CN108760050A - absorbance detection circuit - Google Patents
absorbance detection circuit Download PDFInfo
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- CN108760050A CN108760050A CN201810507495.5A CN201810507495A CN108760050A CN 108760050 A CN108760050 A CN 108760050A CN 201810507495 A CN201810507495 A CN 201810507495A CN 108760050 A CN108760050 A CN 108760050A
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- signal
- module
- logarithm operation
- channel
- electric signal
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- 238000002835 absorbance Methods 0.000 title claims abstract description 18
- 238000001514 detection method Methods 0.000 title claims abstract description 15
- 238000006243 chemical reaction Methods 0.000 claims abstract description 20
- 238000005070 sampling Methods 0.000 claims abstract description 14
- 238000012360 testing method Methods 0.000 abstract description 6
- 238000005259 measurement Methods 0.000 abstract description 4
- 230000009977 dual effect Effects 0.000 abstract description 3
- 230000004044 response Effects 0.000 abstract description 3
- 238000012123 point-of-care testing Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 230000006872 improvement Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 229910052724 xenon Inorganic materials 0.000 description 3
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000013475 authorization Methods 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/28—Investigating the spectrum
- G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J1/00—Photometry, e.g. photographic exposure meter
- G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
- G01J1/44—Electric circuits
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
- G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
- G01J3/02—Details
Abstract
The present invention proposes a kind of absorbance detection circuit, can directly carry out Dual Wavelength Absorbance difference calculating, and test result high resolution, measurement error is small, fast response time, and conducive to simple circuit, at low cost, including:Photoelectric conversion module, for converting multipath light signal to corresponding multi-channel electric signal；Channel selecting module is transferred to logarithm operation module for choosing two path signal；Logarithm operation module, for the two path signal to be carried out logarithm operation；Sampling control module, for the consequential signal of logarithm operation to be carried out analog-to-digital conversion acquisition.
Description
Technical field
Real-time test engineering device technique field in terms of the present invention relates to biology is especially a kind of absorbance detection circuit.
Background technology
POCT, real-time test（point-of-care testing）, refer to the clinical detection carried out beside patient（Bedside
Detect bedside-testing）, complex process program of the sample in laboratory inspection is saved, inspection result is quickly obtained
A kind of new method.POCT becomes in-vitro diagnosis instrument（IVD）A segmented industry, rely on convenient, quick advantage, in recent years
As the hot spot of industry development.
Optical absorbance method is one of the important method of inspection for POCT, and corresponding usually structure design is to use one
A light source passes through test sample by light path, the optical signal of different wave length is measured using multiple photoelectric receiving tubes, to obtain sample
This absorbance data to special wavelength light, and then clinical detection is obtained as a result, such as Authorization Notice No. is CN101620182B
A kind of disclosed multi-wavelength nucleic acid protein chromatographic separation detecting system.Aforementioned structure can introduce light for the unstable light source of light intensity
The measurement error that source wave zone comes, while doing logarithm operation under digital signal and can lose resolution ratio.
Invention content
The technical problem to be solved by the present invention is to, it overcomes the deficiencies of existing technologies, a kind of absorbance detection circuit is provided,
Dual Wavelength Absorbance difference calculating can be directly carried out, test result high resolution, measurement error is small, fast response time, and is conducive to
It is simple circuit, at low cost.
In order to solve the above technical problems, the present invention proposes a kind of absorbance detection circuit, including:Photoelectric conversion module is used
In converting multipath light signal to corresponding multi-channel electric signal；Channel selecting module is transferred to pair for choosing two path signal
Number computing module；Logarithm operation module, for the two path signal to be carried out logarithm operation；Sampling control module is used for
The consequential signal of logarithm operation is subjected to analog-to-digital conversion acquisition.
The operation principle of the present invention is that multipath light signal is converted to multi-channel electric signal by photoelectric conversion module, is transferred to logical
Road selecting module；Multi-channel electric signal is selected wherein two-way by channel selecting module, is transferred to logarithm operation module；Logarithm operation mould
Two paths of signals is carried out logarithm operation by block, is transferred to sampling control module；Consequential signal is carried out modulus and turned by sampling control module
Change acquisition.
With the above structure, compared with prior art, the present invention has the following advantages：It is transmitted by the signal of each module
And cooperation, it realizes the processing to the multipath light signal acquired in photoelectric conversion module, it is poor can directly to carry out Dual Wavelength Absorbance
It calculates, test result high resolution, measurement error is small, fast response time, and conducive to simple circuit, at low cost.
As an improvement, sampling control module further includes channel selecting control unit, chosen for control channel selecting module
Two path signal in multi-channel electric signal, in this way, being more conducive to optimization circuit.
As an improvement, channel selecting module includes two channel units, respectively first passage unit and second channel list
Member；First passage unit is used to export wherein one in the electric signal of the roads 1~N-1 for inputting the roads 1~N-1 electric signal
Road electric signal；Second channel unit is used to export in the electric signal of the roads 2~N wherein for inputting the roads 2~N electric signal
Electric signal all the way while satisfaction combination needs, is more advantageous to optimization circuit, keeps circuit simple in this way, being arranged by differentiation
Clean, combination refers to the combination of two path signal, for example first passage unit exports the 1st road electric signal, second channel unit output the 2nd
Road electric signal, then the 1st road electric signal and the 2nd road electric signal then constitute a kind of combination.
As an improvement, consequential signal is voltage signal, in this way, being more advantageous to simplified circuit, and facilitate rear class analog-to-digital conversion
Processing of circuit.
As an improvement, the two path signal that channel selecting module is transferred to logarithm operation module is current signal, in this way,
It realizes envelope eapsulotomy simultaneously, is more advantageous to simplified circuit.
Description of the drawings
Fig. 1 is a kind of application scenarios.
Fig. 2 is the frame principle figure of absorbance detection circuit of the present invention.
Fig. 3 is a kind of interlock circuit of spectrometer.
Fig. 4 is a kind of interlock circuit of first passage unit.
Fig. 5 is a kind of interlock circuit of second channel unit.
Fig. 6 is a kind of interlock circuit of logarithm operation module.
Fig. 7 is a kind of interlock circuit of sampling control module.
As shown in the figure, 1, xenon flashtube module, 2, micro-fluidic reagent disc, 3, colorimetric hole, 4, spectrometer, 5, spectrometer light
Door screen, 6, direct current generator, 7, processing circuit.
Specific implementation mode
The present invention is described in further detail below：
Of the invention for ease of understanding, Fig. 1 show a kind of application scenarios, and the structure in Fig. 1 includes xenon flashtube module 1, miniflow
Reagent disc 2, colorimetric hole 3, spectrometer 4, spectrometer diaphragm 5, direct current generator 6, processing circuit 7 are controlled, xenon flashtube module 1 is light
Source, is placed with sample in the colorimetric hole 3 of micro-fluidic reagent disc 2, and the optical signal that light source irradiates after sample is collected through spectrometer diaphragm 5
Enter spectrometer 4 afterwards, electric signal is converted by spectrometer 4, spectrometer 4 is photoelectric conversion module, and processing circuit 7 includes：Channel
Selecting module is transferred to logarithm operation module for choosing two path signal；Logarithm operation module, for the two-way is electric
Signal carries out logarithm operation；Sampling control module, for the consequential signal of logarithm operation to be carried out analog-to-digital conversion acquisition.
Fig. 2 show the frame principle figure of absorbance detection circuit of the present invention, embodies the connection relation of each module, i.e. light
Sequentially signal connects for electric conversion module, channel selecting module, logarithm operation module, sampling control module, and channel selecting module is also
It is connect with sampling control module signal, channel selecting module selects it under the management of sampling control module, by multi-channel electric signal
Middle two-way is transferred to logarithm operation module, is specifically chosen which two-way, sampled control module setting.
Fig. 3 is that a kind of interlock circuit of spectrometer is operated in the reverse-biased of 6V voltages using the spectrometer of NEWPORT producers
Under pattern, the photo-signal of 9 wavelength is exported, current signal is sent to channel selecting module by the resistance of a 1K；Light
Electric conversion module can also use photodiode array detector to realize that multipath light signal is converted, is more in addition to using spectrometer
A photoelectric receiving tube realizes the technical solutions such as multipath light signal conversion.
Fig. 4 is that a kind of interlock circuit of first passage unit, i.e. analog switch chip are realized by analog switch chip
First passage unit is used to export wherein electric all the way in the electric signal of the roads 1~N-1 for inputting the roads 1~N-1 electric signal
Signal；Second channel unit is also based on analog switch chip, as shown in figure 5, second channel unit is for inputting the roads 2~N
Electric signal, and for exporting the wherein electric signal all the way in the electric signal of the roads 2~N；It is 9 tunnels in this example, then N is 9, as shown in the figure
1st tunnel is PD_OUTA, the 2nd tunnel is PD_OUTB..., and so on.
In addition to using analog switch chip, multiple relays can also be used to realize and choose control, multiple metal-oxide-semiconductor channels reality
Now choose the structures such as control.
Fig. 6 is a kind of interlock circuit of logarithm operation module, that is, uses logarithm operation chip, can realize that two-way electric current is believed
Number logarithm operation, and logarithm operation result is output to acquisition control module in the form of a voltage.
Fig. 7 is a kind of interlock circuit of sampling control module, in addition to analog-to-digital conversion acquires, is also realized to channel selecting module
The control of any two-way current signal is chosen, sampling control module includes modulus conversion chip and fpga chip, is specifically adopted in this example
With：Modulus conversion chip AD9243MQFP realizes analog-to-digital conversion, using this fpga chip of LFXP2-17E-Q208 as control
Unit realizes the control of channel selecting and modulus conversion chip.
Acquisition control module can also use ADC chips（Modulus conversion chip）With CPU, FPGA, the combination electricity of dsp chip
Road directly uses CPU, FPGA with ADC functions, dsp chip.
The above is only the better embodiment of the present invention, therefore all constructions according to described in present patent application range,
The equivalent change or modification that feature and principle are done, is included within the scope of present patent application.
Claims (5)
1. a kind of absorbance detection circuit, which is characterized in that including:
Photoelectric conversion module, for converting multipath light signal to corresponding multi-channel electric signal；
Channel selecting module is transferred to logarithm operation module for choosing two path signal；
Logarithm operation module, for the two path signal to be carried out logarithm operation；
Sampling control module, for the consequential signal of logarithm operation to be carried out analog-to-digital conversion acquisition.
2. absorbance detection circuit according to claim 1, which is characterized in that sampling control module further includes channel selecting
Control unit chooses the two path signal in multi-channel electric signal for control channel selecting module.
3. absorbance detection circuit according to claim 1, which is characterized in that channel selecting module includes two channel lists
Member, respectively first passage unit and second channel unit；First passage unit is used for inputting the roads 1~N-1 electric signal
In exporting the wherein electric signal all the way in the electric signal of 1~N-1 roads；Second channel unit is used to input the roads 2~N electric signal,
And for exporting the wherein electric signal all the way in the electric signal of the roads 2~N.
4. absorbance detection circuit according to claim 1, which is characterized in that consequential signal is voltage signal.
5. absorbance detection circuit according to claim 1, which is characterized in that channel selecting module is transferred to logarithm operation
The two path signal of module is current signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810507495.5A CN108760050A (en) | 2018-05-24 | 2018-05-24 | absorbance detection circuit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810507495.5A CN108760050A (en) | 2018-05-24 | 2018-05-24 | absorbance detection circuit |
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| Publication Number | Publication Date |
|---|---|
| CN108760050A true CN108760050A (en) | 2018-11-06 |
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| CN201810507495.5A Pending CN108760050A (en) | 2018-05-24 | 2018-05-24 | absorbance detection circuit |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111122474A (en) * | 2020-01-13 | 2020-05-08 | 迈迪卫盾(北京)科技发展有限公司 | Detection system applied to food and water quality inspection |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101339198A (en) * | 2007-07-06 | 2009-01-07 | 株式会社东芝 | Automatic analysis apparatus and automatic analysis method |
| CN102216784A (en) * | 2008-11-17 | 2011-10-12 | 株式会社日立高新技术 | Automatic analysis device |
| US20160249836A1 (en) * | 2012-07-16 | 2016-09-01 | Sandeep Gulati | Sample optical pathlength control using a noninvasive analyzer apparatus and method of use thereof |
| CN208125274U (en) * | 2018-05-24 | 2018-11-20 | 宁波美康盛德生物科技有限公司 | absorbance detection circuit |
-
2018
- 2018-05-24 CN CN201810507495.5A patent/CN108760050A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101339198A (en) * | 2007-07-06 | 2009-01-07 | 株式会社东芝 | Automatic analysis apparatus and automatic analysis method |
| CN102216784A (en) * | 2008-11-17 | 2011-10-12 | 株式会社日立高新技术 | Automatic analysis device |
| US20160249836A1 (en) * | 2012-07-16 | 2016-09-01 | Sandeep Gulati | Sample optical pathlength control using a noninvasive analyzer apparatus and method of use thereof |
| CN208125274U (en) * | 2018-05-24 | 2018-11-20 | 宁波美康盛德生物科技有限公司 | absorbance detection circuit |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111122474A (en) * | 2020-01-13 | 2020-05-08 | 迈迪卫盾(北京)科技发展有限公司 | Detection system applied to food and water quality inspection |
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