CN108771701A - 葛根鲜提真空干燥粉末饮片 - Google Patents
葛根鲜提真空干燥粉末饮片 Download PDFInfo
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- CN108771701A CN108771701A CN201810733381.2A CN201810733381A CN108771701A CN 108771701 A CN108771701 A CN 108771701A CN 201810733381 A CN201810733381 A CN 201810733381A CN 108771701 A CN108771701 A CN 108771701A
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- pueraria lobata
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- 235000010575 Pueraria lobata Nutrition 0.000 title claims abstract description 19
- 241000219781 Pueraria montana var. lobata Species 0.000 title claims abstract description 19
- 239000000843 powder Substances 0.000 title claims abstract description 10
- 238000001291 vacuum drying Methods 0.000 title claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims abstract description 7
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims description 17
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 239000000463 material Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000366676 Justicia pectoralis Species 0.000 description 1
- 241001126925 Lobata Species 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000002893 slag Substances 0.000 description 1
- 238000009461 vacuum packaging Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公布了“一种葛根鲜提真空干燥粉末饮片”,其主要特征在于:在葛根采收后,趁鲜洗涤、切片、榨汁、提取,提取液浓缩成清膏后,再真空干燥至含水量少于10%,粉碎、过筛后真空包装。本饮片质量稳定,既可以入汤剂煎煮,也可以直接入丸剂、散剂、片剂、胶囊剂,利于携带,临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域,尤其属于葛根饮片的加工领域。
背景技术
中药葛根为豆科植物野葛Pueraria lobata (Willd.) Ohwi的干燥根,具有解肌退热,生津止渴,透疹,升阳止泻,通经活络,解酒毒的功效。常用于外感发热头痛,项背强痛,口渴,消渴,麻疹不透,热痢,泄泻,眩晕头痛等的治疗,是中医临床上常用的一味中药。传统葛根的加工方法为:将药材采挖后,趁鲜切成厚片或小块,干燥,打包,储运。此类饮片体积庞大,卫生学标准差,易于受潮、长霉、生虫,不利于保管,储存和运输成本高。此外,这样的葛根饮片质量稳定性差,临床疗效难以保障,病人服用不方便,起效慢。因此,开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型葛根饮片,势在必行。目前市场上的葛根饮片,除了传统饮片之外,还有超微粉饮片和浓缩颗粒饮片两种形式,但两者都是以传统饮片为原料,其质量决定于传统饮片的质量,且超微饮片不能解决药材污染的问题;浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“葛根鲜提真空干燥粉末饮片”,其主要特征在于:在葛根采收后,及时净选,去除泥沙等杂质和非药用部位,于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中,浸泡并时时搅拌5~30分钟,过滤,药渣压榨取汁。所得药渣中再加入5~10倍重量的水,煮沸10~30分钟,趁热过滤,药渣再次榨汁,收集药汁。合并上述药汁,过60~100目筛,减压浓缩,温度为50~75℃,浓缩至相对密度为1.15~1.25的清膏。将所得的清膏在60~80℃下真空干燥至含水量低于10%,粉碎,过60目筛,真空包装,即得成品。成品饮片含葛根素(C21H20O9)不低于4.0%。本发明葛根饮片临床一般使用量为1~5g,既可入汤剂煎服、冲服,也可直接入丸剂、散剂、胶囊剂及片剂中,从而大大提高了临床使用的便捷性和顺应性,有利于临床急症的治疗。
本发明解决了传统葛根饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点,由于是趁鲜提取,质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将葛根药材采收后,净选,除去泥沙等杂质和非药用部位,在6小时内趁鲜用自来水洗净,并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水,搅拌30分钟,过滤,药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水,煮沸20分钟提取,趁热过滤,药渣再次榨汁,收集药汁。合并上述药汁,减压浓缩,温度为设定为70℃,浓缩至相对密度为1.20的清膏。将所得的清膏于80℃下真空干燥至含水量为8%,粉碎,过60目筛,真空包装,即得成品。成品饮片含葛根素(C21H20O9)为4.5%。
Claims (2)
1.一种葛根鲜提真空干燥粉末饮片,其主要特征在于:在葛根采收后,及时净选,去除泥沙等杂质和非药用部位,于24小时内趁鲜用自来水洗净并切成2~5mm厚的片,加入1~5倍重量50~70℃的水,浸泡并时时搅拌5~30分钟,过滤,药渣压榨取汁;所得药渣中再加入5~10倍重量的水,煮沸10~30分钟,趁热过滤,药渣再次榨汁,收集药汁;合并上述药汁,过60~100目筛,减压浓缩,温度为50~75℃,浓缩至相对密度为1.15~1.25的清膏;将所得的清膏在60~80℃下真空干燥至含水量低于10%,粉碎,过60目筛,真空包装,即得成品;成品饮片含葛根素(C21H20O9)不低于4.0%。
2.根据权利要求1所述的葛根鲜提真空干燥粉末饮片,其主要特征在于:临床一般使用量为1~5g,既可入汤剂煎服、冲服,也可直接入丸剂、散剂、胶囊剂及片剂中。
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CN201810733381.2A CN108771701A (zh) | 2018-07-06 | 2018-07-06 | 葛根鲜提真空干燥粉末饮片 |
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2018
- 2018-07-06 CN CN201810733381.2A patent/CN108771701A/zh not_active Withdrawn
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Application publication date: 20181109 |