CN108744102A - The interior enhanced dialyzer of filtration - Google Patents
The interior enhanced dialyzer of filtration Download PDFInfo
- Publication number
- CN108744102A CN108744102A CN201810722810.6A CN201810722810A CN108744102A CN 108744102 A CN108744102 A CN 108744102A CN 201810722810 A CN201810722810 A CN 201810722810A CN 108744102 A CN108744102 A CN 108744102A
- Authority
- CN
- China
- Prior art keywords
- outer housing
- dialyzer
- hemisphere jut
- pressure
- arc deflector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001914 filtration Methods 0.000 title claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 16
- 239000012528 membrane Substances 0.000 claims abstract description 14
- 239000000835 fiber Substances 0.000 claims abstract description 12
- 230000010354 integration Effects 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000000977 initiatory effect Effects 0.000 claims description 8
- 238000005452 bending Methods 0.000 claims description 3
- 239000012510 hollow fiber Substances 0.000 abstract description 19
- 238000000502 dialysis Methods 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 230000001225 therapeutic effect Effects 0.000 abstract description 5
- 238000001631 haemodialysis Methods 0.000 abstract description 4
- 239000000385 dialysis solution Substances 0.000 description 7
- 230000008859 change Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002441 uremic toxin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The enhanced dialyzer of filtration, is related to the dialyzer for haemodialysis, including outer housing and hollow-fibre membrane tow in a kind of, it is characterised in that：The outer housing inner wall is equipped at least one pressure-reducing ring, the pressure-reducing ring include be made into integration with outer housing, in the axial upper equally distributed hemisphere jut of outer inner walls, each hemisphere jut on the phase back side of dialyzate flow direction equipped with arc deflector.Not the advantages that interior filtration with raising dialyzer does not introduce non-dialysis device manufacture material again simultaneously, fully ensures that the safety of dialyzer, safe and reliable, and the utilization rate of hollow fiber film thread is high, and therapeutic effect is good.
Description
Technical field
The present invention relates to the dialyzer for haemodialysis, more specifically one kind can increase β2Microglobulin is removed
The enhanced dialyzer of interior filtration.
Background technology
It deepens continuously for what uremic toxins were studied with the continuous development and people of dialysis, with β2Microglobulin
It is received more and more attention for the middle macromolecular of representative.For β2The removing of microglobulin there are mainly two types of mode-absorption and
Convection current.Most of dialyzer removes β by the way of convection current2Microglobulin.Traditional small throughput dialyzer can not remove β2Microballoon
Albumen, and the high flux hemodialysis device continued to develop can effectively remove β2Microglobulin.The hole of change dialysis membrane can be passed through
Structure, dialyzate flowing etc. change dialyzer to β2The removing of microglobulin.It is continuous with haemodialysis water water quality
It improves, the application of the interior enhanced dialyzer of filtration is also continuously increased, to further enhance β2The cleaning performance of microglobulin.
Currently, it is mainly in length or the reduction started with from dialysis membrane and change dialyzer to improve the method filtered in dialyzer
The internal diameter of hollow fiber or the structure for changing dialyzer.Due to the limitation of dialyzer manufacturing process, the above method can enhance dialysis
The interior filtration (full name is internal enhancing filtration) of device, but effect is limited.
State Intellectual Property Office discloses a patent name filed in 26 days December in 2003：Dialyzer and its manufacture
The patent of invention of method, Patent No. 200310119358.8, which disclose following technical characteristics：Shell equipped with tubular
Body, outer housing is interior to be equipped with hollow-fibre membrane tow, and tubular elastic tube is equipped between outer inner walls and hollow-fibre membrane tow,
Elastic tube periphery is equipped with the protrusion that is fitting to connection with outer housing inner wall, and elastic tube and outer housing inner wall contact fluid tightly；In
Hollow fiber film wire inner cavity forms hematology lab, is formed between outer housing inner wall and hollow fiber film thread and between hollow fiber film thread
Dialysis fluid chamber.This dialyzer increases tubular elastic tube to increase dialysis fluid chamber pressure drop between outer housing and film wire, although
Increase the interior filtration of dialyzer, but due to introducing non-dialysis device manufacture material in outer enclosure interior, safety needs to be considered,
And using concave-convex connection between outer housing and tubular elastic tube, stability is poor, has in the case where 4 hours high flow rate dialyzates impact
The elastic tube of elasticity is easy to fall off, can not ensure whole validity；On the outside of tubular elasticity inside pipe wall and hollow-fibre membrane tow
Hollow fiber film thread is in close contact, and makes the outside of a big chunk hollow fiber film thread that can not be contacted with dialyzate, doughnut
The utilization rate of film wire is low, and therapeutic effect is poor.Simultaneously because the presence of tubular elastomer, affects the flowing of dialyzate, causes
The decline of parser mass-transfer efficiency.
Invention content
Present invention aim to address above-mentioned the deficiencies in the prior art, a kind of interior filtration improving dialyzer while again is provided
Non-dialysis device manufacture material is not introduced, fully ensures that the safety of dialyzer, safe and reliable, the utilization of hollow fiber film thread
Rate is high, the good enhanced dialyzer of interior filtration of therapeutic effect.
Technical solution is used by the present invention solves above-mentioned the deficiencies in the prior art：
The enhanced dialyzer of filtration in a kind of, including outer housing and hollow-fibre membrane tow, it is characterised in that：The outer housing
Inner wall is equipped at least one pressure-reducing ring, and the pressure-reducing ring includes being made into integration with outer housing, axial in outer inner walls
Upper equally distributed hemisphere jut, each hemisphere jut on the phase back side of dialyzate flow direction equipped with arc deflector.
The water conservancy diversion initiating terminal of heretofore described arc deflector is located at center of the hemisphere jut in outer housing axial direction
The flow tip at position, arc deflector is located at the opposite of the hemisphere jut central part adjacent with hemisphere jut at initiating terminal
Place, arc deflector are tangent with dialyzate flow direction at water conservancy diversion initiating terminal.
Heretofore described arc deflector is identical as the height of hemisphere jut in the width of outer housing radial direction.
Front or middle part in heretofore described outer housing are equipped at least two pressure-reducing rings, two neighboring pressure-reducing ring
The bending direction of arc deflector is opposite.Dialyzate is posteriorly flowed from front in outer housing, i.e., pressure-reducing ring is arranged in outer housing
Interior dialyzate entrance is between middle part.
A heretofore described pressure-reducing ring is made of 10-40 hemisphere jut, and the height of hemisphere jut is outer housing
The bottom of 0.01-0.1 times of internal diameter, hemisphere jut is sequentially connected at outer inner walls.
Arc deflector of the present invention to central angle be 60-90 °, arc deflector surface is smooth and shell
Using identical material.The height of arc deflector and hemispherical protuberances it is highly consistent, width is the 0.5- of hemispherical protuberances
1.5 again.The liquid flow direction of two adjacent rings deflector is opposite.
Heretofore described hemisphere jut surface is smooth, and material is identical as outer housing material.Surface is smooth to be conducive to fluid
Flowing.
Packed density of the heretofore described hollow-fibre membrane tow in outer shell is 40%-70%.
The present invention in use dialyzate pass through outer housing inner wall and hollow fiber film thread between space and
Space between hollow fiber film thread（Dialysate circuit）Sectional area becomes smaller at pressure-reducing ring, increases the pressure of dialyzer dialysis fluid chamber
Power lose, to increase dialyzer dialysis fluid chamber entrance and dialyzer hematology lab outlet between pressure difference and hematology lab's import and thoroughly
The pressure difference between liquid outlet is analysed, has the function that filtration in enhancing.The present invention improve dialyzer interior filtration while again not
Non-dialysis device manufacture material is introduced, has fully ensured that the safety of dialyzer, pressure-reducing ring material identical as outer housing are made into integration,
It will not fall off, it is safe and reliable.Perfect condition is point contact between pressure-reducing ring and hollow fiber film thread, and practical is the line of small area
The utilization rate of contact, hollow fiber film thread is high, and therapeutic effect is good.Water conservancy diversion is set along dialyzate flow direction in pressure-reducing ring simultaneously
Plate compensates for the influence flowed to dialyzate due to pressure-reducing ring.
Description of the drawings
Fig. 1 is the structural schematic diagram of present invention removal hollow-fibre membrane tow rear casing body.
Fig. 2 is cross-sectional view of the present invention at pressure-reducing ring.
Specific implementation mode
The enhanced dialyzer of interior filtration as shown in Figure 1, 2, including outer housing 1 and hollow-fibre membrane tow 4, outer housing 1
It is cylindrical in shape, hollow-fibre membrane tow 4 is arranged in outer housing 1, and packed density of the hollow-fibre membrane tow 4 in outer housing 1 is
40%-70%；Hollow fiber film thread inner cavity forms hematology lab, between outer housing inner wall and hollow fiber film thread and hollow-fibre membrane
Silk between form hematology lab, above structure is same as the prior art, repeats no more, it is of the invention it is characterized in that：Described is outer
1 inner wall axial direction of shell be equipped at least one pressure-reducing ring, the pressure-reducing ring include be made into integration with outer housing, in outer housing
The upper equally distributed hemisphere jut 3 of inner wall axial direction, a pressure-reducing ring includes 10-40 hemisphere jut 3, the height of hemisphere jut 3
(in the size of outer housing radially) is 0.01-0.1 times of outer housing internal diameter, 3 bottom of hemisphere jut at outer inner walls according to
It is secondary to be connected.Each hemisphere jut 3 on the phase back side of dialyzate flow direction be equipped with arc deflector 2；Arc deflector 2 is led
Stream initiating terminal is located at hemisphere jut（In outer housing axial direction）Central part, the flow tip of arc deflector 2 is located at and rises
The adjacent hemisphere jut of hemisphere jut at beginning（In outer housing axial direction）Central part（It is axial）Opposite place；Arc deflector
Tangent with dialyzate flow direction at water conservancy diversion initiating terminal, arc deflector width direction is radially arranged along outer housing, in shell
The width of body radial direction is identical as the height of hemisphere jut.
The present invention is further improved, and the middle part in the outer housing is arranged with two decompressions with shell axial centre
Ring, the bending direction of the arc deflector of two neighboring pressure-reducing ring is on the contrary, avoid dialyzate from being led by the arc of two pressure-reducing rings
It rotates and moves ahead in outer housing after flowing plate water conservancy diversion in the same direction.
Heretofore described hemisphere jut surface is smooth, and material is identical as outer housing material；The arc deflector
In quadrant arcuation（Central angle is 90 °）, surface is smooth, and identical material is used with shell.Arc deflector is in shell
Size in body axial direction is 0.5-1.5 times of hemispherical protuberances.
The present invention in use dialyzate pass through outer housing inner wall and hollow fiber film thread between space and
Space between hollow fiber film thread（Dialysate circuit）Sectional area becomes smaller at pressure-reducing ring, increases the pressure of dialyzer dialysis fluid chamber
Power lose, to increase dialyzer dialysis fluid chamber entrance and dialyzer hematology lab outlet between pressure difference and hematology lab's import and thoroughly
The pressure difference between liquid outlet is analysed, has the function that filtration in enhancing；The setting of hemisphere jut makes swiftly flowing dialyzate in ball
The dialyzate flow direction phase back side of shape protrusion is unevenly distributed, and so that the hollow fiber film thread utilization rate at this is reduced, arc water conservancy diversion
The dialyzate flowed through between two neighboring hemisphere jut to the dialyzate flow direction phase back side water conservancy diversion of hemisphere jut, is used for by plate
Compensation hemisphere jut leads to being unevenly distributed for dialyzate.The present invention is not introduced into non-again while improving the interior filtration of dialyzer
Dialyzer manufacture material has fully ensured that identical as the outer housing material of the safety of dialyzer, pressure-reducing ring and arc deflector one
System at, will not fall off, it is safe and reliable.Perfect condition is point contact between pressure-reducing ring and hollow fiber film thread, and practical is small
The line of area contacts, and the utilization rate of hollow fiber film thread is high, and therapeutic effect is good.It is set simultaneously along dialyzate flow direction in pressure-reducing ring
Arc deflector is set, the influence flowed to dialyzate due to pressure-reducing ring is compensated for.
Claims (7)
1. the enhanced dialyzer of filtration in a kind of, including outer housing and hollow-fibre membrane tow, it is characterised in that：The shell
Internal wall is equipped at least one pressure-reducing ring, the pressure-reducing ring include be made into integration with outer housing, in outer inner walls axis
Upward equally distributed hemisphere jut, each hemisphere jut on the phase back side of dialyzate flow direction equipped with arc deflector.
2. the interior enhanced dialyzer of filtration according to claim 1, it is characterised in that the water conservancy diversion of the arc deflector
Initiating terminal is located at central part of the hemisphere jut in outer housing axial direction, the flow tip of arc deflector be located at at initiating terminal
The opposite place of the adjacent hemisphere jut central part of hemisphere jut, arc deflector at water conservancy diversion initiating terminal with dialyzate flowing side
To tangent.
3. the interior enhanced dialyzer of filtration according to claim 1 or 2, it is characterised in that the front in the outer housing
Or middle part is equipped at least two pressure-reducing rings, the bending direction of the arc deflector of two neighboring pressure-reducing ring is opposite.
4. the interior enhanced dialyzer of filtration according to claim 3, it is characterised in that the arc deflector is in shell
The width of body radial direction is identical as the height of hemisphere jut.
5. the interior enhanced dialyzer of filtration according to claim 4, it is characterised in that a pressure-reducing ring is by 10-40
A hemisphere jut composition, the height of hemisphere jut are 0.01-0.1 times of outer housing internal diameter, and the bottom of hemisphere jut is in outer housing
It is sequentially connected at inner wall.
6. the enhanced dialyzer of interior filtration according to claim 5, it is characterised in that the arc deflector to
Central angle is 60-90 °, and arc deflector surface is smooth, uses identical material with shell.
7. the interior enhanced dialyzer of filtration according to claim 1, it is characterised in that the hemisphere jut and arc is led
The surface of flowing plate is smooth, and material is identical as outer housing material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810722810.6A CN108744102B (en) | 2018-07-04 | 2018-07-04 | Internal filtering enhanced dialyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810722810.6A CN108744102B (en) | 2018-07-04 | 2018-07-04 | Internal filtering enhanced dialyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108744102A true CN108744102A (en) | 2018-11-06 |
| CN108744102B CN108744102B (en) | 2024-08-09 |
Family
ID=63975879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810722810.6A Active CN108744102B (en) | 2018-07-04 | 2018-07-04 | Internal filtering enhanced dialyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108744102B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331270A (en) * | 2018-12-17 | 2019-02-15 | 班遵浦 | A kind of haemodialysis dialyzer |
| CN109718426A (en) * | 2019-02-26 | 2019-05-07 | 京东方科技集团股份有限公司 | Transfusion control device and system, transfusion system |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5862994A (en) * | 1996-06-25 | 1999-01-26 | Grinnell Corporation | Deflector for upright-type fire sprinklers |
| JP2003334244A (en) * | 2002-03-14 | 2003-11-25 | Nipro Corp | Dialyzer and manufacturing method therefor |
| CN101361994A (en) * | 2008-09-12 | 2009-02-11 | 北京工业大学 | Artificial heart blood-pump capable of increasing blood pressure step by step |
| US20090107335A1 (en) * | 2007-02-27 | 2009-04-30 | Deka Products Limited Partnership | Air trap for a medical infusion device |
| CN205073372U (en) * | 2015-09-25 | 2016-03-09 | 珠海健帆生物科技股份有限公司 | Compound blood purifying device |
| CN107362399A (en) * | 2017-09-12 | 2017-11-21 | 东莞科威医疗器械有限公司 | A kind of spiral stream guidance integrated form membrane oxygenator |
| CN209204252U (en) * | 2018-07-04 | 2019-08-06 | 威海威高血液净化制品有限公司 | The interior enhanced dialyzer of filtration |
-
2018
- 2018-07-04 CN CN201810722810.6A patent/CN108744102B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5862994A (en) * | 1996-06-25 | 1999-01-26 | Grinnell Corporation | Deflector for upright-type fire sprinklers |
| JP2003334244A (en) * | 2002-03-14 | 2003-11-25 | Nipro Corp | Dialyzer and manufacturing method therefor |
| US20090107335A1 (en) * | 2007-02-27 | 2009-04-30 | Deka Products Limited Partnership | Air trap for a medical infusion device |
| CN101361994A (en) * | 2008-09-12 | 2009-02-11 | 北京工业大学 | Artificial heart blood-pump capable of increasing blood pressure step by step |
| CN205073372U (en) * | 2015-09-25 | 2016-03-09 | 珠海健帆生物科技股份有限公司 | Compound blood purifying device |
| CN107362399A (en) * | 2017-09-12 | 2017-11-21 | 东莞科威医疗器械有限公司 | A kind of spiral stream guidance integrated form membrane oxygenator |
| CN209204252U (en) * | 2018-07-04 | 2019-08-06 | 威海威高血液净化制品有限公司 | The interior enhanced dialyzer of filtration |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109331270A (en) * | 2018-12-17 | 2019-02-15 | 班遵浦 | A kind of haemodialysis dialyzer |
| CN109718426A (en) * | 2019-02-26 | 2019-05-07 | 京东方科技集团股份有限公司 | Transfusion control device and system, transfusion system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108744102B (en) | 2024-08-09 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: No.20, Xingshan Road, torch hi tech Industrial Development Zone, Huancui District, Weihai City, Shandong Province 264200 Applicant after: Shandong Weigao blood purification products Co.,Ltd. Address before: No.20, Xingshan Road, torch hi tech Industrial Development Zone, Huancui District, Weihai City, Shandong Province 264200 Applicant before: WEIHAI WEIGAO BLOOD PURIFICATION PRODUCTS Co.,Ltd. |
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| GR01 | Patent grant |