CN108771019A - A kind of feed addictive for piglet opening food calling and promotion enteron aisle and skeleton development - Google Patents
A kind of feed addictive for piglet opening food calling and promotion enteron aisle and skeleton development Download PDFInfo
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- CN108771019A CN108771019A CN201810603369.XA CN201810603369A CN108771019A CN 108771019 A CN108771019 A CN 108771019A CN 201810603369 A CN201810603369 A CN 201810603369A CN 108771019 A CN108771019 A CN 108771019A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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Abstract
The present invention provides a kind of feed addictive for piglet opening food calling and promotion enteron aisle and skeleton development, it calculates by weight, it is characterized in that, it, which prepares raw material, includes at least modified 2-15 parts of chitosan oligomer, 0.1-5 parts of PORPHYRIN IRON, 5-10 parts of cheese, 2-15 parts of amino acid, 5-25 parts of vitamin, 1-5 parts of N- carbamylglutamic acid chelated coppers, 1-5 parts of N- carbamylglutamic acid chelated zincs, 1-5 parts of manganese methionine, 2-15 parts of glucose, 6-20 parts of sodium butyrate, 1-5 parts of yeast selenium；Wherein, the modified chitosan oligomer is that chitosan graft aurantiin dihydrochalcone and bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of 2- (2,4- difluorophenyl) -1,3- are prepared.
Description
Technical field
The present invention relates to field of feed additive technology, in particular it relates to it is a kind of for piglet opening food calling and
Promote the feed addictive of enteron aisle and skeleton development.
Background technology
With the development of pig breeding industry, the operation on pig farm is also increasingly intended to specialization.Sow and child care-fattening field
Separation is so that piglet transaction becomes increased.However, piglet is since digestive system and developing immune system are not perfect, nutrition supplying
The variation for giving environment often causes piglet stress reaction, leads to the declines such as feed intake, growth performance, intestinal health, occurs
Daily gain is low, diarrhea, even dead severe patient phenomena such as.It is existing slow down piglet stress means mainly by feed or drink
In water large dosage addition antibiotic reduce Infection in Piglets disease chance, but can not fundamentally solve intestine of young pigs damage,
The problem of immunosupress and growth slow down, and a large amount of uses of antibiotic can make pathogen generate drug resistance, to further prestige
Coerce the health of animals and humans.
In addition, piglet anaemia, body reduces the digestibility of nutriment, and piglet obtains nutrition and reduces, and then leads
Cause pig weight light, survival rate is low.
Therefore, for the above situation, the present invention provides a kind of for piglet opening food calling and promotion enteron aisle and skeleton development
Feed addictive, promote piglet digestive system and developing immune system it is perfect, feed intake, growth performance, intestinal health etc.
Rise, fundamentally solves the problems, such as that intestine of young pigs damage, immunosupress and growth slow down；In addition, described be open for piglet
Food calling and the feed addictive of promotion enteron aisle and skeleton development also have excellent stability.
Invention content
To solve the above-mentioned problems, the present invention, which provides, a kind of for piglet opening food calling and promotes enteron aisle and skeleton development
Feed addictive calculates by weight, prepare raw material include at least modified 2-15 parts of chitosan oligomer, 0.1-5 parts of PORPHYRIN IRON,
5-10 parts of cheese, 2-15 parts of amino acid, 5-25 parts of vitamin, 1-5 parts of N- carbamylglutamic acid chelated coppers, N- carbamylglutamic acids
1-5 parts of chelated zinc, 1-5 parts of manganese methionine, 2-15 parts of glucose, 6-20 parts of sodium butyrate, 1-5 parts of yeast selenium；Wherein, the modification
Chitosan oligomer is that chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4 difluorobenzene base) -1,3- are double
(1H-1,2,4- triazol-1-yls) -2- propyl alcohol (86386-73-4) is prepared.
In one embodiment, calculate by weight, prepare raw material include at least modified 5-10 parts of chitosan oligomer,
0.1-5 parts of PORPHYRIN IRON, 5-10 parts of cheese, 2-10 parts of amino acid, 5-20 parts of vitamin, 1-3 parts of N- carbamylglutamic acid chelated coppers,
1-3 parts of N- carbamylglutamic acid chelated zincs, 1-3 parts of manganese methionine, 5-10 parts of glucose, 6-12 parts of sodium butyrate, yeast selenium 2-3
Part.
In one embodiment, it calculates by weight, prepares raw material and include at least modified 8 parts of chitosan oligomer, porphin
2 parts of quinoline iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N- carbamylglutamic acids chelated copper, N- carbamylglutamic acid chelas
Close 3 parts of zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, 2 parts of yeast selenium.
In one embodiment, the chitosan and the aurantiin dihydrochalcone, the 2- (2,4- difluorobenzenes
Base) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of -1,3- molar ratio be 1：(0.01-0.2)：(0.01-0.1).
In one embodiment, the molecular weight of the modified chitosan oligomer is 3000~50000.
In one embodiment, the amino acid includes one or more in lysine, cysteine, glutamic acid.
In one embodiment, lysine described in the amino acid and the cysteine, the weight of the glutamic acid
Amount is than being 1：(1-2)：(0.1-1).
In one embodiment, the vitamin includes vitamin A, vitamin C, vitamine D3, vitamin E, dimension life
It is one or more in plain K, vitamin B1, vitamin B2, vitamin B6, vitamin B12.
In one embodiment, the vitamin is vitamin A, vitamin C, vitamin E, vitamin K, vitamin
The weight ratio of B12, the vitamin A and the vitamin C, the vitamin E, the vitamin K, the vitamin B12 is
1：(1-2)：(1-2)：(0.1-0.2)：(0.1-0.5).
Another aspect of the present invention provides a kind of for piglet opening food calling and the addition of the feed of promotion enteron aisle and skeleton development
The preparation method of agent, at least includes the following steps：
It (1) by weight will modified chitosan oligomer, N- carbamylglutamic acids chelated copper, N- carbamylglutamic acids chelating
Zinc, manganese methionine are uniformly mixed, obtain pre-mixing agent；
(2) vitamin is added into step (1) by weight, after mixing, PORPHYRIN IRON, cheese, amino acid, Portugal is added
Grape sugar, sodium butyrate, yeast selenium obtain described for piglet opening food calling and promoting enteron aisle and skeleton development after mixing
Feed addictive.
The above-mentioned of the application and other features, aspect and advantage is more readily understood with reference to following detailed description.
Specific implementation mode
The detailed description for preferred implementation method of the invention below of participating in the election of and including embodiment this hair can be more easily understood
Bright content.Unless otherwise defined, all technologies used herein and scientific terminology have common with fields of the present invention
The normally understood identical meaning of technical staff.When there is a conflict, the definition in this specification shall prevail.
As used herein term " by ... prepare " it is synonymous with "comprising".Term "comprising" used herein, " comprising ",
" having ", " containing " or its any other deformation, it is intended that cover non-exclusionism includes.For example, the combination comprising listed elements
Object, step, method, product or device are not necessarily limited to those elements, but may include not expressly listed other elements or
Such composition, step, method, product or the intrinsic element of device.
Conjunction " Consists of " excludes any element that do not point out, step or component.If in claim, this
Phrase will make claim be closed, so that it is not included the material in addition to the material of those descriptions, but relative normal
Except rule impurity.When being rather than immediately following after theme in the clause that phrase " Consists of " appears in claim main body,
It is only limited to the element described in the clause；Other elements are not excluded except the claim as a whole.
Equivalent, concentration or other values or parameter are excellent with range, preferred scope or a series of upper limit preferred values and lower limit
When the Range Representation that choosing value limits, this, which should be understood as, specifically discloses by any range limit or preferred value and any range
Any pairing of lower limit or preferred value is formed by all ranges, regardless of whether the range separately discloses.For example, when open
When range " 1 to 5 ", described range should be interpreted as including range " 1 to 4 ", " 1 to 3 ", " 1 to 2 ", " 1 to 2 and 4 to
5 ", " 1 to 3 and 5 " etc..When numberical range is described herein, unless otherwise stated, otherwise range intention includes its end
Value and all integers and score in the range.
Singulative includes that plural number discusses object, unless the context clearly dictates otherwise." optional " or it is " arbitrary
It is a kind of " refer to that the item described thereafter or event may or may not occur, and the description include situation that event occurs and
The situation that event does not occur.
Approximate term in specification and claims is used for modifying quantity, and it is specific to indicate that the present invention is not limited to this
Quantity further includes the modified part of the acceptable change without lead to related basic function close to the quantity.Phase
It answers, modifies a numerical value with " about ", " about " etc., mean that the present invention is not limited to the exact numericals.In some examples, approximate
Term likely corresponds to the precision of the instrument of measured value.In present specification and claims, range limits can be with
Combination and/or exchange, these ranges include all subranges contained therebetween if not stated otherwise.
In addition, indefinite article "an" before element of the present invention or component and "one" quantitative requirement to element or component
(i.e. occurrence number) unrestriction.Therefore "one" or "an" should be read as including one or at least one, and odd number
The element or component of form also include plural form, unless the apparent purport of the quantity refers to singulative.
The present invention provides a kind of feed addictive for piglet opening food calling and promotion enteron aisle and skeleton development, by weight
Part calculates, and prepares raw material and includes at least modified 2-15 parts of chitosan oligomer, 0.1-5 parts of PORPHYRIN IRON, 5-10 parts of cheese, amino acid
2-15 parts, 5-25 parts of vitamin, 1-5 parts of N- carbamylglutamic acid chelated coppers, 1-5 parts of N- carbamylglutamic acid chelated zincs, egg ammonia
Sour manganese 1-5 parts, 2-15 parts of glucose, 6-20 parts of sodium butyrate, 1-5 parts of yeast selenium；Wherein, the modified chitosan oligomer is poly- for shell
Bis- (1H-1,2,4- triazoles-the 1- of sugar grafting aurantiin dihydrochalcone (18916-17-1) and 2- (2,4 difluorobenzene base) -1,3-
Base) -2- propyl alcohol (86386-73-4) is prepared.
Chitosan is the product of chitin deacetylation, is alkaline polysaccharide, and a small number of electrically charged one of natural products,
Have the function of broad-spectrum antibacterial, enhancing immunity of organisms, improves breeding performonce fo animals, improves animal meat and purify water, and
And derive from a wealth of sources, nontoxic, noresidue has no drug resistance, safe and efficient, is a kind of feed addition of great Development volue
Agent.
Chitosan has obviously the various bacterias such as Escherichia coli, gold-coloured staphylococci and pseudomonas aeruginosa and Candida albicans
Inhibition and killing effect, show stronger antibacterial activity.But compared with existing chemical synthesis antiseptic, antibacterial activity according to
So relatively low and there is no inhibitory activity to Mycophyta, in addition the inhibiting effect of chitosan also subtracts because of the increase of molecular weight
Weak, this is bigger with chitosan molecule amount, water-soluble more poor related, weakens so as to cause biocidal property.
Aurantiin dihydrochalcone can damage bacterial cell plasma membrane, inhibit the synthesis of bacterial nucleic acid, inhibit the energy of bacterium
Amount metabolism, inhibits the synthesis of bacteria cell wall, inhibits the synthesis of bacterial cell membrane.
Bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of 2- (2,4 difluorobenzene base) -1,3- and Cu2+The complexing that ion is formed
Object supermolecule is much better than the bis- (1H-1,2,4- triazoles -1- of 2- (2,4 difluorobenzene base) -1,3- to the activity of anti-candida albicans
Base) -2- propyl alcohol, and the complex compound supermolecule has rejection ability to Candida albicans.
The preparation method of the modified chitosan oligomer includes the following steps：
(1) hydrochloric acid solution of chitosan, 2mol/L are added into reactor, stirring to chitosan is dissolved, by reaction system
It is placed in ice bath, when the temperature to -5-0 DEG C, sodium nitrite, insulation reaction is added, until detecting that reaction solution makes starch iodate
Potassium test paper stops reaction in bluish violet, and extra sodium nitrite is neutralized with urea；The chitosan and the hydrochloric acid solution,
The weight ratio of the sodium nitrite is 1：20：1.1；The molecular weight of the chitosan is 8000；
(2) it is passed through nitrogen into step (1), is warming up to 20 DEG C, with 1mol/L sodium hydroxide solutions by the PH of reaction system
Value is adjusted to 7.5, is slowly added to aurantiin dihydrochalcone, then 2- (2,4- difluorophenyl) -1,3- is added in insulation reaction 2h
Bis- (1H-1,2,4- triazol-1-yls) -2- propyl alcohol, insulation reaction 1.5h, filtering, with water washing is purified 3 times, 60 DEG C are dried under reduced pressure
For 24 hours, the modified chitosan oligomer is obtained.
In one embodiment, calculate by weight, prepare raw material include at least modified 5-10 parts of chitosan oligomer,
0.1-5 parts of PORPHYRIN IRON, 5-10 parts of cheese, 2-10 parts of amino acid, 5-20 parts of vitamin, 1-3 parts of N- carbamylglutamic acid chelated coppers,
1-3 parts of N- carbamylglutamic acid chelated zincs, 1-3 parts of manganese methionine, 5-10 parts of glucose, 6-12 parts of sodium butyrate, yeast selenium 2-3
Part.
In one embodiment, it calculates by weight, prepares raw material and include at least modified 8 parts of chitosan oligomer, porphin
2 parts of quinoline iron, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N- carbamylglutamic acids chelated copper, N- carbamylglutamic acid chelas
Close 3 parts of zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, 2 parts of yeast selenium.
In one embodiment, the chitosan and the aurantiin dihydrochalcone, the 2- (2,4- difluorobenzenes
Base) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of -1,3- molar ratio be 1：(0.01-0.2)：(0.01-0.1)；It is preferred that
Ground, the chitosan and the aurantiin dihydrochalcone, the 2- (2,4- difluorophenyl) -1,3- it is bis- (1H-1,2,4- tri-
Azoles -1- bases) -2- propyl alcohol molar ratio be 1：0.12：0.05.
In one embodiment, the molecular weight of the modified chitosan oligomer is 3000~50000；Preferably, described
The molecular weight of modified chitosan oligomer is 8000~10000.
In one embodiment, the amino acid includes one or more in lysine, cysteine, glutamic acid.
In one embodiment, lysine described in the amino acid and the cysteine, the weight of the glutamic acid
Amount is than being 1：(1-2)：(0.1-1)；Preferably, the weight ratio of the lysine and the cysteine, the glutamic acid is 1：
1.2：0.6.
In one embodiment, the vitamin includes vitamin A, vitamin C, vitamine D3, vitamin E, dimension life
It is one or more in plain K, vitamin B1, vitamin B2, vitamin B6, vitamin B12.
In one embodiment, the vitamin is vitamin A, vitamin C, vitamin E, vitamin K, vitamin
The weight ratio of B12, the vitamin A and the vitamin C, the vitamin E, the vitamin K, the vitamin B12 is
1：(1-2)：(1-2)：(0.1-0.2)：(0.1-0.5)；Preferably, the vitamin A and the vitamin C, the vitamin
E, the vitamin K, the vitamin B12 weight ratio be 1：1.5：1.2：0.12：0.3.
Another aspect of the present invention provides a kind of for piglet opening food calling and the addition of the feed of promotion enteron aisle and skeleton development
The preparation method of agent, at least includes the following steps：
It (1) by weight will modified chitosan oligomer, N- carbamylglutamic acids chelated copper, N- carbamylglutamic acids chelating
Zinc, manganese methionine are uniformly mixed, obtain pre-mixing agent；
(2) vitamin is added into step (1) by weight, after mixing, PORPHYRIN IRON, cheese, amino acid, Portugal is added
Grape sugar, sodium butyrate, yeast selenium obtain described for piglet opening food calling and promoting enteron aisle and skeleton development after mixing
Feed addictive.
N- carbamylglutamic acids chelated copper, N- carbamylglutamic acids chelated zinc, manganese methionine, vitamin, porphin in the present invention
Quinoline iron, cheese, amino acid, glucose, sodium butyrate, yeast selenium can greatly improve piglet feed intake and daily gain, improve piglet life
Long performance；N- carbamylglutamic acids chelated copper and N- carbamylglutamic acids chelated zinc can not only provide organic trace element, also
Intestine of young pigs health and anti-stress ability can be improved.Glucose and sodium butyrate quickly can provide energy for intestine of young pigs, effectively
Improve piglet gastrointestinal function, improves piglet digestion power and feed intake, reduce enterogastric diseases.
Modified chitosan oligomer not only reads ball to Escherichia coli, gold-coloured staphylococci and pseudomonas aeruginosa and white in the present invention
The various bacterias such as bacterium have apparent inhibition and killing effect, show stronger antibacterial activity, and feed addictive is promoted to preserve
Stability；But also can solve glutamine it is unstable, hold degradation-labile defect.
In addition aurantiin dihydrochalcone also has excellent anti-oxidation function, and Peroxynitrite ONOO- can be inhibited to draw
The nitration reaction of the protein risen；It can be complexed with transition metal ions, promote N- carbamylglutamic acids chelated copper, N- ammonia first
It efficiently absorbs and utilizes in acyl glutamate chelate zinc, manganese methionine piglet body.
Inventive formulation reasonable design while providing comprehensive, balanced nutrition for piglet, provides the hematopoiesis tonifying Qi of original creation
Nutrition, solves food in one's mouth piglet and anaemia problem often occurs in growth period, and sufficient nutrition, survival rate are provided for the development of piglet fast-growth
It is high；On the other hand, piglet feed intake becomes larger, intestinal health, autoimmunity enhancing.
It is heretofore described to be used to add for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
It is described for piglet opening food calling and the feed of enteron aisle and skeleton development to be promoted to add to preparing piglet feed feed in piglet diet
The dosage of agent is added to be equivalent to the 0.1-0.5% of the piglet feed feeding quality.
The present invention is specifically described below by embodiment.It is necessarily pointed out that following embodiment is only used
In the invention will be further described, it should not be understood as limiting the scope of the invention, professional and technical personnel in the field
Some the nonessential modifications and adaptations made according to the content of aforementioned present invention, still fall within protection scope of the present invention.
In addition, if without other explanations, it is raw materials used to be all commercially available, it is purchased from traditional Chinese medicines chemical reagent.
Embodiment 1
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy ammonia
2 parts of sour chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium 2
Part；Wherein, the modified chitosan oligomer is chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4- bis-
Fluorophenyl) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol (86386-73-4) of -1,3- are prepared, the chitosan and institute
State aurantiin dihydrochalcone, bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of the 2- (2,4 difluorobenzene base) -1,3- rub
You are than being 1：0.12：0.05；The amino acid is lysine, cysteine, glutamic acid, the lysine and the half Guang ammonia
The weight ratio of sour, the described glutamic acid is 1：1.2：0.6；The vitamin be vitamin A, vitamin C, vitamin E, vitamin K,
Vitamin B12, the vitamin A and the vitamin C, the weight of the vitamin E, the vitamin K, the vitamin B12
Amount is than being 1：1.5：1.2：0.12：0.3；
The preparation method for piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development, including with
Lower step：
It (1) by weight will modified chitosan oligomer, N- carbamylglutamic acids chelated copper, N- carbamylglutamic acids chelating
Zinc, manganese methionine are uniformly mixed, obtain pre-mixing agent；
(2) vitamin is added into step (1) by weight, after mixing, PORPHYRIN IRON, cheese, amino acid, Portugal is added
Grape sugar, sodium butyrate, yeast selenium obtain described for piglet opening food calling and promoting enteron aisle and skeleton development after mixing
Feed addictive.
The preparation method of the modified chitosan oligomer includes the following steps：
(1) hydrochloric acid solution of chitosan, 2mol/L are added into reactor, stirring to chitosan is dissolved, by reaction system
It is placed in ice bath, when the temperature to -5-0 DEG C, sodium nitrite, insulation reaction is added, until detecting that reaction solution makes starch iodate
Potassium test paper stops reaction in bluish violet, and extra sodium nitrite is neutralized with urea；The chitosan and the hydrochloric acid solution,
The weight ratio of the sodium nitrite is 1：20：1.1；The molecular weight of the chitosan is 8000；
(2) it is passed through nitrogen into step (1), is warming up to 20 DEG C, with 1mol/L sodium hydroxide solutions by the PH of reaction system
Value is adjusted to 7.5, is slowly added to aurantiin dihydrochalcone, then 2- (2,4- difluorophenyl) -1,3- is added in insulation reaction 2h
Bis- (1H-1,2,4- triazol-1-yls) -2- propyl alcohol, insulation reaction 1.5h, filtering, with water washing is purified 3 times, 60 DEG C are dried under reduced pressure
For 24 hours, the modified chitosan oligomer is obtained.
Embodiment 2
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 5 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy ammonia
2 parts of sour chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium 2
Part；Wherein, the modified chitosan oligomer is chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4- bis-
Fluorophenyl) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol (86386-73-4) of -1,3- are prepared, the chitosan and institute
State aurantiin dihydrochalcone, bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of the 2- (2,4 difluorobenzene base) -1,3- rub
You are than being 1：0.12：0.05；The amino acid is lysine, cysteine, glutamic acid, the lysine and the half Guang ammonia
The weight ratio of sour, the described glutamic acid is 1：1.2：0.6；The vitamin be vitamin A, vitamin C, vitamin E, vitamin K,
Vitamin B12, the vitamin A and the vitamin C, the weight of the vitamin E, the vitamin K, the vitamin B12
Amount is than being 1：1.5：1.2：0.12：0.3；
It is described for the preparation method of piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development, described change
The preparation method is the same as that of Example 1 for property chitosan oligomer.
Embodiment 3
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 10 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy
2 parts of propylhomoserin chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium
2 parts；Wherein, the modified chitosan oligomer is chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4-
Difluorophenyl) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol (86386-73-4) of -1,3- are prepared, the chitosan with
The aurantiin dihydrochalcone, the 2- (2,4 difluorobenzene base) -1,3- bis- (1H-1,2,4- triazol-1-yls) -2- propyl alcohol
Molar ratio is 1：0.12：0.05；The amino acid is lysine, cysteine, glutamic acid, the lysine and the half Guang ammonia
The weight ratio of sour, the described glutamic acid is 1：1.2：0.6；The vitamin be vitamin A, vitamin C, vitamin E, vitamin K,
Vitamin B12, the vitamin A and the vitamin C, the weight of the vitamin E, the vitamin K, the vitamin B12
Amount is than being 1：1.5：1.2：0.12：0.3；
It is described for the preparation method of piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development, described change
The preparation method is the same as that of Example 1 for property chitosan oligomer.
Embodiment 4
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy ammonia
2 parts of sour chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium 2
Part；Wherein, the modified chitosan oligomer is chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4- bis-
Fluorophenyl) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol (86386-73-4) of -1,3- are prepared, the chitosan and institute
State aurantiin dihydrochalcone, bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of the 2- (2,4 difluorobenzene base) -1,3- rub
You are than being 1：0.01：0.1；The amino acid is lysine, cysteine, glutamic acid, the lysine and the cysteine,
The weight ratio of the glutamic acid is 1：1.2：0.6；The vitamin is vitamin A, vitamin C, vitamin E, vitamin K, dimension
Raw element B12, the weight of the vitamin A and the vitamin C, the vitamin E, the vitamin K, the vitamin B12
Than being 1：1.5：1.2：0.12：0.3；
It is described for the preparation method of piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development, described change
The preparation method is the same as that of Example 1 for property chitosan oligomer.
Embodiment 5
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy ammonia
2 parts of sour chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium 2
Part；Wherein, the modified chitosan oligomer is chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4- bis-
Fluorophenyl) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol (86386-73-4) of -1,3- are prepared, the chitosan and institute
State aurantiin dihydrochalcone, bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of the 2- (2,4 difluorobenzene base) -1,3- rub
You are than being 1：0.2：0.01；The amino acid is lysine, cysteine, glutamic acid, the lysine and the cysteine,
The weight ratio of the glutamic acid is 1：1.2：0.6；The vitamin is vitamin A, vitamin C, vitamin E, vitamin K, dimension
Raw element B12, the weight of the vitamin A and the vitamin C, the vitamin E, the vitamin K, the vitamin B12
Than being 1：1.5：1.2：0.12：0.3；
It is described for the preparation method of piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development, described change
The preparation method is the same as that of Example 1 for property chitosan oligomer.
Comparative example 1
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy ammonia
2 parts of sour chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium 2
Part；Wherein, the modified chitosan oligomer is that chitosan graft aurantiin dihydrochalcone (18916-17-1) is prepared, institute
The molar ratio for stating chitosan and the aurantiin dihydrochalcone is 1：0.12；The amino acid is lysine, cysteine, paddy
The weight ratio of propylhomoserin, the lysine and the cysteine, the glutamic acid is 1：1.2：0.6；The vitamin is that dimension is given birth to
Plain A, vitamin C, vitamin E, vitamin K, vitamin B12, the vitamin A and the vitamin C, the vitamin E, institute
State vitamin K, the weight ratio of the vitamin B12 is 1：1.5：1.2：0.12：0.3；
The preparation method for piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development is same to be implemented
Example 1.
The preparation method of the modified chitosan oligomer is as follows：
(1) hydrochloric acid solution of chitosan, 2mol/L are added into reactor, stirring to chitosan is dissolved, by reaction system
It is placed in ice bath, when the temperature to -5-0 DEG C, sodium nitrite, insulation reaction is added, until detecting that reaction solution makes starch iodate
Potassium test paper stops reaction in bluish violet, and extra sodium nitrite is neutralized with urea；The chitosan and the hydrochloric acid solution,
The weight ratio of the sodium nitrite is 1：20：1.1；The molecular weight of the chitosan is 8000；
(2) it is passed through nitrogen into step (1), is warming up to 20 DEG C, with 1mol/L sodium hydroxide solutions by the PH of reaction system
Value is adjusted to 7.5, is slowly added to aurantiin dihydrochalcone, insulation reaction 2h, filtering, with water washing is purified 3 times, 60 DEG C depressurize
Drying for 24 hours, obtains the modified chitosan oligomer.
Comparative example 2
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes modified 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamyl paddy ammonia
2 parts of sour chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, yeast selenium 2
Part；Wherein, the modified chitosan oligomer is chitosan graft 2- (2,4- difluorophenyl) -1,3- bis- (1H-1,2,4- triazoles -
1- yls) -2- propyl alcohol (86386-73-4) is prepared, the chitosan and the bis- (1H- of the 2- (2,4- difluorophenyl) -1,3-
1,2,4- triazol-1-yls) -2- propyl alcohol molar ratio be 1：0.05；The amino acid is lysine, cysteine, glutamic acid, institute
The weight ratio for stating lysine and the cysteine, the glutamic acid is 1：1.2：0.6；The vitamin is vitamin A, dimension life
Plain C, vitamin E, vitamin K, vitamin B12, the vitamin A and the vitamin C, the vitamin E, the vitamin
K, the weight ratio of the vitamin B12 is 1：1.5：1.2：0.12：0.3；
The preparation method for piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development is same to be implemented
Example 1.
The preparation method of the modified chitosan oligomer is as follows：
(1) hydrochloric acid solution of chitosan, 2mol/L are added into reactor, stirring to chitosan is dissolved, by reaction system
It is placed in ice bath, when the temperature to -5-0 DEG C, sodium nitrite, insulation reaction is added, until detecting that reaction solution makes starch iodate
Potassium test paper stops reaction in bluish violet, and extra sodium nitrite is neutralized with urea；The chitosan and the hydrochloric acid solution,
The weight ratio of the sodium nitrite is 1：20：1.1；The molecular weight of the chitosan is 8000；
(2) it is passed through nitrogen into step (1), is warming up to 20 DEG C, with 1mol/L sodium hydroxide solutions by the PH of reaction system
Value is adjusted to 7.5, is slowly added to bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol of 2- (2,4- difluorophenyl) -1,3-, and heat preservation is anti-
1.5h is answered, is filtered, with water washing is purified 3 times, 60 DEG C are dried under reduced pressure for 24 hours, obtain the modified chitosan oligomer.
Comparative example 3
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamylglutamic acid chelas
Close 2 parts of copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, 2 parts of yeast selenium；Its
In, the molecular weight of the chitosan is 8000；The amino acid is lysine, cysteine, glutamic acid, the lysine and institute
State cysteine, the weight ratio of the glutamic acid is 1：1.2：0.6；The vitamin be vitamin A, vitamin C, vitamin E,
Vitamin K, vitamin B12, the vitamin A and the vitamin C, the vitamin E, the vitamin K, the vitamin
The weight ratio of B12 is 1：1.5：1.2：0.12：0.3；
The preparation method for piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development is same to be implemented
Example 1.
Comparative example 4
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, N- carbamylglutamic acid chelas
Close 2 parts of copper, 3 parts of N- carbamylglutamic acids chelated zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, 2 parts of yeast selenium；Its
In, the modified chitosan oligomer is chitosan graft aurantiin dihydrochalcone (18916-17-1) and 2- (2,4- difluorobenzenes
Base) bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol (86386-73-4) of -1,3- are prepared, the molecular weight of the chitosan
It is 20000；The vitamin is vitamin A, vitamin C, vitamin E, vitamin K, vitamin B12, the vitamin A and institute
State vitamin C, the vitamin E, the vitamin K, the vitamin B12 weight ratio be 1：1.5：1.2：0.12：0.3；
The preparation method for piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development is same to be implemented
Example 1.
Comparative example 5
It calculates by weight, it is described to be prepared for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
Raw material includes 2 parts of PORPHYRIN IRON, 3 parts of cheese, 7 parts of amino acid, 16 parts of vitamin, 2 parts of N- carbamylglutamic acids chelated copper, N- ammonia first
3 parts of acyl glutamate chelate zinc, 1 part of manganese methionine, 8 parts of glucose, 10 parts of sodium butyrate, 2 parts of yeast selenium；Wherein, the amino acid
For lysine, cysteine, glutamic acid, the weight ratio of the lysine and the cysteine, the glutamic acid is 1：1.2：
0.6；The vitamin is vitamin A, vitamin C, vitamin E, vitamin K, vitamin B12, the vitamin A and the dimension
Raw element C, the vitamin E, the vitamin K, the vitamin B12 weight ratio be 1：1.5：1.2：0.12：0.3；
The preparation method for piglet opening food calling and the feed addictive for promoting enteron aisle and skeleton development is same to be implemented
Example 1.
Performance test
1, piglet 550 after 28 ages in days transport is chosen, is designed using single factor experiment, 10 is assigned at random by weight and gender
A processing group, control group do not add the additive of the present invention, and processing group adds the feed addictive of the present invention of 0.1 (wt) %, examination
Test the phase 21 days.The influence of this feed addictive weaned piglets and diarrhea rate
2, the feed addictive stability for piglet opening food calling and promotion enteron aisle and skeleton development
It is wet by temperature 45 C, air is placed in for piglet opening food calling and the feed addictive of promotion enteron aisle and skeleton development
It is placed 40 days under conditions of degree 90%, observation is used for piglet opening food calling and promotes the feed addictive of enteron aisle and skeleton development
Color and luster and smell；
All features and standard sample of 5 points of products are completely the same；
4 points of products can receive, but the somewhat difference compared with standard sample；
3 points of products can receive, but have significant difference compared with standard sample；
2 points of products cannot a little receive；
1 point of product cannot receive completely.
1 the performance test results of table
It is seen from the above data that one kind provided by the invention is for piglet opening food calling and promotes enteron aisle and bone hair
The feed addictive educated promotes piglet digestive system and developing immune system perfect, feed intake, growth performance, intestinal health
Deng rising, fundamentally solve the problems, such as that intestine of young pigs damage, immunosupress and growth slow down；In addition, described open for piglet
Mouth food calling and the feed addictive of promotion enteron aisle and skeleton development also have excellent stability.
Example above-mentioned is merely illustrative, some features for explaining the method for the invention.Appended right is wanted
The range as wide as possible for being intended to require to be contemplated that is sought, and embodiments as presented herein is only according to all possible implementation
The explanation of the embodiment of the selection of the combination of example.Therefore, the purpose of applicant is that the attached claims are not illustrated this hair
The exemplary selectional restriction of bright feature.Some numberical ranges used also include sub- model in the claims
It encloses, the variation in these ranges should also be construed to be covered by the attached claims in the conceived case.
Claims (10)
1. a kind of feed addictive for piglet opening food calling and promotion enteron aisle and skeleton development calculates by weight, special
Sign is, prepares raw material and includes at least modified 2-15 parts of chitosan oligomer, 0.1-5 parts of PORPHYRIN IRON, 5-10 parts of cheese, amino acid
2-15 parts, 5-25 parts of vitamin, 1-5 parts of N- carbamylglutamic acid chelated coppers, 1-5 parts of N- carbamylglutamic acid chelated zincs, egg ammonia
Sour manganese 1-5 parts, 2-15 parts of glucose, 6-20 parts of sodium butyrate, 1-5 parts of yeast selenium；Wherein, the modified chitosan oligomer is poly- for shell
Sugar grafting aurantiin dihydrochalcone and bis- (1H-1,2,4- the triazol-1-yls) -2- propyl alcohol systems of 2- (2,4 difluorobenzene base) -1,3-
It is standby to obtain.
2. being used for piglet opening food calling according to claim 1 and promoting the feed addictive of enteron aisle and skeleton development, by weight
It measures part to calculate, which is characterized in that it prepares raw material and includes at least modified 5-10 parts of chitosan oligomer, 0.1-5 parts of PORPHYRIN IRON, cheese
5-10 parts, 2-10 parts of amino acid, 5-20 parts of vitamin, 1-3 parts of N- carbamylglutamic acid chelated coppers, N- carbamylglutamic acids chelating
1-3 parts of zinc, 1-3 parts of manganese methionine, 5-10 parts of glucose, 6-12 parts of sodium butyrate, 2-3 parts of yeast selenium.
3. being used for piglet opening food calling according to claim 2 and promoting the feed addictive of enteron aisle and skeleton development, by weight
It measures part to calculate, which is characterized in that it prepares raw material and includes at least modified 8 parts of chitosan oligomer, 2 parts of PORPHYRIN IRON, 3 parts of cheese, ammonia
7 parts of base acid, 16 parts of vitamin, 2 parts of N- carbamylglutamic acids chelated copper, 3 parts of N- carbamylglutamic acids chelated zinc, manganese methionine 1
Part, 8 parts of glucose, 10 parts of sodium butyrate, 2 parts of yeast selenium.
4. it is used for piglet opening food calling according to claim 1 and promotes the feed addictive of enteron aisle and skeleton development, it is special
Sign is, the chitosan and the aurantiin dihydrochalcone, the 2- (2,4- difluorophenyl) -1,3- it is bis- (1H-1,2,4-
Triazol-1-yl) -2- propyl alcohol molar ratio be 1：(0.01-0.2)：(0.01-0.1).
5. it is used for piglet opening food calling according to claim 1 and promotes the feed addictive of enteron aisle and skeleton development, it is special
Sign is that the molecular weight of the modified chitosan oligomer is 3000~50000.
6. it is used for piglet opening food calling according to claim 1 and promotes the feed addictive of enteron aisle and skeleton development, it is special
Sign is that the amino acid includes one or more in lysine, cysteine, glutamic acid.
7. it is used for piglet opening food calling according to claim 1 and promotes the feed addictive of enteron aisle and skeleton development, it is special
Sign is that the weight ratio of lysine described in the amino acid and the cysteine, the glutamic acid is 1：(1-2)：(0.1-
1)。
8. it is used for piglet opening food calling according to claim 1 and promotes the feed addictive of enteron aisle and skeleton development, it is special
Sign is that the vitamin includes vitamin A, vitamin C, vitamine D3, vitamin E, vitamin K, vitamin B1, vitamin
It is one or more in B2, vitamin B6, vitamin B12.
9. it is used for piglet opening food calling according to claim 1 and promotes the feed addictive of enteron aisle and skeleton development, it is special
Sign is that the vitamin is vitamin A, vitamin C, vitamin E, vitamin K, vitamin B12, the vitamin A and institute
State vitamin C, the vitamin E, the vitamin K, the vitamin B12 weight ratio be 1：(1-2)：(1-2)：(0.1-
0.2)：(0.1-0.5).
10. according to being used for piglet opening food calling described in claim any one of 1-9 and the feed of enteron aisle and skeleton development being promoted to add
Add the preparation method of agent, which is characterized in that at least include the following steps：
It (1) by weight will modified chitosan oligomer, N- carbamylglutamic acids chelated copper, N- carbamylglutamic acids chelated zinc, egg
Propylhomoserin manganese is uniformly mixed, obtains pre-mixing agent；
(2) vitamin is added into step (1) by weight, after mixing, PORPHYRIN IRON, cheese, amino acid, grape is added
Sugar, sodium butyrate, yeast selenium obtain the feeding for piglet opening food calling and promotion enteron aisle and skeleton development after mixing
Feed additives.
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| Application Number | Priority Date | Filing Date | Title |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN105669878A (en) * | 2016-03-28 | 2016-06-15 | 宁波科瑞特动物药业有限公司 | Modified oligochitosan for aquaculture and preparation method thereof |
| CN105777381A (en) * | 2016-04-12 | 2016-07-20 | 河南捷农生化有限公司 | Medium trace element compound fertilizer containing vitamin B and preparation method thereof |
-
2018
- 2018-06-12 CN CN201810603369.XA patent/CN108771019B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104938866A (en) * | 2015-07-14 | 2015-09-30 | 漳州傲农牧业科技有限公司 | Feed additive with piglet stress resistance and intestinal tract improvement effects and preparation method and application |
| CN105669878A (en) * | 2016-03-28 | 2016-06-15 | 宁波科瑞特动物药业有限公司 | Modified oligochitosan for aquaculture and preparation method thereof |
| CN105777381A (en) * | 2016-04-12 | 2016-07-20 | 河南捷农生化有限公司 | Medium trace element compound fertilizer containing vitamin B and preparation method thereof |
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