CN209253964U - A kind of boron neutron capture therapy system of guided by magnetic resonance - Google Patents
A kind of boron neutron capture therapy system of guided by magnetic resonance Download PDFInfo
- Publication number
- CN209253964U CN209253964U CN201821443230.5U CN201821443230U CN209253964U CN 209253964 U CN209253964 U CN 209253964U CN 201821443230 U CN201821443230 U CN 201821443230U CN 209253964 U CN209253964 U CN 209253964U
- Authority
- CN
- China
- Prior art keywords
- boron
- mri
- guided
- magnetic resonance
- capture therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The utility model belongs to field of medical device, discloses a kind of boron neutron capture therapy system of guided by magnetic resonance, which includes: MRI angiography system, for carrying out radiography to focal zone, determines position and the boron concentration of tumour；BNCT treatment system, for adjusting patient body position and adjustment therapeutic scheme according to visualisation, to be treated to focal zone.The boron neutron capture therapy system provides the accurate organizational information in BNCT therapeutic process by MRI angiography system, and learn boron preparation in real-time, quantitative, the DYNAMIC DISTRIBUTION information in irradiated lesion area, the adjustment of BNCT parameter in therapeutic process can be guided by MRI image, realize the treatment of more precision.
Description
Technical field
The utility model relates to field of medical device more particularly to a kind of boron neutron capture therapy systems of guided by magnetic resonance
System.
Background technique
Boron neutron capture therapy (Boron Neutron Capture Therapy, BNCT) is using boron preparation to superthermal
Neutron has the characteristic of high capture cross-section, by10B(n,α)7Li neutron absorption and nuclear fission reaction generate4He and7Two weights of Li
Charged particle.The range of two heavy burden charged particle is respectively 9um and 5um, and the integrated range of two heavy burden charged particle is approximately equivalent to one
A cell size, therefore the radiation injury for caused by biology can be confined to cell level, when boron preparation is selectively gathered in
In tumour cell, neutron appropriate of arranging in pairs or groups penetrates source, just can reach kill under the premise of normal tissue does not cause too major injury
The purpose of tumour cell.
In BNCT therapeutic process, the dosage that patient receives directly determines the tumor control rate and complication of BNCT treatment
Incidence, and then influence the quality of the life after patient's treatment.So accurately tumor-localizing, accurately treatment plan, accurately
Irradiating execution is three key links that BNCT is precisely treated, and " accurately irradiation executes " therein still suffers from many be stranded
It is difficult.It is to be occurred from nuclear reaction by thermal neutron and boron -10, and boron -10 can be with boron preparation that BNCT, which treats generated dosage,
Patient's body metabolic process and time of origin-changes in spatial distribution.The change in time and space of this boron preparation metabolism has obvious
Randomness, there is deviation between the dosage received so as to cause patient and the dosage for the treatment of plan defined.Big deviation
The tumor control rate decline or complication rate that may result in BNCT treatment increase.
For tumour position can be accurately judged to, it is clinically often used magnetic resonance radiography equipment (Magnetic
Resonance Imaging, MRI) or computerized tomography image (Computed Tomography, CT) progress tumour location
Domain judgement.Magnetic resonance imaging is a kind of newer medical imaging technology, just formal for clinic from 1982 in the world.It
Tissue is imaged using magnetostatic field and RF magnetic field, in imaging process, neither with electronics from radiation, without contrast agent
It is achieved with the clear image of high contrast.MR imaging apparatus in addition to have based on X-ray effect CT anatomic image it
Outside, atom nuclear relaxation time can be also accurately measured by nuclear magnetic resonance principle, by tissue in relation to the letter of chemical structure
Breath reflects, and the different chemical structures of the different tissues of same density and same tissue can be shown by image and symbolized
Come, has great superiority, the comparison of soft tissue to the early diagnosis effect of tissue necrosis, malignant disease and degenerative disorders
It spends also more accurate.
In order to accurately know the boron concentration distribution of knub position, in recent years, in improved BNCT clinical workflow, Huan Zhehui
It first bestows and has high-affinity to tumour18F-BPA drug utilizes positron e mission computed tomography (Positron
Emission Computed Tomography, PET) drug is observed in body accumulation degree, the boron preparation of patient is judged whereby
Whether good effect is built up, and according to the drug distribution difference of tumor tissues on PET image and normal tissue, as treatment plan
Calculation basis, treatment process are as shown in Figure 1.In the boron for proposing a kind of plate PET guidance in Chinese patent CN206026890U
Neutron capture therapy system, the system are mixed into boron preparation by capture18F marker, during boron neutron capture therapy compared with
Accurately to obtain real-time in irradiated lesion area, quantitative, the dynamic distributed intelligence of boron preparation.But since PET visualisation is empty
Between resolution ratio it is bad, the visualisation only can be used as boron preparation distributed intelligence reference, can not as human body inner tissue structure align,
Patient puts position confirmation before still needing to be treated using the devices such as photographic camera or computerized tomography image in clinical application,
Spend a large amount of waiting time.
Based on the above situation, it is necessary to which the boron neutron capture therapy system and its application method of image guidance are changed
Into to solve above-mentioned problem of the prior art.
Utility model content
One purpose of the utility model is, proposes a kind of boron neutron capture therapy system of guided by magnetic resonance, passes through
MRI angiography system provides the accurate organizational information in BNCT therapeutic process, and learns boron preparation in irradiated lesion
Real-time, quantitative, the DYNAMIC DISTRIBUTION information in area.
The another object of the utility model is, provides a kind of operation of the boron neutron capture therapy system of guided by magnetic resonance
Method can guide the adjustment of BNCT parameter in therapeutic process by MRI angiography system, realize the treatment of more precision.
For this purpose, the utility model uses following technical scheme:
A kind of boron neutron capture therapy system of guided by magnetic resonance, comprising:
MRI angiography system determines position and the boron concentration of tumour for carrying out radiography to focal zone；
BNCT treatment system, for according to visualisation adjust patient body position and adjustment therapeutic scheme, with to focal zone into
Row treatment.
Preferably, the BNCT treatment system includes bearing system, and the bearing system is suffered from for carrying patient and adjustment
Person's position, and matched with the MRI angiography system.
Preferably, the bearing system includes: irradiation bed and lifting device.The lifting device can control the irradiation
The movement of bed is to carry out patient body position's adjustment.
Preferably, the focal zone contains radiography agent composition, and the radiography agent composition includes boron preparation and MRI radiography
Agent.
In recent years, in addition to the development of contrast apparatus is increasingly flourishing, novel state boron preparation also has significant progress, wherein having one
Class boron preparation is mixed with MRI contrast agent, allows to be measured by MRI angiography system, equally rich in high tumor affinity after mixing.
This boron preparation provides possibility for the dynamic of focal zone drug concentration, real-time, quantitative, on-line monitoring.Meanwhile MRI radiography
High image spatial resolution is provided, to realize that image-guided boron neutron capture treats (Image Guided Boron
Neutron Capture Therapy, IG-BNCT) provide possibility.
Preferably, the MRI angiography system (100) includes image workstation.
Specifically, the image workstation function has two, the first function be the position of tumour is determined according to MRI image, and
It is compared with the image for the treatment of plan, to correct patient body position；Second function is to determine focal zone boron concentration according to MRI image
Distribution, and be compared with the boron concentration for the treatment of plan, to adjust treatment plan.
It is further preferred that the image workstation includes MRI signal acquisition and memory module, image reconstruction module, no
It is registrated with medical image dense with automatic area-of-interest division module, focal zone boron preparation manually with comparison module, medical image
Spend analysis module and real time MRI image and treatment planning systems image comparison module.
Specifically, the first function is embodied as according to MRI signal acquisition and memory module MRI signal collected,
Rebuilding remodelling by described image is 3-D image, then is registrated by different medical images and comparison module, and clinic is controlled
For the 3-D image rebuild before treating compared with treatment plan image registration, the difference medical image registration can be right with comparison module
The images such as MRI, CT, PET are identified and are compared, once notable difference occurs in the two image, then be can pass through patient and are put position again
Irradiation position is adjusted, or utilizes therapeutic bed, lifting device movement mechanism, realizes that multiple degrees of freedom is mobile in space, adjusts patient
Relative to BNCT treatment system position, make itself and treatment planning systems images match, realizes IG-BNCT.The realization of second function
It is then that boron in the radiography agent composition of area-of-interest is learnt with automatic area-of-interest division module manually according to medical image
The potassium ion distribution of preparation is redeveloped into the dynamic point of the three-dimensional boron preparation in patient by area-of-interest boron formulation concentrations analysis module
The result as a result, be originally inputted by cloth by real time MRI image with treatment planning systems image comparison module with treatment plan again
It is compared, as treatment parameter differences amendment, to be adjusted treatment plan in therapeutic process in real time.
Preferably, the MRI angiography system (100) further includes magnet, spectrometer, MRI screening arrangement.
It is further preferred that the magnet is selected from open magnet or cyclic formula magnet.
Specifically, the structure of the open magnet is that a magnetic material, the generated constant magnetic of master are respectively arranged up and down
Field is perpendicular to ground；The structure of the cyclic formula magnet is a closed annular, and main perseverance is generated in closed annular space
Fixed-field.
Preferably, the BNCT treatment system further include: neutron generates equipment, moderation of neutrons device, beam outlet and neutron
Irradiation system controls work station.
It is further preferred that the neutron generate equipment be selected from radionuclide, proton precessional magnetometer bombardment metal targets or
Any one in nuclear reactor.
Specifically, the neutron, which generates equipment, generates neutron beam, the moderation of neutrons device is then directed to different neutrons and generates dress
It sets characteristic and is adjusted geometry and material, make neutron energy by slowly to about 0.5eV~40keV, so that irradiation neutron beam
Reach best BNCT therapeutic effect, the beam outlet exports irradiation neutron beam to patient's focal zone.
Preferably, the neutron exposure system control work station includes line monitoring system, dosage monitoring system and irradiation
Visual field control system, for controlling irradiation neutron beam relevant parameter, including visual field size, irradiation time, irradiation mode and irradiation
Angle etc..
On the other hand, a kind of operating method of the boron neutron capture therapy system of guided by magnetic resonance, MRI angiography system are provided
Radiography is carried out to focal zone, determines position and the boron concentration of tumour；BNCT treatment system adjusts patient body position according to visualisation
And adjustment therapeutic scheme, to be treated to focal zone.
Preferably, the operating method of the boron neutron capture therapy system of the guided by magnetic resonance, specifically includes the following steps:
S1: according to treatment plan, radiography agent composition is injected in patient's body；
S2: the MRI image of patient is obtained using MRI angiography system；
S3: the MRI image is compared with treatment plan image, judges whether are MRI image and treatment plan image
In setting error range；
When being, step S4 is executed；
When no, patient position is adjusted, step S2 is repeated；
S4: neutron beam irradiation is carried out using BNCT treatment system；
S5: obtaining the boron concentration of area-of-interest using MRI angiography system, and calculates required radiation parameters；
S6: the required radiation parameters are compared with treatment plan radiation parameters, are judged required radiation parameters and are controlled
Whether identical treat plan radiation parameters；
When being, step S7 is executed；
When no, treatment plan radiation parameters are adjusted, then execute step S4；
S7: practical exposure dose is compared with treatment plan exposure dose, judges whether practical exposure dose reaches
Treatment plan exposure dose；
When being, step S8 is executed；
When no, step S4 is executed；
S8: stopping neutron beam irradiation, completes BNCT treatment.
The boron neutron capture therapy system of guided by magnetic resonance provided by the utility model controls MRI angiography system with BNCT
Treatment system carries out good integration, firstly, pass high-resolution MRI image back by MRI angiography system, and with treatment plan image
It is compared to adjust patient body position, realizes IG-BNCT；Secondly, it is real-time to obtain patient's body by MRI angiography system
Boron preparation potassium ion distribution, and being compared with treatment plan, provides accurate radiation parameters modifying factor to adjust treatment plan,
The radiation therapy of precision is given for focal zone.
Detailed description of the invention
Fig. 1 is the BNCT treatment flow chart of the prior art；
Fig. 2 is the structural schematic diagram of utility model device；
Fig. 3 is the structural schematic diagram at another visual angle of utility model device；
Fig. 4 is the process for using figure of utility model device.
Wherein, MRI angiography system 100, magnet 110；BNCT treatment system 200, neutron generate equipment 210, moderation of neutrons
Device 220, beam outlet 230；Bearing system 300 irradiates bed 310, lifting device 320.
Specific embodiment
The utility model is described in further detail with reference to the accompanying drawings and examples.It is understood that herein
Described specific embodiment is used only for explaining the utility model, rather than the restriction to the utility model.It further needs exist for
It is bright, part relevant to the utility model is illustrated only for ease of description, in attached drawing rather than entire infrastructure.
Embodiment one
A kind of boron neutron capture therapy system of guided by magnetic resonance, comprising:
MRI angiography system 100 determines position and the boron concentration of tumour for carrying out radiography to focal zone；
BNCT treatment system 200, for adjusting patient body position and adjustment therapeutic scheme according to visualisation, to focal zone
It is treated.
BNCT treatment system 200 include bearing system 300, for carry patient and adjustment patient body position, and with MRI radiography
System 100 matches.
In BNCT therapeutic process, before beamlet in use is irradiated, need to inject boron preparation, boron system to patient's body
Agent has close tumour property, can be enriched in tumor region, the nucleus medical image at patient target area position be acquired after the completion of enrichment, to obtain
It takes current boron preparation in the distribution characteristics of patient's body, and establishes the boron preparation model of Rapid Dose Calculation, carry out treatment plan accordingly
It formulates, treatment plan parameters include tumor target parameter, radiation parameters and dosage etc., and tumor target parameter includes tumour position
It sets, tumor size etc., radiation parameters needed for curing tumour include boron formulation parameters and neutron beam parameter, and boron formulation parameters include
- 10 concentration distribution of boron and its in vivo metabolic chart, neutron beam parameter include irradiation time, irradiating angle, exposure intensity etc..It needs
It is noted that boron preparation and -10 concentration of boron have one-to-one relationship, i.e. boron formulation concentrations can be obtained by unit conversion
- 10 concentration of boron.It is found that the determination of each parameter is the boron preparation distribution based on patient's body before irradiation treatment in treatment plan, and
Boron -10 can with boron preparation patient's body metabolic process and time of origin-changes in spatial distribution, that is, patient is actually required
Radiation parameters and practical exposure dose can and treatment plan have certain deviation.Big deviation may result in BNCT treatment
Tumor control rate decline or complication rate increase.
In the utility model, when BNCT is treated, the visualisation of MRI angiography system 100 is first passed through, determines the specific of tumour
Visualisation is compared with treatment plan for position, so that the position to patient is adjusted, opens again after meeting treatment plan
Beginning neutron exposure treatment；By the visualisation of MRI angiography system 100 real-time in therapeutic process, area-of-interest is determined
Real-time boron concentration, obtains actually required radiation parameters, to instruct adjustment treatment plan, is more accurately treated with reaching.And show
There is the boron concentration that can only detect area-of-interest in technology before neutron exposure, cannot achieve according to real-time boron concentration results tune
Whole treatment plan.
The present embodiment also provides the operating method of the boron neutron capture therapy system of above-mentioned guided by magnetic resonance, MRI radiography system
System carries out radiography to focal zone, determines position and the boron concentration of tumour；BNCT treatment system adjusts patient's body according to visualisation
Position and adjustment therapeutic scheme, to be treated to focal zone.
Embodiment two
Improvement project of the present embodiment as embodiment one, the difference with embodiment one are:
In this present embodiment, more accurate visualisation in order to obtain, needs to the focal zone containing radiography agent composition
Radiography is carried out, radiography agent composition includes boron preparation and MRI contrast agent.It is mixed specifically, injecting contrast agent to patient before radiography
Object is closed, wherein boron preparation and MRI contrast agent are mixed into radiography agent composition, and such radiography agent composition is both rich in high tumour parent
And power, it can be enriched in human tumor region, while radiography agent composition can be measured again by MRI contrast apparatus, therefore scheme in MRI
It, can be by mixing colours by high boron formulation concentrations tumor region and low boron formulation concentrations tumor region and tumor region and just as in
Often tissue is distinguished, and can sketch out exact tumor region according to the difference of color, clearly determine tumour boundary and
The concentration of the wherein concentration distribution of boron preparation, boron preparation can be scaled boron concentration.
In this present embodiment, radiography agent composition is Gd/B/L-LDL compound.It is low using the connection of carborane unit
Density lipoprotein (Low-Density Lipoprotein, LDL) is used as carrier, while linking gadolinium-tetraazacyclododecanand list acyl
Amine compound (Gd-DOTA) forms Gd/B/L-LDL compound, as radiography agent composition.When Gd/B/L-LDL compound exists
Intracellular accumulation amount is each cell 109When, it can pass through MRI angiography system at this time and observe the cell, while the accumulation amount is
Boron neutron capture therapy is carried out enough.I.e. angiographic procedure needs to rely on boron preparation, and BNCT treatment is also required to rely on boron preparation, usually
Patient needs to inject boron preparation twice, when using this radiography agent composition, it is only necessary to inject a boron preparation, can meet
The requirement of MRI radiography and BNCT treatment.
In this present embodiment, as shown in Figure 2 and Figure 3, MRI angiography system 100, comprising: magnet 110, spectrometer, MRI screen
Cover device and image workstation.
Magnet 110 is selected from open magnet or cyclic formula magnet.The structure of open magnet is that a magnetic is respectively arranged up and down
Property material, generated main stationary magnetic field is perpendicular to ground；The structure of cyclic formula magnet is a closed annular, closed
Main stationary magnetic field is generated in annular space.
As a kind of improvement of the utility model, image workstation includes MRI signal acquisition and memory module, image reconstruction
Module, different medical image registration and comparison module, medical image manually with automatic area-of-interest division module, region of interest
Domain boron formulation concentrations analysis module and real time MRI image and treatment planning systems image comparison module.
Specifically, the image workstation function has two, the first function be the position of tumour is determined according to MRI image, and
It is compared with the image for the treatment of plan, to correct patient body position；Second function is to determine focal zone boron concentration according to MRI image
Distribution, and be compared with the boron concentration for the treatment of plan, to adjust treatment plan.Wherein, MRI signal acquisition is used with memory module
In acquisition MRI signal；Image reconstruction module is the image processing tool accelerated based on GPU, for MRI signal to be redeveloped into three-dimensional
Image to get arrive MRI contrastographic picture；Different medical image registrations can know the images such as MRI, CT, PET with comparison module
Not and compare, for by the reconstruction 3-D image before clinical treatment with treatment plan image registration compared with, when the two image appearance
Patient then be can adjust when notable difference relative to BNCT treatment system position, make MRI contrastographic picture and treatment planning systems image
IG-BNCT is realized in matching；Medical image is used to learn the radiography of area-of-interest with automatic area-of-interest division module manually
The potassium ion distribution of boron preparation in agent composition；Focal zone boron formulation concentrations analysis module is used to be rebuild according to boron preparation distribution situation
For the three-dimensional boron preparation DYNAMIC DISTRIBUTION in patient as a result, real time MRI image and treatment planning systems image comparison module and should
As a result it is originally inputted and is compared with treatment plan, as treatment parameter differences amendment, to be controlled in therapeutic process in real time
Treat Plan rescheduling.
It should be noted that area-of-interest described in the utility model includes tumor region and normal tissue regions.Tool
Body, when MRI radiography is can to carry out radiography to entire human body, but only need to obtain the visualisation of focal zone.
Preferably, the MRI angiography system further include: magnet, spectrometer, MRI screening arrangement.Although boron preparation has parent
Tumour property also has a certain amount of boron preparation in the normal tissue and exists, while in neutron exposure, although irradiation port
Can be conformal with tumor size as far as possible, but due to the influence of detection accuracy and machining accuracy, also have the normal tissue meeting of part
It is irradiated to by neutron beam, when the neutron beam exposure dose received in normal tissue is excessive, meeting normal tissue is damaged.Cause
This can preferably instruct adjustment treatment plan, count treatment by detecting the boron concentration of tumor region and normal tissue regions
Draw the purpose for being not only able to achieve treatment tumour but also the safety that can ensure that normal tissue.
As shown in Fig. 2, BNCT treatment system 200, further includes: neutron generates equipment 210, moderation of neutrons device 220, beam and goes out
Mouth 230 and neutron exposure system control work station.
Neutron generates the appointing in radionuclide, proton precessional magnetometer bombardment metal targets or nuclear reactor of equipment 210
It anticipates one kind.Neutron generates equipment 210 and is then directed to different neutron generation device characteristics for generating neutron beam, moderation of neutrons device 220
Geometry and material are adjusted, reaches neutron energy slowly to about 0.5eV~40keV, most so as to irradiate neutron beam
Good BNCT therapeutic effect, beam outlet 230 export irradiation neutron beam to patient's focal zone.
Neutron exposure system control work station includes line monitoring system, dosage monitoring system and irradiation visual field control system
System, for controlling irradiation neutron beam relevant parameter, including visual field size, irradiation time, irradiation mode and irradiating angle etc..
Dosage monitoring system is executed for adjusting treatment plan and controlling treatment plan, including adjustment treatment plan module,
Neutron beam radiation parameters adjust module and boron preparation adjusts module.
Specifically, the adjustment treatment plan module of dosage monitoring system is obtained according to the visualisation of MRI angiography system 100
Present period is calculated in conjunction with the accumulative irradiation time under current dose rates in -10 concentration distribution of boron in current interest region
Dosage received by patient is integrated by the m- acceptable dose curve of clock synchronization, the practical acceptable dose of patient can be obtained and control
The deviation between dosage in the works is treated, in conjunction with current -10 concentration distribution of boron, generates treatment plan Adjusted Option, treatment meter
Drawing Adjusted Option includes boron preparation infusion scheme and neutron beam illumination scheme, the neutron dose and neutron received by tissue
Beam irradiation time, neutron beam exposure intensity, -10 concentration of boron are all proportional.When needing to be implemented boron preparation infusion scheme, lead to
It crosses the adjustment module control of boron preparation to execute, when needing to be implemented neutron beam illumination scheme, adjusts mould by neutron beam radiation parameters
Block control executes.
It should be noted that neutron beam can pass through normal tissue before reaching focal zone, for example, neutron beam is needed through skin
Skin just can enter tumor region, and neutron dose received by skin is no more than safety standard；Meanwhile in therapeutic process
In, when the neutron dose deficiency received at tumour, it will usually first adjust neutron beam parameter, ensure tumour such as irradiation time
The neutron dose that region receives meets treatment and requires, but the too long neutron that may result in normal tissue and receive of irradiation time
Dosage is excessively high, then can cause harm to the human body, it is therefore desirable to control -10 concentration of boron of tumor region in certain safe range
It is interior, to ensure that neutron dose that normal tissue receives in safe range, guarantees the personal safety of patient.
For example, generating neutron beam illumination scheme, neutron beam illumination scheme if current -10 concentration of boron meets safety requirements
In neutron beam illumination scheme is adjusted, including irradiating angle, irradiation time etc..For example, if current -10 concentration of boron is discontented
Sufficient safety requirements generates boron preparation infusion scheme, is adjusted in boron preparation infusion scheme to boron preparation infusion scheme, including past
The amount of patient's body supplement infusion boron preparation, with -10 concentration of boron etc. for improving patient's body.BNCT treatment is avoided because irradiating target
Area's underdosage and occur tumor control rate decline or because normal tissue dose is exceeded and occur complication rate increase etc.
Problem.
Bearing system 300 is matched for carrying patient, and with the MRI angiography system and the BNCT treatment system；
It include: irradiation bed 310 and lifting device 320.Irradiation bed 310 is mounted on lifting device 320, and lifting device 320 can control
The movement of bed 310 is irradiated to carry out position adjustment.
When in use, patient setup is first moved to MRI angiography system 100 on irradiation bed 310, then by bed 310 is irradiated
Magnetic field range in, form the irradiation visual field above patient, then carry out MRI radiography, bed is irradiated according to MRI contrastographic picture
The adjustment of 310 positions is adapted patient and the position of irradiation outlet 230, is irradiated ginseng according to boron formulation concentrations distribution results
Number adjustment, carries out BNCT treatment again later.
As shown in figure 4, a kind of operating method of the boron neutron capture therapy system of guided by magnetic resonance, specifically includes following step
It is rapid:
S1: according to treatment plan, radiography agent composition is injected in patient's body；
S2: the MRI image of patient is obtained；
S3: the MRI image is compared with treatment plan image, judges whether are MRI image and treatment plan image
In setting error range；
When being, step S4 is executed；
When no, patient position is adjusted, step S2 is repeated；
S4: neutron beam irradiation is carried out；
S5: obtaining the boron concentration of area-of-interest, and calculates required radiation parameters；
S6: the required radiation parameters are compared with treatment plan radiation parameters, are judged required radiation parameters and are controlled
Whether identical treat plan radiation parameters；
When being, step S7 is executed；
When no, treatment plan radiation parameters are adjusted, then execute step S4；
S7: practical exposure dose is compared with treatment plan exposure dose, judges whether practical exposure dose reaches
Treatment plan exposure dose；
When being, step S8 is executed；
When no, step S4 is executed；
S8: stopping neutron beam irradiation, completes BNCT treatment.
Finally, it should be noted that above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations；
Although the utility model is described in detail with reference to the foregoing embodiments, it will be understood by those of skill in the art that its according to
It can so modify to technical solution documented by previous embodiment, or part of technical characteristic is replaced on an equal basis
It changes；And these are modified or replaceed, various embodiments of the utility model technical solution that it does not separate the essence of the corresponding technical solution
Spirit and scope.
Claims (8)
1. a kind of boron neutron capture therapy system of guided by magnetic resonance characterized by comprising
MRI angiography system (100) determines position and the boron concentration of tumour for carrying out radiography to focal zone；
BNCT treatment system (200), for according to visualisation adjust patient body position and adjustment therapeutic scheme, with to focal zone into
Row treatment.
2. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that the BNCT is controlled
Treatment system (200) includes bearing system (300), and the bearing system (300) is used to carry patient and adjusts patient body position, and with
The MRI angiography system (100) matches.
3. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that the focal zone
Containing radiography agent composition, the radiography agent composition includes boron preparation and MRI contrast agent.
4. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that the MRI makes
Shadow system (100) includes image workstation.
5. the boron neutron capture therapy system of guided by magnetic resonance according to claim 4, which is characterized in that the image work
Making station includes MRI signal acquisition and memory module, image reconstruction module, different medical images registration and comparison module, medicine shadow
As manually with automatic area-of-interest division module, focal zone boron formulation concentrations analysis module and real time MRI image and treatment
Planning system image comparison module.
6. the boron neutron capture therapy system of guided by magnetic resonance according to claim 4, which is characterized in that the MRI makes
Shadow system (100) further includes magnet, spectrometer, MRI screening arrangement.
7. the boron neutron capture therapy system of guided by magnetic resonance according to claim 1, which is characterized in that BNCT treatment system
System (200) includes: that neutron generates equipment (210), moderation of neutrons device (220), beam outlet (230) and the control of neutron exposure system
Work station.
8. the boron neutron capture therapy system of guided by magnetic resonance according to claim 2, which is characterized in that the carrying system
System (300) includes: irradiation bed (310) and lifting device (320).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821443230.5U CN209253964U (en) | 2018-09-03 | 2018-09-03 | A kind of boron neutron capture therapy system of guided by magnetic resonance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821443230.5U CN209253964U (en) | 2018-09-03 | 2018-09-03 | A kind of boron neutron capture therapy system of guided by magnetic resonance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209253964U true CN209253964U (en) | 2019-08-16 |
Family
ID=67552775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821443230.5U Active CN209253964U (en) | 2018-09-03 | 2018-09-03 | A kind of boron neutron capture therapy system of guided by magnetic resonance |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209253964U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108744320A (en) * | 2018-09-03 | 2018-11-06 | 东莞东阳光高能医疗设备有限公司 | A kind of the boron neutron capture therapy system and its operating method of guided by magnetic resonance |
| CN112330626A (en) * | 2020-11-04 | 2021-02-05 | 南京航空航天大学 | Boron neutron capture treatment dose distribution prediction method based on artificial intelligence and application and device thereof |
| CN113101541A (en) * | 2021-03-16 | 2021-07-13 | 青岛中际康医疗科技有限公司 | Neutron diagnosis and treatment device and method based on neutron field measurement and inversion |
| CN114367061A (en) * | 2020-10-14 | 2022-04-19 | 中硼(厦门)医疗器械有限公司 | Boron neutron capture treatment system and treatment plan generation method thereof |
-
2018
- 2018-09-03 CN CN201821443230.5U patent/CN209253964U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108744320A (en) * | 2018-09-03 | 2018-11-06 | 东莞东阳光高能医疗设备有限公司 | A kind of the boron neutron capture therapy system and its operating method of guided by magnetic resonance |
| CN114367061A (en) * | 2020-10-14 | 2022-04-19 | 中硼(厦门)医疗器械有限公司 | Boron neutron capture treatment system and treatment plan generation method thereof |
| CN114367061B (en) * | 2020-10-14 | 2023-06-23 | 中硼(厦门)医疗器械有限公司 | Boron neutron capture treatment system and treatment plan generation method thereof |
| CN112330626A (en) * | 2020-11-04 | 2021-02-05 | 南京航空航天大学 | Boron neutron capture treatment dose distribution prediction method based on artificial intelligence and application and device thereof |
| CN113101541A (en) * | 2021-03-16 | 2021-07-13 | 青岛中际康医疗科技有限公司 | Neutron diagnosis and treatment device and method based on neutron field measurement and inversion |
| CN113101541B (en) * | 2021-03-16 | 2023-03-07 | 国科中子刀(青岛)医疗科技有限公司 | Neutron diagnosis and treatment device and method based on neutron field measurement and inversion |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6907177B2 (en) | A system for delivering isometric radiation therapy while simultaneously imaging soft tissues | |
| CN108744320A (en) | A kind of the boron neutron capture therapy system and its operating method of guided by magnetic resonance | |
| CN209253964U (en) | A kind of boron neutron capture therapy system of guided by magnetic resonance | |
| CN103281968B (en) | System and method for image guidance during medical procedures | |
| CN113877073B (en) | Radiation therapy system and method for generating therapy plan thereof | |
| AU2016201333B2 (en) | System for delivering conformal radiation therapy while simultaneously imaging soft tissue | |
| CN108348768A (en) | Therapy planning device | |
| Romero-Expósito et al. | Individualized evaluation of the total dose received by radiotherapy patients: Integrating in-field, out-of-field, and imaging doses | |
| Bidmead et al. | Quality Assurance of Treatment Delivery | |
| Morin et al. | Megavoltage cone-beam IGRT | |
| Van Wyk | Analysis of set-up parameters in head and neck patients receiving radiotherapy at Charlotte Maxeke Johannesburg Academic Hospital: a review of current clinical practice | |
| Pouliot | Olivier Morin | |
| Schweins et al. | Detection of an internal density change in an anthropomorphic head phantom via tracking of charged nuclear fragments in carbon‐ion radiotherapy | |
| Dempsey | Daniel A. Low Richard Stark | |
| Hoeppner et al. | From beam production to beam delivery, treatment planning and clinical requirements: The point of view of the vendors | |
| Kunath et al. | Comparison of PET Concepts for Dose Delivery Monitoring of Particle Therapy | |
| Lowe et al. | Development of a Dynamic Phantom for Validation of 4D Imaging and Radiotherapy Treatment Delivery |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230719 Address after: Room 1001, Unit 1, Building 1, No. 1 Yiran Road, Songshanhu Park, Dongguan City, Guangdong Province, 523808 Patentee after: Guoke Neutron Medical Technology Co.,Ltd. Address before: 523808 No. 1318 Building A1, Guangda West Valley, Songshan Lake High-tech Industrial Development Zone, Dongguan City, Guangdong Province Patentee before: DONGGUAN DONGYANGGUANG GAONENG MEDICAL EQUIPMENT Co.,Ltd. |