CN109011221A - A kind of the neutron capture therapy system and its operating method of dosage guidance - Google Patents
A kind of the neutron capture therapy system and its operating method of dosage guidance Download PDFInfo
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- CN109011221A CN109011221A CN201811024435.4A CN201811024435A CN109011221A CN 109011221 A CN109011221 A CN 109011221A CN 201811024435 A CN201811024435 A CN 201811024435A CN 109011221 A CN109011221 A CN 109011221A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
Abstract
The invention belongs to radiation therapy technology fields, disclose a kind of boron neutron capture therapy system of dosage guidance, comprising: low energy linear accelerator system, for providing stable proton beam；Neutron exposure system is irradiated patient's target area of irradiation for providing treatment neutron beam, including neutron beam irradiates port；Auxiliary system is treated, positions and formulates for patient, verifying, execute treatment plan；Dosage guides system, for monitoring and adjusting treatment plan.The treatment system, realize the real time monitoring at patient's target area of irradiation position in BNCT therapeutic process, obtain three-dimensional -10 concentration distribution of boron at patient's target area of irradiation position, and according to -10 concentration distribution of three-dimensional boron of patient, treatment plan is adjusted, the accurate irradiation for having reached treatment plan executes, and occurs tumor control rate decline because of target area of irradiation underdosage to be avoided as much as possible BNCT treatment or the problems such as complication rate increase occurs because normal tissue dose is exceeded.
Description
Technical field
A kind of guided the invention belongs to radiation therapy technology field more particularly to dosage neutron capture therapy system and its
Operating method.
Background technique
Boron neutron capture therapy (Boron Neutron Capture Therapy, BNCT) is a kind of " medical instruments combination ", peace
The better biological targeting binary radiotherapy mode of full property, with the excellent of the means such as radiotherapy, chemotherapy, heavy particle therapy from principle
Point is most hopeful to realize the wonderful dream that the mankind eradicate tumour.BNCT treatment will be first by that will have the nontoxic of close tumor tissues
Boron-doping infusion of medicine blood of human body, it is multi-direction suitable using epithermal neutron after boron-doping (boron -10) drug-rich after tumor tissues
Shape irradiates tumor locus, and -10 nucleic of boron in neutron and cancer cell meets and occurs nuclear reaction, the alpha particle of releasing and
- 7 particle of lithium has very strong lethality to cell, and fragmentation effect is higher than existing X-ray, gamma ray radiotherapy and proton and puts
It treats, the side effect of BNCT is smaller, and further increasing with boron-doping drug parent's tumor effect, BNCT normal tissue
Damage will further decrease.The expansion in extensive range, and having can treat proton, heavy particle therapy not of the tumour indication of BNCT
Dissipate the tumor cases that recur again after type malignant tumour or treatment, such as in glioblastoma multiforme (the pernicious cancer of the brain), multiple
Hair property head and neck cancer, maligna element cutaneum carcinoma, metastatic liver cancer etc., therapeutic effect is significantly better than existing treatment technology.
In BNCT therapeutic process, the dosage that patient receives directly determines the tumor control rate and complication of BNCT treatment
Incidence, and then influence the quality of the life after patient's treatment.So accurately tumor-localizing, accurately treatment plan, accurately
Irradiating execution is three key links that BNCT is precisely treated, and " accurately irradiation executes " therein still suffers from many be stranded
It is difficult.It is to be occurred from nuclear reaction by thermal neutron and boron -10, and boron -10 can be with boron-doping medicine that BNCT, which treats generated dosage,
Object patient's body metabolic process and time of origin-changes in spatial distribution.The change in time and space of this boron-doping drug metabolism has
There is deviation between the dosage received so as to cause patient and the dosage for the treatment of plan defined in apparent randomness.Big
Deviation may result in the tumor control rate decline of BNCT treatment or complication rate increases.
In current BNCT treatment clinical course, boron concentration changes with time takes following approximate evaluation method:
In boron-doping Study of Drug Infusion Process before irradiation, the blood sample of a patient is acquired at interval of a period of time, detects blood sample
In boron concentration, in conjunction with by18The tumor tissues of F-BPA-PET nucleus medical image means measurement and the ratio of blood boron concentration
(T/N), the experience curve that revision boron-doping drug is metabolized at any time, and finally determine irradiation time.The problem is that tumor group
The boron concentration changes with time knitted is based on empirical model derivation rather than On-line sampling system is not as a result, account for boron concentration sky yet
Between nonunf ormity influence, causing the practical dosage received of patient, there are biggish uncertainties.
Based on the above situation, we it is necessary to design a kind of neutron capture therapy system for being able to solve the above problem.
Summary of the invention
It is an object of the invention to: it proposes a kind of neutron capture therapy system of dosage guidance, is based on BNCT therapeutic process
Middle thermal neutron and boron -10 react prompt fission gammas's photon of releasing, by detector array to being opened according to object target area of irradiation
Three-dimensional measurement is opened up, the gammaphoton of releasing is detected and is reflected as being shone real-time -10 concentration of boron of object target area of irradiation by calculating
The 3-dimensional dose distribution for being distributed and receiving, is accordingly adjusted the parameter for the treatment of plan, controls so that BNCT be greatly improved
The precision level for the treatment of process.
For this purpose, first aspect present invention proposes a kind of boron neutron capture therapy system of dosage guidance, comprising:
Low energy linear accelerator system, for providing stable proton beam；
Neutron exposure system, including neutron beam irradiation port, for providing treatment neutron beam to by according to object irradiation target
Area is irradiated, and is connect with the low energy linear accelerator system；
Auxiliary system is treated, for being shone tumor-localizing, the treatment plan system of object during neutron capture tumor therapy
The verifying of fixed and treatment plan and execution；
Dosage guides system, for the real-time dosage monitoring and real-time treatment plan tune during neutron capture tumor therapy
It is whole, it is connect respectively with the neutron exposure system, the treatment auxiliary system.
It should be noted that it is heretofore described by according to object refer mainly to receive neutron beam irradiation treatment with tumour
Patient, abbreviation patient.
Further, the treatment auxiliary system includes treatment planning systems, control system, localization and positioning system, control
Module, preparation room, Isolated Shield room and exposure cell, the Isolated Shield room be set to the exposure cell and the exposure cell it
Between, the neutron beam irradiation port of the neutron exposure system is set in the exposure cell.
Further, the treatment planning systems, including plan module and plan authentication module.The plan
Treatment plan can be generated in module, and the plan authentication module can verify treatment plan.Treatment plan verifying is completed
Afterwards, it can be treated according to treatment plan.
Further, the treatment planning systems further include treatment and curative effect evaluation module, to therapeutic process and curative effect
It is assessed.
Further, the localization and positioning system include simulation irradiation port, therapeutic bed, guide rail, automatic contraposition device and
It puts position and verifies device, the guide rail is laid on the preparation room and extends in the exposure cell, and the therapeutic bed is along described
Guide rail moves back and forth between the preparation room and the exposure cell.The automatic contraposition device can with quick lock in therapeutic bed,
Determine the position of the therapeutic bed；The pendulum position verifying system is used to quickly be put position, and confirmation in place to photograph according to object
Penetrate position.Further, the dosage guidance system includes dosage monitoring system, boron medicine infusion system, treatment plan adjustment system
System, the dosage monitoring system, the boron medicine infusion system are connect with treatment plan adjustment system electric signal respectively, described
Treatment plan adjusts system and carries out data acquisition and action control to the dosage monitoring system and the boron medicine infusion system.
Further, the dosage guidance system includes dosage monitoring system, boron medicine infusion system, treatment plan adjustment system
System, the dosage monitoring system, the boron medicine infusion system are connect with treatment plan adjustment system respectively, the treatment meter
It draws adjustment system and data acquisition and action control is carried out to the dosage monitoring system and the boron medicine infusion system respectively.
Further, the dosage monitoring system includes radiation detection portion, calculation part, and the radiation detection portion is for detecting
By the prompt fission gammas's photon released according to object and it is converted into gamma-spectrometric data, the calculation part is used to detect in the radiation detection portion
It is -10 concentration distribution of boron that the gamma-spectrometric data arrived, which calculates analysis,.
Further, the radiation detection portion includes collimation body, detection body, shield, the collimation body, the detection body
It is arranged in inside the shield.The collimation body is used to collimate on the ray issued at tested object, the detection body
For converting electric signal and gamma-spectrometric data for the optical signal after collimation.Further, the collimating aperture on the collimation body is with two
Dimension array format is evenly arranged.Further, the collimation body is grid collimator made of tungsten plate or stereotype.
Further, the detection body is made of multiple probe units, and each probe unit is arranged in matrix, the spy
It surveys unit and the collimating aperture corresponds.
Further, each probe unit includes crystal detection module, signal collection and amplification module, signal processing
Module, crystal detection module, signal collection and amplification module, signal processing module are sequentially connected.The crystal detection module is used
The optical signal after detection collimation, the signal collection and amplification module put the signal that crystal detection module is detected
Greatly, amplified signal is digitally converted by the signal processing module, and is generated opposite with incident gamma ray energy
The multiple tracks gamma-spectrometric data answered.
Further, the radiation detection portion is pairs of, and is arranged in a symmetrical by according to around object.By right
Claim setting radiation detection portion, in conjunction with anticoincidence circuit, can efficiently screen the energy that electron-positron pair annihilation reaction is released is
511keV, contrary gammaphoton, to eliminate noise gammaphoton.
Further, the radiation detection portion can be rotated around object is shone.Specifically, its spatial position can root
It needs to be adjusted by translation or rotation according to detection, the distance between pairs of radiation detection portion can need to carry out according to detection
Adjustment.
Further, the multiple tracks gamma-spectrometric data that the calculation part of the dosage monitoring system detects the radiation detection portion
Analytical calculation is carried out, obtains the distribution of -10 capture reaction rate of boron and the boron Distribution of dose rate of target area of irradiation, and further calculate
Current -10 concentration distribution of boron is obtained to get the real-time three-dimensional distribution situation of -10 concentration of target area of irradiation boron is arrived.
Further, the boron medicine infusion system, for being further transfused to patient as needed during BNCT is treated
Boron-doping drug, including infusion line, infusion pump, boron medicine storage container.
Further, the infusion pump, the boron medicine storage container are arranged in outside exposure cell, and the room of being illuminated is avoided to radiate
Irradiation, the infusion line can by boron-doping drug import exposure cell in to patient carry out boron-doping infusion of drug.
Further, the treatment plan adjustment system includes computing module and operation module, and the computing module is used for
Processing acquisition calculates irradiation time and adjusts amplitude from radiotherapy planning system, the information of dosage monitoring system and boron medicine infusion system
With supplement be transfused boron dose, generate treatment plan Adjusted Option, the operation module for show treatment plan Adjusted Option with
And operation treatment plan Adjusted Option.
Further, the treatment auxiliary system includes treatment planning systems, control system, localization and positioning system, prepares
Room, Isolated Shield room and exposure cell, the Isolated Shield room are set between the exposure cell and the preparation room, the neutron
The neutron beam irradiation port of irradiation system is set in the exposure cell.
Further, the localization and positioning system include simulation irradiation port, therapeutic bed, guide rail, automatic contraposition device and
It puts position and verifies device, the guide rail is laid on the preparation room and extends in the exposure cell, and the therapeutic bed is along described
Guide rail moves back and forth between the preparation room and the exposure cell.
Second aspect of the present invention proposes a kind of operating method of the boron neutron capture therapy system of dosage guidance, including with
Lower step:
A, proton beam is provided by low energy linear accelerator system 100；
B, neutron beam is converted for proton beam by neutron beam system；
C, treatment plan is provided by treatment auxiliary system 300 and complete to position；
D, according to treatment plan, patient target area is irradiated using neutron beam；
E, system 400 is guided to formulate treatment Adjusted Option by dosage；
F, treatment plan Adjusted Option is compared with treatment plan, and judged whether within the scope of acceptable error,
If it is not, D step is executed after then adjusting treatment plan according to treatment plan Adjusted Option, if so, performing the next step rapid；
G, practical exposure dose is compared with treatment plan exposure dose, and judges whether practical exposure dose reaches
Treatment plan exposure dose executes D step if it is not, then continuing, if so, performing the next step rapid；
H, stop neutron beam irradiation, complete BNCT treatment.
The invention has the benefit that
The present invention provides a kind of boron neutron capture therapy system of dosage guidance, on the one hand, realizes BNCT therapeutic process
The real time monitoring at middle patient's target area of irradiation position obtains -10 concentration distribution of three-dimensional boron of patient's target area of irradiation, reduces because of boron-doping
Drug causes the uncertainty of patient's acceptable dose in body metabolism difference, on the other hand, according to the three of patient's target area of irradiation
- 10 concentration distribution of boron is tieed up, treatment plan is adjusted, the accurate irradiation for having reached accurate radiotherapy planning executes, to the greatest extent may be used
It has been avoided that BNCT treatment occurs tumor control rate decline because of target area of irradiation underdosage or because normal tissue dose is exceeded
And there is the problems such as complication rate increase.
Detailed description of the invention
Fig. 1 is structural block diagram of the invention；
Fig. 2 is structural schematic diagram of the invention；
Fig. 3 is schematic diagram in exposure cell of the invention；
Fig. 4 is operating method flow diagram of the invention.
Wherein, low energy linear accelerator system 100；Neutron exposure system 200, neutron beam irradiate port 210；Treatment auxiliary
System 300, preparation room 310, simulation irradiation port 321, therapeutic bed 322, guide rail 323, the first docking mechanism 3241, the second docking
Mechanism 3242, the first optical camera 3251, the second optical camera 3252, Isolated Shield room 330, exposure cell 340；Dosage guidance system
System 400, radiation detection portion 411.
Specific embodiment
, there are further understanding and understanding in the effect of to make to structure feature of the invention and being reached, to preferable
Examples and drawings cooperation detailed description, is described as follows:
As shown in Figure 1, a kind of boron neutron capture therapy system of dosage guidance, comprising: low energy linear accelerator system
100, neutron exposure system 200, treatment auxiliary system 300 and dosage guide system 400, and neutron exposure system 200 and low energy are straight
Line accelerator system 100 connects, and neutron exposure system 200, treatment auxiliary system 300 and dosage guidance 400 electric signal of system connect
It connects.
Low energy linear accelerator system 100, can produce proton beam and by proton beam energies accelerate to 2.5-20MeV it
Between, to be preferably that neutron exposure system 200 provides stable, satisfactory proton beam.
Neutron exposure system 200, including neutron beam irradiate port 210, low energy linear accelerator system 100 can be provided
Proton beam be converted into primary neutron beam, and the primary neutron Shu Jinhang power spectrum of generation is moulded, is obtained based on epithermal neutron
Treatment neutron beam, neutron beam projects from neutron beam irradiation port 210, patient's target area of irradiation is reached, and according to treatment
The parameter of plan is irradiated treatment.
As shown in Fig. 2, treatment auxiliary system 300, including treatment planning systems, control system, localization and positioning system, preparation
Room 310, Isolated Shield room 330 and exposure cell 340, Isolated Shield room 330 are set between preparation room 310 and exposure cell 340, in
The neutron beam irradiation port 210 of sub- irradiation system 200 is set in exposure cell 340.Specifically, treatment planning systems are set to
In preparation room 310, localization and positioning system and dosage guidance 400 sub-unit of system are set in preparation room 310 and exposure cell 340,
Patient can be made to receive irradiation treatment in exposure cell 340, and other medical staff only need to be monitored in preparation room 310
And operation, confirm the safety of medical staff.
As an improvement of the present invention, treatment planning systems, including plan module and plan authentication module.Plan
Formulating module can be generated treatment plan, and plan authentication module can verify treatment plan.
In BNCT therapeutic process, before beamlet in use is irradiated, needs to inject boracic drug to patient's body, contain
Boron drug has close tumour property, can be enriched in tumor region, the nucleus medical image at patient target area position is acquired after the completion of enrichment,
Current boron-doping drug is obtained in the distribution characteristics of patient's body, and establish the boron-doping drug model of Rapid Dose Calculation, carried out accordingly
Treatment plan is formulated, and input parameter includes tumor target parameter, boron-doping drug parameters and neutron beam parameter, tumor target parameter packet
Include knub position, tumor size etc., boron-doping drug parameters include -10 concentration distribution of boron and its metabolic chart in vivo, neutron beam
Parameter includes irradiation time, irradiating angle, exposure intensity etc..It should be noted that this paper boron-doping drug concentration and -10 concentration of boron
With one-to-one relationship, i.e. boron-doping drug concentration can obtain the physical quantity of -10 concentration of boron by unit conversion.According to foundation
Model can make treatment plan, verified by treatment plan of the authentication module to formulation, after being verified i.e.
Treatment can be irradiated according to treatment plan.However the determination of each parameter is based on patient's body before irradiation treatment in treatment plan
The distribution of boron preparation, however boron -10 can with boron preparation in the metabolic process of patient's body and time of origin-spatial distribution becomes
Change, that is, the actually required radiation parameters of patient and practical exposure dose can and treatment plan have certain deviation.Big deviation can
The tumor control rate decline or complication rate that BNCT treatment can be will lead to increase.
Treatment planning systems further include treatment and curative effect evaluation system, to assess therapeutic process and curative effect.Assessment
It can be and the therapeutic effect after the treatment parameter and treatment in therapeutic process is assessed, to evaluate the feasible for the treatment of plan
Property, reference is provided to formulate and verifying treatment plan later.
As an improvement of the present invention, localization and positioning system includes simulation irradiation port 321, therapeutic bed 322, guide rail
323, device is verified in automatic contraposition device and pendulum position, and guide rail 323 is laid on preparation room 310 and extends in exposure cell 340, treats
Bed 322 moves back and forth between preparation room 310 and exposure cell 340 along guide rail 323.Automatic contraposition device can be controlled with quick lock in
Bed 322 is treated, determines the position of therapeutic bed 322；Verifying system in pendulum position is used to quickly put patient position, and confirmation in place to irradiation
Position.Automatic contraposition device is mainly used for determination and the fixation for treatment bed 322 of 322 position of therapeutic bed, and system master is verified in pendulum position
It is used for the determination of the position of tumour and normal tissue.
Wherein, the setting of therapeutic bed 322 is adapted position in neutron beam irradiation port 210, so that patient can receive neutron
Beam irradiation treatment, in the present embodiment, the placing direction of therapeutic bed 322 is parallel to neutron beam grain direction.
Automatic contraposition device includes the first docking mechanism 3241 for being mounted on preparation room 310, is mounted on the of exposure cell 340
Two docking mechanisms 3242, the first docking mechanism 3241 and the second docking mechanism 3242 can be locked with therapeutic bed 322.Wherein, mould
Quasi- irradiation port 321 is consistent with position of the neutron beam outlet in exposure cell 340 in the position in preparation room 310, and simulation is shone
Penetrate position of the port 321 relative to the position of the first docking mechanism 3241 and neutron beam outlet relative to the second docking mechanism 3242
It is consistent.
Putting position verifying device includes the first optical camera 3251, the second optical camera 3252 and image recognition and processing dress
It sets.The surface after being tested object pendulum position in preparation room 310 is arranged in first optical camera 3251, and the second optical camera 3252 is set
Set the surface after being tested object pendulum position in exposure cell 340；First optical camera 3251 and the second optical camera 3252 with
Image recognition and the connection of processing unit electric signal.
Specifically, the first optical camera 3251, the second optical camera 3252 are separately positioned on preparation room 310 and exposure cell
Same position right above 322 position of therapeutic bed in 340, faces patient from the top down and takes pictures；Image recognition and
Processing unit can extract patient body position's body surface profile from captured photo.
Patient can complete to position and put position in preparation room 310 as a result, and it is complete to enter exposure cell 340 without medical staff
At positioning and pendulum position.
Over the course for the treatment of, first in the therapeutic bed 322 in preparation room 310 by positioning device complete patient target area with
Normal organ positioning and pendulum position, and fixation postures, are then moved to exposure cell 340 by guide rail 323 for therapeutic bed 322 and patient,
Device confirmation is verified by pendulum position again and arrives irradiation position in place, neutron beam photograph can be carried out according to treatment plan after confirmation is in place
It penetrates.Wherein, medical staff can complete patient in preparation room 310 and put the work such as position and manipulation execution treatment plan, then will
Patient and therapeutic bed 322 are moved in exposure cell 340, and medical staff is not necessarily to enter in exposure cell 340, to ensure medical staff's
Healthy and safe, the Isolated Shield room 330 being arranged between exposure cell 340 and preparation room 310 can further mask exposure cell
340 radiation further ensures that medical staff's is healthy and safe.
As shown in Figure 2 and Figure 3, dosage guidance system 400 includes dosage monitoring system, boron medicine infusion system, treatment plan tune
Whole system, dosage monitoring system, boron medicine infusion system are connect with treatment plan adjustment system respectively, and treatment plan adjusts system pair
Radiation-monitoring system and boron medicine infusion system carry out data acquisition and action control.
Specifically, dosage monitoring system can detect the thermal neutron of target area of irradiation and boron -10 occurs what nuclear reaction was released
Characteristic gamma ray signal, and detectable signal is digitized, generate multiple tracks energy corresponding with incident gamma ray energy
Modal data obtains the distributed in three dimensions of -10 concentration of patient's target area of irradiation boron dosage and boron by analytical calculation.
As an improvement of the present invention, dosage monitoring system includes radiation detection portion 411, calculation part.Radiation detection portion
For detecting by prompt fission gammas's photon according to object releasing and being converted into gamma-spectrometric data, calculation part is for detecting radiation detection portion
It is -10 concentration distribution of boron that the gamma-spectrometric data arrived, which calculates analysis,.
Radiation detection portion 411 includes collimation body, detection body, shield, and collimation body, detection body are arranged in inside shield,
Collimation body is used to collimate on the ray issued at tested object, and detection body is used to convert telecommunications for the optical signal after collimation
Number and gamma-spectrometric data.The collimating aperture of collimation body is evenly arranged with two-dimensional array form, and it is tungsten plate or lead that body is collimated in the present embodiment
Grid collimator made of plate；Detection body is made of multiple probe units, and each probe unit is arranged in matrix, each detection
Unit includes crystal detection module, signal collection and amplification module, signal processing module, crystal detection module, signal collection with
Amplification module, signal processing module are sequentially connected.The signal that signal collection and amplification module are detected crystal detection module
It amplifies, amplified signal is digitally converted by signal processing module, and is generated and incident gamma ray energy phase
Corresponding multiple tracks gamma-spectrometric data.
Wherein, the corresponding detector cells of each collimating aperture, each detector cells may detect gamma ray letter
Number, by grid collimator, the interference signal of scattered ray can be effectively filtered out, obtains what radiation detection portion 411 was covered
The incident gamma ray data of plane domain, by analyzing incident gamma ray data, you can get it is covered calculation part
The concentration distribution of the boron-doping drug of lid plane, wherein the concentration of boron-doping drug can also be scaled the concentration of boron -10, further, lead to
Overshoot probe portion 411 does rotation around patient and carries out different direction detection to tested object, and search coverage can cover
Entirely tested object, calculation part carries out sectional analysis by -10 concentration distribution of boron to these different directions, so as to obtain
The three dimensional concentration of the boron -10 of patient's body is distributed, and can obtain the actual dosage distribution situation of irradiation area, more accurately to suffer from
Person can obtain more accurately treating.
Radiation detection portion 411 is pairs of, and is arranged in around tested object in a symmetrical, by being symmetrical arranged radiation
Probe portion 411 can be screened efficiently in conjunction with anticoincidence circuit and remove noise gammaphoton.Specifically, being shone in neutron beam
When penetrating, it can be reacted with boron and generate gammaphoton, it is the gammaphoton for needing to detect that usually energy, which is the gammaphoton of 478keV,
Signal, but neutron beam can also generate gammaphoton with other substance reactions in the detection process in addition to this, as electron-positron pair falls into oblivion
Go out what reaction was released, energy 511keV, two contrary beam gammaphotons, to differentiation 478keV gammaphoton position and letter
Number exist and to interfere to a certain degree, referred to as noise gammaphoton can impact testing result, and needs remove.This implementation
In example, the pairs of radiation detection portion 411 of symmetrical arrangement is set, can be detected simultaneously by and differentiate this two beams noise gamma light
Son, then this noise gammaphoton signal is reduced, this noise gammaphoton can be eliminated.The spatial position in radiation detection portion 411 is also
It can need to be adjusted by translation or rotation according to detection, the distance between pairs of radiation detection portion 411 can be according to detection
It needs to be adjusted.
In the present embodiment, radiation detection portion 411 is located at the left and right sides of therapeutic bed 322, to guarantee to detect irradiation target
The gammaphoton that area issues.
As an improvement of the present invention, boron medicine infusion system, for BNCT treatment during as needed to patient into
One step is transfused boron-doping drug, including infusion line, infusion pump, boron medicine storage container.
In the present embodiment, infusion pump, boron medicine storage container are arranged in preparation room 310, avoid being illuminated 340 spoke of room
The irradiation of ray is imported boron-doping drug to carry out boron-doping infusion of drug to patient in exposure cell 340 by infusion line,
In, to reduce infusion line by the risk of radiation pollution, infusion line is needed replacing before every patient irradiation, it is ensured that every trouble
Person uses a set of independent infusion line.
As an improvement of the present invention, treatment plan adjustment system includes computing module and operation module, computing module
For handling information of the acquisition from dosage monitoring system and boron medicine infusion system, irradiation time adjustment amplitude and supplement infusion are calculated
Boron dose generates radiotherapy planning Adjusted Option, and operation module is for showing treatment plan Adjusted Option and operation treatment plan
Adjusted Option.Computing module gets current -10 concentration distribution of boron of target area of irradiation from dosage monitoring system, in conjunction with present dose
Dosage received by current detection period patient is calculated, by all detection periods in accumulative irradiation time under rate
Patient's acceptable dose integrates, and the deviation between the dosage in the practical acceptable dose of patient and treatment plan can be obtained, then tie
Current -10 concentration distribution of boron is closed, treatment plan Adjusted Option is generated.Treatment plan Adjusted Option includes boron-doping infusion of drug scheme
With neutron beam illumination scheme, the neutron dose received by tissue and neutron beam irradiation time, neutron beam exposure intensity,
- 10 concentration of boron is all proportional.
It should be noted that neutron beam can pass through normal tissue before reaching focal zone, for example, neutron beam is needed through skin
Skin just can enter tumor region, and neutron dose received by skin is no more than safety standard；On the other hand, target area of irradiation
For neutron beam irradiation region, focal zone be patient tumors region, it is generally the case that target area of irradiation be equal to focal zone, because
When neutron beam irradiation treatment, beam outlet can be adapted with tumor size, so that target area of irradiation is covered focal zone, to ensure neutron beam
Only tumor region is irradiated, but since beam exports the influence of production precision or tumor size boundary confirmation difficulty etc.,
Target area of irradiation may be slightly larger than focal zone, it will cause to receive neutron beam photograph in the part normal tissue in tumor boundaries region
It penetrates.As known from the above, over the course for the treatment of, inevitably, neutron beam irradiation can be received by some normal tissues, work as neutron
Dosage is excessively high, then can cause harm to the human body.
Meanwhile over the course for the treatment of, when the neutron dose deficiency received at tumour, it will usually first adjust neutron beam ginseng
Number ensures that neutron dose that tumor region receives meets treatment and requires such as irradiation time, but irradiation time is too long may
The neutron dose for causing normal tissue to receive is excessively high, then can cause harm to the human body, it is therefore desirable to control the boron-of tumor region
10 concentration, to ensure neutron dose that normal tissue receives in safe range, guarantee patient in certain safe range
Personal safety.
For example, generating neutron beam illumination scheme, neutron beam illumination scheme if current -10 concentration of boron meets safety requirements
In neutron beam illumination scheme is adjusted, including irradiating angle, irradiation time etc..For example, if current -10 concentration of boron is discontented
Sufficient safety requirements generates boron-doping infusion of drug scheme, is adjusted in boron-doping infusion of drug scheme to boron-doping infusion of drug scheme,
Including the amount toward patient's body supplement infusion boron-doping drug, with -10 concentration of boron etc. for improving patient's body.Avoid BNCT treatment
Occur tumor control rate decline because of target area of irradiation underdosage or complication occurs because normal tissue dose is exceeded
The problems such as rate increases.
The treatment plan Adjusted Option of generation is shown in operation module, and can execute treatment plan by operation module
Adjusted Option.In the present embodiment, operation module includes touch screen, and touch screen is placed in preparation room 310, the treatment plan of generation
Adjusted Option is shown on touch screen, and doctor selects suitable treatment plan Adjusted Option as needed, by manipulating touch screen
The boron-doping infusion of drug scheme or neutron beam illumination scheme executed in treatment plan Adjusted Option can be operated, wherein execution is mixed
When boron infusion of drug scheme, operation module needs to control the movement of boron medicine infusion system, when executing neutron beam illumination scheme, operation
Module needs to control the movement of neutron exposure system 200.
For example, being treated according to treatment plan, no when -10 concentration of target area of irradiation boron is consistent with treatment plan
It needs to adjust treatment plan.
For example, be not consistent with treatment plan when -10 concentration of target area of irradiation boron, -10 concentration of boron in safe range when, execution
Neutron beam illumination scheme controls neutron exposure system 200, is adjusted to neutron beam parameter.
For example, be not consistent with treatment plan when -10 concentration of target area of irradiation boron, -10 concentration of boron not in safe range when, hold
Row boron-doping infusion of drug scheme controls boron medicine infusion system, toward patient's body supplement infusion boron-doping drug.
As shown in figure 4, the operating method that the dosage in the boron neutron capture therapy system guides, comprising the following steps:
A, proton beam is provided by low energy linear accelerator system 100；
B, neutron beam is converted for proton beam by neutron beam system；
C, treatment plan is provided by treatment auxiliary system 300 and complete to position；
D, according to treatment plan, patient target area is irradiated using neutron beam；
E, system 400 is guided to formulate treatment Adjusted Option by dosage；
F, treatment plan Adjusted Option is compared with treatment plan, and judged whether within the scope of acceptable error,
If it is not, D step is executed after then adjusting treatment plan according to treatment plan Adjusted Option, if so, performing the next step rapid；
G, practical exposure dose is compared with treatment plan exposure dose, and judges whether practical exposure dose reaches
Treatment plan exposure dose executes D step if it is not, then continuing, if so, performing the next step rapid；
H, stop neutron beam irradiation, complete BNCT treatment.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of skill in the art that it still can be right
Technical solution documented by previous embodiment is modified, or is replaced on an equal basis to part of technical characteristic；And these
It modifies or replaces, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (10)
1. a kind of boron neutron capture therapy system of dosage guidance characterized by comprising
Low energy linear accelerator system (100), for providing stable proton beam；
Neutron exposure system (200), including neutron beam irradiation port (210), for providing treatment neutron beam to by according to object
Target area of irradiation is irradiated, and is connect with the low energy linear accelerator system (100)；
It treats auxiliary system (300), is shone during neutron capture tumor therapy based on the localization and positioning and treatment of object
It draws fixed, verifying and executes；
Dosage guide system (400), for during neutron capture tumor therapy dosage monitoring and treatment plan adjustment, respectively
It is connect with the neutron exposure system (200), the treatment auxiliary system (300).
2. the boron neutron capture therapy system of dosage guidance according to claim 1, which is characterized in that the dosage guidance
System (400) includes dosage monitoring system, boron medicine infusion system, treatment plan adjustment system, the dosage monitoring system, described
Boron medicine infusion system is connect with treatment plan adjustment system respectively, and the treatment plan adjustment system is respectively to the dosage
Monitoring system and the boron medicine infusion system carry out data acquisition and action control.
3. the boron neutron capture therapy system of dosage guidance according to claim 2, which is characterized in that the dosage monitoring
System includes radiation detection portion (411), calculation part, and the radiation detection portion is used to detect the prompt fission gammas's light released according to object
Son is simultaneously converted into gamma-spectrometric data, and the calculation part, which is used to the gamma-spectrometric data that the radiation detection portion detects calculating analysis, is
- 10 concentration distribution of boron.
4. the boron neutron capture therapy system of dosage guidance according to claim 3, which is characterized in that the radiation detection
Portion (411) includes collimation body, detection body, shield, and the collimation body, the detection body are arranged in inside the shield, institute
It states collimation body to be used to collimate on the ray issued at tested object, the detection body is for the optical signal conversion after collimating
For electric signal and gamma-spectrometric data, the collimating aperture being evenly arranged with two-dimensional array form is provided on the collimation body.
5. the boron neutron capture therapy system of dosage guidance according to claim 3, which is characterized in that the radiation detection
Portion (411) is pairs of, and is arranged in is shone around object in a symmetrical, and can be rotated around object is shone.
6. the boron neutron capture therapy system of dosage guidance according to claim 2, which is characterized in that the boron medicine infusion
System includes infusion line, infusion pump, boron medicine storage container.
7. the boron neutron capture therapy system of dosage guidance according to claim 2, which is characterized in that the treatment plan
Adjustment system includes computing module and operation module, and the computing module is for obtaining the dosage monitoring system, the boron medicine
The data of infusion system simultaneously generate treatment plan Adjusted Option, the operation module for show treatment plan Adjusted Option and
Control executes treatment plan Adjusted Option.
8. the boron neutron capture therapy system of dosage guidance according to claim 1, which is characterized in that the treatment auxiliary
System (300) include treatment planning systems, control system, localization and positioning system, preparation room (310), Isolated Shield room (330) and
Exposure cell (340), the Isolated Shield room (330) are set between the exposure cell (340) and the preparation room (310), institute
Neutron beam irradiation port (210) for stating neutron exposure system (200) is set in the exposure cell (340).
9. the boron neutron capture therapy system of dosage guidance according to claim 8, which is characterized in that the localization and positioning
System includes that device, institute are verified in simulation irradiation port (321), therapeutic bed (322), guide rail (323), automatic contraposition device and pendulum position
Guide rail (323) is stated to be laid on the preparation room (310) and extend in the exposure cell (340), the therapeutic bed (322) along
The guide rail (323) moves back and forth between the preparation room (310) and the exposure cell (340).
10. the operating method of the boron neutron capture therapy system of -9 described in any item dosage guidance according to claim 1, special
Sign is, comprising the following steps:
A, proton beam is provided by low energy linear accelerator system (100)；
B, neutron beam is converted for proton beam by neutron exposure system (200)；
C, treatment plan is provided by treatment auxiliary system (300) and complete to position；
D, it according to treatment plan, is irradiated using neutron beam to by photograph object target area；
E, treatment plan Adjusted Option is formulated by dosage guidance system (400)；
F, treatment plan Adjusted Option is compared with treatment plan, and judged whether within the scope of acceptable error, if it is not,
D step is executed after then adjusting treatment plan according to treatment plan Adjusted Option, if so, performing the next step rapid；
G, practical exposure dose is compared with treatment plan exposure dose, and judges whether practical exposure dose reaches treatment
Plan exposure dose and execute D step if it is not, then continuing, if so, performing the next step rapid；
H, stop neutron beam irradiation, complete BNCT treatment.
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