CN108744232A - Subtract stream apparatus and system for preventing bleeding is perfused - Google Patents
Subtract stream apparatus and system for preventing bleeding is perfused Download PDFInfo
- Publication number
- CN108744232A CN108744232A CN201810672035.8A CN201810672035A CN108744232A CN 108744232 A CN108744232 A CN 108744232A CN 201810672035 A CN201810672035 A CN 201810672035A CN 108744232 A CN108744232 A CN 108744232A
- Authority
- CN
- China
- Prior art keywords
- current limiting
- limiting element
- subtracting
- stream device
- main body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12163—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a string of elements connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0001—Catheters; Hollow probes for pressure measurement
- A61M2025/0002—Catheters; Hollow probes for pressure measurement with a pressure sensor at the distal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
Abstract
Subtracting stream apparatus and system for preventing bleeding is perfused the invention discloses a kind of, specifically, it includes n current limiting element that this, which subtracts stream device, wherein 1≤n≤5, current limiting element flow the distal end of device positioned at subtracting.Main body：The wall of the main body is equipped with n fluid passage, and current limiting element is set to the distal end in main body, and is connected to fluid passage, and current limiting element is connected to fluid passage one-to-one correspondence；And n liquid injection port, liquid injection port are located at the proximal end for subtracting stream device, are fixed in main body, and be connected to fluid passage, liquid injection port is connected to fluid passage one-to-one correspondence.This, which subtracts stream device, can be furnished with pressure measurement silk.As partition apparatus, the blood in blood vessel can be carried out to subtract stream controllablely current limiting element in the present invention by being filled by control current limiting element.
Description
Technical field
The present invention relates to medical instruments field, relates more specifically to a kind of carrying out blood vessel to carotid artery stenosis or cerebral arterial stenosis
After plasty, subtract stream apparatus and system for preventing bleeding is perfused.
Background technology
In recent years, clinically there are many cerebral arterial stenosis or carotid artery stenosis illness.In order to give these patients to solve disease
Bitterly, it improves the quality of living, it will usually carry out angioplerosis or stent-assisted angioplasty.
Angioplasty can make narrow blood vessel be restored to the similar size of blood vessel full size, former narrow to allow
Narrow place's restoration of blood flow.But while the recovery of the vascular flows such as arteria carotis or cerebral artery, new problem or complication are will produce,
In an important symptom be exactly high perfusion.
Brain Hyper-perfusion syndrome (Cerebral Hyperper-fusion Syndrome (CHS)) is due to original low filling
Note area's cerebral blood flow (CBF) is increased significantly over a kind of severe complication caused by brain tissue metabolism needs.The risk of usual CHS because
It is known as：Age is more than 75 years old, has history of stroke, long-term hypertension history, homonymy internal carotid severe stenosis, offshoot circulation foundation is not
Fully, preoperative TCD (transcranial Doppler ultrasound) prompt Ipsilateral blood flow velocity in middle cerebral is less than 40% or more normal value, offside
Internal carotid severe stenosis or occlusion etc..
Clinically slowly expanded on a small quantity to reach operation every time using the angioplasty being performed in multiple times sometimes now
The sectional area at big narrow position reaches the perfusion for being slowly increased blood in blood vessel, but repeatedly angioplasty increases operation
Expense and operating difficulty psychologically can also increase the pressure of sufferer and patient' s family to can psychologically contradict Repeated Operation；
Also the blood pressure for reducing sufferer using the drug of blood pressure lowering sometimes, to reach the hemoperfusion for reducing postangioplasty,
But when using antihypertensive drugs, come when being depressured, when being depressured to the blood pressure of needs from very high pressure, difficulty is big, effect is poor, and it is difficult
Control the stabilization of blood pressure.
Therefore, clinically still lack a kind of effective medical instrument for preventing high perfusion bleeding.
Invention content
Subtracting stream apparatus and system for preventing perfusion bleeding the purpose of the present invention is to provide a kind of, of the invention subtract stream
N (1≤n≤5) a current limiting element is arranged in device, can be filled by adjusting current limiting element controllably may be used to the blood progress in blood vessel
Ground is adjusted to subtract stream.
Subtracting stream device for preventing bleeding is perfused the present invention provides a kind of, which is characterized in that described subtract flows device packet
Include n current limiting element, wherein 1≤n≤5, the current limiting element are located at the distal end for subtracting stream device；Main body, in the main body
Equipped with n fluid passage, the current limiting element is set to the distal end of the main body, and is connected to the fluid passage, the limit
Fluid element is connected to fluid passage one-to-one correspondence；And n liquid injection port, the liquid injection port are located at described
The proximal end for subtracting stream device, is fixed on the proximal end of the main body, and be connected to the fluid passage, the liquid injection port and described
Fluid passage is to correspond connection.
In another preferred example, the outer diameter of the current limiting element is d, and the internal diameter of the blood vessel is D, wherein d < D.
In another preferred example, channel centered on the hollow channel of the main body.
In another preferred example, the main body is hollow elongated tubular.
In another preferred example, a length of l of the main body, a diameter of r, wherein l/r >=20.
In another preferred example, the current limiting element can be fusiformis, cylindrical, spherical shape (such as：Elliposoidal, ball
Shape etc.), apple shape, the various rules such as wax gourd shape or irregular shapes.
It should be noted that the interlude that " the wax gourd shape " refers to the current limiting element is cylindrical, and its both ends
For hemispheric shape；" apple shape " refers to that the both ends of the current limiting element are hemispherical, and the hemispheric diameter in one end
Larger, the hemispheric diameter of the other end is smaller, and the interlude of the current limiting element is truncated cone-shaped, and the interlude is by the half of both ends
Spherical structure connects to form entirety.
In another preferred example, when the interlude of the current limiting element is cylindrical, both ends are hemispherical or circle
Taper type.
In another preferred example, a current limiting elements of n (2≤n≤5) can be that shape is identical, can also be shape
Different.
In another preferred example, when multiple current limiting element shapes are identical, multiple current limiting elements can be big
It is small the same, can also be in different size.
In another preferred example, according to actual demand, a current limiting element can be all or part of (as 2≤n≤5) by n
It is used.
In another preferred example, the central passage of the main body passes through for seal wire.
In another preferred example, the current limiting element surface is coated with anticoagulant, such as heparin.
In another preferred example, when having multiple current limiting elements, the adjacent current limiting element is spaced a distance.
In another preferred example, when having multiple current limiting elements, the current limiting element is equally spacedly set in turn in the master
On body.
In another preferred example, the diameter after the n current limiting elements are full is identical.
In another preferred example, the diameter after the n current limiting elements are full is from the proximal end for subtracting stream device to distal end
It reduces successively.
In another preferred example, the center of the main body is set there are one central passage, is passed through for seal wire, the fluid passage
It is evenly distributed on the periphery of the central passage.
In another preferred example, the eccentric channel is located at the side of main body section, passes through for seal wire, the fluid passage
Positioned at the other side of the eccentric channel.
In another preferred example, when the current limiting element is 1, the current limiting element is compliance current limiting element；When
Current limiting element be 2-5 when, the current limiting element for compliance, non-compliance or semi-compliant current limiting element in one kind or
It is a variety of.
In another preferred example, shrinkage operation is carried out to the current limiting element after filling, which is by more
What a stage carried out, for only there are one stream device is subtracted described in the current limiting element, once only shrinking the current limiting element body
A long-pending part, and twice 0.5-5h is spaced between shrinkage operation；Preferably, 2-4h；More preferably, 2.5-3.5h；It is more for having
The described of a current limiting element subtracts stream device, once only shrinks a current limiting element, and twice between shrinkage operation between
Every 0.5-5h；Preferably, 2-4h；More preferably, 2.5-3.5h.
In another preferred example, the stream device that subtracts includes guiding catheter.
In another preferred example, it is described subtract stream device controllable adjusting can be carried out to the blood flow in blood vessel, to blood flow into
Can slowly it become larger again while row current limliting.The either single current limiting element or multiple current limiting elements, it is described to subtract
It is all point multiple stage gradients incrementally regulating blood flow to flow device.I.e. blood flow is initially adjusted to the value of a very little, then more
It is secondary incremental, finally increase to it is intravascular unobstructed when blood flow it is suitable.
In another preferred example, when it is described subtract stream device and adjust intravascular flow when, the blood flow regulation amount in each stage can be with
It is definite value, can also be to fluctuate in a certain range.The blood flow regulation amount in each stage can have because divided stage quantity is different
Different regulated quantity, as the regulated quantity of the adjacent stage blood flow of stage quantity more multidate is fewer；It is each when the stage, quantity was identical
Stage blood flow regulation amount also can be different, and such as each stage blood flow regulation amount is suitable, each stage blood flow regulation amount is linearly increasing, each rank
The non-linear increase of section blood flow regulation amount, each stage blood flow regulation amount, which linearly reduce, each stage blood flow regulation amount is non-linear reduces, is each
Stage blood flow regulation amount is irregular etc..
In another preferred example, the material of the current limiting element for subtracting stream device is elastomeric material, the elastomer material
Material is selected from the group：Silica gel, latex, TPU and TPE.
In the second aspect of the present invention, a kind of streaming system that subtracts for preventing that bleeding is perfused is provided, it is described to subtract streaming system
Including sacculus, the sacculus is for expanding blood vessel；Current limiting element, the current limiting element are located at the distal end for subtracting streaming system, and
It is located at the more distal end for subtracting streaming system compared to the sacculus current limiting element, the current limiting element is used to reduce the blood of blood vessel
Flow；Main body, the wall of the main body are equipped with fluid passage, and the current limiting element is set in the main body, and with the liquid
Body channel is connected to, and the current limiting element and the fluid passage connect one to one；And liquid injection port, the liquid
Inlet is located at the proximal end for subtracting streaming system, fixes on the body, and be connected to the fluid passage, the liquid note
Entrance and the fluid passage are one-to-one.
In another preferred example, the diameter of the sacculus in the expanded state is greater than or equal to the caliber of the blood vessel.
In another preferred example, the sacculus is arranged in the distal end of foley's tube.
In another preferred example, the guiding catheter for subtracting stream device is for guiding the foley's tube to introduce blood vessel.
In another preferred example, the foley's tube enters the guiding catheter, and the distal end of the foley's tube is stretched
Go out the guiding catheter and enter blood vessel, the sacculus for being located at the foley's tube distal end also enters blood vessel, and blood described in expanse
Pipe.
In another preferred example, after expansion, the sacculus is shunk, and the sacculus is withdrawn from described with the foley's tube
Main body.
In another preferred example, after the balloon inflation is expanded, the current limiting element is started to work.
In another preferred example, after expansion, the sacculus is shunk, and the sacculus is withdrawn in the catheter channel,
The foley's tube stays in the main body, last entire described to subtract streaming system and withdraw from blood vessel together.
In another preferred example, the sacculus is arranged in the distal end of the main body, and the main body is equipped with balloon inflation channel, institute
It states sacculus with the balloon inflation channel to be connected, the sacculus carries out expanse by the balloon inflation channel.
In another preferred example, the sacculus is to carry out expanse by injecting liquid.
In another preferred example, the balloon surface is coated with anticoagulant.
In another preferred example, injection liquid expansion is carried out to the sacculus by the balloon inflation channel, and then expands blood
Pipe.
In another preferred example, after blood vessel dilatation, the sacculus release controls the blood vessel by the current limiting element
Blood flow.
In another preferred example, the stream device that subtracts is furnished with pressure measurement silk.
In another preferred example, the streaming system that subtracts is furnished with pressure measurement silk.
In another preferred example, pressure measurement silk navigates within the guidewire lumen subtracted inside stream device, and pressure measurement silk distal end is equipped with pressure and passes
There are pressure monitoring device in sensor, proximal end, and the pressure display screen on pressure monitoring device shows instant pressure, can play real-time prison
Survey the effect of current limiting element distal end blood pressure.Pressure measurement silk can will subtract fluid element and be transported to as the guide wire for subtracting stream device simultaneously
Need to position, this pressure measurement silk and subtract stream device be two parts, can separate, be seperated.
It should be noted that.The guidewire lumen is the central passage or eccentric channel.
In another preferred example, pressure measurement silk is embedded in subtracting inside stream device, and pressure measurement silk distal end is equipped with pressure sensor, and proximal end has
Pressure monitoring device, the pressure display screen in supervision equipment show instant pressure, can play monitoring current limiting element distal end in real time
The effect of blood pressure.Simultaneously pressure measurement silk can be used as subtract stream device built-in supporting wire, subtract fluid element be delivered to need reach
Enhancing push power when position, while pressure measurement silk can will subtract fluid element and be transported to needs in place as the guide wire for subtracting stream device
Set, this pressure measurement silk and subtract stream device be an entirety, can not separate, be integrated.
In another preferred example, the material of pressure measurement silk is selected from the group：Stainless steel, NiTi, platinum, iridium, macromolecule (such as PTFE,
Pebax, Nylon etc.).
In another preferred example, the outer diameter of pressure measurement silk is 0.005-0.05 inches, more preferably 0.01-0.04 inches, optimal
Ground 0.010-0.038 inches；Its outer diameter can be certain value, can also be variation.
In another preferred example, the length of pressure measurement silk be 500-5000 millimeters, more preferably 1000-3500 millimeters, optimally
1200-3000 millimeters.
It should be understood that within the scope of the present invention, above-mentioned each technical characteristic of the invention and have in below (eg embodiment)
It can be combined with each other between each technical characteristic of body description, to form a new or preferred technical solution.As space is limited, exist
This no longer tires out one by one states.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to do simply to introduce, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention for those of ordinary skill in the art without creative efforts, can be with
Obtain other attached drawings according to these attached drawings.
Fig. 1 is tool in an example of the invention also to exist there are three the fusiformis current limiting element of identical maximum outside diameter and sacculus
The structural schematic diagram for subtracting streaming system in its main body.
Fig. 2 is tool in an example of the invention also to exist there are three the fusiformis current limiting element of different maximum gauges and sacculus
The structural schematic diagram for subtracting streaming system in its main body.
Fig. 3 is the sectional view of the Section A-A in Fig. 1 and/or Fig. 2.
Fig. 4 is another sectional view of the Section A-A in Fig. 1 and/or Fig. 2.
Fig. 5 is that there are three the elliposoidal current limiting elements and sacculus of identical maximum outside diameter for the tool in an example of the invention
The structural schematic diagram for subtracting streaming system in its main body.
Fig. 6 is that there are three the elliposoidal current limiting elements and sacculus of different maximum outside diameters for the tool in an example of the invention
The structural schematic diagram for subtracting streaming system in its main body.
Fig. 7 is that there are three the wax gourd shape current limiting elements and sacculus of identical maximum outside diameter for the tool in an example of the invention
The structural schematic diagram for subtracting streaming system in its main body.
Fig. 8 is that there are three the wax gourd shape current limiting elements and sacculus of different maximum outside diameters for the tool in an example of the invention
The structural schematic diagram for subtracting streaming system in its main body.
Fig. 9 be tool in an example of the invention there are one fusiformis current limiting element subtract streaming system and sacculus is also in its master
Structural schematic diagram on body.
Figure 10 is tool in an example of the invention, and there are one elliposoidal current limiting element and sacculus also in its main body
Subtract the structural schematic diagram of streaming system.
Figure 11 is tool in an example of the invention, and there are one wax gourd shape current limiting element and sacculus also in its main body
Subtract the structural schematic diagram of streaming system.
Figure 12 is the sectional view of the section B-B of any figure in Fig. 9, Figure 10, Figure 11 and Figure 17.
Figure 13 is another sectional view of the section B-B of any figure in Fig. 9, Figure 10, Figure 11 and Figure 17.
Figure 14 is that there are three the fusiformis current limiting elements and sacculus of identical maximum outside diameter for the tool in an example of the invention
The streaming system that subtracts in its main body integrally closes at structural schematic diagram in guiding catheter.
Figure 15 is that there are three the fusiformis current limiting elements and sacculus of identical maximum outside diameter for the tool in an example of the invention
Three current limiting elements for subtracting streaming system and sacculus in its main body all stretch out guiding catheter and full structural schematic diagram.
Figure 16 is that there are three the fusiformis current limiting elements and sacculus of identical maximum outside diameter for the tool in an example of the invention
Subtract streaming system in its main body, two current limiting elements of distal end stretch out guiding catheter and full structural schematic diagram.
Figure 17 is tool in an example of the invention, and there are one cylindrical current limiting element and sacculus also in its main body
Subtract the structural schematic diagram of streaming system.
Figure 18 be tool in an example of the invention there are one fusiformis current limiting element and sacculus is independent on foley's tube
Subtract the structural schematic diagram of streaming system.
Figure 19 be tool in an example of the invention there are one cylindrical current limiting element and sacculus is independent on foley's tube
The structural schematic diagram for subtracting streaming system.
Figure 20 be tool in an example of the invention there are one oval current limiting element and sacculus is independent on foley's tube
The structural schematic diagram for subtracting streaming system.
Figure 21 be tool in an example of the invention there are one wax gourd shape current limiting element and sacculus is independent on foley's tube
The structural schematic diagram for subtracting streaming system.
Figure 22 is the sectional view in the sections C-C of any figure in Figure 18, Figure 19, Figure 20 and Figure 21.
Figure 23 is another sectional view in the sections C-C of any figure in Figure 18, Figure 19, Figure 20 and Figure 21.
It should be noted that the sectional view in the sections D-D of any figure can also be configured to Figure 22 in Figure 19, Figure 20 and Figure 21
Or the structure in Figure 23, only 8 indicate be foley's tube central passage or eccentric channel, 7 indicate be foley's tube
Fluid passage, 6 indicate foley's tubes outer wall.
Figure 24 be tool in an example of the invention there are one fusiformis current limiting element and sacculus is independent on foley's tube, and
There are the structural schematic diagram for subtracting streaming system of one and the pressure measurement silk for subtracting stream device independent separate.
Figure 25 be tool in an example of the invention there are one fusiformis current limiting element and sacculus is independent on foley's tube, and
There is an insertion to subtract the structural schematic diagram for subtracting streaming system for the pressure measurement silk that stream device is integral with.
In each attached drawing, each mark is as follows：
1- subtracts streaming system；
2- current limiting elements；
3- main bodys；
4- liquid injection ports；
5- guiding catheters；
6- body outer walls；
7- fluid passages；
8- central passages or eccentric channel；
9- sacculus；
10- foley's tubes；
11- pressure measurement silks.
Specific implementation mode
The present inventor after extensive and in-depth study, by largely screening, develops a kind of for preventing perfusion for the first time
Bleeding subtracts stream apparatus and system, and the protective device for subtracting stream device and being postoperative as carotid artery vascular of the invention, this subtracts stream dress
It sets including one or more current limiting elements, when in use, this is subtracted into stream device and is placed in blood vessel, current limiting element is adjusted by full
(it is full adjust after current limiting element as partition apparatus) blood is carried out to subtract stream, reach reduction blood flow to reduce perfusion
Purpose completes the present invention on this basis.
Term
As used herein, term " compliance " refers to the variation of the current limiting element volume in one unit pressure of every change
Value, under normal conditions：Compliance is non-compliance current limiting element when being not more than 1.1；It is semi-compliant when compliance is 1.3-1.8
Current limiting element；Compliance is compliance current limiting element when being more than 2.
Subtracting stream device for preventing bleeding is perfused the present invention provides a kind of, it be it is a kind of there is specific structure subtract stream
Device.
Typically, the protective device for subtracting stream device and being postoperative as carotid artery vascular of the invention, specifically, including master
Body, current limiting element and liquid injection port.Channel centered on the center of main body, main body are equipped with n fluid passage, the fluid passage
One end be connected to current limiting element, the other end is connected to liquid injection port, wherein current limiting element is fixed on the distal end of main body, liquid
Body inlet is fixed on the proximal end of main body, and the quantity of current limiting element is n, wherein this is subtracted stream device and is placed on blood by 1≤n≤5
Guan Zhonghou subtracts stream by the way that its current limiting element is adjusted to fill to blood.
It should be noted that " multiple " described herein refer to two or more.
In addition, current limiting element, which can not only be shunk, becomes as low as one tiny size, but also intracavitary can fill in the blood vessels to one
Fixed size.Current limiting element can be filled under external force (pressure of application) effect, is removed external force (unloading pressure) and is passed through
One hollow tube (guiding catheter) and it may return to former fine size.
Current limiting element can be pulled in guiding by a guiding catheter, after current limiting element release and led by the contraction of current limiting element
The process of tube cavity is exactly the process that current limiting element is shunk, and after current limiting element is released guiding catheter inner cavity, current limiting element is full
Injection liquid keeps it full.
Can be fusiformis, cylinder, spherical shape or other shapes in single current limiting element shape.Current limiting element is cylinder
When, both ends are dome-type or cone type.Entire current limiting element is high molecular material.
Gap section between current limiting element and vascular wall can have blood flow to pass through.Current limiting element pair in this way under expanded state
The transport of blood has barrier effect, can reduce blood flow.When product only has single current limiting element, pass through current limiting element cross section
Change to control the variation of blood flow；When product has multiple current limiting elements, multiple current limiting elements just have multiple blocking, repeatedly step by step
Reduce blood flow.Different current limiting element diameters can be the same or different.
It, can when multiple current limiting elements in the blood vessels work under expanded state when product has multiple current limiting elements
To work simultaneously, can also it is therein some or certain it is several work, in this way by the quantity of the current limiting element to work
Difference will have blood flow different blocking reduction effect.Adjacent current limiting element is spaced a distance.Wherein, between barriers
Away from for 5-50mm；Preferably, 10-30mm；More preferably, 15-30mm.
When product only has single current limiting element, single current limiting element works under expanded state in the blood vessels, current limliting member
Part from a cross section when being converted to another cross section, it should it stays for some time in the state of previous cross section,
Purpose be allow the brain vessel blood of original low perfusion region of sufferer be slowly increased and to the increase of each blood flow there are one slowly
Adaptation process, rather than instantaneous a large amount of blood flow enters former Low perfusion region.When product has multiple current limiting elements, multiple current limlitings
During element works under expanded state in the blood vessels, each current limiting element need to be perisystolic in the current limiting element before shrinking
It is stopped the regular hour under blood flow state, purpose is also that the brain vessel blood of original low perfusion region of sufferer is allowed to be slowly increased and right
There are one slow adaptation process for the increase of each blood flow, rather than instantaneous a large amount of blood flow enters former Low perfusion region.In this way
The brain tissue metabolism of former low perfusion region is slowly increased enhancing, is also become larger to blood flow demand, is not easy because of original low perfusion region brain blood
Flow is increased significantly over brain tissue metabolism and needs and high perfusion bleeding be in the presence of.
The operating process for subtracting stream device of the present invention：
A) developed by medicine and determined at carotid artery stenosis；
B) under medicine development, the stream device that subtracts for alleviating high perfusion bleeding is transported to arteria carotis by guiding catheter and worn
It crosses at carotid artery stenosis, subtracts stream device and stretched out from guiding catheter front end, current limiting element is sent to outside guiding catheter, to current limiting element
Injection liquid keeps current limiting element full；
C) under medicine development, the instrument (such as stent system) of Percutaneous Transluminal Angioplasty of carotid is transported to narrow arteria carotis
At blood vessel, and angioplasty is implemented to carotid artery vascular, narrow carotid artery vascular is filled；
D) blood flow increases at former stenotic carotid artery full at this time, when blood flow is at full current limiting element,
Blood is influenced flow by full current limiting element and is become smaller step by step.The blood flow of the distal end of current limiting element is than current limiting element proximal end
Blood flow is small；
E) in (such as 3 hours) after a certain period of time of postangioplasty：
For only there are one current limiting elements, the liquid volume of injection current limiting element is reduced, its volume is made to reduce, it is horizontal at this time
Section also reduces, and the blood flow in blood vessel becomes larger；Keep current limiting element volume that above-mentioned volume for a period of time after, after
The continuous liquid volume for reducing injection current limiting element, current limiting element volume are again reduced to a smaller value, at this time cross section
It is decreased to a smaller value, the blood flow in blood vessel continues to become larger；Keep the volume of current limiting element in that above-mentioned volume
After a period of time, continue the liquid volume for reducing injection current limiting element, current limiting element volume is again reduced to smaller value, same horizontal
Section is also again reduced to smaller value, and the blood flow in blood vessel continues to become bigger；And so on shunk completely to current limiting element,
At this moment the blood flow in blood vessel and original blood flow (blood flow in blood vessel when without hindrance block material) quite, subtract stream device and exit people
Body；For there are multiple current limiting elements, first current limiting element of proximal end is shunk, at this moment in current limiting element device distal vessels
Blood flow become larger；After shrinking the current limiting element of proximal end first, the blood flow state (such as 3 hours) for a period of time is kept, then
Continue to shrink next (proximal end second) current limiting element；And so on, it all needs to stop one section before often shrinking a current limiting element
Time subtracts stream device and exits human body until all current limiting elements all shrink completion.
In addition, particularly, any time before the current limiting element of the present invention is full, in filling, after filling, using pressure measurement
Silk is monitored the blood flow in intracranial vessel.Sufferer lesion both can be quickly understood in time by the monitoring means of pressure measurement silk
Locate the blood flow state of blood vessel, and can feed back the present invention by the blood flow result measured subtracts control of the stream device to blood flow
Situation.
Main advantages of the present invention include：
(a) present invention is placed on blood vessel using the partition apparatus of fusiformis, cylindrical shape, spherical shape, elliposoidal or other shapes
In stream is subtracted to blood, achieve the purpose that reduce blood flow to reduce perfusion.
(b) present invention is placed on blood using one or more fusiformis, cylindrical shape or the partition apparatus of spherical shape or other shapes
Stream is subtracted to blood in pipe, reach can different proportion, controllable reduce blood flow and allow sufferer slowly to adapt to reduce perfusion
The purpose of hemoperfusion.
(c) partition apparatus in the present invention, can be used compliance, non-compliance or semi-compliant current limiting element are made, body
Product is stably and controllable, and by adjusting current limiting element, expanded state accurately controls blood flow in the blood vessel.
Present invention will be further explained below with reference to specific examples.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, attached drawing is schematic diagram, therefore apparatus of the present invention and equipment are not shown by described
The size or ratio of intention limit.
It should be noted that in the claim and specification of this patent, such as first and second or the like relationship
Term is only used to distinguish one entity or operation from another entity or operation, without necessarily requiring or implying
There are any actual relationship or orders between these entities or operation.Moreover, the terms "include", "comprise" or its
Any other variant is intended to non-exclusive inclusion so that including the processes of a series of elements, method, article or
Equipment includes not only those elements, but also includes other elements that are not explicitly listed, or further include for this process,
Method, article or the intrinsic element of equipment.In the absence of more restrictions, being wanted by what sentence " including one " limited
Element, it is not excluded that there is also other identical elements in the process, method, article or apparatus that includes the element.
Embodiment 1
The present embodiment for prevent high perfusion bleeding to subtract streaming system as shown in figs. 1 and 3.It includes master that this, which subtracts streaming system 1,
Body 3, current limiting element 2, sacculus 9 and liquid injection port 4.The central passage 8 of main body 3, sets that there are four fluid passages on body outer wall 6
7,7 central symmetry of fluid passage is distributed in body outer wall 6, and one end of the fluid passage 7 is connected to current limiting element 2 or sacculus 9,
The other end is connected to liquid injection port 4, wherein current limiting element 2, sacculus 9 are fixed on the distal end of main body 3, and liquid injection port 4 is fixed
In the proximal end of main body 3, the quantity of current limiting element 2 is three, and three current limiting elements 2 are equally spaced, and current limiting element
The quantity of diameter all same after full, sacculus 9 is one.
As illustrated in figures 14-16, streaming system 1 will be subtracted to take in guiding catheter 5, subtract streaming system 1 and blood is entered by guiding catheter 5
Pipe, will subtract streaming system 1 gradually release guiding catheter 5 until all current limiting elements 2, sacculus 9 release guiding catheter 5, to sacculus 9 into
Row injection liquid, to narrow blood vessel dilatation, current limiting element 2 to be adjusted and fills to subtract stream to blood.
It is intravascular when subtracting three current limiting elements 2 of streaming system 1 from guiding catheter 5 and entering, when three current limiting elements in blood
When all full, blood flow is only 25% or so (15%-35%) of blood flow in the case of current limiting element is not full, when contraction most proximal end
Current limiting element after and when being removed guiding catheter 5 blood flow becomes larger to current limiting element 50% of blood flow in the case of not full
Left and right (40%-60%), after two current limiting elements for shrinking most proximal end and when being removed into guiding catheter 5 blood flow become larger to
75% or so (65%-85%) of blood flow in the case of current limiting element is not full, wherein owns (three) current limiting elements when shrinking
When, the blood flow in the case of blood flow becomes larger and do not filled with current limiting element is suitable.
The present embodiment subtract streaming system can different proportion, controllable reduce blood flow and reduce perfusion to reach and allow disease
Suffer from the purpose for slowly adapting to hemoperfusion.
Embodiment 2
The present embodiment for prevent high perfusion bleeding to subtract streaming system as shown in Figures 2 and 3.The present embodiment subtracts streaming system
Similar to Example 1, different, the diameter after three current limiting elements 2 of the present embodiment are full is different, and from subtracting
The distal end of streaming system 1 to proximal end, current limiting element 2 it is full after diameter be sequentially increased.
When the diameter of current limiting element after full is identical, current limiting element cross section is the same, and each current limiting element is to blood vessel
Interior Oligemia amount is the same；In contrast, when the diameter difference of current limiting element after full, current limiting element cross section is differed
Sample, each current limiting element are different to endovascular Oligemia amount.Current limiting element makes Diameter Gradual Change, can be in different amounts
To control the decrement of intravascular blood flow.
Embodiment 3
The present embodiment for prevent high perfusion bleeding to subtract streaming system as shown in figs. 1 and 4.The present embodiment subtracts streaming system
Similar to Example 1, different, the eccentric channel 8 of the present embodiment is located at the side of catheter section, fluid passage 7
In the other side of catheter section so that seal wire is not easy to be intertwined with fluid passage.
Embodiment 4
Similar to Example 1, different, this reality that subtracts streaming system for preventing high perfusion bleeding of the present embodiment
The quantity for applying the current limiting element of example is two, and the quantity of sacculus 9 is one, and the quantity of corresponding fluid passage is also three, right
The quantity for the liquid injection port answered also three.
It is intravascular when subtracting two current limiting elements of streaming system from guiding catheter and entering, when two current limiting elements in blood all
When full, blood flow is only 30% or so (20%-40%) of blood flow in the case of current limiting element is not full, when shrink wherein some
Blood flow becomes larger to 65% or so (55%-75%) of current limiting element blood flow in the case of not full when current limiting element, works as contraction
When the current limiting element of wherein all (two), the blood flow in the case of blood flow becomes larger and do not filled with current limiting element is suitable.
The present embodiment subtract streaming system can different proportion, controllable reduce blood flow and reduce perfusion to reach and allow disease
Suffer from the purpose for slowly adapting to hemoperfusion.
Embodiment 5
As shown in figure 5, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 1, therewith not
Together, shape of the current limiting element of the present embodiment under expanded state is elliposoidal.
Embodiment 6
As shown in fig. 6, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 2, therewith not
Together, shape of the current limiting element 2 of the present embodiment under expanded state is elliposoidal.
Embodiment 7
As shown in fig. 7, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 1, therewith not
Together, shape of the current limiting element 2 of the present embodiment under expanded state is wax gourd shape.
Embodiment 8
As shown in figure 8, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 2, therewith not
Together, shape of the current limiting element 2 of the present embodiment under expanded state is wax gourd shape.
Embodiment 9
As shown in figure 9, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 1, therewith not
With the quantity of the current limiting element 2 of the present embodiment is 1, and the quantity of sacculus 9 is also 1, the number of corresponding fluid passage 7
Amount is also 2, the quantity of corresponding liquid injection port 4 also 2, wherein eccentric channel 8 is located at the one of main body section
Side, fluid passage 7 are located at the other side of catheter section.The cross sectional shape of fluid passage 7 can be pisiform as shown in figure 12,
It can also be round as shown in fig. 13 that, the cross sectional shape of fluid passage 7 do not limited specifically, as long as the fluid passage energy
It is enough that liquid injection is carried out to current limiting element, sacculus.When product only has 1 current limiting element 2, which filled
Size especially cross section is controllable in journey, and the size of current limiting element 2 is controlled into the liquid in current limiting element 2 by controlling
(cross section).
Such as by controlling the liquid injected in current limiting element 2, to adjust the volume at current limiting element 2.For example pass through tune
Section injects the volume of liquid at current limiting element 2 to adjust the volume of current limiting element 2, and when 2 volume of current limiting element increases, its is transversal
Face also increases.
So that its cross section is increased by full current limiting element 2, endovascular blood flow can be reduced.In use, can adjust
2 volume of current limiting element is first increased to a larger value by the amount of liquid of injection, and same cross section also increases to a larger value,
At this moment due to the blocking of current limiting element 2, the blood flow in blood vessel fades to the about original blood flow (blood flow in blood vessel when without hindrance block material
Amount) 25% or so (15%-35%)；Keep the volume of current limiting element 2 that above-mentioned volume for a period of time after (such as 3
Hour), at this moment the volume of current limiting element 2 is decreased to the value of a relatively centre, and same cross section is also decreased to a relatively centre
Value, at this moment due to the blocking of current limiting element 2, the blood flow in blood vessel fades to about original blood flow (in blood vessel when without hindrance block material
Blood flow) 50% or so (40%-60%)；Keep current limiting element 2 volume that above-mentioned volume for a period of time after
(such as 3 hours), at this moment continue the amount of liquid for reducing current limiting element 2, the volume of full current limiting element 2 be again reduced to one compared with
Small value, same cross section are also decreased to a smaller value, at this moment due to the blocking of current limiting element 2, the blood flow in blood vessel
Fade to 75% or so (65%-85%) of about original blood flow (blood flow in blood vessel when without hindrance block material)；Keep current limiting element 2
Volume that above-mentioned volume for a period of time after (such as 3 hours), at this moment continue reduce current limiting element 2 amount of liquid, limit
2 volume of fluid element is decreased to minimum value, and same cross section is also decreased to minimum value, at this moment the blood flow in blood vessel and original blood flow
It is suitable to measure (blood flow in blood vessel when without hindrance block material).
Embodiment 10
As shown in Figure 10, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 9, therewith not
With the shape of the current limiting element of the present embodiment is elliposoidal.
Embodiment 11
As shown in figure 11, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 9, therewith not
With the shape of the current limiting element of the present embodiment is wax gourd shape.
Embodiment 12
As shown in figure 17, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 9, therewith not
With the shape of the current limiting element of the present embodiment is cylinder.
Embodiment 13
As shown in figure 18, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 1, therewith not
Quantity with, the sacculus 9 of the present embodiment is also 1, but the sacculus is independent without in the main body for subtracting streaming system, the sacculus
9 in the distal end of an independent foley's tube 10.
Embodiment 14
As shown in figure 19, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 13, therewith
Unlike, the shape of the current limiting element of the present embodiment is cylinder.
Embodiment 15
As shown in figure 20, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 13, therewith
Unlike, the shape of the current limiting element of the present embodiment is ellipse.
Embodiment 16
As shown in figure 21, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 13, therewith
Unlike, the shape of the current limiting element of the present embodiment is wax gourd shape.
Embodiment 17
As shown in figure 24, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 13, therewith
Unlike, there are one pressure measurement silk in the present embodiment, the pressure measurement silk is independent without on subtracting stream device, this pressure measurement silk and subtracts stream dress
Two parts are set to, can be separated, are seperated.Pressure measurement silk navigates within the guidewire lumen subtracted inside stream device and (subtracts in stream device
Heart hole 8 or eccentric orfice 8).Pressure measurement silk distal end is equipped with pressure sensor, and there is pressure monitoring device in proximal end, the pressure in supervision equipment
Display screen shows instant pressure, can play the role of monitoring current limiting element distal end blood pressure in real time.Pressure measurement silk can conduct simultaneously
The guiding wire for subtracting stream device, will subtract fluid element and is transported to and need to position.
Embodiment 18
As shown in figure 25, the present embodiment for prevent high perfusion bleeding to subtract streaming system similar to Example 13, therewith
Unlike, there are one pressure measurement silk in the present embodiment, which, which is embedded in, subtracts inside stream device, this pressure measurement silk is with stream device is subtracted
One entirety, can not separate, and be integrated.Pressure measurement silk distal end is equipped with pressure sensor, and proximal end has pressure monitoring device, monitoring to set
Standby upper pressure display screen shows instant pressure, can play the role of monitoring current limiting element distal end blood pressure in real time.It surveys simultaneously
Silk pressing can push power as the built-in supporting wire for subtracting stream device to subtract enhancing when fluid element is delivered to the position for needing to reach,
Pressure measurement silk can be used as the guiding wire for subtracting and flowing device simultaneously, will subtract fluid element and be transported to and need to position.
All references mentioned in the present invention is incorporated herein by reference, independent just as each document
It is incorporated as with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can
To be made various changes or modifications to the present invention, such equivalent forms equally fall within model defined by the application the appended claims
It encloses.
Claims (10)
1. a kind of subtracting stream device for preventing bleeding is perfused, which is characterized in that described subtract flows device and include
N current limiting element, wherein 1≤n≤5, the current limiting element are located at the distal end for subtracting stream device, the current limiting element
Blood flow for reducing blood vessel；
Main body, the wall of the main body are equipped with n fluid passage, and the current limiting element is set to the distal end of the main body, and with
The fluid passage connection, the current limiting element are connected to fluid passage one-to-one correspondence；And
N liquid injection port, the liquid injection port are located at the proximal end for subtracting stream device, fix on the body, and with
The fluid passage connection, the liquid injection port are connected to fluid passage one-to-one correspondence.
2. subtracting stream device as described in claim 1, which is characterized in that the outer diameter of the current limiting element be d, the blood vessel it is interior
Diameter is D, wherein d < D.
3. subtracting stream device as described in claim 1, which is characterized in that the current limiting element surface is coated with anticoagulant.
4. subtracting stream device as described in claim 1, which is characterized in that the diameter after the n current limiting elements are full is identical
's；Or
Diameter after n current limiting elements are full is from the proximal end for subtracting stream device to distally reducing successively.
5. subtracting stream device as described in claim 1, which is characterized in that the main body be equipped with for seal wire by central passage or
Eccentric channel；
The central passage is located at the center of the main body, and the fluid passage is located in the main wall, and is evenly distributed on
The periphery of the central passage；
The eccentric channel is located at the side of the main body section, and the eccentric channel passes through for seal wire, the fluid passage position
In the other side of the main body section.
6. subtracting stream device as described in claim 1, which is characterized in that the stream device that subtracts is furnished with pressure measurement silk.
7. subtracting stream device as described in claim 1, which is characterized in that when the current limiting element is 1, the current limiting element
For compliance current limiting element；Or
When current limiting element is 2-5, the current limiting element is in the current limiting element of compliance, non-compliance or semi-compliant
It is one or more.
8. subtracting stream device as described in claim 1, which is characterized in that carry out contraction behaviour to the current limiting element after full
Make, which is carried out by multiple stages, for only there are one stream device is subtracted described in the current limiting element, once
A part for the current limiting element volume is only shunk, and is spaced 0.5-5h between shrinkage operation twice；
Subtract stream device described in multiple current limiting elements for having, once only shrinks a current limiting element, and receive twice
It is spaced 0.5-5h between contracting operation.
9. subtracting stream device as described in claim 1, which is characterized in that the material of the current limiting element for subtracting stream device is elasticity
Body material, the elastomeric material are selected from the group：Silica gel, latex, TPU and TPE.
10. a kind of subtracting streaming system for preventing perfusion bleeding, which is characterized in that the streaming system that subtracts includes
Sacculus, the sacculus is for expanding blood vessel；
Current limiting element, the current limiting element are located at the distal end for subtracting streaming system, and the current limiting element is used to reduce the blood of blood vessel
Flow, when in use, the sacculus are arranged close to the proximal end of the current limiting element；
Main body, the wall of the main body are equipped with fluid passage, and the current limiting element is set in the main body, and with the liquid
Channel is connected to, and the current limiting element and the fluid passage connect one to one；And
Liquid injection port, the liquid injection port are located at the proximal end for subtracting streaming system, it is fixed on the body, and with it is described
Fluid passage is connected to, and the liquid injection port and the fluid passage are one-to-one.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810672035.8A CN108744232B (en) | 2018-06-26 | 2018-06-26 | Flow reducing device and system for preventing perfusion bleeding |
| PCT/CN2018/096662 WO2020000548A1 (en) | 2018-06-26 | 2018-07-23 | Flow-reducing device and system for preventing perfusion hemorrhage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810672035.8A CN108744232B (en) | 2018-06-26 | 2018-06-26 | Flow reducing device and system for preventing perfusion bleeding |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108744232A true CN108744232A (en) | 2018-11-06 |
| CN108744232B CN108744232B (en) | 2021-01-15 |
Family
ID=63977784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810672035.8A Active CN108744232B (en) | 2018-06-26 | 2018-06-26 | Flow reducing device and system for preventing perfusion bleeding |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN108744232B (en) |
| WO (1) | WO2020000548A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110353752A (en) * | 2019-06-28 | 2019-10-22 | 北京康瑞迪医疗科技有限公司 | Heart coronaries Venous Occlusion device |
| CN112823818A (en) * | 2019-11-19 | 2021-05-21 | 尼尔拉维有限公司 | Isolated endovascular therapy with perfusion bypass |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050283181A1 (en) * | 2004-06-21 | 2005-12-22 | Sundaram Ravikumar | Catheter device and method for selective occlusion of arteries of the descending aorta |
| CN102125721A (en) * | 2011-03-10 | 2011-07-20 | 微创医疗器械(上海)有限公司 | Novel interventional medical device |
| CN203852722U (en) * | 2014-05-28 | 2014-10-01 | 乐普（北京）医疗器械股份有限公司 | Aspiration and injection catheter apparatus with flow-limiting bladders |
| CN205729956U (en) * | 2016-06-10 | 2016-11-30 | 韩新巍 | A kind of multi-functional compliant balloon conduit |
| CN107812300A (en) * | 2017-11-24 | 2018-03-20 | 翎秀生物科技（上海）有限公司 | For preventing the protection foley's tube of high perfusion bleeding |
| CN107997852A (en) * | 2017-11-30 | 2018-05-08 | 上海煜蔺生物科技发展有限公司 | For alleviating the umbrella of high perfusion bleeding |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8814826B2 (en) * | 2007-04-04 | 2014-08-26 | Abbott Cardiovascular Systems Inc. | Sequentially inflatable balloons for delivery of treatment agents |
-
2018
- 2018-06-26 CN CN201810672035.8A patent/CN108744232B/en active Active
- 2018-07-23 WO PCT/CN2018/096662 patent/WO2020000548A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050283181A1 (en) * | 2004-06-21 | 2005-12-22 | Sundaram Ravikumar | Catheter device and method for selective occlusion of arteries of the descending aorta |
| CN102125721A (en) * | 2011-03-10 | 2011-07-20 | 微创医疗器械(上海)有限公司 | Novel interventional medical device |
| CN203852722U (en) * | 2014-05-28 | 2014-10-01 | 乐普（北京）医疗器械股份有限公司 | Aspiration and injection catheter apparatus with flow-limiting bladders |
| CN205729956U (en) * | 2016-06-10 | 2016-11-30 | 韩新巍 | A kind of multi-functional compliant balloon conduit |
| CN107812300A (en) * | 2017-11-24 | 2018-03-20 | 翎秀生物科技（上海）有限公司 | For preventing the protection foley's tube of high perfusion bleeding |
| CN107997852A (en) * | 2017-11-30 | 2018-05-08 | 上海煜蔺生物科技发展有限公司 | For alleviating the umbrella of high perfusion bleeding |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110353752A (en) * | 2019-06-28 | 2019-10-22 | 北京康瑞迪医疗科技有限公司 | Heart coronaries Venous Occlusion device |
| CN112823818A (en) * | 2019-11-19 | 2021-05-21 | 尼尔拉维有限公司 | Isolated endovascular therapy with perfusion bypass |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020000548A1 (en) | 2020-01-02 |
| CN108744232B (en) | 2021-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10335152B2 (en) | Partial aortic occlusion devices and methods for cerebral perfusion augmentation | |
| US4777951A (en) | Procedure and catheter instrument for treating patients for aortic stenosis | |
| KR920000467B1 (en) | Angioplasty catheter | |
| JP2723672B2 (en) | Dispensing and temporary stent catheter | |
| US5306250A (en) | Method and apparatus for intravascular drug delivery | |
| CN105764411A (en) | Systems and methods for determining fractional flow reserve without adenosine or other pharmacological agents | |
| US9011374B2 (en) | Balloon catheter with three lumens | |
| CN208785546U (en) | For preventing the protection foley's tube of high perfusion bleeding | |
| CN109821139B (en) | Thrombolytic balloon catheter device | |
| JP2004529741A (en) | Endoluminal treatment catheter with inflatable helical member | |
| CN108744232A (en) | Subtract stream apparatus and system for preventing bleeding is perfused | |
| US20180263801A1 (en) | Controller For Controlling The Inflation Of A Balloon In A Balloon Stent Catheter System | |
| CN103957982A (en) | Balloon catheter | |
| CN103599588B (en) | Improved balloon catheter exhibiting rapid inflation and deflation | |
| CN208927393U (en) | A kind of adjustable perfusion system and perfusion conduit | |
| CN110270001A (en) | A kind of adjustable perfusion system and perfusion conduit | |
| Schwartz | Effect of distal coronary pressure on rigid and compliant coronary stenoses | |
| Gruentzig | PTCA technique with a double-lumen dilatation catheter | |
| CN117017402A (en) | Vena cava occlusion device with stabilization system | |
| NO901227L (en) | ANGIOPLASTIC CATS. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230614 Address after: 6th Floor, Building 4, No. 85 Mingnan Road, Songjiang District, Shanghai, 201613 Patentee after: Jieruo medical technology (Shanghai) Co.,Ltd. Address before: Room 303, building 21, no.1-28, Lane 588, Tianxiong Road, Pudong New Area, Shanghai, 200120 Patentee before: ENODAR MEDICAL (SHANGHAI) Co.,Ltd. |
|
| TR01 | Transfer of patent right |