ko) * 2019-06-04 2022-04-15 아르커스 바이오사이언시즈 인코포레이티드 2,3,5-삼치환 피라졸로[1,5-a]피리미딘 화합물
WO2022017371A1 (zh) * 2020-07-21 2022-01-27 中国医药研究开发中心有限公司 具有磷脂酰肌醇3-激酶δ和γ的双重抑制剂活性的杂环化合物及其医药用途
CN115611883B (zh) * 2021-07-13 2025-03-28 生物岛实验室 一种双环结构的PI3Kα抑制剂及其制备方法和用途
WO2024046454A1 (zh) * 2022-09-01 2024-03-07 上海海雁医药科技有限公司 杂芳基取代的吡啶并吡咯酮衍生物、其药物组合物及应用
CN117683036A (zh) * 2022-09-09 2024-03-12 上海璎黎药业有限公司 一种含氮杂环化合物、其药物组合物及应用
CN116813608B (zh) * 2023-06-08 2024-03-22 英矽智能科技(上海)有限公司 噻唑类化合物及其应用
CN121816181A (zh) 2023-06-30 2026-04-07 柏林合作研究学会 噻唑并四氢喹啉化合物作为ii类磷酸肌醇3-激酶抑制剂

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484452A (zh) * 2006-05-03 2009-07-15 阿斯利康(瑞典)有限公司 噻唑衍生物及其作为抗肿瘤药物的用途
CN101535307A (zh) * 2006-08-30 2009-09-16 塞尔佐姆有限公司 作为激酶抑制剂的三唑衍生物
WO2010096389A1 (en) * 2009-02-17 2010-08-26 Vertex Pharmaceuticals Incorporated Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase
CN102762548A (zh) * 2009-12-22 2012-10-31 沃泰克斯药物股份有限公司 磷脂酰肌醇3-激酶的异吲哚啉酮抑制剂
CN104379573A (zh) * 2012-04-20 2015-02-25 艾伯维公司 异吲哚酮衍生物
CN105722838A (zh) * 2013-09-25 2016-06-29 沃泰克斯药物股份有限公司 磷脂酰肌醇3-激酶-γ的选择性抑制剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
WO2006089106A2 (en) * 2005-02-17 2006-08-24 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
MY149143A (en) * 2006-01-18 2013-07-15 Amgen Inc Thiazole compounds as protien kinase b (pkb) inhibitors
WO2010024258A1 (ja) * 2008-08-29 2010-03-04 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体
KR20160145780A (ko) 2014-04-24 2016-12-20 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 아미노 피리딘 유도체
EP3134397A1 (en) 2014-04-24 2017-03-01 Novartis AG Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
KR20160141856A (ko) 2014-04-24 2016-12-09 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101484452A (zh) * 2006-05-03 2009-07-15 阿斯利康(瑞典)有限公司 噻唑衍生物及其作为抗肿瘤药物的用途
CN101535307A (zh) * 2006-08-30 2009-09-16 塞尔佐姆有限公司 作为激酶抑制剂的三唑衍生物
WO2010096389A1 (en) * 2009-02-17 2010-08-26 Vertex Pharmaceuticals Incorporated Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase
CN102762548A (zh) * 2009-12-22 2012-10-31 沃泰克斯药物股份有限公司 磷脂酰肌醇3-激酶的异吲哚啉酮抑制剂
CN104379573A (zh) * 2012-04-20 2015-02-25 艾伯维公司 异吲哚酮衍生物
CN105722838A (zh) * 2013-09-25 2016-06-29 沃泰克斯药物股份有限公司 磷脂酰肌醇3-激酶-γ的选择性抑制剂

Also Published As

Publication number Publication date
MX387125B (es) 2025-03-18
US20210047312A1 (en) 2021-02-18
CA3015893C (en) 2021-11-09
EP3426652A1 (en) 2019-01-16
AU2017229445B2 (en) 2019-07-11
JP6893520B2 (ja) 2021-06-23
EA201891931A1 (ru) 2019-04-30
AR107840A1 (es) 2018-06-13
US20200299289A1 (en) 2020-09-24
WO2017153527A1 (en) 2017-09-14
TW201808945A (zh) 2018-03-16
EA036388B1 (ru) 2020-11-03
JP2019507788A (ja) 2019-03-22
US10858355B2 (en) 2020-12-08
CA3015893A1 (en) 2017-09-14
AU2017229445A1 (en) 2018-10-25
BR112018068075A2 (pt) 2019-01-08
MX2018010894A (es) 2018-11-09
CN108779110A (zh) 2018-11-09
KR20180117693A (ko) 2018-10-29
EP3426652B1 (en) 2021-12-01
TWI746525B (zh) 2021-11-21

Similar Documents

Publication Publication Date Title
CN108779110B (zh) 磷脂酰肌醇3-激酶γ的新颖抑制剂
US12540141B2 (en) Spiropyrrolidine derived antiviral agents
EP4001279A1 (en) Novel spiropyrrolidine derived antiviral agents
WO2023086350A1 (en) Alkyne-containing antiviral agents
US20210246130A1 (en) Dual inhibitors of phosphatidylinositol 3-kinase delta & gamma
KR20130049766A (ko) 트리사이클릭 피라졸 아민 유도체
KR20150054994A (ko) 브루톤 티로신 키나아제의 억제제
WO2016197078A1 (en) Compounds for the modulation of myc activity
WO2023107417A1 (en) Heterocyclic antiviral agents
KR102858857B1 (ko) 오렉신 수용체 길항제로서의 치환된 2-아자바이사이클로[3.1.1]헵탄 및 2-아자바이사이클로[3.2.1]옥탄 유도체
HK1257837A1 (en) Novel inhibitors of phosphatidylinositol 3-kinase gamma
KR102539761B1 (ko) 2-티옥소티아졸리딘-4-온 유도체 화합물 및 이의 용도
RU2827867C1 (ru) Пиримидин- и азотсодержащее бициклическое соединение
HK40071048A (en) Novel spiropyrrolidine derived antiviral agents
HK40011664B (en) 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro- 1 h-isoindol-1 -one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta&gamma
HK40011664A (en) 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro- 1 h-isoindol-1 -one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta&gamma

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1257837

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20211029

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1257837

Country of ref document: HK