CN112546454A - Neutron capture treatment equipment and use method of irradiation parameter selection device - Google Patents
Neutron capture treatment equipment and use method of irradiation parameter selection device Download PDFInfo
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Abstract
A neutron capture treatment device and a use method of an irradiation parameter selection device are provided, the neutron capture treatment device comprises: the control system comprises an irradiation parameter selection device for selecting an optimal irradiation point and an irradiation angle, the irradiation parameter selection device comprises a sampling part and a calculation part, the sampling part selects multiple groups of irradiation points and irradiation angles, and the calculation part calculates evaluation values corresponding to each group of irradiation points and irradiation angles and outputs a report.
Description
Technical Field
The invention relates to a radiation therapy device and a method for using a parameter selection device, in particular to a neutron capture therapy device and a method for using an irradiation parameter selection device.
Background
With the development of atomic science, radiation therapy such as cobalt sixty, linacs, electron beams, etc. has become one of the main means of cancer treatment. However, the traditional photon or electron therapy is limited by the physical conditions of the radiation, and can kill tumor cells and damage a large amount of normal tissues in the beam path; in addition, due to the difference in the sensitivity of tumor cells to radiation, conventional radiotherapy is often ineffective in treating malignant tumors with relatively high radiation resistance, such as multiple glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma).
In order to reduce the radiation damage of normal tissues around tumor, the target therapy concept in chemotherapy (chemotherapy) is applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high Relative Biological Effect (RBE) are also actively developed, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. The Neutron Capture Therapy combines the two concepts, such as Boron Neutron Capture Therapy (BNCT), and provides a better cancer treatment option than conventional radiation by specific accumulation of Boron-containing drugs in tumor cells in combination with precise beam modulation.
Boron neutron capture therapy utilizing boron-containing (10B) The medicine has high capture cross section for thermal neutrons, and is generated by 10B (n, alpha) 7Li neutron capture and nuclear fission reaction4He and7the total range of the two heavily charged particles is about equal to one cell size, so that the radiation damage to organisms can be limited to the cell level, and when boron-containing drugs selectively gather in tumor cells and are matched with a proper neutron source, the aim of locally killing the tumor cells can be achieved on the premise of not causing too much damage to normal tissues.
In the conventional neutron capture treatment planning system, the irradiation geometric angle is manually determined and defined according to experience. Because the human body structure is quite complex, and the sensitivities of various tissues or organs to radiation are greatly different, the better irradiation angle is probably ignored by only manual judgment, and the treatment effect is greatly reduced.
Therefore, it is necessary to provide a neutron capture treatment apparatus and a method of using an irradiation parameter selection device that can perform determination of the merits of an irradiation point and an irradiation angle.
Disclosure of Invention
In order to overcome the defects of the prior art, the inventor provides a neutron capture treatment device and a use method of an irradiation parameter selection device, which can judge the advantages and disadvantages of an irradiation point and an irradiation angle.
The present application provides a neutron capture treatment device, characterized by comprising: the control system comprises an irradiation parameter selection device for selecting an optimal irradiation point and an irradiation angle, the irradiation parameter selection device comprises a sampling part and a calculation part, the sampling part selects multiple groups of irradiation points and irradiation angles, and the calculation part calculates evaluation values corresponding to each group of irradiation points and irradiation angles and outputs a report.
Further, the calculation part calculates the incident depth of the neutron beam entering the patient and the type of the organ passing through, and then judges whether the tumor falls within the maximum treatable depth range corresponding to the group of irradiation points and irradiation angles according to the trajectory information of the neutron beam passing through the human body, if so, the evaluation value corresponding to the group of irradiation points and irradiation angles is calculated by using the trajectory information as the basis according to the data of boron-containing concentration of the organ, radiation sensitivity factor of the organ, neutron beam characteristic information and the like set by a user; if not, the worst evaluation value is given.
Further, the calculation section outputs data of the irradiation point and the irradiation angle and their corresponding evaluation values in the form of a 3D or 2D image.
Further, the weighting factor (w (i)) of the organ i corresponding to a certain irradiation point, an irradiation angle and a certain irradiation track is calculated by using the formula one:
w (i) x s (i) x c (i) (formula one)
Wherein I (i), S (i) and C (i) are neutron intensity, radiation sensitivity factor of organ i and boron-containing concentration of organ i, respectively.
Further, the i (i) is calculated by using the formula two which simulates the depth intensity or dose curve integral of the human body according to the used beam:
where i (x) is the depth intensity or dose curve function of the therapeutic beam in the approximate human body, and x0-x is the depth range of the organ (i) in the beam trajectory.
Further, the evaluation factor is calculated by adopting a formula three:
wherein Q (x, y, z, phi, theta) is equal to the sum of the weighting factors of the organs in the organ track as the evaluation factor.
Further, the ratio of the evaluation factor to the tumor evaluation factor (QR (x, y, z, Φ, θ)) is calculated using equation four:
wherein W (tumor) is the weighting factor of the tumor.
The application also provides a use method of the irradiation parameter selection device, which comprises the following steps: the sampling part reads images with definite human anatomy such as CT/MRI/PET-CT of a patient, defines the outlines of each organ, tissue and tumor one by one, gives set material types and densities, and selects an irradiation point and an irradiation angle of a neutron beam after the definitions of the outlines, the materials and the densities are finished; the calculation part calculates the track of the organ through which the neutron beam passes, namely calculates the type and thickness of the organ through which the neutron beam passes after entering the human body, judges whether the tumor falls in the maximum treatable depth range after acquiring the track information of the neutron beam passing through the human body, and calculates the evaluation value corresponding to the irradiation point and the irradiation angle according to the track information by combining the information of the organ boron-containing concentration, the organ radiation sensitivity factor, the neutron beam characteristic and the like set by a user if the tumor falls in the maximum treatable depth range; if not, the worst evaluation value is given, and after the evaluation value is calculated, the irradiation point, the irradiation angle and the corresponding evaluation value are recorded.
Furthermore, the selection of the irradiation point and the irradiation angle can be forward selection or reverse selection, wherein the forward selection is to determine the irradiation point at a position outside the human body and sample the irradiation point sequentially according to a fixed angle or distance interval, or sample the irradiation point in a random sampling manner; the reverse selection is to determine the irradiation point within the tumor range, wherein the irradiation point can be the center of mass or the deepest part of the tumor, and the irradiation angle can be performed by random sampling or sampling at predetermined interval angles; the neutron beam angle can be set to the vector direction from the irradiation point to the center of mass or the deepest part of the tumor.
Further, the calculation section outputs data of the irradiation point and the irradiation angle and their corresponding evaluation values in the form of a 3D or 2D image.
Drawings
FIG. 1 is a schematic diagram of a boron neutron capture reaction.
FIG. 2 is10B(n,α)7Li neutron capture nuclear reaction equation.
Fig. 3 is a schematic view of a neutron capture therapy device in an embodiment of the invention.
Fig. 4 is a schematic diagram of a control system in an embodiment of the invention.
Fig. 5 is a logic block diagram of calculation of evaluation values of irradiation parameters of a neutron beam in the embodiment of the present invention.
Fig. 6 is a schematic view of an organ track during neutron beam irradiation in an embodiment of the present invention.
Detailed Description
Embodiments of the present invention will be described in further detail below with reference to the accompanying drawings so that those skilled in the art can implement the embodiments with reference to the description.
Neutron capture therapy has been increasingly used in recent years as an effective means of treating cancer, with boron neutron capture therapy being the most common, the neutrons that supply boron neutron capture therapy being supplied by nuclear reactors or accelerators. Boron Neutron Capture Therapy (BNCT) utilizes Boron-containing (B: (B-N-C-B-N-C-10B) The medicine has the characteristic of high capture cross section for thermal neutrons10B(n,α)7Li neutron capture and nuclear fission reaction generation4He and7li two types of heavily charged particles. Referring to FIGS. 1 and 2, schematic and graphical illustrations of boron neutron capture reactions are shown, respectively10B(n,α)7Li neutron capture nuclear reaction equation, the average Energy of two heavy charged particles is about 2.33MeV, and the two heavy charged particles have the characteristics of high Linear Energy Transfer (LET) and short range, the Linear Energy and range of alpha particles are 150 keV/mum and 8μm respectively, and7li heavy-charge particles of 175keVAnd 5 μm, the total range of the two particles corresponds to about one cell size, so that the radiation damage to the organism can be limited to the cell level. When the boron-containing medicine selectively gathers in the tumor cells, the purpose of accurately killing the tumor cells can be achieved by matching with a proper neutron source on the premise of not causing too much damage to normal tissues.
Whether the neutron source of boron neutron capture treatment comes from a nuclear reactor or the nuclear reaction of charged particles and a target material, a mixed radiation field is generated, namely a beam comprises neutrons with low energy and high energy and photons; for boron neutron capture therapy of deep tumors, the greater the amount of radiation other than epithermal neutrons, the greater the proportion of non-selective dose deposition in normal tissue, and therefore the radiation that would cause unnecessary dose deposition should be minimized. To better understand the dose distribution of neutrons in the human body, in addition to the air beam quality factor, the embodiment of the present invention uses a human head tissue prosthesis to perform dose distribution calculation, and uses the prosthesis beam quality factor as a design reference of the neutron beam.
The International Atomic Energy Agency (IAEA) gives five air beam quality factor suggestions aiming at a neutron source for clinical boron neutron capture treatment, and the five suggestions can be used for comparing the advantages and disadvantages of different neutron sources and serving as reference bases for selecting neutron generation paths and designing beam integrators. The five proposals are as follows:
epithermal neutron beam flux Epithermal neutron flux>1x 109n/cm2s
Fast neutron contamination<2x 10-13Gy-cm2/n
Photon contamination of Photon contamination<2x 10-13Gy-cm2/n
Thermal to epithermal neutron flux ratio of thermal to epithermal neutron flux ratio <0.05
Neutron current to flux ratio epithermal neutron current to flux ratio >0.7
Note: the super-thermal neutron energy region is between 0.5eV and 40keV, the thermal neutron energy region is less than 0.5eV, and the fast neutron energy region is greater than 40 keV.
1. Epithermal neutron beam flux:
the neutron beam flux and the boron-containing drug concentration in the tumor together determine the clinical treatment time. If the concentration of the boron-containing drug in the tumor is high enough, the requirement on the neutron beam flux can be reduced; conversely, if the boron-containing drug concentration in the tumor is low, high-throughput epithermal neutrons are required to administer a sufficient dose to the tumor. IAEA requirements for epithermal neutron beam flux are greater than 10 epithermal neutrons per second per square centimeter9The neutron beam at this flux can generally control the treatment time within one hour for the current boron-containing drugs, and the short treatment time can effectively utilize the limited residence time of the boron-containing drugs in the tumor besides having advantages on the positioning and comfort of the patient.
2. Fast neutron contamination:
since fast neutrons cause unnecessary normal tissue doses and are therefore considered contamination, the dose magnitude and neutron energy are positively correlated, and the fast neutron content should be minimized in the neutron beam design. Fast neutron contamination is defined as the fast neutron dose accompanied by a unit epithermal neutron flux, and the recommendation for fast neutron contamination by IAEA is less than 2x 10-13Gy-cm2/n。
3. Photon contamination (gamma ray contamination):
gamma rays belong to the intense penetrating radiation and can non-selectively cause the deposition of dose on all tissues on the neutron beam path, so that the reduction of the content of the gamma rays is also the necessary requirement of beam design, the gamma ray pollution is defined as the gamma ray dose accompanied by unit epithermal neutron flux, and the recommendation of IAEA for the gamma ray pollution is less than 2x 10-13Gy-cm2/n。
4. Thermal neutron to epithermal neutron flux ratio:
because the thermal neutrons have high attenuation speed and poor penetrating power, most energy is deposited on skin tissues after entering a human body, and the thermal neutrons content is reduced aiming at deep tumors such as brain tumors and the like except that the epidermal tumors such as melanoma and the like need to use thermal neutrons as a neutron source for boron neutron capture treatment. The IAEA to thermal neutron to epithermal neutron flux ratio is recommended to be less than 0.05.
5. Neutron current to flux ratio:
the neutron current to flux ratio represents the directionality of the beam, the larger the ratio is, the better the beam directionality is, the high-directionality neutral beam can reduce the dosage of the surrounding normal tissues caused by neutron divergence, and in addition, the treatable depth and the positioning posture elasticity are also improved. The IAEA to neutron current to flux ratio is recommended to be greater than 0.7.
The prosthesis is used to obtain the dose distribution in the tissue, and the quality factor of the prosthesis beam is deduced according to the dose-depth curve of the normal tissue and the tumor. The following three parameters can be used to make comparisons of therapeutic benefits of different neutron beams.
1. Effective treatment depth:
the tumor dose is equal to the depth of the maximum dose of normal tissue, after which the tumor cells receive a dose less than the maximum dose of normal tissue, i.e. the advantage of boron neutron capture is lost. This parameter represents the penetration of the beam, with greater effective treatment depth indicating a greater depth of tumor that can be treated, in cm.
2. Effective treatment depth dose rate:
i.e. the tumor dose rate at the effective treatment depth, is also equal to the maximum dose rate for normal tissue. Because the total dose received by normal tissues is a factor influencing the size of the total dose which can be given to the tumor, the parameter influences the length of the treatment time, and the larger the effective treatment depth dose rate is, the shorter the irradiation time required for giving a certain dose to the tumor is, and the unit is cGy/mA-min.
3. Effective therapeutic dose ratio:
the average dose ratio received from the surface of the brain to the effective treatment depth, tumor and normal tissues, is called the effective treatment dose ratio; the average dose can be calculated by integrating the dose-depth curve. The larger the effective therapeutic dose ratio, the better the therapeutic benefit of the beam.
In order to make the beam shaper design more dependent, in addition to the five IAEA suggested in the beam quality factor in air and the three parameters mentioned above, the following parameters for evaluating the beam dose performance are also utilized in the embodiments of the present invention:
1. the irradiation time is less than or equal to 30min (proton current used by an accelerator is 10mA)
2. 30.0RBE-Gy for treating depth greater than or equal to 7cm
3. Maximum tumor dose is more than or equal to 60.0RBE-Gy
4. Maximum dose of normal brain tissue is less than or equal to 12.5RBE-Gy
5. Maximum skin dose not greater than 11.0RBE-Gy
Note: RBE (relative Biological effect) is the relative Biological effect, and since the Biological effects caused by photons and neutrons are different, the above dose terms are multiplied by the relative Biological effects of different tissues to obtain the equivalent dose.
As shown in fig. 3, a neutron capture therapy system 100 for implementing neutron capture therapy includes a neutron beam generating module 1, an irradiation room 2 for irradiating a subject, such as a patient, with a neutron beam, a preparation room 3 for performing preparation before irradiation, a communication room 4 for communicating the irradiation room 2 with the preparation room 3, a management room 5 for performing irradiation control, a positioning device (not shown) for positioning the patient, a table 6 that moves in the preparation room 3 and the irradiation room 2 for placing the patient, and a control system 7 for controlling and managing a therapy process.
The neutron beam generating module 1 is configured to generate a neutron beam outside the irradiation chamber 2 and to irradiate the patient placed in the irradiation chamber 2 with the neutron beam, and a collimator 20 is provided in the irradiation chamber 2. The preparation room 3 is a room for performing a preparation work required before the irradiation of the patient with the neutron beam, and the preparation work includes fixing the patient on the table 6, positioning the tumor of the patient, and providing a three-dimensional positioning mark and the like, and the preparation room 3 is provided with the collimator 30. The management room 5 is a room for managing and controlling the entire treatment process performed by the boron neutron capture therapy system 100, and for example, a manager visually checks the state of the preparation work in the preparation room 3 from the room of the management room 5, and the manager operates the control system 7 to control the start and stop of the irradiation of the neutron beam, the position adjustment of the table 6, and the like, and the table 6 is configured to rotate, translate, and move up and down with the patient. The control system 7 is a general term, and may be a single set of control system, in which the start and stop of irradiation of the neutron beam, the position adjustment of the stage 6, and the like are controlled by a single set of system, or may be a plurality of sets of control systems, in which the start and stop of irradiation of the neutron beam, the position adjustment of the stage 6, and the like are controlled by a single set of control system.
Referring to fig. 4, before performing boron neutron capture therapy, the manager needs to determine the angle from which the neutron beam irradiates the patient to kill tumor cells to the maximum extent and reduce the damage of radiation to surrounding normal tissues as much as possible, and after determining the optimal irradiation point and irradiation angle, adjust the table 6 on which the patient is placed to the corresponding position. Specifically, the control system 7 includes an irradiation parameter selection device 71 for selecting an optimum irradiation point and an irradiation angle, a conversion unit 72 for converting the optimum irradiation parameter into a coordinate parameter of the stage 6, an adjustment unit 73 for adjusting the stage 6 to a predetermined position, and a start/stop unit 74 for controlling start and stop of irradiation with the neutron beam.
As shown in fig. 4, each set of irradiation parameters includes irradiation points and irradiation angles of the neutron beam, the irradiation parameter selection device 71 includes a sampling unit 711, a calculation unit 712, and a selection unit 713, wherein the sampling unit 711 selects a plurality of sets of irradiation points and irradiation angles, the calculation unit 712 calculates evaluation values corresponding to the irradiation points and the irradiation angles of each set, and the selection unit 713 selects a set of optimal executable irradiation parameters from all the sampled irradiation points and irradiation angles according to the evaluation values calculated by the calculation unit 712, specifically, the selection unit 713 rejects the irradiation parameters that are not executable in the actual treatment process and selects a set of optimal executable irradiation parameters. The selection of the irradiation points and the irradiation angles by the sampling part 711 can be random or regular, the calculation of the evaluation value calculates the organ track through which the neutron beam passes, that is, the calculation part 712 calculates the incident depth and the type of the organ through which the neutron beam enters the human body, and then judges whether the tumor falls within the maximum treatable depth range corresponding to the group of irradiation parameters according to the track information of the neutron beam passing through the human body, if so, the evaluation value corresponding to the group of irradiation points and the irradiation angles is calculated by using the track information as the basis of the data, such as the boron-containing concentration of the organ, the organ radiation sensitivity factor, the neutron beam characteristic information and the like, set by a user; if not, giving a worst evaluation value to the irradiation point and the irradiation angle, and sampling and calculating the irradiation point and the irradiation angle of the neutron beam again. After the evaluation values corresponding to the plurality of groups of irradiation points and irradiation angles are calculated, the advantages and disadvantages of each group of irradiation points and irradiation angles can be visually ranked according to the evaluation values. Since the position of the collimator 20 is fixed and a positioning device or the like is further provided in the irradiation chamber 2, there are cases where some positions of the patient cannot be moved and some movement positions of the couch interfere with each other, and some parts of the patient, such as eyes, cannot be irradiated, so that some irradiation points and irradiation angles cannot be irradiated, and in the actual treatment process, the preferred part 713 is required to eliminate the irradiation points and irradiation angles that cannot be irradiated.
Referring to fig. 5 and 6, a detailed description will be given of a method for using the irradiation parameter selecting device 71, which includes the following steps: the sampling part 711 reads images with clear human anatomy, such as CT/MRI/PET-CT, etc., defines the outlines of organs, tissues and tumors one by one, gives the set material types and densities, selects the irradiation points and irradiation angles of neutron beams after the definitions of the outlines, the materials and the densities are completed, and selects the irradiation points and the irradiation angles, wherein the selection of the irradiation points can be forward selection or reverse selection, the forward selection is to determine the irradiation points at the positions outside the human body and can sample according to fixed angles or distance intervals in sequence, and the sampling can also be performed in a random sampling mode; the neutron beam angle can be set as the vector direction from the irradiation point to the center of mass of the tumor or the deepest part of the tumor; the reverse selection is to determine the irradiation point within the tumor range, wherein the irradiation point can be the center of mass or the deepest part of the tumor, and the neutron beam angle can be performed by random sampling or sampling at predetermined interval angles; after the irradiation point and the irradiation angle of the neutron beam are determined, the calculation part 712 calculates the track of the organ through which the neutron beam passes, i.e. calculates the type and the thickness of the organ through which the neutron beam passes after entering the human body, and after the track information of the neutron beam passing through the human body is obtained, judges whether the tumor falls within the maximum treatable depth range, if so, calculates the evaluation values corresponding to the irradiation point and the irradiation angle according to the track information and the information of the organ boron concentration, the organ radiation sensitivity factor, the neutron beam characteristic and the like set by the user, and returns to sample the irradiation point and the irradiation angle of the beam; and if not, giving the worst evaluation value, sampling the irradiation point and the irradiation angle of the neutron beam again, and recording the irradiation point, the irradiation angle and the corresponding evaluation value after the evaluation value is calculated. Repeatedly sampling and calculating to a certain number, and outputting a report; the optimizing unit 713 selects an optimal set of implementable irradiation parameters among all the sampled irradiation parameters. The calculation unit 712 may output data of the irradiation point, the irradiation angle, and the evaluation value corresponding thereto in the form of a 3D or 2D image, and in this case, the doctor or the physicist can more intuitively determine the merits of the irradiation point and the irradiation angle.
Preferably, the priority selection unit 713 ranks the merits of each set of irradiation points and irradiation angles, and then verifies whether each set of irradiation points and irradiation angles is practicable in order from the merits to the demerits until finding a set of optimum irradiation points and irradiation angles that is practicable. Of course, the preference part 713 may also find out all the non-implementable irradiation points and irradiation angles after calculating the evaluation value, then eliminate the non-implementable irradiation points and irradiation angles, and finally select an optimal group of the remaining irradiation points and irradiation angles to implement the neutron capture treatment; the preference unit 713 may exclude, in advance, the irradiation points and the irradiation angles that are not applicable before the calculation of the evaluation value, and may select an optimal set of irradiation points and irradiation angles to perform the neutron capture therapy after the calculation is completed.
The preference process may be performed completely automatically by the relevant equipment, or may be performed partially manually, or may be performed completely manually, that is, without setting the preference part 713, for example: the impracticable irradiation points and irradiation angles can be listed by experienced doctors, or can be determined by related equipment simulation, and so on are the ranking of the evaluation values and the action of selecting the optimal irradiation points and irradiation angles after excluding the impracticable irradiation points and irradiation angles.
After the optimum irradiation point and irradiation angle that can be implemented are obtained, the conversion unit 72 converts the parameters of the irradiation point and irradiation angle into coordinate parameters that the table 6 needs to be moved into position during irradiation, in conjunction with CT/MRI/PET-CT information, positioning information, configuration information of the table 6, and the like of the patient, and the adjustment unit 73 adjusts the table 6 to a predetermined position based on the coordinate information obtained from the conversion unit 72. After the table 6 is adjusted to the predetermined position, the positioning device further confirms whether the irradiation point and the irradiation angle of the neutron beam relative to the patient tumor correspond to the pre-selected and implementable optimal irradiation point and irradiation angle, and if not, the patient positioning or the table 6 position is manually adjusted by a human to ensure that the neutron beam irradiates the patient tumor at the optimal irradiation point and irradiation angle, or the table 6 position is adjusted by the driving adjusting part 73 to ensure that the neutron beam irradiates the patient tumor at the optimal irradiation point and irradiation angle.
In order to prevent radiation in the irradiation room 2 from scattering outside the irradiation room 2, a first shield door 21 is provided between the irradiation room 2 and the communication room 4, and a second shield door 31 is provided between the communication room 4 and the preparation room 3. In other embodiments, the first and second screen doors 21, 31 may be replaced with screen walls providing a labyrinth having a shape including, but not limited to, "Z" -shaped, "bow" -shaped, "hex" -shaped.
A specific example of calculating the evaluation value by the calculation unit 712 will be described in detail, but the evaluation value is not limited to this example, and other methods and presentations may be used. The evaluation value is calculated based on neutron beam characteristics, organ radiation sensitivity factors and organ boron-containing concentration, and the weight factor (W (i)) of the organ i corresponding to a certain irradiation point, an irradiation angle and a certain irradiation track is calculated as shown in formula I, wherein I (i), S (i) and C (i) are neutron intensity, the radiation sensitivity factor of the organ i and the boron-containing concentration of the organ i respectively.
W (i) x s (i) x c (i) (formula one)
Wherein I (i) is obtained by integrating the depth intensity or dose curve of the neutron beam in the simulated human body, as shown in formula II, wherein i (x) is the depth intensity or dose of the neutron beam in the therapeutic treatment in the simulated human bodyFunction of the quantity curve, x0-x is the depth range of the organ i in the neutron beam trajectory.
After the calculation of the weighting factors of each organ in the organ track is sequentially completed by the algorithm, the weighting factors are summed up to obtain the evaluation value corresponding to the neutron beam, as shown in formula three, in the calculation, the weighting factors of the tumor should not be included in the calculation.
Based on the above evaluation values, the degree of damage to normal tissues during treatment can be determined more intuitively. In addition to the evaluation of the irradiation position and angle using the evaluation value, the evaluation may also be performed using an evaluation ratio factor, which is defined as a ratio of the evaluation value to the tumor weight factor, as shown in equation four, so that the desired therapeutic effect of the irradiation position and angle can be more fully exhibited.
In the above embodiments, the steps of "reading the images with definite human anatomy of the patient, such as CT/MRI/PET-CT, etc., defining the contour of each organ, tissue and tumor one by one, and setting the material type and density. "patent application entitled" geometric model building method based on medical image data "filed by the applicant at 11/17/2015 under the name of 201510790248.7, which is filed by the national intellectual property office, is incorporated herein in its entirety.
As is well known to those skilled in the art, some simple transformations of equations one through four above, such as I (i), S (i), and C (i), transform from multiplicative to additive; i (i), S (i) and C (i) are multiplied by the power n, n being the caseAnd, the integral multiple of 1 can be also other multiples; i (x) may be x0The mean or median number between x times (x)0-x), or any calculation method that can achieve a result that is consistent with the intensity integration calculation.
Although illustrative embodiments of the invention have been described above to facilitate the understanding of the invention by those skilled in the art, it should be understood that the invention is not limited to the scope of the embodiments, and that various changes will become apparent to those skilled in the art within the spirit and scope of the invention as defined and defined in the appended claims.
Claims (10)
1. A neutron capture therapy device, characterized by comprising: the control system comprises an irradiation parameter selection device for selecting an optimal irradiation point and an irradiation angle, the irradiation parameter selection device comprises a sampling part and a calculation part, the sampling part selects multiple groups of irradiation points and irradiation angles, and the calculation part calculates evaluation values corresponding to each group of irradiation points and irradiation angles and outputs a report.
2. The neutron capture therapy device of claim 1, wherein: the calculation part calculates the incident depth of the neutron beam entering the patient and the type of the organ passing through, then judges whether the tumor falls in the maximum treatable depth range corresponding to the group of irradiation points and the irradiation angles according to the track information of the neutron beam passing through the human body, and calculates the evaluation value corresponding to the group of irradiation points and the irradiation angles according to the track information and the data of the organ boron-containing concentration, the organ radiation sensitivity factor, the neutron beam characteristic information and the like set by a user if the tumor falls in the maximum treatable depth range corresponding to the group of irradiation points and the irradiation angles; if not, the worst evaluation value is given.
3. The neutron capture therapy device of any of claims 1-2, wherein: the calculation unit outputs data of the irradiation point, the irradiation angle, and the evaluation value corresponding thereto in the form of a 3D or 2D image.
4. The neutron capture therapy device of claim 2, wherein: the weighting factor (w (i)) of the organ i corresponding to a certain irradiation point, an irradiation angle and a certain irradiation track is calculated by the following formula:
w (i) x s (i) x c (i) (formula one)
Wherein I (i), S (i) and C (i) are neutron intensity, radiation sensitivity factor of organ i and boron-containing concentration of organ i, respectively.
5. The neutron capture therapy device of claim 4, wherein: the I (i) is calculated by adopting a formula II which simulates the depth intensity or dose curve integral of a human body according to the used beam:
wherein i (x) is a function of the intensity of the depth or dose curve of the therapeutic beam in the approximate human body, x0-x is the depth range of the organ (i) in the beam trajectory.
6. The neutron capture therapy device of claim 5, wherein: the evaluation factor is calculated by adopting a formula III:
wherein Q (x, y, z, phi, theta) is equal to the sum of the weighting factors of the organs in the organ track as the evaluation factor.
7. The neutron capture therapy device of claim 6, wherein: the ratio of the evaluation factor to the tumor evaluation factor (QR (x, y, z, Φ, θ)) is calculated using equation four:
wherein W (tumor) is the weighting factor of the tumor.
8. The method of using an illumination parameter selection apparatus according to claim 1, wherein: the method comprises the following steps:
the sampling part reads images with definite human anatomy such as CT/MRI/PET-CT of a patient, defines the outlines of each organ, tissue and tumor one by one, gives set material types and densities, and selects an irradiation point and an irradiation angle of a neutron beam after the definitions of the outlines, the materials and the densities are finished;
the calculation part calculates the track of the organ through which the neutron beam passes, namely calculates the type and thickness of the organ through which the neutron beam passes after entering the human body, judges whether the tumor falls in the maximum treatable depth range after acquiring the track information of the neutron beam passing through the human body, and calculates the evaluation value corresponding to the irradiation point and the irradiation angle according to the track information by combining the information of the organ boron-containing concentration, the organ radiation sensitivity factor, the neutron beam characteristic and the like set by a user if the tumor falls in the maximum treatable depth range; if not, the worst evaluation value is given, and after the evaluation value is calculated, the irradiation point, the irradiation angle and the corresponding evaluation value are recorded.
9. The use method of the irradiation parameter selection device according to claim 8, wherein: the selection of the irradiation point and the irradiation angle can be forward selection or reverse selection, wherein the forward selection is to determine the irradiation point at a position outside the human body and sample the irradiation point in sequence according to a fixed angle or distance interval, and can also sample the irradiation point in a random sampling mode; the reverse selection is to determine the irradiation point within the tumor range, wherein the irradiation point can be the center of mass or the deepest part of the tumor, and the irradiation angle can be performed by random sampling or sampling at predetermined interval angles; the neutron beam angle can be set to the vector direction from the irradiation point to the center of mass or the deepest part of the tumor.
10. Use of an illumination parameter selection device according to any one of claims 8 to 9, characterized in that: the calculation unit outputs data of the irradiation point, the irradiation angle, and the evaluation value corresponding thereto in the form of a 3D or 2D image.
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910908121.9A CN112546454A (en) | 2019-09-25 | 2019-09-25 | Neutron capture treatment equipment and use method of irradiation parameter selection device |
| PCT/CN2020/117285 WO2021057828A1 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| EP20867547.0A EP4035731A4 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| CA3150365A CA3150365C (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| JP2022518985A JP7437491B2 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection device and method of using the same, control system including the device and method of using the same |
| AU2020355832A AU2020355832B2 (en) | 2019-09-25 | 2020-09-24 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
| TW111107862A TWI791390B (en) | 2019-09-25 | 2020-09-25 | Application method of neutron capture therapy equipment and irradiation parameter selection device |
| TW109133373A TWI761966B (en) | 2019-09-25 | 2020-09-25 | An irradiation parameter selection device and its using method |
| TW109133375A TWI760862B (en) | 2019-09-25 | 2020-09-25 | A control system for controlling neutron capture therapy equipment and a method of use thereof |
| US17/690,134 US20220193452A1 (en) | 2019-09-25 | 2022-03-09 | Irradiation parameter selection apparatus and usage method thereof and control system comprising the apparatus and usage method thereof |
| AU2024200068A AU2024200068A1 (en) | 2019-09-25 | 2024-01-04 | Irradiation parameter selection apparatus and usage method thereof and control system comprising said apparatus and usage method thereof |
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