CN108743415A - A kind of net protecting skin product of fullerene and its application method - Google Patents
A kind of net protecting skin product of fullerene and its application method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
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- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
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Abstract
The present invention relates to skin care field, a kind of net protecting skin product of fullerene and its application method are provided, for solving the problems, such as that VC derivatives are oxidizable.A kind of net protecting skin product of fullerene provided by the invention and its application method, including the net protecting skin product of fullerene and solvent；The freeze-dried powder includes 2 ~ 5 mass parts of water-soluble fullerene, 3 ~ 8 mass parts of VC derivatives, 0.5 ~ 1 mass parts of trehalose, 75 ~ 90 mass parts of water；The solvent includes 0.1 ~ 0.5 mass parts of carnosine, 6 ~ 12 mass parts of auxiliary agent, inverse bright 1 ~ 3 mass parts of skin agent of sugar, 80 ~ 99 mass parts of water.VC derivatives can inhibit melanin pigmentation, but it is easily aoxidized, it is not easy to be absorbed by the skin, therefore it needs to be modified it and improves its oxidation resistance, and fullerene has efficient oxidation resistance, the two is compounded, and adds trehalose or the inverse bright skin agent of sugar to improve its moistening effect, addition auxiliary agent improves it and inhibits telling on for melanin；Carnosine can enhance the antioxidant effect of fullerene, with part radical reaction.
Description
Technical field
The present invention relates to skin care fields, and in particular to a kind of net protecting skin product of fullerene and its application method.
Background technology
At present bright color, clean clean cunning, uniform skin product in main function mechanism be to inhibit the shape of melanin
At, it is anti-oxidant, remove free radical etc., it includes mainly VC and derivative to have the cosmetic material that this respect acts on the market at present,
Ursin, niacinamide, nonapeptide -1, carnosine and some other plant extracts etc. achieve the effect that satisfied and safety and stability for it,
It is noted that the collaboration compatibility effect between giving full play to recipe ingredient, paying attention to each raw material respectively has certain characteristic and some spies
Fixed requirement.
CN104188887A discloses a kind of lightening compositions and its is applied in Skin whitening care cosmetics, the lightening compositions
Contain following components in percentage by weight：Oil-soluble VC derivatives 1~10%, light Radix Glycyrrhizae pyridine 0.05~0.2%, niacinamide 1~
5%, hydrogenated soy phosphatidyl choline 1~5%, gorgonian extracting solution 0.1~0.5%, amino acid humectant 0.5~2%.The invention system
Standby lightening compositions whitening, freckle effect are notable, have given full play to the whitening and skin-protecting effect of VC derivatives, but the invention is not
Solve the problems, such as that VC derivatives are easily aoxidized.
When being formulated design, raw material is selected to consider that its is safe and stable for resource, product strict implement cosmetics state
Family's sanitary standard specification, recipe ingredient are that (formation that is anti-oxidant, inhibiting melanin participates in the main mechanism of action with VC derivatives
The synthesis of collagen）, freeze-dried powder form is made in product（VC is reduced using hypothermic lyophilization technology to be not easy to be aoxidized）, freeze-drying
Powder solvent adds nonapeptide -1, carnosine is collaboration compatibility effect.Through overtesting antioxidant effect not persistently, effect is slow, is not easy by skin
Skin absorbs.It needs to solve the problems, such as that VC derivatives are easily aoxidized, improves the net skin effect of whitening of VC derivatives.
Fullerene（Fullerene) it is the third allotrope that simple substance carbon is found.It is any by a kind of element group of carbon
At with spherical, substance existing for ellipticity or tubular structure can be called fullerene, and fullerene refers to a kind of object
Matter.Fullerene has efficient anti-oxidation function, the mixed with fullerene in VC derivatives, may change VC derivatives and easily be aoxidized
The characteristics of.
Invention content
Present invention solves the technical problem that for the oxidizable problem of VC derivatives, provide a kind of net protecting skin product of fullerene and
Its application method.
In order to solve the above technical problem, the present invention provides technical solution be：
A kind of net protecting skin product of fullerene and its application method, including freeze-dried powder and solvent；The freeze-dried powder includes water-soluble rich
Strangle 2 ~ 5 mass parts of alkene, 3 ~ 8 mass parts of VC derivatives, 0.5 ~ 1 mass parts of trehalose, 75 ~ 90 mass parts of water；The solvent includes
0.1 ~ 0.5 mass parts of carnosine, 6 ~ 12 mass parts of auxiliary agent, inverse bright 1 ~ 3 mass parts of skin agent of sugar, 80 ~ 99 mass parts of water.
VC derivatives（VC ethylethers, VC phosphates magnesium, VC sodium phosphates etc.）It can inhibit melanin pigmentation, but it is easily
It is aoxidized, is not easy to be absorbed by the skin, it is therefore desirable to compounding is carried out to it improves its oxidation resistance, and fullerene has efficiently
Oxidation resistance compounds the two, and adds trehalose or the inverse bright skin agent of sugar to improve its moistening effect, and addition auxiliary agent improves it
Inhibit telling on for melanin；Carnosine can enhance the antioxidant effect of fullerene, with part radical reaction.
Fullerene improves the antioxidative mechanism of VC derivatives and is that the same radical reaction of fullerene consumes part
Free radical makes more VC be used to promote the maturation of collagen.
Fullerene can significantly improve the antioxygenic property of VC derivatives, alleviate VC derivative oxidation stain problems.
Preferably, the freeze-dried powder includes 3 ~ 5 mass parts of water-soluble fullerene, 6 ~ 8 mass parts of VC derivatives, trehalose
0.8 ~ 1 mass parts, 82.4 ~ 90 mass parts of water；The solvent includes 0.2 ~ 0.5 mass parts of carnosine, 9 ~ 12 mass parts of auxiliary agent, inverse sugar
Bright 2 ~ 3 mass parts of skin agent, 88.3 ~ 99 mass parts of water.Within this range, VC derivatives can be effectively used for control, promote
The synthesis of collagen, fullerene can be effectively protected VC derivatives and be attacked from free radical.
Preferably, the freeze-dried powder includes 3 mass parts of water-soluble fullerene, 6 mass parts of VC derivatives, 0.8 matter of trehalose
Measure part, 82.4 mass parts of water；The solvent includes 0.2 mass parts of carnosine, 9 mass parts of auxiliary agent, inverse bright 2 mass parts of skin agent of sugar, water
88.3 mass parts.The amount that VC derivatives are aoxidized at this time is minimum, is preferably technical solution.
Preferably, in the freeze-dried powder further include 5 ~ 9 mass parts of mannitol, 0.2 ~ 0.6 matter of budding short stalk enzyme polysaccharide
Measure part, 0.05 ~ 0.2 mass parts of glycerine, 0.1 ~ 0.5 mass parts of glycine.Mannitol, budding short stalk enzyme polysaccharide, glycerine conduct
The binder of freeze-dried powder, glycine are by mixed pH adjusting agents such as fullerene, VC derivatives.
Preferably, further include 7 mass parts of mannitol in the freeze-dried powder, 0.4 mass parts of budding short stalk enzyme polysaccharide, sweet
Oily 0.1 mass parts, 0.3 mass parts of glycine.
Preferably, the auxiliary agent is the one of which of water, glycerine or nonapeptide -1, and the VC derivatives are VC phosphates
Magnesium, VC sodium phosphates, tetra- different palmitates of VC, VC palmitates, VC ethylethers are one such or several.Trehalose and inverse sugar
Bright skin agent has moisturizing, improves the infiltrative effect of product, and water, glycerine, nonapeptide -1 can effectively enhance the antioxygen of fullerene
Change effect, the activity of melanoblast can be weakened, reduce melanin yield, VC ethylethers are that common VC derives
Object easily obtains and whitening spot-removing effect is good, and VC phosphates magnesium, VC sodium phosphates, tetra- different palmitates of VC, VC palmitates also may be used
For the skin care item, effect has no marked difference.
It is further preferred that the freeze-dried powder includes 3 mass parts of water-soluble fullerene, and 6 mass parts of VC ethylethers, trehalose
0.8 mass parts, 82.4 mass parts of water, 7 mass parts of mannitol, 0.4 mass parts of budding short stalk enzyme polysaccharide, 0.1 mass parts of glycerine,
0.3 mass parts of glycine；The solvent includes 0.2 mass parts of carnosine, and nonapeptide -1 is 9 mass parts, inverse bright 2 mass parts of skin agent of sugar,
88.3 mass parts of water.The entrance of receptor and various factor signals, weakens on the emulative closing melanoblast of nonapeptide -1
The activity of melanoblast reduces melanin yield, plays the effect of uniform bright color.
As another preferred embodiment of the present invention, the freeze-dried powder includes 3 mass parts of water-soluble fullerene, VC ethylethers
6 mass parts, 0.8 mass parts of trehalose, 82.4 mass parts of water, 7 mass parts of mannitol, 0.4 mass parts of budding short stalk enzyme polysaccharide,
0.1 mass parts of glycerine, 0.3 mass parts of glycine；The solvent includes 0.2 mass parts of carnosine, and glycerine is 9 mass parts, and inverse sugar is bright
2 mass parts of skin agent, 88.3 mass parts of water.Glycerine is common daily necessities, has the function of moisturizing, humectation, also has high activity, antioxygen
It is not oxidized can to enhance protection VC derivatives in solvent for the function of change.
Preferably, in the net protecting skin product of fullerene freeze-dried powder manufacturing method, include the following steps：It is filling, it will be described
After freeze-dried powder is configured to liquid in formula composition ratio, by the ratio requirement it is filling after, be freeze-dried；Freeze-drying,
Pre-freeze is no less than 3 hours at -45 DEG C, and 1Pa is evacuated at -40 DEG C, then controls temperature and is improved to 30 by -40 DEG C
DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time per temperature gradient is no less than 30min, and the total time of freeze-drying is many
In 26h；Lid encapsulation is rolled, after freeze-drying, is packed under vacuum.
- 45 DEG C of pre-freezes are to ensure temperature in freeze-drying powder mixture eutectic point hereinafter, making coagulable water in mixture
Point fully freeze, prevented partial moisture non-condensing, in order to promote the water sublimate of condensation, temperature gradient to change when subsequent heating
It is to reduce water content to improve yields as far as possible.
Freeze-dried powder is produced using freeze drying process, can more complete the activity for retaining VC derivatives, dehydration is thorough,
Holding time is long, and rehydration is fast, easy to use.
Preferably, in the freezing dry process, -35 DEG C of operations 120 ~ 180min, -25 DEG C of 240 ~ 300min of operation, -
15 DEG C of operations 180 ~ 240min, 0 DEG C, 25 DEG C and 30 DEG C operation 120 ~ 180min, 30 DEG C of 30 ~ 90min of operation.Freezing dry process
In, the speed of temperature change is more crucial, when low temperature, hydrogenesis, simultaneously because being in high vacuum environment, the moisture liter of solidification
The loss from product of Huawei's aqueous vapor comes out, and reaction system is finally discharged.In this process, unsuitable too fast, the mistake of the variation of temperature
Cause solid water to become liquid soon, can not be discharged from system, need to cool down waste of energy, therefore the variation of temperature in turn again
It must mutually coordinate with the distillation of moisture, control in above-mentioned temperature range, it can be effectively by moisture liter in above-mentioned time range
Magnificent discharge system.
Preferably, in the freezing dry process, -35 DEG C of operation 150min, -25 DEG C of operation 260min, -15 DEG C run
210min, 0 DEG C, 25 DEG C and 30 DEG C operation 150min, 30 DEG C of operation 60min.Under such Elevated Temperature Conditions, the yields of freeze-dried powder is more
Height, moisture are no more than 2%.
Freeze-dried powder is produced using freeze drying process, can more complete the activity for retaining VC derivatives, dehydration is thorough,
Holding time is long, and rehydration is fast, easy to use.
A kind of application method of the net protecting skin product of fullerene, is added freeze-dried powder, after stirring evenly, by mixed liquor in solvent
It is applied on skin, the dosage of the solvent is 1 ~ 5ml, and the dosage of the freeze-dried powder is 50 ~ 200mg.Freeze-dried powder can be with
Quickly in dissolving solvent, it is applied to face with water dropper suction, it is easy to use.
Preferably, the dosage of the solvent is 3 ~ 5ml, and the dosage of the freeze-dried powder is 100 ~ 200mg.
Preferably, the dosage of the solvent is 3ml, and the dosage of the freeze-dried powder is 100mg.
Compared with prior art, the device have the advantages that being：VC derivatives can inhibit melanin pigmentation, but its
It is easily aoxidized, is not easy to be absorbed by the skin, it is therefore desirable to it is modified and improves its oxidation resistance, and fullerene has height
The oxidation resistance of effect, the two is compounded, and adds trehalose or the inverse bright skin agent of sugar to improve its moistening effect, and addition auxiliary agent carries
High its inhibits telling on for melanin；Carnosine can enhance the antioxidant effect of fullerene, with part radical reaction.
Description of the drawings
Fig. 1 is the relationship of different skin care item formulas and collagen production.
Protecting effect of the fullerene to the form of epidermal cell after Fig. 2 11h.
Specific implementation mode
Following implementation column is the further explanation to the present invention, is not limitation of the present invention.
Embodiment 1
A kind of net protecting skin product of fullerene,
The freeze-dried powder includes 3 mass parts of water-soluble fullerene, 6 mass parts of VC derivatives, 0.8 mass parts of trehalose, water 82.4
Mass parts；
The solvent includes 0.2 mass parts of carnosine, 9 mass parts of auxiliary agent, inverse bright 2 mass parts of skin agent of sugar, 88.3 mass parts of water.It is described
Freeze-dried powder in further include 7 mass parts of mannitol, 0.4 mass parts of budding short stalk enzyme polysaccharide, 0.1 mass parts of glycerine, glycine
0.3 mass parts.The auxiliary agent is nonapeptide -1, and the VC derivatives are VC ethylethers.
The manufacturing method of freeze-dried powder in the net protecting skin product of fullerene,
It is filling, after the freeze-dried powder is configured to liquid in formula composition ratio, by the mass ratio it is filling after, carry out
Freeze-drying；
Freeze-drying, pre-freeze 3.5 hours at -45 DEG C are evacuated to 1Pa at -40 DEG C, then control temperature and are carried by -40 DEG C
Up to 30 DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time per temperature gradient is no less than 30min, wherein -35 DEG C of fortune
Row 150min, -25 DEG C of operation 260min, -15 DEG C of operation 210min, 0 DEG C, 25 DEG C and 30 DEG C operation 150min, 30 DEG C run
60min, remaining temperature are 30min, the total time of freeze-drying are no less than 26h；
Lid encapsulation is rolled, after freeze-drying, is packed under vacuum.
Under such Elevated Temperature Conditions, the yields higher of freeze-dried powder, moisture is no more than 2%.
The dosage of the solvent is 3ml, and the dosage of the freeze-dried powder is 100mg.
VC derivatives can inhibit melanin pigmentation, but it is easily aoxidized, and be not easy to be absorbed by the skin, it is therefore desirable to it
It is modified and improves its oxidation resistance, and fullerene has efficient oxidation resistance, and the two is compounded, and add trehalose
Or the inverse bright skin agent of sugar, to improve its moistening effect, addition auxiliary agent improves it and inhibits telling on for melanin；Carnosine can enhance
The antioxidant effect of fullerene, with part radical reaction.
Fullerene can significantly improve the antioxygenic property of VC derivatives, alleviate VC derivative oxidation stain problems.
Mannitol, budding short stalk enzyme polysaccharide, binder of the glycerine as freeze-dried powder, glycine are that fullerene, VC derivatives etc. is mixed
PH adjusting agent after conjunction.Trehalose and the inverse bright skin agent of sugar have moisturizing, improve the infiltrative effect of product, and nonapeptide -1 can be effective
Enhancing fullerene antioxidant effect, can weaken the activity of melanoblast, reduce melanin yield, VC ethyls
Ether is common VC derivatives, easily obtains and whitening spot-removing effect is good.
- 45 DEG C of pre-freezes are to ensure temperature in freeze-drying powder mixture eutectic point hereinafter, making coagulable water in mixture
Point fully freeze, prevented partial moisture non-condensing, in order to promote the water sublimate of condensation, temperature gradient to change when subsequent heating
It is to reduce water content to improve yields as far as possible.
Freeze-dried powder is produced using freeze drying process, can more complete the activity for retaining VC derivatives, dehydration is thorough,
Holding time is long, and rehydration is fast, easy to use.
Freeze-dried powder is produced using freeze drying process, can more complete the activity for retaining VC derivatives, dehydration is thorough,
Holding time is long, and rehydration is fast, easy to use.
Embodiment 2
2 difference from Example 1 of embodiment is：
The freeze-dried powder includes 5 mass parts of water-soluble fullerene, 8 mass parts of VC derivatives, 1 mass parts of trehalose, 90 mass of water
Part；
The solvent includes 0.5 mass parts of carnosine, 12 mass parts of auxiliary agent, inverse bright 3 mass parts of skin agent of sugar, 99 mass parts of water.It is described
Freeze-dried powder in further include 9 mass parts of mannitol, 0.6 mass parts of budding short stalk enzyme polysaccharide, 0.2 mass parts of glycerine, glycine
0.5 mass parts.The dosage of the solvent is 5ml, and the dosage of the freeze-dried powder is 200mg.
Embodiment 3
Embodiment 3 with embodiment 1 the difference is that, including the net protecting skin product of fullerene and solvent；
The freeze-dried powder includes 2 mass parts of water-soluble fullerene, 3 mass parts of VC derivatives, 0.5 mass parts of trehalose, 75 matter of water
Measure part；
The solvent includes 0.1 mass parts of carnosine, 6 mass parts of auxiliary agent, 1 mass parts of synergist, 80 mass parts of water.The freeze-drying
Further include 5 mass parts of mannitol, 0.2 mass parts of budding short stalk enzyme polysaccharide, 0.05 mass parts of glycerine, 0.1 matter of glycine in powder
Measure part.Freeze-dried powder is added in solvent, after stirring evenly, mixed liquor is applied on skin, the dosage of the solvent is
The dosage of 1ml, the freeze-dried powder are 50mg.
Embodiment 4
Embodiment 4 with embodiment 1 the difference is that, the freeze-dried powder includes 3 mass parts of water-soluble fullerene, VC ethylethers 6
Mass parts, 0.8 mass parts of trehalose, 82.4 mass parts of water, 7 mass parts of mannitol, 0.4 mass parts of budding short stalk enzyme polysaccharide,
0.1 mass parts of glycerine, 0.3 mass parts of glycine；
The solvent includes 0.2 mass parts of carnosine, and glycerine is 9 mass parts, inverse bright 2 mass parts of skin agent of sugar, 88.3 mass parts of water.
Glycerine is common daily necessities, has the function of moisturizing, humectation, also has high activity, oxidation resistant function, in solvent
It is not oxidized that protection VC derivatives can be enhanced.
Embodiment 5
Embodiment 5 with embodiment 1 the difference is that, the freeze-dried powder includes 3 mass parts of water-soluble fullerene, VC ethylethers 6
Mass parts, 0.8 mass parts of trehalose, 82.4 mass parts of water, 7 mass parts of mannitol, 0.4 mass parts of budding short stalk enzyme polysaccharide,
0.1 mass parts of glycerine, 0.3 mass parts of glycine；The solvent includes 0.2 mass parts of carnosine, inverse bright 2 mass parts of skin agent of sugar, water
97.3 mass parts.
Embodiment 6
Embodiment 6 with embodiment 1 the difference is that, further include decoyl hydroximic acid, Sensiva SC50,1 in the solvent,
2- hexylene glycols and butanediol one of which or several mixtures.
Embodiment 7
Embodiment 7 with embodiment 1 the difference is that, in the freezing dry process, -35 DEG C operation 120min, -25 DEG C fortune
Row 240min, -15 DEG C of operations 180min, 0 DEG C, 25 DEG C and 30 DEG C operation 120min, 30 DEG C of operation 30min.
Embodiment 8
Embodiment 8 with embodiment 1 the difference is that, in the freezing dry process, -35 DEG C operation 180min, -25 DEG C fortune
Row 300min, -15 DEG C of operations 240min, 0 DEG C, 25 DEG C and 30 DEG C operation 180min, 30 DEG C of operation 90min.
Comparative example 1
Comparative example 1 with embodiment 1 the difference is that, in the freeze-dried powder be free of fullerene.
Comparative example 2
Comparative example 2 with embodiment 1 the difference is that, in the freeze-dried powder be free of auxiliary agent.
Comparative example 3
Comparative example 3 with embodiment 1 the difference is that, in the freeze-dried powder manufacturing process, the moisture of freeze-dried powder is more than
2%。
Comparative example 4
Comparative example 4 with embodiment 1 the difference is that, in the freeze-dried powder be free of VC ethylethers.
Comparative example 5
Comparative example 5 with embodiment 1 the difference is that, the freeze-dried powder by way of drying be made.
Experimental example 1
Skin care item in embodiment 1 ~ 6 and comparative example 1 ~ 4 are configured by its application method, and corresponding solution is made, and are added a concentration of
12mmol/L salicylic acids, 0.9mol/LFeSO4, 7.2mmol/LH2O260min is reacted in 37 DEG C of waters bath with thermostatic control.In 5000r/min
Lower centrifugation 10min takes supernatant to be diluted to 10ml and surveys its absorbance at 510nm and 243nm
Hydroxyl radical free radical is since reactivity is very high, so the time-to-live is shorter.It, can if be added in salicylic acid to reaction system
It effectively captures hydroxyl radical free radical and generates darkviolet product（3- hydroxyl salicylic acids）, which has stronger absorption at 510nm, if
The measured matter for having and removing hydroxyl radical free radical function is added, hydroxyl radical free radical will be competed with salicylic acid, to make coloured production
The production quantity of object is reduced.Using fixed reaction time methods, measure the absorbance of the reaction solution containing measured object at 510nm, and with sky
White sample compares, and just can measure antioxidation of the measured object to hydroxyl radical free radical.The residual quantity of VC derivatives can be by ultraviolet
Spectrophotometric Determination.
Former percentage composition is accounted for by the residual quantity of the hydroxyl radical free radical residual volume and VC derivatives of analyzing embodiment 1 ~ 6,
Come judge mixed with fullerene VC spin-offs inoxidizability.
Fullerene can effectively capture free radical, to protect VC derivatives to be inactivated from the destruction of free radical.Free radical
(free radical) is also known as free radical, is the atom containing unpaired electron, and atomic group, molecule, ion or its group all claim
For free radical.There is a large amount of free radical in human body, maintains normal vital movement all to be unable to do without free radical, it is oxygen in human body
Change a kind of active substance discharged in the process.But due to the behaviors such as irregular and smoking of working and resting, excessive freedom is in body
It is interior to attack other molecules, the structure of cell, DNA, RNA and protein is destroyed, the function drop that internal cell tissue, device are dirty is made
It is low, can not be repaired again, so that internal function of immune system is declined, so as to cause the generation, even dead of various diseases.
From embodiment 1 ~ 3 as can be seen that the residual quantity of free radical is closed with the dosage of fullerene at negative sense, this be mainly because
Identical for the main component in embodiment 1 ~ 3, the proportioning of only each substance is different, while also indicating that the dosage abundance in fullerene
In the case of, hydroxyl radical free radical can be trapped effectively, therefore in embodiment 1 ~ 3 VC derivatives residual quantity it is higher, disappeared
The amount of consumption within the acceptable range, therefore can effectively play VC derivatives and inhibit melanin pigmentation, promote collagen
The effect of synthesis.
The auxiliary agent of solvent in embodiment 1,4 and 5 is different, and embodiment 1 selects nonapeptide -1, can adequately inhibit black
Pigment deposition further increases the effect of VC derivatives；Embodiment 4 selects glycerine, can improve fullerene consumption free radical
Effect；Embodiment 5 selects water, can effective control cost, and the protecting effect difference to VC derivatives of three is little, into
One step shows fullerene to protecting VC derivatives from the important function in terms of free radical consumption.
Add a small amount of preservative in the solvent of embodiment 6, the effect of preservative be in order to improve the shelf-life of solvent,
It is user-friendly.
Comparative example 1 is not added with fullerene, it can be seen that free radical still have part is consumed, but the amount of VC derivatives compared to
Other embodiment but declines to a great extent, this shows that VC derivatives can largely be disappeared in the case of no mixed with fullerene by free radical
Consumption, so that the effect of skin care item declines to a great extent.
Embodiment 7 and 8, in comparative example 5, the fabrication process parameters of freeze-dried powder are different, it is seen that the residual quantity of fullerene is not
It changes, the property of fullerene is stablized, and the change of properties of the fullerene in the freeze-dried powder that different process makes is little, and VC spreads out
The property of biology is closely related with production method, and there may be moisture, and halfway situation, the matter of freeze-dried powder is discharged in embodiment 8
It measures bad, the content of VC derivatives is caused to decline, comparative example 5 is resulted in VC derivatives and is largely denaturalized by the way of drying,
And then whitening effect is caused to decline to a great extent.
Experimental example 2
Embodiment 1 is preferably technical solution, and fullerene can effectively consume free radical, and the effect of VC derivatives is
Promote the synthesis of collagen in skin.
Embodiment 1 is to be doped with the VC derivatives of fullerene, and comparative example 4 only contains VC derivatives and is free of fullerene, comparison
The only fullerene of example 1 is free of fullerene and VC derivatives in blank.
From fig. 1, it can be seen that the VC derivatives for being doped with fullerene can improve the production quantity of collagen in skin, it is to contain only
1.3 times or so of the skin care item effect of VC derivatives, this is because fullerene protects destructions of the VC from free radical, more VC
Derivative participates in the synthesis of collagen, significant that skin care item whitening effect is turned up.
In comparative example 1, fullerene can not almost promote the synthesis of collagen, therefore, in order to improve collagen egg in skin
White synthesis, VC derivatives are necessary substances.
Experimental example 3
Embodiment 1 is compared with comparative example 1, and suitable fullerene is added in embodiment 1, and fullerene is not added in comparative example 1,
It can be observed from fig. 2 that after free radical corrodes 11h, the large percentage being destroyed in cell in comparative example 1, and it is thin in embodiment 1
Born of the same parents' form does not almost change, show fullerene Green Tea Extract destroy effect it is stronger, can be effectively protected skin from
The injury of excessive free radical, while improving the effective protecting time of skin care item.
Experimental example 4
According to copper ion reduction method, the inoxidizability of the fullerene of the amount concentration of same substance is the antioxidative of VC derivatives
250 times or so.
Experimental example 5
Compare under different freeze-drying parameters, the yield and moisture content of product, parameter is preferably suitably lyophilized, as setting for freeze-drying curve
Count foundation.
The relationship of table 2 lyophilized technique and product quality
Embodiment 1,7 and 8 can be used for discussing influence of the lyophilized technique to product quality, as known from Table 2, real-time 1 and 8 postpartum
Moisture content it is relatively low, this is because, the freeze-drying time of embodiment 1 and 8 is longer, freeze-drying efficiency is higher, and moisture largely passes through
Distil discharge system；The moisture content and yield of embodiment 7 are all relatively low, but still in tolerance interval.Consider, embodiment 1
Cost and yield, product quality be all preferably process embodiment.
Experimental example 6
VC phosphates magnesium, VC sodium phosphates, tetra- different palmitates of VC, VC palmitates, VC ethylethers can be used as VC derivatives
Raw material as freeze-dried powder.
Wherein, VC phosphates magnesium, VC sodium phosphates are water solubility, and tetra- different palmitates of VC, VC palmitates are oil-soluble,
VC ethylethers are hydrophilic and lipophile, and several VC derivatives can be effectively promoted the synthesis of collagen, different dissolubilities
It is applicable in and different skin.
Above-listed detailed description is illustrating for possible embodiments of the present invention, and above example is not to limit this
The scope of the claims of invention, all equivalence enforcements or change without departing from carried out by the present invention are intended to be limited solely by the scope of the claims of this case.
Claims (10)
1. a kind of net protecting skin product of fullerene, which is characterized in that including freeze-dried powder and solvent；The freeze-dried powder includes water-soluble rich
Strangle 2 ~ 5 mass parts of alkene, 3 ~ 8 mass parts of VC derivatives, 0.5 ~ 1 mass parts of trehalose, 75 ~ 90 mass parts of water；The solvent includes
0.1 ~ 0.5 mass parts of carnosine, 6 ~ 12 mass parts of auxiliary agent, inverse bright 1 ~ 3 mass parts of skin agent of sugar, 80 ~ 99 mass parts of water.
2. the net protecting skin product of fullerene according to claim 1, which is characterized in that the freeze-dried powder includes water-soluble fowler
3 ~ 5 mass parts of alkene, 6 ~ 8 mass parts of VC derivatives, 0.8 ~ 1 mass parts of trehalose, 82.4 ~ 90 mass parts of water；The solvent includes
0.2 ~ 0.5 mass parts of carnosine, 9 ~ 12 mass parts of auxiliary agent, inverse bright 2 ~ 3 mass parts of skin agent of sugar, 88.3 ~ 99 mass parts of water.
3. the net protecting skin product of fullerene according to claim 2, which is characterized in that the freeze-dried powder includes water-soluble fowler
3 mass parts of alkene, 6 mass parts of VC derivatives, 0.8 mass parts of trehalose, 82.4 mass parts of water；The solvent includes 0.2 matter of carnosine
Measure part, 9 mass parts of auxiliary agent, inverse bright 2 mass parts of skin agent of sugar, 88.3 mass parts of water.
4. the net protecting skin product of fullerene according to claim 1, which is characterized in that further include sweet dew in the freeze-dried powder
5 ~ 9 mass parts of sugar alcohol, 0.2 ~ 0.6 mass parts of budding short stalk enzyme polysaccharide, 0.05 ~ 0.2 mass parts of glycerine, 0.1 ~ 0.5 matter of glycine
Measure part.
5. the net protecting skin product of fullerene according to claim 4, which is characterized in that further include sweet dew in the freeze-dried powder
7 mass parts of sugar alcohol, 0.4 mass parts of budding short stalk enzyme polysaccharide, 0.1 mass parts of glycerine, 0.3 mass parts of glycine.
6. the net protecting skin product of fullerene according to claim 1, which is characterized in that the auxiliary agent is water, glycerine or nine
The one of which of peptide -1, the VC derivatives are VC phosphates magnesium, VC sodium phosphates, tetra- different palmitates of VC, VC palmitic acids
Ester, VC ethylethers are one such or several.
7. the net protecting skin product of fullerene according to claim 1, which is characterized in that the freeze-dried powder passes through following steps
It is made：After the freeze-dried powder is configured to liquid in formula composition ratio, by the requirement it is filling after, be freeze-dried；
Freeze-drying, pre-freeze is no less than 3 hours at -45 DEG C, is evacuated at -40 DEG C no more than 1Pa, then controls temperature
It is improved to 30 DEG C by -40 DEG C, control temperature rate of change is 5 DEG C, and the freeze-drying time per temperature gradient is no less than 30min, is freezed
Dry total time is no less than 26h；Lid encapsulation is rolled, after freeze-drying, is packed under vacuum.
8. the net protecting skin product of fullerene according to claim 7, which is characterized in that in the freezing dry process, -35
DEG C operation 120 ~ 180min, -25 DEG C operation 240 ~ 300min, -15 DEG C operation 180 ~ 240min, 0 DEG C, 25 DEG C and 30 DEG C operation
120 ~ 180min, 30 DEG C of 30 ~ 90min of operation.
9. the net protecting skin product of fullerene according to claim 8, which is characterized in that in the freezing dry process, -35
DEG C operation 150min, -25 DEG C operation 260min, -15 DEG C operation 210min, 0 DEG C, 25 DEG C and 30 DEG C operation 150min, 30 DEG C fortune
Row 60min.
10. a kind of net protecting skin product application method of fullerene, the net protecting skin product of fullerene according to claim 1 are special
Sign is, freeze-dried powder is added in solvent, and after stirring evenly, mixed liquor is applied on skin, and the dosage of the solvent is 1
The dosage of ~ 5ml, the freeze-dried powder are 50 ~ 200mg.
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| CN109381357A (en) * | 2018-12-13 | 2019-02-26 | 广州宝莱生物科技有限公司 | A kind of anti-acne moisturizing leech freeze-dried powder |
| CN109806184A (en) * | 2019-04-08 | 2019-05-28 | 安徽复本生物科技有限公司 | A kind of skin base solution enabling skin whitening |
| CN109806185A (en) * | 2019-04-08 | 2019-05-28 | 安徽复本生物科技有限公司 | A kind of freeze-dried powder of anti-aging |
| CN109966158A (en) * | 2019-04-08 | 2019-07-05 | 安徽复本生物科技有限公司 | A kind of freeze-dried powder enabling skin whitening |
| CN110812320A (en) * | 2019-12-14 | 2020-02-21 | 广州伊尔美生物科技有限公司 | Whitening and skin-protecting composition |
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| CN109806184A (en) * | 2019-04-08 | 2019-05-28 | 安徽复本生物科技有限公司 | A kind of skin base solution enabling skin whitening |
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| CN110812320A (en) * | 2019-12-14 | 2020-02-21 | 广州伊尔美生物科技有限公司 | Whitening and skin-protecting composition |
| CN110812320B (en) * | 2019-12-14 | 2022-02-18 | 广州伊尔美生物科技有限公司 | Whitening and skin-protecting composition |
| CN111150695A (en) * | 2020-01-14 | 2020-05-15 | 浙江神英科技股份有限公司 | Preparation method of hand sanitizer with super-strong decontamination effect |
| CN111514041A (en) * | 2020-05-20 | 2020-08-11 | 广州市美夫兰化妆品有限公司 | Firming, wrinkle-removing and skin-beautifying lotion and preparation method thereof |
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