CN108743844A - A kind of drug for treating myocardial ischemia - Google Patents
A kind of drug for treating myocardial ischemia Download PDFInfo
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- CN108743844A CN108743844A CN201810782308.4A CN201810782308A CN108743844A CN 108743844 A CN108743844 A CN 108743844A CN 201810782308 A CN201810782308 A CN 201810782308A CN 108743844 A CN108743844 A CN 108743844A
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Abstract
The present invention provides a kind of drug for treating myocardial ischemia, is made of following raw material：Pharmaceutical composition, polyethylene glycol, superfine silica gel powder, low-substituted hydroxypropyl cellulose, crospovidone, sodium carboxymethylcellulose and deionized water；Compared with prior art, the present invention has following advantageous effect：Have the function of relieving inflammation or internal heat, bushing is enriched blood, tranquilizing the mind QI invigorating, the illnesss such as patient's myocardial ischemia, deficiency of heart-blood can be improved.
Description
Technical field
The present invention is a kind of drug for treating myocardial ischemia, belongs to treating cardiovascular disease technical field.
Background technology
Myocardial ischemia refers to that the hemoperfusion of heart is reduced, and the oxygen supply of heart is caused to reduce, and energy metabolism of myocardial is abnormal,
It cannot support a kind of pathological state of normal heart action.Coronary heart disease is to cause that myocardial ischemia is main, the most common cause of disease.With
The raising of living standards of the people, illness rate of the myocardial ischemia in China is in the trend risen year by year at present.During myocardial ischemia is
Common complaint among the elderly and frequently-occurring disease.
Since myocardial ischemia has the danger that myocardial infarction and sudden death occurs, consequently found that when myocardial ischemia, and early treatment.
The generation of active prevention atherosclerosis has such as occurred, and answers active treatment, prevents pathological development and strives for reversing.Occur
Complications should treat in time, and prevention deteriorates, and extend patient's service life.
For myocardial ischemia, drug therapy is relied primarily in the prior art, cardiac muscle can be lacked according to pharmacological action principle
Blood medicine is divided into following classification：
(1) antiplatelet drug prevents thrombosis, prevents coronary artery and cerebral artery thrombosis embolism, such as aspirin, chlorine pyrrole
Gray.
(2) receptor blocking agent reducing heart rate reduces the oxygen consumption of cardiac muscle, prevents sudden death, such as metoprolol or its sustained release tablets.
(3) calcium ion antagonist.
(4) statins reduce the cholesterol in blood plasma, stablize artery plaque, prevent patch from falling off to form thrombus, such as
Atorvastatin, Rosuvastatin etc..
(5) agent of RAS system blockings can prevent remodeling ventricle, improve heart function, such as benazepil and Valsartan.
(6) nitrate esters medicine coronary artery dilator increases myocardial blood supply, such as Isosorbide-5-Nitrae.
(7) thrombolytic drug dissolves the thrombus of acute formation, is used for acute myocardial infarction AMI.
Curing myocardial ischemia drug listed above, the unconspicuous technological deficiency of generally existing drug effect.In addition, existing skill
Abundant excavation is not yet received to the therapeutic effect of myocardial ischemia in natural medicinal ingredients in art.
Invention content
In view of the deficienciess of the prior art, it is an object of the present invention to provide a kind of drug for treating myocardial ischemia, to solve
The problems mentioned above in the background art.
To achieve the goals above, the present invention is to realize by the following technical solutions：A kind of myocardial ischemia for the treatment of
Drug, it is characterised in that：It is made of following raw material：Pharmaceutical composition, polyethylene glycol, superfine silica gel powder, low substituted hydroxy-propyl fiber
Element, crospovidone, sodium carboxymethylcellulose and deionized water.
Further, described pharmaceutical composition is by Radix Notoginseng 2-3 parts by weight, hawthorn 1-4 parts by weight, Herba Andrographitis 3-4 parts by weight,
Rhodiola root 2-4 parts by weight, Radix Codonopsis 5-7 parts by weight, Prunella vulgaris 2-4 parts by weight, honeysuckle 4-6 parts by weight, Radix Astragali 2-3 parts by weight,
Cimicifugae foetidae 1-3 parts by weight, Radix Angelicae Sinensis 4-5 parts by weight, radix paeoniae rubra 2-3 parts by weight, red-spotted stonecrop ruler spend 5-7 parts by weight, Radix Paeoniae Alba 1-2 parts by weight, the heart of a lotus seed
Seed of jog's tears 7-8 parts by weight, leech 3-5 parts by weight, glutinous rehmannia 5-6 parts by weight, spina date seed 1-2 parts by weight, dried orange peel 6-7 parts by weight, Radix Salviae Miltiorrhizae
5-6 parts by weight, PERICARPIUM TRICHOSANTHIS 5-7 parts by weight, dandelion 2-3 parts by weight.
Further, it takes diameter 2-2.5cm, the hawthorn of thick 0.3-0.4cm, the core for removing impurity and falling off to fry, fries extremely
Surface coke brown, internal yellowish-brown, is then placed in pulverizer and crushes, and sieves with 100 mesh sieve, and sieves to obtain hawthorn in raw material.
Further, take 15-18 centimetres high, rough is strong, cone, and the most fibrous roots of rootstock tool, rhizome is short, thick shape, circle
The dry root and rhizome of cylindrical rhodiola root, excavation after autumn scape is withered, remove tertia, clean, dry, the method for being extracted with water carries
It takes, obtains the rhodiola root in raw material.
Further, it is picked in batches when honeysuckle blooms, in two batches, first is in 5 months, the last ten-days period, in 6 months, the last ten-days period
Adopt second of flower, when bud top expands, by it is green bleach, it is not yet open when harvest, dry or dry immediately after harvesting, drying temperature
Degree is just to dry 30~35 DEG C, and 40 DEG C are risen to after 2h, dries 5~10h, after then controlling 45~50 DEG C of baking 10h of room temperature holding, heating
To 55~60 DEG C, honeysuckle is made to dry rapidly, then the honeysuckle after drying is placed in pulverizer and crushes, crosses 50 mesh sieve,
Sieve to obtain honeysuckle in raw material.
Further, honey is set in pot, is heated to after boiling slowly, used slow boiling instead and slightly boiling, fishing is kept to go to float on the surface
Foam and wax, then use or gauze filter off impurity, after being diluted with boiling water, drench people 2.5~3.5cm of diameter, thickness 0.2~
0.4cm is mixed thoroughly during exocuticle is shallow pale brown or astragalus mongholicus tablet of sepia, then bored profit 4-6 hours sets astragalus mongholicus tablet in frying pan,
With slow boiling frying, stir-fry is deep yellow uniformly to astragalus root color, glossy, then takes out, cools, and is extracted using the method for supercritical extract
Pick and place it is cool after astragalus mongholicus tablet, that is, obtain raw material in Radix Astragali.
Further, take long 6~8mm, wide 4~6mm, the coix seed benevolence of surface milky drying, according to bran fry method fry to
It is yellowish, it is then placed in pulverizer and crushes, obtain the coix seed in raw material.
Further, take 60~80 centimetres high, root is elongated, cylindrical, crust vermilion, the labiate of four prismatic of stem
The dry root and rhizome of Radix Salviae Miltiorrhizae remove silt, dry, are then placed in pulverizer and crush, and smash it through 100 mesh sieve, sieve former
Radix Salviae Miltiorrhizae in material.
Beneficial effects of the present invention：The present invention a kind of drug for treating myocardial ischemia, have relieve inflammation or internal heat, bushing is enriched blood, is pacified
The function of refreshing QI invigorating can improve the illnesss such as patient's myocardial ischemia, deficiency of heart-blood, and there is promoting blood circulation and removing blood stasis, resuscitation with aromatics, promoting the circulation of qi to stop
The function of pain, for treating, mind is not peaceful, deficiency of heart-blood, myocarditis, myocardial strain, angina pectoris, worries beyond measure, seized with terror secondary forgetful
Etc. diseases have notable curative effect.
Specific implementation mode
To make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, with reference to
Specific implementation mode, the present invention is further explained.
The present invention provides a kind of technical solution：A kind of drug for treating myocardial ischemia, is made of following raw material：Pharmaceutical composition
Object, polyethylene glycol, superfine silica gel powder, low-substituted hydroxypropyl cellulose, crospovidone, sodium carboxymethylcellulose and deionization
Water.
Pharmaceutical composition is by Radix Notoginseng 2-3 parts by weight, hawthorn 1-4 parts by weight, Herba Andrographitis 3-4 parts by weight, rhodiola root 2-4 weight
Part, Radix Codonopsis 5-7 parts by weight, Prunella vulgaris 2-4 parts by weight, honeysuckle 4-6 parts by weight, Radix Astragali 2-3 parts by weight, cimicifugae foetidae 1-3 parts by weight,
Radix Angelicae Sinensis 4-5 parts by weight, radix paeoniae rubra 2-3 parts by weight, red-spotted stonecrop ruler flower 5-7 parts by weight, Radix Paeoniae Alba 1-2 parts by weight, coix seed 7-8 parts by weight,
Leech 3-5 parts by weight, glutinous rehmannia 5-6 parts by weight, spina date seed 1-2 parts by weight, dried orange peel 6-7 parts by weight, Radix Salviae Miltiorrhizae 5-6 parts by weight, Snakegourd Fruit
Skin 5-7 parts by weight, dandelion 2-3 parts by weight.
It takes diameter 2-2.5cm, the hawthorn of thick 0.3-0.4cm, the core for removing impurity and falling off to fry, fries brown to surface coke
Color, internal yellowish-brown, is then placed in pulverizer and crushes, and sieves with 100 mesh sieve, and sieves to obtain hawthorn in raw material.
Take 15-18 centimetres high, rough is strong, cone, and the most fibrous roots of rootstock tool, rhizome is short, thick shape, cylindrical red scape
It dry root and rhizome, excavation after autumn scape is withered, removes tertia, cleans, dries, and method extraction is extracted with water, and obtains former
Rhodiola root in material.
Picked in batches when honeysuckle blooms, in two batches, first in 5 months, the last ten-days period, in 6 months, the last ten-days period adopt second
Flower, when bud top expands, by it is green bleach, it is not yet open when harvest, dry or dry immediately after harvesting, drying temperature is, just
30~35 DEG C are dried, 40 DEG C are risen to after 2h, dries 5~10h, after then controlling 45~50 DEG C of baking 10h of room temperature holding, is warming up to 55~60
DEG C, so that honeysuckle is dried rapidly, then the honeysuckle after drying is placed in pulverizer and crushes, crosses 50 mesh sieve, sieve to obtain raw material
In honeysuckle.
Honey is set in pot, is heated to after boiling slowly, slow boiling is used instead and slightly boiling, fishing is kept to remove supernatant foam and wax
Matter, is then used or gauze filters off impurity, after being diluted with boiling water, drenches people 2.5~3.5cm of diameter, 0.2~0.4cm of thickness, exocuticle is shallow
It in pale brown or sepia astragalus mongholicus tablet, mixes thoroughly, then bored profit 4-6 hours sets astragalus mongholicus tablet in frying pan, with slow boiling frying, fry extremely
Astragalus root color is deep yellow uniformly, glossy, then takes out, cools, the Radix Astragali after being cooled using the method extraction of supercritical extract
Piece obtains the Radix Astragali in raw material.
Take long 6~8mm, wide 4~6mm, the coix seed benevolence of surface milky drying is fried method according to bran and fried to yellowish, so
After be put into pulverizer and crush, obtain the coix seed in raw material.
Take 60~80 centimetres high, root is elongated, cylindrical, crust vermilion, the labiate Radix Salviae Miltiorrhizae of four prismatic of stem it is dry
Dry and rhizome remove silt, dry, are then placed in pulverizer and crush, and smash it through 100 mesh sieve, sieve to obtain pellet in raw material
Ginseng.
As an embodiment of the present invention：The present invention a kind of drug for treating myocardial ischemia, have relieve inflammation or internal heat, bushing
It enriches blood, the function of tranquilizing the mind QI invigorating, the illnesss such as patient's myocardial ischemia, deficiency of heart-blood can be improved, there is promoting blood circulation and removing blood stasis, fragrant open
The function of key, promoting qi circulation and relieving pain, it is not peaceful for treatment mind, deficiency of heart-blood, myocarditis, myocardial strain, angina pectoris, worry beyond measure,
The secondary diseases such as forgetful seized with terror have notable curative effect.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention, for this field skill
For art personnel, it is clear that invention is not limited to the details of the above exemplary embodiments, and without departing substantially from the present invention spirit or
In the case of essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action
Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state
Bright restriction, it is intended that including all changes that come within the meaning and range of equivalency of the claims in the present invention
It is interior.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (8)
1. a kind of drug for treating myocardial ischemia, it is characterised in that：It is made of following raw material：It is pharmaceutical composition, polyethylene glycol, micro-
Powder silica gel, low-substituted hydroxypropyl cellulose, crospovidone, sodium carboxymethylcellulose and deionized water.
2. a kind of drug for treating myocardial ischemia according to claim 1, it is characterised in that：Described pharmaceutical composition is by three
Seven 2-3 parts by weight, hawthorn 1-4 parts by weight, Herba Andrographitis 3-4 parts by weight, rhodiola root 2-4 parts by weight, Radix Codonopsis 5-7 parts by weight, summer are withered
Careless 2-4 parts by weight, honeysuckle 4-6 parts by weight, Radix Astragali 2-3 parts by weight, cimicifugae foetidae 1-3 parts by weight, Radix Angelicae Sinensis 4-5 parts by weight, radix paeoniae rubra 2-3
Parts by weight, red-spotted stonecrop ruler spend 5-7 parts by weight, Radix Paeoniae Alba 1-2 parts by weight, coix seed 7-8 parts by weight, leech 3-5 parts by weight, glutinous rehmannia 5-6
Parts by weight, spina date seed 1-2 parts by weight, dried orange peel 6-7 parts by weight, Radix Salviae Miltiorrhizae 5-6 parts by weight, PERICARPIUM TRICHOSANTHIS 5-7 parts by weight, dandelion 2-3
Parts by weight.
3. a kind of drug for treating myocardial ischemia according to claim 2, it is characterised in that：It is described to take diameter 2-2.5cm,
The hawthorn of thick 0.3-0.4cm, the core for removing impurity and falling off, fries, and fries to surface coke brown, internal yellowish-brown is then placed in
It crushes, sieves with 100 mesh sieve in pulverizer, sieve to obtain hawthorn in pharmaceutical composition.
4. a kind of drug for treating myocardial ischemia according to claim 2, it is characterised in that：Take 15-18 centimetres high, rough
Strong, cone, the most fibrous roots of rootstock tool, rhizome is short, thick shape, the dry root and rhizome of cylindrical rhodiola root, autumn scape
Excavation after withered, removes tertia, cleans, dries, and method extraction is extracted with water, obtains the rhodiola root in pharmaceutical composition.
5. a kind of drug for treating myocardial ischemia according to claim 2, it is characterised in that：In batches when honeysuckle blooms
Picking, in two batches, first in 5 months, the last ten-days period, in 6 months, the last ten-days period adopt second of flower, when bud top expands, by it is green bleach,
It is harvested when not yet open, dries or dry immediately after harvesting, drying temperature is just to dry 30~35 DEG C, and 40 DEG C are risen to after 2h, dries 5
~10h is warming up to 55~60 DEG C, honeysuckle is made to dry rapidly, then will after then controlling 45~50 DEG C of baking 10h of room temperature holding
Honeysuckle after drying, which is placed in pulverizer, to crush, and crosses 50 mesh sieve, sieves to obtain honeysuckle in pharmaceutical composition.
6. a kind of drug for treating myocardial ischemia according to claim 2, it is characterised in that：Honey is set in pot, is heated
It to after boiling slowly, uses slow boiling instead and slightly boiling, fishing is kept to go supernatant foam and wax, then use or gauze filters off impurity,
After being diluted with boiling water, people 2.5~3.5cm of diameter is drenched, 0.2~0.4cm of thickness, during exocuticle is shallow pale brown or astragalus mongholicus tablet of sepia,
It mixes thoroughly, then bored profit 4-6 hours sets astragalus mongholicus tablet in frying pan, with slow boiling frying, stir-fry is deep yellow uniformly to astragalus root color, there is light
Pool then takes out, and cools, the astragalus mongholicus tablet after being cooled using the method extraction of supercritical extract is obtained in pharmaceutical composition
Radix Astragali.
7. a kind of drug for treating myocardial ischemia according to claim 2, it is characterised in that：It takes and grows 6~8mm, wide by 4~
6mm, the coix seed benevolence of surface milky drying are fried method according to bran and are fried to yellowish, be then placed in pulverizer and crush, obtain medicine
Coix seed in compositions.
8. a kind of drug for treating myocardial ischemia according to claim 2, it is characterised in that：Take 60~80 centimetres high, root
Elongated, cylindrical, crust vermilion, the dry root and rhizome of the labiate Radix Salviae Miltiorrhizae of four prismatic of stem remove silt, dry,
It is then placed in pulverizer and crushes, smash it through 100 mesh sieve, sieve to obtain Radix Salviae Miltiorrhizae in pharmaceutical composition.
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Application publication date: 20181106 |