CN105675520A - Multisource spectrograph - Google Patents
Multisource spectrograph Download PDFInfo
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- CN105675520A CN105675520A CN201610214067.4A CN201610214067A CN105675520A CN 105675520 A CN105675520 A CN 105675520A CN 201610214067 A CN201610214067 A CN 201610214067A CN 105675520 A CN105675520 A CN 105675520A
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- analog switch
- multiway analog
- optical spectrum
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- led light
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 19
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000001228 spectrum Methods 0.000 claims description 54
- 238000012360 testing method Methods 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 16
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- 238000004519 manufacturing process Methods 0.000 abstract description 3
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
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- 150000002213 flavones Chemical class 0.000 description 4
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 4
- 230000004044 response Effects 0.000 description 4
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- GQODBWLKUWYOFX-UHFFFAOYSA-N Isorhamnetin Natural products C1=C(O)C(C)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 GQODBWLKUWYOFX-UHFFFAOYSA-N 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical group [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- IZQSVPBOUDKVDZ-UHFFFAOYSA-N isorhamnetin Chemical compound C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 0.000 description 2
- 235000008800 isorhamnetin Nutrition 0.000 description 2
- 235000008777 kaempferol Nutrition 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 2
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
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- 244000194101 Ginkgo biloba Species 0.000 description 1
- 239000009429 Ginkgo biloba extract Substances 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
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- 239000003085 diluting agent Substances 0.000 description 1
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- 125000000524 functional group Chemical group 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0162—Arrangements or apparatus for facilitating the optical investigation using microprocessors for control of a sequence of operations, e.g. test, powering, switching, processing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
- G01N2021/3181—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using LEDs
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- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention provides a multisource spectrograph. The multisource spectrograph is provided with a case, a top cover, a charging port, a switch and a working indication lamp, wherein the case is internally provided with a data acquisition card, a cell grid, a quartz glass sheet and a sample pool in sequence from bottom to top; the data acquisition card is provided with a power supply management module, LED (Light Emitting Diode) light sources, photodiodes, a multi-path analogue switch, a programmable amplifier, an A/D (Analogue/Digital) conversion chip, an MCU (Micro-programmed Control Unit) microprocessor and wifi; each grid of the cell grid corresponds to one LED light source and one photodiode; an optical module is composed of the LED light sources and the photodiodes; and the top cover is arranged at the upper end of the sample pool. The multisource spectrograph takes a sample as a reference, and a series of reference signals are formed by changing a reference wavelength; the multisource spectrograph is low in manufacturing cost and utilization cost and is convenient to use; model sharing of different instruments can be realized, and values of big data can be sufficiently expressed; and the multisource spectrograph is a tool capable of providing effective spectrum analysis for Internet.
Description
Technical field
The present invention relates to technical field of analytical instruments, specifically, belong to the analytical tool of chemical composition detection, be a kind of multi-source optical spectrum instrument.
Background technology
Spectrometric instrument is by the most frequently used instrument of chemical composition Structural Identification and quantitative analysis, is widely used in the quantitative-qualitative analysis of the chemical composition in the fields such as food, medicine, agricultural product, chemicals, material. The theoretical basis of spectroanalysis instrument is: the light of different wave length is had different responses by functional groups different in chemical molecular, is carried out in the qualitative analyses such as the Structural Identification of sample, kind judging and sample the quantitative analyses such as the mensuration of contained content of chemical substances by change between the spectrum of response after analyzing incident light spectrum (be usually reference reagent formed absorption reflectance spectrum) and sample effect.
Qualitative spectrometric, quantitative analysis theoretical basis be Lambert-Beer's law:; Wherein:For sample absorbance under setted wavelength,For specific absorbance,For constant,For the concentration of determinand in sample. In real process, generally first carry out reference reagent mensuration: first measure the absorbance of reference reagent, the then absorbance of re-test sample, usually,. Need to select the concentration ranges of suitable reference reagent and sample during test, make Lambert-Beer's law be similar to and be reduced to, namely concentration and absorbance are linear relationship. It is true that existing spectrometric instrument is all fix a reference, generally the signal response in selected spectral regions of this reference reagent is only small, for instance ultraviolet spectra water, ethanol, methanol make reference reagent, make reference reagent with potassium bromide during infrared spectrum analysis. What spectrogrph disclosed in patent documentation ZL0125924, ZL0228024422, CN102967369, CN201837458 all adopted is fixing reference spectrum.
Under normal conditions, reference solvent is all the solvent or the diluent that select sample, and different solvents has different spectral signatures. That is, it is possible to measuring sample under different solvents or spectral conditions, then pass through conversion reference spectrum, the situation of change of spectrum analyzes testing sample per sample.Such as, when differentiating whether a sample is copper sulfate, it is possible to adopt traditional spectrographic technique atomic absorption spectrography (AAS), Cu is measured2+Spectral absorption, then with Cu2+Standard specimen compares, it determines whether there is Cu in sample2+. The chromatography of ions can also be adopted to differentiate in sample whether containIon. Can also adopting exchange solvent method: if anhydrous cupric sulfate is white powder, its aqueous solution is green, adds Na2There is black precipitate after S, add BaCl2After have white precipitate, here it is by change reference reagent. CuSO is differentiated under fixed observer light (visible ray)4。
Raster scan type spectrogrph is grating beam splitting type spectrogrph the earliest, and it is driven grating rotation to carry out spectral scan by motor, uses single point detector detection. The maximum shortcoming of raster scan type spectrogrph is to have mobile parts, and this causes that the shock resistance of instrument is poor, and scanning speed is relatively slow. At present, raster scan type spectrogrph is the use for laboratory instrument that volume is bigger mostly, although have Some Enterprises to have developed the portable raster scan type instrument of miniaturization, but its volume is still bigger than normal lays particular stress on. Generally, owing to needs use mobile parts, portable raster scan type spectrogrph is also fewer.
Portable fixed light path array detection type spectrogrph is more common type, adopts incident illumination to collimate through concave mirror, afterwards by fixed grating spectral, then by concave mirror focus to linear array detector. Most instruments adopt folding staggered form (Czermy-Turner) light path to reduce the volume of instrument. Also having and use concave holographic grating, save for collimating and the spectrogrph type of imaging optic element, they can simplify light path further. Current simplest spectrogrph is only made up of incident optical, concave grating and detector, and this makes spectrogrph more firm compact, improves reliability. In detector, the spectrum of existing detectable below the 1100nm of silicon detector; The response range of InGaAs detector is at 1000～1700nm, and extended pattern can to 2600nm; Additionally also have other detectors of minority. The spectra collection speed of these instruments is more faster than raster scan type, but, owing to linear array detector single pixel area is little, and there is crosstalk between different pixel, the signal to noise ratio of instrument is less better.
The luminous flux of Fourier transformation type spectrogrph is big, resolution is high, and the large-scale instrument of middle-infrared band is relatively more, and the portable instrument of near infrared band is then less, this is because, one is the general not exigent resolution of on-the-spot application due to near-infrared analysis; Two is generally have moveable parts due to Fourier transform spectrometer, and its shock resistance is poor, is difficult to make portable instrument. The light channel structure of Fourier transform spectrometer, is constantly improved in recent years, also some portable or even handheld instruments are occurred in that, these portable or handheld instruments generally use mid-infrared or short wavelength-NIR wave band, are placed on handbarrow or vehicle-mounted use.
In sum, traditional molecular spectrum is due to complicated optical system, the existence moving element and fixing reference, make the complicated structure of instrument and bulky, its range of linearity is narrow, the loss of signal is big, the use of especially dynamic element causes model transplantations difficulty, it is difficulty with model sharing, causes that substantial amounts of data can not be shared, it is impossible to produce higher value.
Summary of the invention
It is an object of the invention to solve the problems referred to above, it is provided that a kind of multi-source optical spectrum instrument, it is not using single fixing reagent as reference, but using sample itself as reference, forms a series of reference signal by changing reference wavelength;Not only manufacturing cost and use cost is low for it, and easy to use, can realize the model sharing between different instrument, can give full play to the value of big data, be a kind of can for the instrument of the effective spectrum analysis in the Internet+provide.
For testing above-mentioned purpose, present invention employs techniques below scheme.
A kind of multi-source optical spectrum instrument, containing casing, top cover, charge port, switch, relay indicating light, described top cover is arranged on the top of described casing, described charge port, switch and relay indicating light are arranged on the one or both sides outside described casing, it is characterized in that, be disposed with data collecting card, lattice grid, quartz glass plate and sample cell in the inside of described casing from bottom to top; Described data collecting card is provided with power management module, LED light source, photodiode, multiway analog switch, programmable amplifier, A/D conversion chip, MCU microprocessor and wifi; The corresponding LED light source of each grid of described lattice grid and a photodiode, formed optical module by described LED light source and photodiode; In described sample cell upper end, top cover is set.
Further, the power management module on described data collecting card connects LED light source, photodiode, programmable amplifier, A/D conversion chip and MCU microprocessor by multiway analog switch and powers.
Further, described data collecting card is provided with two multiway analog switch chips, wherein: the first multiway analog switch chip is used for selecting test wavelength, second multiway analog switch chip is used for selecting reference wavelength, when by programme-control the first multiway analog switch chip Zhong mono-tunnel " leading to ", program just selects the reference analog switch in the second multiway analog switch chip successively, and order is opened 00 tunnel (zero potential) and carried out reference to the n-th path analoging switch; So, the test information of each wavelength of sample uses the information of zero potential and another wavelength as reference respectively.
Further, the signal of described data collecting card collection can be sent to intelligent end by Wifi, and described intelligent end is computer, smart mobile phone or iPad.
Further, described optical module includes at least two spectral regions in ultraviolet spectra district, visible range, near infrared spectrum district and infrared spectral region.
Further, described spectral regions are at least made up of the LED light source of two wavelength.
Further, the corresponding described photodiode of each described LED light source, the other end of described photodiode connects multiway analog switch, the outfan of described multiway analog switch accesses programmable amplifier, the outfan of described programmable amplifier accesses A/D conversion chip, the outfan of described A/D conversion chip accesses MCU microprocessor, and gatherer process is carried out program management.
Having the benefit effect that of a kind of multi-source optical spectrum instrument of the present invention
(1) it is using sample itself as reference, forms a series of reference signal by changing reference wavelength.
(2) not only manufacturing cost and use cost is low, and easy to use, can realize the model sharing between different instrument, can give full play to the value of big data.
(3) be a kind of can for the instrument of the effective spectrum analysis in the Internet+provide.
Accompanying drawing explanation
Fig. 1 is the STRUCTURE DECOMPOSITION figure of a kind of multi-source optical spectrum instrument of the present invention.
Fig. 2 is data collecting card circuit theory diagrams.
Fig. 3 is grille and LED, photoelectric diode assembling relationship figure.
Fig. 4 is the multi-source optical spectrum figure that Application Example 1 gathers.
Fig. 5 is first, second principal component projection figure of Application Example 1 sample.
Fig. 6 is 2 one the Folium Ginkgo samples of the Application Example light intensity at different passages.
Fig. 7 is 3 one powdered milk samples of Application Example light intensity under different passages.
Fig. 8 is distillate curve during Application Example 4 twice column volume 10% ethanol elution macroporous resin column.
Fig. 9 is distillate curve during 4 two select 5 times of column volume 15% ethanol elution macroporous resin column of Application Example.
Figure 10 is distillate curve during Application Example 4 twice column volume 20% ethanol elution macroporous resin column.
Label in figure is respectively as follows:
1, casing; 2, data collecting card;
3, lattice grid; 4, quartz glass plate;
5, sample cell; 6, top cover;
7, charge port; 8, switch;
9, relay indicating light; 21, power management module;
22, LED light source; 23, photodiode;
24, multiway analog switch; 241, the first multiway analog switch chip;
242, the first multiway analog switch chip; 25, programmable amplifier;
26, A/D conversion chip; 27, MCU microprocessor;
28, intelligent end.
Detailed description of the invention
Provide the detailed description of the invention of a kind of multi-source optical spectrum instrument of the present invention below in conjunction with accompanying drawing, however it is necessary that and be pointed out that: the enforcement of the present invention is not limited to following embodiment.
Referring to Fig. 1. A kind of multi-source optical spectrum instrument, containing casing 1, data collecting card 2, lattice grid 3, quartz glass plate 4, sample cell 5, top cover 6, charge port 7, switch 8 and relay indicating light 9. Described casing 1 can adopt black ABS resin to make; Arrange top cover 6 on the top of described casing 1, described top cover 6 may be used without black ABS resin and makes.
Described data collecting card 2, lattice grid 3, quartz glass plate 4 and sample cell 5 is set gradually from bottom to top inside described casing 1. Described data collecting card 2 adopts low-power consumption digital circuit version, arranges power management module 21, LED light source 22, photodiode 23, multiway analog switch 24, programmable amplifier 25, A/D conversion chip 26, MCU microprocessor 27 and wifi(referring to Fig. 2 on data collecting card 2).
Described power management module 21 adopts LTC4054 lithium cell charging chip, and it is to aim at single lithium battery charging to need the monolithic die of design. Described power management module 21 connects LED light source 22 and photodiode 23 by multiway analog switch 24. The present invention selects LED light source 22 as transmitting illuminant, have selected eight kinds of different wave lengths, the scope LED light source 22 from the 265nm of ultraviolet near infrared 1300nm for light source for instrument. The present invention selects PN type, PIN-type, transmitting of bonding, avalanche-type photodiode 23 as light intensity sensor, for the optical signal after sample absorbs is converted to current signal.
Described multiway analog switch 24 adopts ADG408, and this is a single chip CMOS analog multiplexer, built-in 8 single channels, and one of 8 tunnel inputs, according to 3 binary address line A0, the determined address of A1 and A2, are switched to public output by it.
Described programmable amplifier 25 and described A/D conversion chip 26 adopt ADS1248. ADS1248 is 24 low noise temperature survey analog-digital converter products of the low-power consumption maximum set Cheng Du that Texas Instruments releases, it is integrated with double; two matching current digital to analog converter (DAC), low drifting internal reflection, agitator, temperature sensor, open circuit detection and 8 groups of general purpose I/O, amplifies and analog digital conversion for signal.
Described lattice grid 3 are " well " character form structure, and its effect is to stop the scattering interference between different LED light source 22.The corresponding LED light source 22 of each lattice of lattice grid 3 and a photodiode 23. The optical system installed on data collecting card 2 is as shown in Figure 3. Here, the corresponding photodiode 23 of each LED light source 22, each LED light source 22 and a photodiode 23 form one group of optic testing system. Separated by described grille 3 between each group optic testing system.
Continue and see Fig. 2. Data collecting card 2 arranges two multiway analog switch chips, wherein: the first multiway analog switch chip (241) is used for selecting test wavelength, second multiway analog switch chip (242) is used for selecting reference wavelength, when " being led to " by programme-control the first multiway analog switch chip (241) Zhong Yilu, program just selects the reference analog switch in the second multiway analog switch chip (242) successively, and order is opened 00 tunnel (zero potential) and carried out reference to the n-th path analoging switch; So, the test information of each wavelength of sample uses the information of zero potential and another wavelength as reference respectively. Only producing a signal during conventional spectrometers one wavelength of test, and the test sample under each wavelength of multi-source optical spectrum instrument of the present invention can produce n+1 signal, wherein n is number of light sources. When the present invention adopts n light source, produce (n+1) × n/2 test signal, for instance, embodiment 1 has 6 wavelength points, then in Application Example, produces 7 × 6/2=21 signal, as shown in Figure 5. This makes quantity of information that the multi-source optical spectrum instrument of the present invention produces many more than transmission spectra detector.
Input at programmable amplifier 25 is connected with two multiway analog switches 24; Input at multiway analog switch 24 connects even photodiode 23, is linked by the outfan of multiway analog switch 24 on programmable amplifier 25; Another input of programmable amplifier 25 is also connected a multiway analog switch 24, by the foot J of this multiway analog switch 2400Connecting to neutral current potential; By J01-J011Connect photodiode 23. During test, when the path of each multiway analog switch 24 is connected, go through the J all over another multiway analog switch 24 respectively00To J011, to realize under same wavelength, with the signal of different wave length as reference. What programmable amplifier 25 amplified is the signal of a deduction reference, J00For the mensuration without wavelength signals each under reference.
One LED light source 22 is connected with a photodiode 23, the other end of described photodiode 23 connects the input of multiway analog switch 24, the outfan of described multiway analog switch 24 accesses the input of programmable amplifier 25, the outfan of described programmable amplifier 25 accesses the input of A/D conversion chip 26, the outfan of described A/D conversion chip 26 accesses MCU microprocessor 27, and whole spectra collection process is carried out program management.
The signal that described data collecting card 2 gathers can be sent to intelligent end 28 by Wifi, and described intelligent end 28 is smart mobile phone, computer or iPad.
The quartz glass plate 4 arranged on described separation coral 3. Described quartz glass plate 4 is square structure part, and its effect is to prevent sample contamination test system.
Being arranged above with sample cell 5 at described quartz glass plate 4, described sample cell 5 is also square structure part.
Described data collecting card 2, lattice grid 3, quartz glass plate 4 and sample cell 5 are arranged in casing 1, then, top cover 6 are set in casing 1 upper end. One or both sides outside casing 1 (optionally and conveniently) arrange described charge port 7, switch 8 and relay indicating light 9, and these are conventional techniques, repeat no more.
The work process of a kind of multi-source optical spectrum instrument of the present invention is:
During test, sample is put into sample cell 5, top cover 6, sample absorbs the light of also reflex LED light source 22, reflection source is converted to the signal of telecommunication through photodiode 23, amplifies then through data collecting card 2, is converted to data signal through A/D conversion chip 26, uploading to intelligent end 28 through wifi after being processed by MCU microprocessor 27, user may utilize smart mobile phone, computer or iPad and collects these test signals.
Selecting zero potential when each optical source wavelength signal testing is test benchmark, tests the absolute reflectance of sample under this wavelength, namely with the blank reference as sample.
When a wavelength measurement, all as reference and go through all over all wavelengths light source at the reflectance of other wavelength with sample.
The multi-source optical spectrum instrument of the present invention can measure solid sample, it is also possible to measures fluid sample.
Sample can be carried out qualitative detection by the multi-source optical spectrum instrument of the present invention, it is possible to sample is carried out detection by quantitative.
The multi-source optical spectrum instrument of the present invention can carry out on-line checking, it is possible to carries out offline inspection.
The specific embodiment of a kind of multi-source optical spectrum instrument of 4 present invention presented below.
Embodiment 1
A kind of multi-source optical spectrum instrument, the LED light source 22 selecting 2 ultraviolet spectra district wavelength to be 330nm, 360nm; The LED light source 22 selecting 2 visible range wavelength to be 780nm, 840nm; Selecting 2 near infrared spectrum district wavelength again is that the LED light source 22 of 940nm, 1100nm is as light source (as shown in Figure 3), adopting 6 photodiodes 23 to carry out opto-electronic conversion as the reflection light of the LED light source 22 received after testing sample absorbs, adopting 2 ADG408 is multiway analog switch 24; Adopt ADS1248 as differential amplification and A/D conversion chip 26; Adopt Nrf51822 as MCU microprocessor 27; Intelligent end adopts the smart mobile phone of Android system.
Embodiment 2
A kind of multi-source optical spectrum instrument, substantially with embodiment 1, but as different from Example 1:
The LED lamp source 22 adopting ultraviolet spectra district wavelength to be 270nm, 330nm, 360nm; The LED lamp source 22 adopting visible wavelength to be 780nm, 840nm, 940nm; Intelligent end adopts iPad.
Embodiment 3
A kind of multi-source optical spectrum instrument, substantially with embodiment 1, but as different from Example 1:
The LED lamp source 22 adopting ultraviolet spectra district wavelength to be 270nm, 330nm; The LED lamp source 22 adopting visible wavelength to be 780nm, 840nm; The LED lamp source 22 adopting near-infrared region wavelength to be 1100nm, 1400nm; The LED lamp source 22 adopting infrared spectral region wavelength to be 2000nm, 2500nm; Intelligent end adopts notebook computer.
Embodiment 4
A kind of multi-source optical spectrum instrument, substantially with embodiment 1, but as different from Example 1:
Adopt 4 ADG408 as multiway analog switch 24, constitute totally 15 groups of test/reference circuit. The LED lamp source 22 adopting ultraviolet spectra district wavelength to be 254nm, 270nm, 330nm, 360nm; The LED lamp source 22 adopting visible wavelength to be 540nm, 780nm, 840nm, 940nm; The LED lamp source 22 adopting near-infrared region wavelength to be 1100nm, 1300nm, 1400nm, 1700nm; The LED lamp source 22 adopting infrared spectral region wavelength to be 2300nm, 2500nm, 3000nm; Intelligent end adopts Fructus Mali pumilae smart mobile phone.
The Application Example of a kind of multi-source optical spectrum instrument of 4 present invention presented below, but the application of the present invention is not limited to applications below embodiment.
Application Example 1
The multi-source optical spectrum instrument of the present invention is for the discriminating of Chinese crude drug.
After Folium Ginkgo, Flos Lonicerae, Ramulus Cinnamomi, Radix Glycyrrhizae, the Cortex Eucommiae, Radix Notoginseng, 8 kinds of typical Chinese crude drugs of Flos Carthami are dried 3 hours, polished 80 mesh sieves, take 1.0 grams of powder and be put in sample cell 5, the multi-source optical spectrum information (referring to Fig. 4) of employing multi-source optical spectrum instrument collected specimens described in embodiment 1, then with MATLAB2015a software, above-mentioned multi-source optical spectrum signal is carried out principal component analysis, first, second main constituent of sample being projected, result is as shown in Figure 5. As seen from Figure 5, different types of Chinese crude drug obtains good differentiation, and this shows: the information provided according to the multi-source optical spectrum instrument of the present invention, adopts suitable recognition methods can carry out the discriminating of traditional Chinese medicinal materials assortment.
Application Example 2
The multi-source optical spectrum instrument of the present invention is for the discriminating of component content in Chinese crude drug.
According to " Folium Ginkgo content assaying method " in " Pharmacopoeia of People's Republic of China (version one in 2015) " the 316th page, HPLC is utilized to measure the content of total flavones, Quercetin, kaempferol, isorhamnetin in Folium Ginkgo, adopting the multi-source optical spectrum instrument described in embodiment 2 to measure the multi-source optical spectrum information of 48 Ginkgo Leaf samples, Fig. 6 is the Folium Ginkgo sample light intensity at different passages. Choose 1/6 sample in turn as inspection set, adopt KNN-KSR method (Ni Lijun, Zhang Liguo, Zeng Xiaohong etc., KNN Conformal Mapping modeling method and the application in cigarette mainstream flue gas is predicted thereof, East China University of Science's journal, 2008,34(4): 547-552.) testing and obtain the content of the total flavones of each sample, Quercetin, kaempferol, isorhamnetin, result is as shown in table 1.
Table 1. is according to the content of flavone component in multi-source optical spectrum information prediction Folium Ginkgo
。
Application Example 3
The multi-source optical spectrum instrument of the present invention is for the discriminating of different proteins, fat content in milk powder.
The milk powder 3g taking known content is put in sample cell 5, gathers the multi-source optical spectrum information of 60 powdered milk samples with the multi-source optical spectrum instrument described in embodiment 3, and Fig. 7 is powdered milk sample light intensity under different passages. Choosing 1/4 sample in turn as inspection set, adopt KNN-KSR method to test and obtain the protein in each sample and fat content, result is as shown in table 2.
Table 2. is according to protein and fat content in multi-source optical spectrum information prediction milk powder
。
Application Example 4
The multi-source optical spectrum instrument of the present invention is for the On-line Control of Chinese Traditional Medicine.
Chinese Traditional Medicine described here is the process (referring to " Chinese Pharmacopoeia ") extracting flavone from Semen Ginkgo, mixing the process that matter extracts flavone by macroporous resin technique from low alcohol, open the switch 8 of multi-source optical spectrum instrument described in embodiment 4, after relay indicating light 9 is bright, multi-source optical spectrum instrument is placed on below chromatographic column, make sample cell 5 mouthfuls face the outlet of chromatographic column distillate access chromatographic column distillate, often collect 5mL distillate as a sample; Fructus Mali pumilae smart mobile phone is adopted to send sample collecting instruction and accept spectral signal. Distillate sample spectral signal under some passages when Fig. 8,9,10 are to be respectively adopted three kinds of elution requirements to macroporous resin column remove impurity, wherein Fig. 8 is distillate curve during 2 times of column volume 10% ethanol elution macroporous resin column; Fig. 9 is distillate curve during 2.5 times of column volume 15% ethanol elution macroporous resin column; Figure 10 is distillate curve during 2 times of column volume 20% ethanol elution macroporous resin column. Each curve in figure represents the light intensity of each distillate sample under described optical channel.Table 3 is Fig. 8, the result of gained total Content of Flavone Glycosides from Ginkgo biloba Extract content and extraction ratio under three kinds of conditions described in 9,10.
The quality of Folium Ginkgo extract and extraction ratio under the different elution requirement of table 3.
。
As seen from Figure 8: during with 10% ethanol elution macroporous resin column remove impurity of 2 times of column volumes, until eluting terminates, the light intensity signal of distillate sample does not weaken more initial distillate on the contrary and increases, and illustrates that the organic impurities on resin fails effective eluting.
Fig. 9 and Figure 10 shows: the light intensity signal of distillate sample starts to gradually reduce after being stepped up with elution time, illustrates that, under the two elution requirement, the organic impurities on resin obtains effective removing. When 2.5 times of column volumes 15% alcoholic solution eluting (Fig. 9) are terminated, the light intensity of distillate sample is lower than the light intensity of initial distillate, and this shows: under this condition, impurity-eliminating effect is better than 2 times of column volumes 20% ethanol elution (Figure 10).
Table 3 result also demonstrates above-mentioned analysis: effective ingredient flavones content extract obtained under condition shown in Fig. 8 only has 20.4%, lower than the product under two other condition, do not reach the pharmacopoeial requirements of flavonoid of ginkgo biloba > 24%. and under elution requirement shown in Fig. 9, in Folium Ginkgo extract, flavones content and extract yield are above elution requirement shown in Figure 10, this conclusion being better than Figure 10 with impurity-eliminating effect when analyzing gained Fig. 9 according to Fig. 9 and Figure 10 is consistent.
Application Example 4 proves: the optical signalling according to the eluent that the multi-source optical spectrum instrument of the present invention gathers, it can be determined that the height of content of organics in distillate, can monitor the impurity in distillate, and separation and optimization for Effective Component of Chinese Medicine provide and support.
Claims (7)
1. a multi-source optical spectrum instrument, containing casing (1), top cover (6), charge port (7), switch (8), relay indicating light (9), described top cover (6) is arranged on the top of described casing (1), described charge port (7), switch (8) and relay indicating light (9) are arranged on the one or both sides in described casing (1) outside, it is characterized in that, be disposed with data collecting card (2), lattice grid (3), quartz glass plate (4) and sample cell (5) in the inside of described casing (1) from bottom to top; Described data collecting card (2) is provided with power management module (21), LED light source (22), photodiode (23), multiway analog switch (24), programmable amplifier (25), A/D conversion chip (26), MCU microprocessor (27) and wifi; The corresponding LED light source (22) of each grid of described lattice grid (3) and a photodiode (23), formed optical module by described LED light source (22) and photodiode (23); In described sample cell (5) upper end, top cover (6) is set.
2. a kind of multi-source optical spectrum instrument according to claim 1, it is characterized in that, the power management module (21) on described data collecting card (2) connects LED light source (22), photodiode (23), programmable amplifier (25), A/D conversion chip (26) and MCU microprocessor (27) by multiway analog switch (24) and powers.
3. a kind of multi-source optical spectrum instrument according to claim 2, it is characterized in that, described data collecting card (2) is provided with two multiway analog switch chips, wherein: the first multiway analog switch chip (241) is used for selecting test wavelength, second multiway analog switch chip (242) is used for selecting reference wavelength, when by programme-control the first multiway analog switch chip (241) Zhong mono-tunnel " leading to ", program just selects the reference analog switch in the second multiway analog switch chip (242) successively, order is opened 00 tunnel (zero potential) and is carried out reference to the n-th path analoging switch,So, the test information of each wavelength of sample uses the information of zero potential and another wavelength as reference respectively.
4. a kind of multi-source optical spectrum instrument according to claim 2, it is characterised in that the signal that described data collecting card (2) gathers can be sent to intelligent end (28) by Wifi, described intelligent end (28) is computer, smart mobile phone or iPad.
5. a kind of multi-source optical spectrum instrument according to claim 1, it is characterised in that described optical module includes at least two spectral regions in ultraviolet spectra district, visible range, near infrared spectrum district and infrared spectral region.
6. a kind of multi-source optical spectrum instrument according to claim 5, it is characterised in that described spectral regions are at least made up of the LED light source (22) of two wavelength.
7. a kind of multi-source optical spectrum instrument according to claim 5, it is characterized in that, the corresponding described photodiode (23) of each described LED light source (22), the other end of described photodiode (23) connects multiway analog switch (24), the outfan of described multiway analog switch (24) accesses programmable amplifier (25), the outfan of described programmable amplifier (25) accesses A/D conversion chip (26), the outfan of described A/D conversion chip (26) accesses MCU microprocessor (27), and gatherer process is carried out program management.
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