CA3015893C - Novel inhibitors of phosphatidylinositol 3-kinase gamma - Google Patents

Novel inhibitors of phosphatidylinositol 3-kinase gamma Download PDF

Info

Publication number
CA3015893C
CA3015893C CA3015893A CA3015893A CA3015893C CA 3015893 C CA3015893 C CA 3015893C CA 3015893 A CA3015893 A CA 3015893A CA 3015893 A CA3015893 A CA 3015893A CA 3015893 C CA3015893 C CA 3015893C
Authority
CA
Canada
Prior art keywords
dihydro
oxo
thiazol
isoindo1
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3015893A
Other languages
English (en)
French (fr)
Other versions
CA3015893A1 (en
Inventor
Mickael Mogemark
Nils Pemberton
Jens Petersen
Matthew Perry
Konstantinos Karabelas
Pavol Zlatoidsky
Rhona Cox
Christian Tyrchan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CA3015893A1 publication Critical patent/CA3015893A1/en
Application granted granted Critical
Publication of CA3015893C publication Critical patent/CA3015893C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3015893A 2016-03-10 2017-03-09 Novel inhibitors of phosphatidylinositol 3-kinase gamma Active CA3015893C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306328P 2016-03-10 2016-03-10
US62/306,328 2016-03-10
PCT/EP2017/055552 WO2017153527A1 (en) 2016-03-10 2017-03-09 Novel inhibitors of phosphatidylinositol 3-kinase gamma

Publications (2)

Publication Number Publication Date
CA3015893A1 CA3015893A1 (en) 2017-09-14
CA3015893C true CA3015893C (en) 2021-11-09

Family

ID=58264542

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3015893A Active CA3015893C (en) 2016-03-10 2017-03-09 Novel inhibitors of phosphatidylinositol 3-kinase gamma

Country Status (13)

Country Link
US (2) US10858355B2 (https=)
EP (1) EP3426652B1 (https=)
JP (1) JP6893520B2 (https=)
KR (1) KR20180117693A (https=)
CN (1) CN108779110B (https=)
AR (1) AR107840A1 (https=)
AU (1) AU2017229445B2 (https=)
BR (1) BR112018068075A2 (https=)
CA (1) CA3015893C (https=)
EA (1) EA036388B1 (https=)
MX (1) MX387125B (https=)
TW (1) TWI746525B (https=)
WO (1) WO2017153527A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
WO2020102216A1 (en) 2018-11-13 2020-05-22 Incyte Corporation Substituted heterocyclic derivatives as pi3k inhibitors
US11078204B2 (en) 2018-11-13 2021-08-03 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
EP3952870B1 (en) * 2019-04-10 2025-09-24 Nanjing Zenshine Pharmaceuticals Co., Ltd. Phosphatidylinositol 3-kinase inhibitors
KR20220047247A (ko) * 2019-06-04 2022-04-15 아르커스 바이오사이언시즈 인코포레이티드 2,3,5-삼치환 피라졸로[1,5-a]피리미딘 화합물
WO2022017371A1 (zh) * 2020-07-21 2022-01-27 中国医药研究开发中心有限公司 具有磷脂酰肌醇3-激酶δ和γ的双重抑制剂活性的杂环化合物及其医药用途
CN115611883B (zh) * 2021-07-13 2025-03-28 生物岛实验室 一种双环结构的PI3Kα抑制剂及其制备方法和用途
WO2024046454A1 (zh) * 2022-09-01 2024-03-07 上海海雁医药科技有限公司 杂芳基取代的吡啶并吡咯酮衍生物、其药物组合物及应用
CN117683036A (zh) * 2022-09-09 2024-03-12 上海璎黎药业有限公司 一种含氮杂环化合物、其药物组合物及应用
CN116813608B (zh) * 2023-06-08 2024-03-22 英矽智能科技(上海)有限公司 噻唑类化合物及其应用
CN121816181A (zh) 2023-06-30 2026-04-07 柏林合作研究学会 噻唑并四氢喹啉化合物作为ii类磷酸肌醇3-激酶抑制剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200613272A (en) * 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
WO2006089106A2 (en) * 2005-02-17 2006-08-24 Icos Corporation Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation
MY149143A (en) * 2006-01-18 2013-07-15 Amgen Inc Thiazole compounds as protien kinase b (pkb) inhibitors
EP2016075A1 (en) * 2006-05-03 2009-01-21 AstraZeneca AB Thiazole derivatives and their use as anti-tumour agents
EP1894931A1 (en) * 2006-08-30 2008-03-05 Cellzome Ag Triazole derivatives as kinase inhibitors
WO2010024258A1 (ja) * 2008-08-29 2010-03-04 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環アゾール誘導体
CA2752596A1 (en) * 2009-02-17 2010-08-26 Vertex Pharmaceuticals Incorporated Tetrahydrothiazolopyridine inhibitors of phosphatidylinositol 3-kinase
AU2010341573B2 (en) * 2009-12-22 2016-10-13 Vertex Pharmaceuticals Incorporated Isoindolinone inhibitors of phosphatidylinositol 3-kinase
CN104379573A (zh) * 2012-04-20 2015-02-25 艾伯维公司 异吲哚酮衍生物
SG10201802061TA (en) * 2013-09-25 2018-05-30 Vertex Pharma A selective inhibitor of phosphatidylinositol 3-kinase-gamma
KR20160145780A (ko) 2014-04-24 2016-12-20 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 아미노 피리딘 유도체
EP3134397A1 (en) 2014-04-24 2017-03-01 Novartis AG Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
KR20160141856A (ko) 2014-04-24 2016-12-09 노파르티스 아게 포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체

Also Published As

Publication number Publication date
CN108779110B (zh) 2021-10-29
MX387125B (es) 2025-03-18
US20210047312A1 (en) 2021-02-18
EP3426652A1 (en) 2019-01-16
AU2017229445B2 (en) 2019-07-11
JP6893520B2 (ja) 2021-06-23
EA201891931A1 (ru) 2019-04-30
AR107840A1 (es) 2018-06-13
US20200299289A1 (en) 2020-09-24
WO2017153527A1 (en) 2017-09-14
TW201808945A (zh) 2018-03-16
EA036388B1 (ru) 2020-11-03
JP2019507788A (ja) 2019-03-22
US10858355B2 (en) 2020-12-08
CA3015893A1 (en) 2017-09-14
AU2017229445A1 (en) 2018-10-25
BR112018068075A2 (pt) 2019-01-08
MX2018010894A (es) 2018-11-09
CN108779110A (zh) 2018-11-09
KR20180117693A (ko) 2018-10-29
EP3426652B1 (en) 2021-12-01
TWI746525B (zh) 2021-11-21

Similar Documents

Publication Publication Date Title
CA3015893C (en) Novel inhibitors of phosphatidylinositol 3-kinase gamma
CA2870087C (en) Substituted isoquinolin-1(2h)-one compounds and their use as phosphoinositide 3-kinase (pi3k) inhibitors
CA2874445C (en) Tetrahydropyrazolopyrimidine compounds
TWI478714B (zh) 作為Ｊａｎｕｓ激酶３（ＪＡＫ３）抑制劑之含氮雜芳基衍生物類
TWI792158B (zh) 嘧啶酪氨酸激酶抑制劑
AU2017331940B2 (en) 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro-1 H-isoindol-1 -one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta & gamma
IL271104A (en) The traumatic compounds as inhibitors and fines
WO2016197078A1 (en) Compounds for the modulation of myc activity
KR102858857B1 (ko) 오렉신 수용체 길항제로서의 치환된 2-아자바이사이클로[3.1.1]헵탄 및 2-아자바이사이클로[3.2.1]옥탄 유도체
WO2016196910A1 (en) Compounds for the modulation of myc activity
KR102489537B1 (ko) 단백질 키나제 억제제로서의 치환된 피롤로[2,3-d]피리다진-4-온 및 피라졸로[3,4-d]피리다진-4-온
CN115916782B (zh) 化合物及其作为脾酪氨酸激酶抑制剂的应用
HK1257837A1 (en) Novel inhibitors of phosphatidylinositol 3-kinase gamma
HK40011664B (en) 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro- 1 h-isoindol-1 -one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta&gamma
HK40011664A (en) 5-[2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]-2,3-dihydro- 1 h-isoindol-1 -one derivatives and their use as dual inhibitors of phosphatidylinositol 3-kinase delta&gamma

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20190828

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20240911