CN108744320A - A kind of the boron neutron capture therapy system and its operating method of guided by magnetic resonance - Google Patents
A kind of the boron neutron capture therapy system and its operating method of guided by magnetic resonance Download PDFInfo
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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- A61N5/1048—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1071—Monitoring, verifying, controlling systems and methods for verifying the dose delivered by the treatment plan
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- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
- A61N2005/1055—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam using magnetic resonance imaging [MRI]
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- A—HUMAN NECESSITIES
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
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Abstract
The invention belongs to field of medical device, disclose a kind of the boron neutron capture therapy system and its operating method of guided by magnetic resonance, which includes：MRI angiography systems determine position and the boron concentration of tumour for carrying out radiography to focal zone；BNCT treatment systems, for adjusting patient body position and adjustment therapeutic scheme according to visualisation, to be treated to focal zone.The boron neutron capture therapy system and its operating method provide the accurate organizational information in BNCT therapeutic process by MRI angiography systems, and learn boron preparation irradiated lesion area real-time, quantitative, DYNAMIC DISTRIBUTION information, the adjustment of BNCT parameters in therapeutic process can be guided by MRI image, realize the treatment of more precision.
Description
Technical field
The present invention relates to the boron neutron capture therapy system of field of medical device more particularly to a kind of guided by magnetic resonance and its
Operating method.
Background technology
Boron neutron capture therapy (Boron Neutron Capture Therapy, BNCT) is using boron preparation to superthermal
Neutron has the characteristic of high capture cross-section, by10B(n,α)7Li neutron absorptions and nuclear fission reaction generate4He and7Two weights of Li
Charged particle.The range of two heavy burden charged particle is respectively 9um and 5um, and the integrated range of two heavy burden charged particle is approximately equivalent to one
A cell size, therefore radiation injury can be confined to cell level for caused by biology, when boron preparation is selectively gathered in
In tumour cell, neutron appropriate of arranging in pairs or groups penetrates source, just can reach kill under the premise of normal tissue does not cause too major injury
The purpose of tumour cell.
In BNCT therapeutic process, the dosage that patient receives directly determines the tumor control rate and complication of BNCT treatments
Incidence, and then influence the quality of the life after patient's treatment.So accurately tumor-localizing, accurately treatment plan, accurately
It is three key links that BNCT is precisely treated to irradiate execution, and " accurately irradiation executes " therein still suffers from many be stranded
It is difficult.Dosage caused by BNCT treatments is to be occurred from nuclear reaction by thermal neutron and boron -10, and boron -10 can be with boron preparation
Patient's body metabolic process and time of origin-changes in spatial distribution.The change in time and space of this boron preparation metabolism has apparent
Randomness, there is deviation between the dosage received so as to cause patient and the dosage for the treatment of plan defined.Big deviation
The tumor control rate that may result in BNCT treatments declines or complication rate increases.
For tumour position can be accurately judged to, it is clinically often used magnetic resonance radiography equipment (Magnetic
Resonance Imaging, MRI) or computerized tomography image (Computed Tomography, CT) progress tumour location
Domain judges.Magnetic resonance imaging is a kind of newer medical imaging technology, just formal for clinic from 1982 in the world.It
Tissue is set to be imaged using magnetostatic field and RF magnetic field, in imaging process, neither with electronics from radiation, without contrast agent
It is achieved with the clear image of high contrast.MR imaging apparatus in addition to have the CT anatomic images acted on based on X-ray it
Outside, atom nuclear relaxation time can be also accurately measured by nuclear magnetic resonance principle, by the letter in relation to chemical constitution in tissue
Breath reflects, and the different chemical structures of the different tissues of same density and same tissue can be shown by image and symbolized
Come, has great superiority, the comparison of soft tissue to the early diagnosis effect of tissue necrosis, malignant disease and degenerative disorders
Degree is also more accurate.
In order to accurately know the boron concentration distribution of knub position, in recent years, in improved BNCT clinical workflows, Huan Zhehui
It first bestows and has high-affinity to tumour18F-BPA drugs utilize positron e mission computed tomography (Positron
Emission Computed Tomography, PET) drug is observed in body accumulation degree, thereby judge the boron preparation of patient
Whether good effect is built up, and according to the drug distribution difference of tumor tissues on PET images and normal structure, as treatment plan
Calculation basis, treatment flow are as shown in Figure 1.In the boron for proposing a kind of tablet PET guiding in Chinese patent CN206026890U
Neutron capture therapy system, the system are mixed into boron preparation by capture18F markers, during boron neutron capture therapy compared with
Accurately to obtain real-time in irradiated lesion area, quantitative, the dynamic distributed intelligence of boron preparation.But since PET visualisations are empty
Between resolution ratio it is bad, which only can be used as boron preparation distributed intelligence reference, can not be used as the contraposition of human body inner tissue structure,
Patient before being treated using the devices such as photographic camera or computerized tomography image is still needed to put position confirmation in clinical application,
Spend a large amount of stand-by period.
Based on the above situation, it is necessary to change to the boron neutron capture therapy system and its application method of image guiding
Into to solve above-mentioned problem of the prior art.
Invention content
It is an object of the present invention to propose a kind of boron neutron capture therapy system of guided by magnetic resonance, made by MRI
Shadow system provides accurate organizational information in BNCT therapeutic process, and learn boron preparation irradiated lesion area reality
When, quantitative, DYNAMIC DISTRIBUTION information.
Another object of the present invention is to provide a kind of operation sides of the boron neutron capture therapy system of guided by magnetic resonance
Method can guide the adjustment of BNCT parameters in therapeutic process by MRI angiography systems, realize the treatment of more precision.
For this purpose, the present invention uses following technical scheme：
A kind of boron neutron capture therapy system of guided by magnetic resonance, including：
MRI angiography systems determine position and the boron concentration of tumour for carrying out radiography to focal zone；
BNCT treatment systems, for according to visualisation adjust patient body position and adjustment therapeutic scheme, with to focal zone into
Row treatment.
Preferably, the BNCT treatment systems include bearing system, and the bearing system is suffered from for carrying patient and adjustment
Person's position, and matched with the MRI angiography systems.
Preferably, the bearing system includes：Irradiate bed and lifting gear.The lifting gear can control the irradiation
The movement of bed is to carry out patient body position's adjustment.
Preferably, the focal zone contains radiography agent composition, and the radiography agent composition includes boron preparation and MRI radiographies
Agent.
In recent years, in addition to the development of contrast apparatus is increasingly flourishing, novel state boron preparation also has significant progress, wherein having one
Class boron preparation is mixed with MRI contrast agent so that it can be measured by MRI angiography systems, equally rich in high tumor affinity after mixing.
This boron preparation provides possibility for the dynamic of focal zone drug concentration, real-time, quantitative, on-line monitoring.Meanwhile MRI radiographies
High image spatial resolution is provided, to realize that image-guided boron neutron capture treats (Image Guided Boron
Neutron Capture Therapy, IG-BNCT) provide possibility.
Preferably, the MRI angiography systems (100) include image workstation.
Specifically, the image workstation function has two, the first function be the position of tumour is determined according to MRI image, and
It is compared with the image for the treatment of plan, to correct patient body position；Second function is to determine focal zone boron concentration according to MRI image
Distribution, and be compared with the boron concentration for the treatment of plan, to adjust treatment plan.
It is further preferred that the image workstation includes MRI signal acquisition and memory module, image reconstruction module, no
It is registrated with medical image dense with automatic area-of-interest division module, focal zone boron preparation manually with comparing module, medical image
Spend analysis module and real time MRI image and treatment planning systems image comparison module.
Specifically, the MRI signal for being embodied as being acquired with memory module according to MRI signal acquisition of the first function,
It is 3-D view to rebuild remodelling by described image, then is registrated by different medical images and comparing module, and clinic is controlled
For the 3-D view rebuild before treating compared with treatment plan image registration, the difference medical image registration can be right with comparing module
The images such as MRI, CT, PET are identified and compare, once notable difference occurs in the two image, then can pass through patient and put position again
Irradiation position is adjusted, or using therapeutic bed, lifting gear motion, realizes multiple degrees of freedom movement in space, adjust patient
Relative to BNCT treatment systems position, make itself and treatment planning systems images match, realizes IG-BNCT.The realization of second function
It is then boron in the radiography agent composition for learnt manually with automatic area-of-interest division module area-of-interest according to medical image
The distribution scenario of preparation is redeveloped into the dynamic point of the three-dimensional boron preparation in patient by area-of-interest boron formulation concentrations analysis module
The result as a result, be originally inputted by cloth by real time MRI image with treatment planning systems image comparison module with treatment plan again
It is compared, as treatment parameter differences amendment, to be adjusted treatment plan in therapeutic process in real time.
Preferably, the MRI angiography systems (100) further include magnet, spectrometer, MRI screening arrangements.
It is further preferred that the magnet is selected from open magnet or cyclic formula magnet.
Specifically, the structure of the open magnet is that a magnetic material, the generated constant magnetic of master are respectively arranged up and down
Field is perpendicular to ground；The structure of the cyclic formula magnet is a closed annular, and main perseverance is generated in closed annular space
Fixed-field.
Preferably, the BNCT treatment systems further include：Neutron generates equipment, moderation of neutrons device, beam outlet and neutron
Irradiation system controls work station.
It is further preferred that the neutron generate equipment be selected from radionuclide, proton precessional magnetometer bombardment metal targets or
Any one in nuclear reactor.
Specifically, the neutron, which generates equipment, generates neutron beam, the moderation of neutrons device is then directed to different neutrons and generates dress
It sets characteristic and is adjusted geometry and material, make neutron energy by slowly to about 0.5eV~40keV, so that irradiation neutron beam
Reach best BNCT therapeutic effects, the beam outlet exports irradiation neutron beam to patient's focal zone.
Preferably, the neutron exposure system control work station includes line monitoring system, dosage monitoring system and irradiation
Visual field control system, for controlling irradiation neutron beam relevant parameter, including visual field size, irradiation time, irradiation mode and irradiation
Angle etc..
On the other hand, a kind of operating method of the boron neutron capture therapy system of guided by magnetic resonance, MRI angiography systems are provided
Radiography is carried out to focal zone, determines position and the boron concentration of tumour；BNCT treatment systems adjust patient body position according to visualisation
And adjustment therapeutic scheme, to be treated to focal zone.
Preferably, the operating method of the boron neutron capture therapy system of the guided by magnetic resonance, specifically includes following steps：
S1：According to treatment plan, radiography agent composition is injected in patient's body；
S2：The MRI image of patient is obtained using MRI angiography systems；
S3：The MRI image is compared with treatment plan image, judges whether are MRI image and treatment plan image
In setting error range；
When being, step S4 is executed；
When no, patient position is adjusted, step S2 is repeated；
S4：Neutron beam irradiation is carried out using BNCT treatment systems；
S5：The boron concentration of area-of-interest is obtained using MRI angiography systems, and calculates required radiation parameters；
S6：The required radiation parameters are compared with treatment plan radiation parameters, required radiation parameters is judged and controls
Whether identical treat plan radiation parameters；
When being, step S7 is executed；
When no, treatment plan radiation parameters are adjusted, then execute step S4；
S7：Practical exposure dose is compared with treatment plan exposure dose, judges whether practical exposure dose reaches
Treatment plan exposure dose；
When being, step S8 is executed；
When no, step S4 is executed；
S8：Stop neutron beam irradiation, completes BNCT treatments.
The boron neutron capture therapy system of guided by magnetic resonance provided by the invention, by MRI angiography systems and BNCT treatments system
System carries out good integration, first, passes high-resolution MRI image back by MRI angiography systems, and carry out with treatment plan image
It compares to adjust patient body position, realizes IG-BNCT；Secondly, the real-time boron system of patient's body can also be obtained by MRI angiography systems
Agent distribution scenario, and being compared with treatment plan, provides accurate radiation parameters modifying factor to adjust treatment plan, for
Focal zone gives the radiation therapy of precision.
Description of the drawings
Fig. 1 is the BNCT treatment flow charts of the prior art；
Fig. 2 is the structural schematic diagram of apparatus of the present invention；
Fig. 3 is the structural schematic diagram at another visual angle of apparatus of the present invention；
Fig. 4 is the process for using figure of apparatus of the present invention.
Wherein, MRI angiography systems 100, magnet 110；BNCT treatment systems 200, neutron generate equipment 210, moderation of neutrons
Device 220, beam outlet 230；Bearing system 300 irradiates bed 310, lifting gear 320.
Specific implementation mode
The present invention is described in further detail with reference to the accompanying drawings and examples.It is understood that this place is retouched
The specific embodiment stated is used only for explaining the present invention rather than limitation of the invention.It also should be noted that in order to just
Only the parts related to the present invention are shown in description, attached drawing rather than entire infrastructure.
Embodiment one
A kind of boron neutron capture therapy system of guided by magnetic resonance, including：
MRI angiography systems 100 determine position and the boron concentration of tumour for carrying out radiography to focal zone；
BNCT treatment systems 200, for adjusting patient body position and adjustment therapeutic scheme according to visualisation, with to focal zone
It is treated.
BNCT treatment systems 200 include bearing system 300, for carry patient and adjustment patient body position, and with MRI radiographies
System 100 matches.
In BNCT therapeutic process, before beamlet in use is irradiated, need to inject boron preparation, boron system to patient's body
Agent has close tumour property, can be enriched in tumor region, the nucleus medical image at patient target area position be acquired after the completion of enrichment, to obtain
It takes current boron preparation in the distribution characteristics of patient's body, and establishes the boron preparation model of Rapid Dose Calculation, carry out treatment plan accordingly
It formulates, treatment plan parameters include tumor target parameter, radiation parameters and dosage etc., and tumor target parameter includes tumour position
It sets, tumor size etc., the radiation parameters cured needed for tumour include boron formulation parameters and neutron beam parameter, and boron formulation parameters include
- 10 concentration distribution of boron and its in vivo metabolic chart, neutron beam parameter include irradiation time, irradiating angle, exposure intensity etc..It needs
It is noted that boron preparation with -10 concentration of boron there is one-to-one relationship, i.e. boron formulation concentrations can be obtained by unit conversion
- 10 concentration of boron.It is found that the determination of each parameter is the boron preparation distribution based on patient's body before irradiation treatment in treatment plan, and
Boron -10 can with boron preparation patient's body metabolic process and time of origin-changes in spatial distribution, that is, patient is actually required
Radiation parameters and practical exposure dose can and treatment plan have certain deviation.Big deviation may result in BNCT treatments
Tumor control rate declines or complication rate increases.
In the present invention, when BNCT is treated, the visualisation of MRI angiography systems 100 is first passed through, determines the specific position of tumour
It sets, visualisation is compared with treatment plan, to be adjusted to the position of patient, start again after meeting treatment plan
Neutron exposure is treated；By the visualisation of real-time MRI angiography systems 100 in therapeutic process, the reality of area-of-interest is determined
When boron concentration, obtain actually required radiation parameters, to instruct adjustment treatment plan, more accurately treated with reaching.And it is existing
The boron concentration that area-of-interest can only be detected in technology before neutron exposure cannot achieve and be adjusted according to real-time boron concentration results
Treatment plan.
The present embodiment also provides the operating method of the boron neutron capture therapy system of above-mentioned guided by magnetic resonance, MRI radiographies system
System carries out radiography to focal zone, determines position and the boron concentration of tumour；BNCT treatment systems adjust patient's body according to visualisation
Position and adjustment therapeutic scheme, to be treated to focal zone.
Embodiment two
Improvement project of the present embodiment as embodiment one, with embodiment one difference lies in：
In this present embodiment, more accurate visualisation in order to obtain, needs to the focal zone containing radiography agent composition
Radiography is carried out, radiography agent composition includes boron preparation and MRI contrast agent.It is mixed specifically, injecting contrast agent to patient before radiography
Object is closed, wherein boron preparation is mixed into radiography agent composition with MRI contrast agent, and such radiography agent composition is both rich in high tumour parent
And power, it can be enriched in human tumor region, while radiography agent composition can be measured again by MRI contrast apparatus, therefore scheme in MRI
It, can be by mixing colours by high boron formulation concentrations tumor region and low boron formulation concentrations tumor region and tumor region and just as in
Often tissue is distinguished, you can exact tumor region is sketched out according to the difference of color, clearly determine tumour boundary and
The concentration of the wherein concentration distribution of boron preparation, boron preparation can be scaled boron concentration.
In this present embodiment, radiography agent composition is Gd/B/L-LDL compounds.It is low using the connection of carborane unit
Density lipoprotein (Low-Density Lipoprotein, LDL) is used as carrier, while linking gadolinium-tetraazacyclododecanand list acyl
Amine compound (Gd-DOTA) forms Gd/B/L-LDL compounds, as radiography agent composition.When Gd/B/L-LDL compounds exist
Intracellular accumulation amount is each cell 109When, it can pass through MRI angiography systems at this time and observe the cell, while the accumulation amount is
Boron neutron capture therapy is carried out enough.I.e. angiographic procedure needs to rely on boron preparation, and BNCT treatments are also required to rely on boron preparation, usually
Patient needs to inject boron preparation twice, with when using this radiography agent composition, it is only necessary to inject a boron preparation, you can meets
The requirement of MRI radiographies and BNCT treatments.
In this present embodiment, as shown in Figure 2 and Figure 3, MRI angiography systems 100, including：Magnet 110, spectrometer, MRI shieldings
Device and image workstation.
Magnet 110 is selected from open magnet or cyclic formula magnet.The structure of open magnet is that a magnetic is respectively arranged up and down
Property material, generated main stationary magnetic field is perpendicular to ground；The structure of cyclic formula magnet is a closed annular, closed
Main stationary magnetic field is generated in annular space.
As an improvement of the present invention, image workstation includes MRI signal acquisition and memory module, image reconstruction mould
Block, different medical image registration and comparing module, medical image manually with automatic area-of-interest division module, area-of-interest
Boron formulation concentrations analysis module and real time MRI image and treatment planning systems image comparison module.
Specifically, the image workstation function has two, the first function be the position of tumour is determined according to MRI image, and
It is compared with the image for the treatment of plan, to correct patient body position；Second function is to determine focal zone boron concentration according to MRI image
Distribution, and be compared with the boron concentration for the treatment of plan, to adjust treatment plan.Wherein, MRI signal acquisition is used with memory module
In acquisition MRI signal；Image reconstruction module is the image processing tool accelerated based on GPU, for MRI signal to be redeveloped into three-dimensional
Image is to get to MRI contrastographic pictures；Different medical image registrations can know the images such as MRI, CT, PET with comparing module
Not and compare, for by the reconstruction 3-D view before clinical treatment with treatment plan image registration compared with, when the two image appearance
Patient then be can adjust when notable difference relative to BNCT treatment systems position, make MRI contrastographic pictures and treatment planning systems image
IG-BNCT is realized in matching；Medical image is used to learn the radiography of area-of-interest with automatic area-of-interest division module manually
The distribution scenario of boron preparation in agent composition；Focal zone boron formulation concentrations analysis module is used to be rebuild according to boron preparation distribution situation
For the three-dimensional boron preparation DYNAMIC DISTRIBUTION in patient as a result, real time MRI image and treatment planning systems image comparison module and should
As a result it is originally inputted and is compared with treatment plan, as treatment parameter differences amendment, to be controlled in therapeutic process in real time
Treat Plan rescheduling.
It should be noted that heretofore described area-of-interest includes tumor region and normal tissue regions.Specifically,
It is the visualisation that can be carried out radiography to entire human body, but only need to obtain focal zone when MRI radiographies.
Preferably, the MRI angiography systems further include：Magnet, spectrometer, MRI screening arrangements.Although boron preparation has parent
Tumour property also has a certain amount of boron preparation and exists in the normal tissue, while in neutron exposure, although irradiation port
Can be conformal with tumor size as possible, but due to the influence of accuracy of detection and machining accuracy, also have the normal structure meeting of part
It is irradiated to by neutron beam, when the neutron beam exposure dose received in normal structure is excessive, meeting normal tissue damages.Cause
This can preferably instruct adjustment treatment plan, treatment is made to count by detecting the boron concentration of tumor region and normal tissue regions
Drawing can realize that the purpose for the treatment of tumour can ensure that the safety of normal structure again.
As shown in Fig. 2, BNCT treatment systems 200, further include：Neutron generates equipment 210, moderation of neutrons device 220, beam and goes out
Mouth 230 and neutron exposure system control work station.
Neutron generates the appointing in radionuclide, proton precessional magnetometer bombardment metal targets or nuclear reactor of equipment 210
Meaning is a kind of.Neutron generates equipment 210 and is then directed to different neutron generation device characteristics for generating neutron beam, moderation of neutrons device 220
Geometry and material are adjusted, makes neutron energy by slowly to about 0.5eV~40keV, reaches most so as to irradiate neutron beam
Good BNCT therapeutic effects, beam outlet 230 export irradiation neutron beam to patient's focal zone.
Neutron exposure system control work station includes line monitoring system, dosage monitoring system and irradiation visual field control system
System, for controlling irradiation neutron beam relevant parameter, including visual field size, irradiation time, irradiation mode and irradiating angle etc..
Dosage monitoring system is executed for adjusting treatment plan and controlling treatment plan, including adjustment treatment plan module,
Neutron beam radiation parameters adjust module and boron preparation adjusts module.
Specifically, the adjustment treatment plan module of dosage monitoring system is obtained according to the visualisation of MRI angiography systems 100
Present period is calculated in conjunction with the accumulative irradiation time under current dose rates in -10 concentration distribution of boron in current interest region
Dosage received by patient is integrated by the m- acceptable dose curve of clock synchronization, the practical acceptable dose of patient can be obtained and control
The deviation between dosage in the works is treated, in conjunction with -10 concentration distribution of current boron, generates treatment plan Adjusted Option, treatment meter
It includes boron preparation infusion scheme and neutron beam illumination scheme, the neutron dose and neutron received by tissue to draw Adjusted Option
Beam irradiation time, neutron beam exposure intensity, -10 concentration of boron are all proportional.When needing to execute boron preparation infusion scheme, lead to
It crosses the adjustment module control of boron preparation to execute, when needing to execute neutron beam illumination scheme, mould is adjusted by neutron beam radiation parameters
Block control executes.
It should be noted that neutron beam can pass through normal structure before reaching focal zone, for example, neutron beam needs to penetrate skin
Skin could enter tumor region, and the neutron dose received by skin is no more than safety standard；Meanwhile in therapeutic process
In, when the neutron dose deficiency received at tumour, it will usually first adjust neutron beam parameter, ensure tumour such as irradiation time
The neutron dose that region receives meets treatment and requires, but the long neutron that may result in normal structure and receive of irradiation time
Dosage is excessively high, then can be damaged to human body, it is therefore desirable to control -10 concentration of boron of tumor region in certain safe range
It is interior, to ensure that neutron dose that normal structure receives in safe range, ensures the personal safety of patient.
For example, if current -10 concentration of boron meets safety requirements, neutron beam illumination scheme, neutron beam illumination scheme are generated
In neutron beam illumination scheme is adjusted, including irradiating angle, irradiation time etc..For example, if -10 concentration of current boron is discontented
Sufficient safety requirements generates boron preparation infusion scheme, is adjusted to boron preparation infusion scheme in boron preparation infusion scheme, including past
The amount of patient's body supplement infusion boron preparation, with -10 concentration of boron etc. for improving patient's body.BNCT treatments are avoided because irradiating target
Area's underdosage and occur tumor control rate decline or because normal tissue dose is exceeded and occur complication rate increase etc.
Problem.
Bearing system 300 is matched for carrying patient, and with the MRI angiography systems and the BNCT treatment systems；
Including：Irradiate bed 310 and lifting gear 320.It irradiates bed 310 to be mounted on lifting gear 320, lifting gear 320 can control
The movement of bed 310 is irradiated to carry out position adjustment.
When in use, patient setup is first moved to MRI angiography systems 100 on irradiation bed 310, then by bed 310 is irradiated
Magnetic field range in, form the irradiation visual field above patient, then carry out MRI radiographies, bed is irradiated according to MRI contrastographic pictures
310 positions adjust, and so that patient and the position of irradiation outlet 230 is adapted, ginseng is irradiated according to boron formulation concentrations distribution results
Number adjustment, carries out BNCT treatments again later.
As shown in figure 4, a kind of operating method of the boron neutron capture therapy system of guided by magnetic resonance, specifically includes following step
Suddenly：
S1：According to treatment plan, radiography agent composition is injected in patient's body；
S2：Obtain the MRI image of patient；
S3：The MRI image is compared with treatment plan image, judges whether are MRI image and treatment plan image
In setting error range；
When being, step S4 is executed；
When no, patient position is adjusted, step S2 is repeated；
S4：Carry out neutron beam irradiation；
S5：The boron concentration of area-of-interest is obtained, and calculates required radiation parameters；
S6：The required radiation parameters are compared with treatment plan radiation parameters, required radiation parameters is judged and controls
Whether identical treat plan radiation parameters；
When being, step S7 is executed；
When no, treatment plan radiation parameters are adjusted, then execute step S4；
S7：Practical exposure dose is compared with treatment plan exposure dose, judges whether practical exposure dose reaches
Treatment plan exposure dose；
When being, step S8 is executed；
When no, step S4 is executed；
S8：Stop neutron beam irradiation, completes BNCT treatments.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of skill in the art that it still can be right
Technical solution recorded in previous embodiment is modified, or is replaced on an equal basis to which part technical characteristic；And these
Modification or replacement, the spirit and scope for various embodiments of the present invention technical solution that it does not separate the essence of the corresponding technical solution.
Claims (10)
1. a kind of boron neutron capture therapy system of guided by magnetic resonance, which is characterized in that including：
MRI angiography systems (100) determine position and the boron concentration of tumour for carrying out radiography to focal zone；
BNCT treatment systems (200), for according to visualisation adjust patient body position and adjustment therapeutic scheme, with to focal zone into
Row treatment.
2. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that the BNCT is controlled
Treatment system (200) includes bearing system (300), and the bearing system (300) is used to carry patient and adjusts patient body position, and with
The MRI angiography systems (100) match.
3. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that the focal zone
Containing radiography agent composition, the radiography agent composition includes boron preparation and MRI contrast agent.
4. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that the MRI makes
Shadow system (100) includes image workstation.
5. the boron neutron capture therapy system of guided by magnetic resonance according to claim 4, which is characterized in that the image work
It includes MRI signal acquisition and memory module, image reconstruction module, different medical images registration and comparing module, medicine shadow to make station
As manually with automatic area-of-interest division module, focal zone boron formulation concentrations analysis module and real time MRI image with treatment
Planning system image comparison module.
6. the boron neutron capture therapy system of guided by magnetic resonance according to claim 4, which is characterized in that the MRI makes
Shadow system (100) further includes magnet, spectrometer, MRI screening arrangements.
7. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that BNCT treatments system
System (200) include：Neutron generates equipment (210), moderation of neutrons device (220), beam outlet (230) and the control of neutron exposure system
Work station.
8. the boron neutron capture therapy system of guided by magnetic resonance according to claim 2, which is characterized in that the carrying system
System (300) include：Irradiate bed (310) and lifting gear (320).
9. a kind of operating method of such as boron neutron capture therapy system of claim 1-8 any one of them guided by magnetic resonance,
It is characterized in that, MRI angiography systems carry out radiography to focal zone, position and the boron concentration of tumour are determined；BNCT treatment system roots
Patient body position and adjustment therapeutic scheme are adjusted according to visualisation, to be treated to focal zone.
10. the operating method of the boron neutron capture therapy system of guided by magnetic resonance according to claim 9, feature exist
In specifically including following steps：
S1：According to treatment plan, radiography agent composition is injected in patient's body；
S2：The MRI image of patient is obtained using MRI angiography systems；
S3：The MRI image is compared with treatment plan image, judges whether MRI image is setting with treatment plan image
Determine in error range；
When being, step S4 is executed；
When no, patient body position is adjusted, step S2 is repeated；
S4：Neutron beam irradiation is carried out using BNCT treatment systems；
S5：The boron concentration of area-of-interest is obtained using MRI angiography systems, and calculates required radiation parameters；
S6：The required radiation parameters are compared with treatment plan radiation parameters, judge that required radiation parameters are counted with treatment
Whether within the allowable range to draw radiation parameters；
When being, step S7 is executed；
When no, treatment plan radiation parameters are adjusted, then execute step S4；
S7：Practical exposure dose is compared with treatment plan exposure dose, judges whether practical exposure dose reaches treatment
Plan exposure dose；
When being, step S8 is executed；
When no, step S4 is executed；
S8：Stop neutron beam irradiation, completes BNCT treatments.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113870251A (en) * | 2021-10-19 | 2021-12-31 | 中南大学湘雅二医院 | Heart image processing method for accurate positioning of radiotherapy |
| CN113877081A (en) * | 2020-07-03 | 2022-01-04 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy apparatus and monitoring system operation steps thereof |
| RU2810811C1 (en) * | 2020-07-03 | 2023-12-28 | Нойборон Терапи Систем Лтд. | Neutron capture therapy device and operation stages of its monitoring system |
| WO2024088170A1 (en) * | 2022-10-24 | 2024-05-02 | 中硼(厦门)医疗器械有限公司 | Boron neutron capture therapy system and working method therefor |
| WO2024099253A1 (en) * | 2022-11-07 | 2024-05-16 | 中硼(厦门)医疗器械有限公司 | Boron neutron capture treatment system and working method therefor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015231497A (en) * | 2014-06-10 | 2015-12-24 | フジデノロ株式会社 | Boron neutron capture therapy system |
| JP2016214760A (en) * | 2015-05-25 | 2016-12-22 | 株式会社東芝 | Treatment device for boron neutron capture therapy, and control method thereof |
| CN206026890U (en) * | 2016-07-18 | 2017-03-22 | 北京大学 | Boron neutron capture treatment system of dull and stereotyped PET guide |
| CN209253964U (en) * | 2018-09-03 | 2019-08-16 | 东莞东阳光高能医疗设备有限公司 | A kind of boron neutron capture therapy system of guided by magnetic resonance |
-
2018
- 2018-09-03 CN CN201811018118.1A patent/CN108744320A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015231497A (en) * | 2014-06-10 | 2015-12-24 | フジデノロ株式会社 | Boron neutron capture therapy system |
| JP2016214760A (en) * | 2015-05-25 | 2016-12-22 | 株式会社東芝 | Treatment device for boron neutron capture therapy, and control method thereof |
| CN206026890U (en) * | 2016-07-18 | 2017-03-22 | 北京大学 | Boron neutron capture treatment system of dull and stereotyped PET guide |
| CN209253964U (en) * | 2018-09-03 | 2019-08-16 | 东莞东阳光高能医疗设备有限公司 | A kind of boron neutron capture therapy system of guided by magnetic resonance |
Non-Patent Citations (2)
| Title |
|---|
| SILVIA CAPUANI等: "10B-editing 1H-detection and 19FMRI strategies to optimize boron neutron capture therapy" * |
| SIMONETTA GENINATTI-CRICH等: "MRI-Guided Neutron Capture Therapy by Use of a Dual Gadolinium/Boron Agent Targeted at Tumour Cells through Upregulated Low-Density Lipoprotein Transporters" * |
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| EP4176932A4 (en) * | 2020-07-03 | 2023-12-27 | Neuboron Therapy System Ltd. | Neutron capture treatment device |
| JP2023531287A (en) * | 2020-07-03 | 2023-07-21 | 中硼（厦▲門▼）医▲療▼器械有限公司 | Operation steps of neutron capture therapy equipment and its monitoring system |
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| CN113877077A (en) * | 2020-07-03 | 2022-01-04 | 中硼(厦门)医疗器械有限公司 | Neutron capture therapy device |
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