CN108742959A - A kind of blood saccule, balloon-stent drug release device and its medicine release method - Google Patents
A kind of blood saccule, balloon-stent drug release device and its medicine release method Download PDFInfo
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- CN108742959A CN108742959A CN201810582937.2A CN201810582937A CN108742959A CN 108742959 A CN108742959 A CN 108742959A CN 201810582937 A CN201810582937 A CN 201810582937A CN 108742959 A CN108742959 A CN 108742959A
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- double
- layer
- sacculus
- balloon
- drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
Abstract
The invention discloses a kind of blood saccule, balloon-stent drug release device and its medicine release method；A kind of blood saccule drug release device, including single layer sacculus and double-layered balloon；The surface layer of single layer sacculus is provided with multiple degradable micropins for being ranked sequentially interior drug containing, and double-layered balloon includes internal layer, middle layer and outer layer, and middle layer is drug containing in cavity, and the surface layer of outer layer is equipped with multiple tactic tip-like through holes；A kind of blood saccule stent drug release device, including single layer sacculus or double-layered balloon and holder, single layer sacculus or double-layered balloon are arranged at the middle part of holder；Profit pumps up and makes single layer or double-layered balloon expand to strut holder, and after single layer sacculus struts, the degradable micropin of drug containing is by infusion of medicine blood vessel in surface layer, and after double-layered balloon struts, middle layer contained drug is by surface layer tip-like through hole by infusion of medicine blood vessel；Nocuity of the present invention is small, and anti-blood coagulation is with obvious effects, and occupation mode is simple.
Description
Technical field
The present invention relates to the field of medical instrument technology, more particularly to a kind of blood saccule, balloon-stent drug
Release device and its medicine release method.
Background technology
Intravascular stent refers to that it is narrow to reach support to be placed in inner support in lesion on the basis of lumen of vessels is expanded and shaped
Section blood vessel is occluded, blood vessel elasticity retraction and again contracting shape, the purpose for keeping tube chamber blood flow unobstructed are reduced.Part inner support also has pre-
The effect of anti-restenosis is broadly divided into coronary artery bracket, cerebrovascular stent, renal artery stent, aortic stent etc..
Wherein ideal holder should have following characteristics：(1) preferable biocompatibility：Minimum blood coagulation enhancing effect, implantation
After be not susceptible to Coagulation test and thrombus, be not easy to cause the inflammatory reaction of vascular wall and endometrial hyperplasia；(2) easy polarization；(3) have
There is preferable flexibility, easily shifts diseased region onto；(4) easily expansion, support force is strong and has mechanical robustness.But existing blood vessel
Most of holder is only simply played a supporting role, it is difficult to carry out drug therapy to lesion, therapeutic effect is poor.
The patent document of publication number CN1360951A discloses a kind of intravascular stent with anti-restenosis coating layer, by
The surface of intravascular stent increases by a coating, inhibits the excessive increasing of smooth muscle cell after injury of blood vessel using the active constituent in coating
It grows, to slow down the generation for even being eliminated reangiostenosis, but the intravascular stent is to coat medicine on the surface of intravascular stent
Object, human body are relatively low to the absorptivity of drug.
In view of the above problems, intravascular stent is designed to the intravascular stent containing sacculus by R & D design personnel.Wherein sacculus
Using double-layer structure, internal layer is made by titanium dioxide material, is arranged on outer layer and in the hangnail of blade shapes, coating
Drug on hangnail.When intravascular stent enters designated position, iodine solution is injected in sacculus internal layer, struts intravascular stent, if
The hangnail set on superficies opens therewith, and is pierced into blood vessel inner layer, so that intravascular stent is fixed in the blood vessels.Simultaneously
It is absorbed by blood vessel coated in the drug on hangnail.It borrows the devices such as CT and judges whether sacculus is placed into correct position, wait for that position is true
After fixed, holder will stay in intravascular, play the role of support blood vessels.
Although whether the intravascular stent containing sacculus can be placed into correct position by location determination holder, and improve
Human body to the absorption efficiency of drug, but due to be arranged the hangnail in sacculus outer layer be easy that the inner layer tube wall of blood vessel can be generated compared with
Big injury, and by drug coat on hangnail, blood vessel absorption dose is small, to the therapeutic effect unobvious of some diseases.
Therefore, how the blood saccule that a kind of nocuity is small, with obvious effects to be provided, balloon-stent drug release device and its
The problem of medicine release method is those skilled in the art's urgent need to resolve.
Invention content
In view of this, the present invention provides a kind of blood saccule, balloon-stent drug release device and its drug release side
Method, not only nocuity is small, but also with obvious effects, and mode is simple, great market application and promotional value.
To achieve the goals above, the present invention adopts the following technical scheme that：
A kind of blood saccule drug release device, including single layer sacculus or double-layered balloon；The surface layer of the single layer sacculus is set
It is equipped with multiple degradable micropins for being ranked sequentially interior drug containing, the double-layered balloon includes internal layer, middle layer and outer layer, described
Middle layer is set as cavity, drug containing in the cavity, and the surface layer of outer layer is equipped with multiple tactic tip-like through holes.
Degradable micropin or tip-like through hole can be while intravascular stent strut, and being pierced into vascular wall release prevents
The drugs such as antiplatelet aggregation agent, anti-inflammatory, anti-tampon form, prevent vascular wall inflammation from infecting again.Nocuity of the present invention is small,
Release amount of medicine is big, and drug effect is long, easy to operate.
Further, the outer layer both ends Yu middle part of the double-layered balloon are all coated with a circle metal coating, and with conduit phase
Even a circle metal coating of one end is equipped with the through-hole being connect with conduit.
The both ends of double-layered balloon of the present invention, which are all coated with a circle metal coating with middle part, can simplify setting of using during surgery
Standby, metal coating positioning is more accurate, saves operating time.
Preferably, the single layer sacculus and the material of double-layered balloon and metal coating are tool biocompatibility material.
A kind of blood saccule stent drug release device, including above-mentioned single layer sacculus or double-layered balloon and holder, institute
It states single layer sacculus or double-layered balloon is arranged at the middle part of the holder.
Blood saccule adds the structure of holder that can ensure that blood vessel is placed in inner support to reach support stenosis occlusion in lesion
Section blood vessel reduces blood vessel elasticity retraction and again contracting shape, the purpose for keeping tube chamber blood flow unobstructed.Drug in blood saccule has pre-
The effect of preventing restenosis of blood vessel, it is ensured that the blood saccule holder using effect time is long.
The medicine release method of single layer sacculus and single layer balloon-stent drug release device, which is characterized in that single layer ball
The medicine release method of medicine capsule release device, includes the following steps：
(1) single layer sacculus being placed into designated position, profit, which pumps up, injects contrast agent the inside of sacculus internal layer,
The contrast agent of detecting instrument detecting sacculus internal layer is used in combination, judges whether intravascular stent is rivals in a contest position；
(2) contrast agent is injected into single layer balloon interior using by pump pressurization, makes balloon inflation, is located at drug containing in sacculus surface layer
The degradable micropin of object injects in vascular wall immediately；
(3) after the drug all injection vessel outer wall, the single layer sacculus is recycled；
The medicine release method of single layer balloon-stent drug release device, includes the following steps：
(1) single layer sacculus is placed on internal stent, intravascular stent is placed into designated position, profit pumps up radiography
The inside of sacculus internal layer is injected in agent, and single layer balloon inflation is made to strut holder, and the contrast agent of detecting instrument detecting sacculus internal layer is used in combination,
Judge whether intravascular stent is rivals in a contest position；
(2) contrast agent is injected into single layer balloon interior using by pump pressurization, makes balloon inflation, is located at drug containing in sacculus surface layer
The degradable micropin of object with i.e. will be in infusion of medicine vascular wall；
(3) after the drug all injection vessel outer wall, the single layer sacculus is recycled；
The medicine release method of double-layered balloon and double-layered balloon stent drug release device, which is characterized in that double-layer ball
The medicine release method of medicine capsule release device, includes the following steps：
(1) cavity, as middle layer are constituted by the outer layer of the internal layer of the double-layered balloon and the sacculus, drug is pre-
First inject the cavity inside；
(2) double-layered balloon is placed into designated position, is used for detecting sacculus and whether is rivals in a contest position there are two types of mode, (a) profit
It pumps up and contrast agent is injected to the inside of sacculus internal layer, the contrast agent of detecting instrument detecting double-layered balloon internal layer is used in combination, judges
Whether double-layered balloon is rivals in a contest position, and (b) profit, which pumps up, injects liquid into the inside of double-layered balloon internal layer, and detecting instrument is used in combination to detect
Both ends and the intermediate ends metal coating for surveying double-layered balloon outer layer judge whether intravascular stent is rivals in a contest position；
(3) it is strutted therewith using double-layered balloon, the tip-like through hole of the double-layered balloon outer layer described in pump pressurizing and propping,
The drug of the cavity inside of the double-layered balloon is injected by the tip-like through hole in vascular wall；
(4) after the drug all injection blood vessel, the sacculus is recycled.
Preferably, the detecting instrument includes CT machines, fluorescence analyser, X-ray.
Optionally, the contrast agent include sulfuric acid to methylamino phenol, to hydroxymethyl aniline sulfate, iodine solution.
Optionally, the liquid includes that distilled water etc. is non-corrosive, non-toxic liquid.
Preferably, in said medicine method for releasing, the drug can be anticoagulant, anti-infectious agent, anticarcinogen and
Anti-inflammatory medicine etc. contributes to prevention of postoperative infection medicine.
Preferably, in said medicine method for releasing, pump is forced into 5~12 standard atmospheric pressures in the step (2).
The medicine release method of double-layered balloon stent drug release device, includes the following steps：
(1) cavity, as middle layer are constituted by the outer layer of the internal layer of the double-layered balloon and the sacculus, drug is pre-
First inject the cavity inside；
(2) double-layered balloon is placed on internal stent, intravascular stent is placed into designated position, there are two types of modes to be used for detecing
Survey whether sacculus is rivals in a contest position, (a) profit, which pumps up, injects contrast agent the inside of sacculus internal layer, is used in combination detecting instrument detecting double
The contrast agent of layer sacculus internal layer, judges whether intravascular stent is rivals in a contest position, and (b) profit, which pumps up, injects liquid into sacculus internal layer
Both ends and the middle part metal coating of detecting instrument detecting double-layered balloon outer layer is used in combination in inside, judges whether intravascular stent is rivals in a contest position
It sets；
(3) using pump pressurizing and propping holder while, the tip-like through hole of the double-layered balloon outer layer struts therewith, institute
The drug for stating the cavity inside of double-layered balloon is injected by the tip-like through hole in vascular wall；
(4) after the drug all injection blood vessel, the sacculus is recycled.
Preferably, the detecting instrument includes CT machines, fluorescence analyser, X-ray.
Optionally, the contrast agent include sulfuric acid to methylamino phenol, to hydroxymethyl aniline sulfate, iodine solution.
Optionally, the liquid includes that distilled water etc. is non-corrosive, non-toxic liquid.
Preferably, in said medicine method for releasing, the drug can be anticoagulant, anti-infectious agent, anticarcinogen and
Anti-inflammatory medicine etc. contributes to prevention of postoperative infection medicine.
Preferably, in said medicine method for releasing, pump is forced into 5~12 standard atmospheric pressures in the step (3).
It can be seen via above technical scheme that compared with prior art, the present disclosure provides a kind of blood saccule, balls
Capsule stent drug release device and its medicine release method, on the one hand by the way that the surface layer of blood saccule is fabricated to degradable micropin
Or tip-like, the hangnail relative to traditional blood saccule outer layer are designed, are not only reduced to the injury of blood vessel, but also be more suitable for medicine
The release of object；On the other hand profit pumps up and is directly directly injected into drug by the through-hole that degradable micropin or tip-like design
In vascular wall, rather than the surface layer coated in blood saccule, the injection rate of drug can not only be increased, and blood vessel pair can be improved
The assimilation effect of drug, so that targetedly more efficiently, finally blood saccule is used in combination with holder for drug therapy,
It can ensure that blood vessel is placed in inner support to reach support stenosis occlusion section blood vessel in lesion, reduce blood vessel elasticity retraction and contract again
Shape, the purpose for keeping tube chamber blood flow unobstructed.Drug in blood saccule has the function of pre- preventing restenosis of blood vessel, it is ensured that blood
The pipe balloon-stent using effect time is long.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 attached drawings are the structural schematic diagram of 1 single layer balloon-stent of the embodiment of the present invention.
Fig. 2 attached drawings are the structural schematic diagram of 2 double-layered balloon holder of the embodiment of the present invention.
Fig. 3 attached drawings are the structural schematic diagram of 3 double-layered balloon holder of the embodiment of the present invention.
Fig. 4 attached drawings are the surface texture surface enlarged drawing of single layer sacculus of the present invention.
Fig. 5 attached drawings are the surface texture surface enlarged drawing of double-layered balloon of the present invention
Fig. 6 attached drawings are the medicine release method flow chart of 2 single layer balloon-stent drug release device of embodiment.
Fig. 7 attached drawings are the medicine release method flow chart of 3 double-layered balloon stent drug release device of embodiment.
Fig. 8 attached drawings are the medicine release method flow chart of 4 double-layered balloon stent drug release device of embodiment.
In figure：1 is holder；21 be single layer sacculus；22 be double-layered balloon；3 be degradable micropin；31 be through hole；4 be interior
Layer；5 be outer layer；6 be metal coating.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The embodiment of the invention discloses a kind of blood saccule, balloon-stent drug release device and its drug release side
Method, not only nocuity is small, but also with obvious effects, and mode is simple, great market application and promotional value.
A kind of blood saccule drug release device, including single layer sacculus 21 and double-layered balloon 22；The surface layer of single layer sacculus 21
It is provided with multiple degradable micropins 3 for being ranked sequentially interior drug containing, double-layered balloon 22 includes internal layer 4, middle layer and outer layer 5,
Middle layer is set as cavity, drug containing in cavity, and the surface layer of outer layer 5 is equipped with multiple tactic tip-like through holes 31.
5 both ends of outer layer of double-layered balloon 22 are all coated with a circle metal coating 6 with middle part, and are connected the one of one end with conduit
Circle metal coating is equipped with the through-hole being connect with conduit.
Single layer sacculus 21 and the material of double-layered balloon 22 and metal coating 6 are tool biocompatibility material, more specifically
For materials such as nickel chromium stainless steel, vitallium and titaniums.
A kind of blood saccule stent drug release device, including above-mentioned single layer sacculus 21 or double-layered balloon 22 and holder
1, single layer sacculus 21 or double-layered balloon 22 are arranged at the middle part of holder 1.
Embodiment 1：
A kind of blood saccule drug release device, including single layer sacculus 21 or double-layered balloon 22；The surface layer of single layer sacculus 21
It is provided with multiple degradable micropins 3 for being ranked sequentially interior drug containing, double-layered balloon 22 includes internal layer 4, middle layer and outer layer 5,
Middle layer is set as cavity, drug containing in cavity, and the surface layer of outer layer 5 is equipped with multiple tactic tip-like through holes 31.
5 both ends of outer layer of double-layered balloon 22 are all coated with a circle metal coating 6 with middle part, and are connected the one of one end with conduit
Circle metal coating is equipped with the through-hole being connect with conduit.
Single layer sacculus 21 and the material of double-layered balloon 22 and metal coating 6 are tool biocompatibility material, more specifically
For materials such as nickel chromium stainless steel, vitallium and titaniums.
The medicine release method of single layer sacculus drug release device, includes the following steps：
(1) single layer sacculus 21 is placed into designated position, being forced into 1 standard atmospheric pressure using pump notes contrast agent
The inside of the intracapsular layer of goal is used in combination CT machines, fluorescence analyser, X-ray instrument to detect the contrast agent inside single layer sacculus 21, judges that it is
No position of being rivals in a contest
(2) 7 standard atmospheric pressures are forced by inside contrast agent injection single layer sacculus 21 using by pump, make single layer sacculus 21
Expansion, be located at 21 surface layer of single layer sacculus in drug containing degradable micropin 3 with i.e. will be in infusion of medicine vascular wall；
(3) after said medicine all injection vessel outer wall, single layer sacculus 21 is recycled；
The medicine release method of double-layered balloon drug release device, includes the following steps：
(1) internal layer 4 of double-layered balloon 22 and outer layer 5 constitute a cavity, as middle layer, and drug is previously implanted in cavity
Portion；
(2) double-layered balloon 22 is placed into designated position, is used for detecting sacculus and whether is rivals in a contest position there are two types of mode, utilizes
Pump be forced into 1.2 standard atmospheric pressures by distilled water inject 22 internal layer 4 of double-layered balloon inside, be used in combination CT machines, fluorescence analyser,
X-ray instrument detects both ends and the intermediate ends metal coating of 22 outer layer 5 of double-layered balloon, judges whether intravascular stent is rivals in a contest position；
(3) 12 standard atmospheric pressures are forced into using pump and strut double-layered balloon 22, the tip-like of 22 outer layer 5 of double-layered balloon is passed through
Perforation struts therewith, and the drug of the cavity inside of double-layered balloon is injected by tip-like through hole 31 in vascular wall；
(4) after drug all injection blood vessel, double-layered balloon 22 is recycled.
Embodiment 2:
As shown in Fig. 1, Fig. 4 and Fig. 6, a kind of blood saccule stent drug release device, the intravascular stent is by 1 He of holder
21 two parts of single layer sacculus form, and single layer sacculus 21 is arranged at the middle part of holder 1；The surface layer of single layer sacculus 21 is provided with multiple suitable
The degradable micropin 3 of drug containing in sequence arrangement；
The medicine release method of single layer sacculus and single layer balloon-stent drug release device uses a kind of blood among the above
Pipe balloon-stent drug release device, including single layer sacculus and single layer balloon-stent.
The medicine release method of single layer sacculus drug release device, includes the following steps：
(1) single layer sacculus 21 is placed into designated position, using pump be forced into 1.5 standard atmospheric pressures by with single layer ball
The conduit that capsule 21 connects is pushed into contrast agent, and CT machines, fluorescence analyser, X-ray instrument is used in combination to detect the contrast agent inside single layer sacculus 21,
Judge its position of whether being rivals in a contest；
(2) 5 standard atmospheric pressures are forced into using pump, the inside of contrast agent injection single layer sacculus 21 is allowed to strut ball
The degradable micropin 3 on capsule surface layer, the infusion of medicine vascular wall that degradable micropin 3 will include；
(3) said medicine all injection vessel outer walls are waited for, after holder supports to place, contrast agent etc. will be with single layer sacculus 2
Recycling；
The medicine release method of single layer balloon-stent drug release device, includes the following steps：
(1) single layer sacculus 21 is placed on inside holder 1, holder 1 is placed into designated position, 1.5 are forced into using pump
A standard atmospheric pressure is pushed into contrast agent by the conduit being connect with single layer sacculus 21, and CT machines, fluorescence analyser, X-ray instrument is used in combination to detect
The contrast agent for surveying single layer balloon interior, judges its position of whether being rivals in a contest；
(2) 7 standard atmospheric pressures are forced into using pump, the inside of contrast agent injection single layer sacculus 21 is allowed to strut branch
Frame 1, the degradable micropin 3 positioned at 21 surface layer of single layer sacculus strut therewith, the infusion of medicine blood vessel that degradable micropin 3 will include
Wall；
(3) drug all injection vessel outer walls are waited for, after holder 1 supports to place, contrast agent etc. will be with single layer sacculus
21 recycling；
The embodiment of the present invention 1 is suitable for blood vessel Minimal change, generates slight embolism, and the present invention can be by drug by can
Degradation 3 drug of micropin is directly released into blood vessel, and specific aim is stronger, also smaller to the destructiveness of blood vessel, and unit area
Dose is big, can ensure that the blood vessel of diseased region not will produce the effect of restenosis for a long time.
Embodiment 3：
As shown in Fig. 2, Fig. 5 and Fig. 7, a kind of blood saccule stent drug release device, the intravascular stent be by 1 holder and
22 two parts of double-layered balloon form, and double-layered balloon 22 is arranged at the middle part of holder 1；；Double-layered balloon 22 includes internal layer 4 and outer layer
5, internal layer 4 is previously implanted with formation cavity, as middle layer, drug among outer layer 5 inside middle layer, the surface layer setting of outer layer 5
There are multiple tactic tip-like through holes 31；
The medicine release method of double-layered balloon and double-layered balloon stent drug release device uses a kind of blood among the above
Pipe balloon-stent drug release device, including double-layered balloon and double-layered balloon holder.
The medicine release method of double-layered balloon drug release device, includes the following steps：
(1) inside the middle layer for constituting the outer layer 5 of internal layer 4 and sacculus that drug is previously implanted double-layered balloon；
(2) double-layered balloon is placed into designated position, it is double by contrast agent injection to be forced into 1.5 standard atmospheric pressures using pump
The inside of layer 22 internal layer of sacculus is used in combination the contrast agent of CT machines, X-ray instrument detecting 22 internal layer of double-layered balloon, judges whether holder 1 is rivals in a contest
Position；
(3) the tip-like through hole 31 that 8 22 outer layers 5 of standard atmospheric pressure double-layered balloon are forced into using pump is strutted, double-deck
The drug of the cavity inside of sacculus 22 injects vascular wall by tip-like through hole 31；
(4) after said medicine all injection blood vessel, contrast agent etc. will be recycled with double-layered balloon 22.
The medicine release method of double-layered balloon stent drug release device, includes the following steps：
(1) inside the middle layer for constituting the outer layer 5 of internal layer 4 and sacculus that drug is previously implanted double-layered balloon；
(2) double-layered balloon is placed on inside holder 1, holder 1 is placed into designated position, 2 marks are forced into using pump
Contrast agent is injected the inside of 22 internal layer of double-layered balloon by quasi- atmospheric pressure, and CT machines, X-ray instrument is used in combination to detect making for 22 internal layer of double-layered balloon
Shadow agent judges whether holder 1 is rivals in a contest position；
(3) while being forced into 8 standard atmospheric pressures using pump and strut holder 1 using double-layered balloon 22, it is located at double-layer ball
The tip-like through hole 31 of 22 outer layer 5 of capsule struts therewith, and the drug of the cavity inside of double-layered balloon 22 passes through tip-like through hole
31 injection vascular walls；
(4) drug all injection blood vessels are waited for, after holder 1 supports to place, contrast agent etc. will be returned with double-layered balloon 22
It receives.
Embodiment 4：
As shown in Fig. 3, Fig. 5 and Fig. 8, a kind of blood saccule stent drug release device, the intravascular stent is by 1 He of holder
22 two parts of double-layered balloon form, and double-layered balloon 22 is arranged at the middle part of holder 1；Double-layered balloon 22 includes internal layer 4 and outer layer
5, internal layer 4 is previously implanted with formation cavity, as middle layer, drug among outer layer 5 inside middle layer, the surface layer setting of outer layer 5
There are multiple tactic tip-like through holes 31；The both ends of double-layered balloon 22 are all coated with a circle metal coating 6 with middle part, and
The metal coating 6 of one end of being connected with conduit is equipped with the through-hole that is connect with conduit；
The medicine release method of double-layered balloon and double-layered balloon stent drug release device uses a kind of blood among the above
Pipe balloon-stent drug release device, including double-layered balloon and double-layered balloon holder.
The medicine release method of double-layered balloon drug release device, includes the following steps：
(1) in the middle layer for constituting the outer layer 5 of internal layer 4 and double-layered balloon 22 that drug is previously implanted double-layered balloon 22
Portion；
(2) double-layered balloon 22 is placed into designated position, is used for detecting sacculus and whether is rivals in a contest position there are two types of mode, (a)
Profit pumps up 2 standard atmospheric pressures by the inside of contrast agent injection 22 internal layer of double-layered balloon, utilizes CT machines, fluorescence analyser, X
Light instrument detects the contrast agent of 22 internal layer of double-layered balloon, judges whether holder 1 is rivals in a contest position；(b) profit pumps up 2 normal atmospheres
Distilled water is injected the inside of 22 internal layer of double-layered balloon by pressure, and the both ends of CT machines detecting double-layered balloon outer layer is used in combination to be applied with middle part metal
Layer 6 judges whether double-layered balloon 22 is rivals in a contest position；
(3) the tip-like through hole 31 that 12 22 outer layers 5 of standard atmospheric pressure double-layered balloon are forced into using pump is strutted therewith,
The drug of the cavity inside of double-layered balloon 22 injects vascular wall by tip-like through hole 31；
(4) after said medicine all injection blood vessel, contrast agent or distilled water are recycled with double-layered balloon 22.
The medicine release method of double-layered balloon stent drug release device, includes the following steps：
(1) in the middle layer for constituting the outer layer 5 of internal layer 4 and double-layered balloon 22 that drug is previously implanted double-layered balloon 22
Portion；
(2) double-layered balloon 22 is placed on inside holder 1, holder 1 is placed into designated position, there are two types of modes to be used for detecing
Survey whether sacculus is rivals in a contest position, (a) profit 2 standard atmospheric pressures that pump up inject contrast agent in 22 internal layer of double-layered balloon
Portion detects the contrast agent of 22 internal layer of double-layered balloon using CT machines, fluorescence analyser, X-ray instrument, judges whether holder 1 is rivals in a contest position；
(b) profit pumps up 2 standard atmospheric pressures by the inside of distilled water injection 22 internal layer of double-layered balloon, and CT machines is used in combination to detect double-layer ball
The both ends of capsule outer layer and middle part metal coating 6 judge whether holder 1 is rivals in a contest position；
(3) while being forced into 12 standard atmospheric pressure double-layered balloons 22 using pump and strut holder 1, it is located at double-layered balloon 22
The tip-like through hole 31 of outer layer 5 struts therewith, and the drug of the cavity inside of double-layered balloon 22 passes through 31 note of tip-like through hole
Enter vascular wall；
(4) after the drug all injection blood vessel, after holder 1 supports to place, contrast agent or distilled water are with double-layered balloon
22 recycling.
The embodiment of the present invention 3 and 4 is suitable for blood vessel moderate or severe lesion, generates serious embolism, and the present invention can incite somebody to action
Drug is directly released into blood vessel by 31 drug of tip-like through hole, and specific aim is stronger, also smaller to the destructiveness of blood vessel,
And unit area dose bigger can ensure that the blood vessel of diseased region not will produce the effect of restenosis for a long time.
In medicine release method in above-described embodiment 1,2,3,4, contrast agent include sulfuric acid to methylamino phenol, to hydroxyl
Methyl aniline sulfate, iodine solution, liquid include water, medicinal alcohol or other non-corrosive, non-toxic liquid.
In medicine release method in above-described embodiment 1,2,3,4, drug is anticoagulant, anti-infectious agent, anticarcinogen
And anti-inflammatory medicine.
During intravascular stent is prevented, internal blood vessel can unavoidably by some small " scuffings ", it is this " stroke
Wound " can also activate the clotting mechanism of our bodies, blood platelet that can go out clustering phenomena, thus be likely to form another thrombus, this
Drug can be directly released into blood vessel, specific aim by drug by invention by degradable micropin 3 or tip-like through hole 31
It is stronger, it is also smaller to the destructiveness of blood vessel, and unit area dose is big, can ensure that the blood vessel of support portions for a long time will not
Generate the effect of restenosis.
Each embodiment is described by the way of progressive in this specification, the highlights of each of the examples are with other
The difference of embodiment, just to refer each other for identical similar portion between each embodiment.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so description is fairly simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (10)
1. a kind of blood saccule drug release device, which is characterized in that including single layer sacculus or double-layered balloon；The single layer sacculus
Surface layer be provided with multiple degradable micropins for being ranked sequentially interior drug containing, the double-layered balloon include internal layer, middle layer and
Outer layer, the middle layer are set as cavity, drug containing in the cavity, and the surface layer of outer layer is equipped with multiple tactic tip-likes
Through hole.
2. a kind of blood saccule drug release device according to claim 1, which is characterized in that outside the double-layered balloon
Layer both ends and middle part are all coated with a circle metal coating, and a circle metal coating of the one end that is connected with conduit is equipped with and is connect with conduit
Through-hole.
3. a kind of blood saccule drug release device according to claim 2, which is characterized in that the single layer sacculus and double
The material of layer sacculus and metal coating is tool biocompatibility material.
4. a kind of blood saccule stent drug release device, which is characterized in that including claim 1-3 any one of them single layers
Sacculus or double-layered balloon and holder, the single layer sacculus or double-layered balloon are arranged at the middle part of the holder.
5. the medicine release method of single layer sacculus and single layer balloon-stent drug release device, which is characterized in that single layer sacculus
The medicine release method of drug release device, includes the following steps：
(1) single layer sacculus is placed into designated position, profit, which pumps up, injects contrast agent the inside of sacculus internal layer, is used in combination
Detecting instrument detects the contrast agent of sacculus internal layer, judges whether intravascular stent is rivals in a contest position；
(2) contrast agent is injected into single layer balloon interior using by pump pressurization, makes balloon inflation, be located at drug containing in sacculus surface layer
Degradable micropin with i.e. will be in infusion of medicine vascular wall；
(3) after the drug all injection vessel outer wall, the single layer sacculus is recycled；
The medicine release method of single layer balloon-stent drug release device, includes the following steps：
(1) single layer sacculus is placed on internal stent, intravascular stent is placed into designated position, profit, which pumps up, notes contrast agent
The inside of the intracapsular layer of goal, makes single layer balloon inflation strut holder, and the contrast agent of detecting instrument detecting sacculus internal layer is used in combination, judges
Whether intravascular stent is rivals in a contest position；
(2) contrast agent is injected into single layer balloon interior using by pump pressurization, makes balloon inflation, be located at drug containing in sacculus surface layer
Degradable micropin injects in vascular wall immediately；
(3) drug all injection vessel outer walls are waited for, after holder supports to place, contrast agent is recycled with the single layer sacculus；.
6. the medicine release method of double-layered balloon and double-layered balloon stent drug release device, which is characterized in that double-layered balloon
The medicine release method of drug release device, includes the following steps：
(1) cavity, as middle layer are constituted by the outer layer of the internal layer of the double-layered balloon and the sacculus, drug is noted in advance
Enter the cavity inside；
(2) double-layered balloon is placed into designated position, is used for detecting sacculus and whether is rivals in a contest position there are two types of mode, (a) utilizes pump
Contrast agent is injected the inside of sacculus internal layer by pressurization, and the contrast agent of detecting instrument detecting double-layered balloon internal layer is used in combination, judges blood vessel
Whether holder is rivals in a contest position, and (b) profit, which pumps up, injects liquid into the inside of sacculus internal layer, and balloon inflation is made to strut holder, and
Both ends and the intermediate ends metal coating that double-layered balloon outer layer is detected with detecting instrument judge whether intravascular stent is rivals in a contest position；
(3) using double-layered balloon described in pump pressurizing and propping, the tip-like through hole of the double-layered balloon outer layer struts therewith, described
The drug of the cavity inside of double-layered balloon is injected by the tip-like through hole in vascular wall；
(4) after the drug all injection vessel outer wall, the sacculus is recycled.
The medicine release method of double-layered balloon stent drug release device, includes the following steps：
(1) cavity, as middle layer are constituted by the outer layer of the internal layer of the double-layered balloon and the sacculus, drug is noted in advance
Enter the cavity inside；
(2) double-layered balloon is placed on internal stent, holder is placed into designated position, there are two types of modes for detecting sacculus is
No position of being rivals in a contest, (a) profit, which pumps up, injects contrast agent the inside of sacculus internal layer, is used in combination in detecting instrument detecting double-layered balloon
The contrast agent of layer, judges whether holder is rivals in a contest position, and (b) profit, which pumps up, injects liquid into the inside of sacculus internal layer, and inspection is used in combination
Both ends and the middle part metal coating for surveying instrument detecting double-layered balloon outer layer judge whether intravascular stent is rivals in a contest position；
(3) using pump pressurizing and propping holder while, the tip-like through hole of the double-layered balloon outer layer struts therewith, described double
The drug of the cavity inside of layer sacculus is injected by the tip-like through hole in vascular wall；
(4) drug all injection vessel outer walls are waited for, after holder supports to place, contrast agent or distilled water are returned with double-layered balloon
It receives.
7. the medicine release method of single layer sacculus according to claim 5 and single layer balloon-stent drug release device,
It is characterized in that, the detecting instrument includes CT machines, fluorescence analyser, X-ray.
8. the medicine release method of single layer sacculus according to claim 5 and single layer balloon-stent drug release device,
It is characterized in that, the contrast agent include sulfuric acid to methylamino phenol, to hydroxymethyl aniline sulfate, iodine solution；The liquid
For distilled water or other non-corrosive, non-toxic liquid.
9. the medicine release method of single layer sacculus according to claim 5 and single layer balloon-stent drug release device,
It is characterized in that, the drug is anticoagulant, anti-infectious agent, anticarcinogen and anti-inflammatory medicine.
10. the medicine release method of single layer sacculus according to claim 5 and single layer balloon-stent drug release device,
It is characterized in that, pump is forced into 5~12 standard atmospheric pressures in the step (2).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018103630326 | 2018-04-21 | ||
| CN201810363032 | 2018-04-21 |
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| CN108742959A true CN108742959A (en) | 2018-11-06 |
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| CN201820878762.5U Active CN209790103U (en) | 2018-04-21 | 2018-06-07 | Drug release device for blood vessel saccule and saccule support |
| CN201810582937.2A Pending CN108742959A (en) | 2018-04-21 | 2018-06-07 | A kind of blood saccule, balloon-stent drug release device and its medicine release method |
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| CN110786174A (en) * | 2019-11-06 | 2020-02-14 | 贵州省烟草公司黔南州公司 | Embedded type plant medicine injection device |
| CN111905240A (en) * | 2019-05-08 | 2020-11-10 | 上海微创医疗器械（集团）有限公司 | Drug balloon and preparation method thereof |
| CN114225185A (en) * | 2021-11-05 | 2022-03-25 | 广东博迈医疗科技股份有限公司 | Drug delivery balloon and drug delivery device |
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| CN209790103U (en) * | 2018-04-21 | 2019-12-17 | 李皇德 | Drug release device for blood vessel saccule and saccule support |
| CN113018660A (en) * | 2021-03-16 | 2021-06-25 | 中国科学技术大学 | Microneedle balloon for interventional drug delivery |
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| CN209790103U (en) | 2019-12-17 |
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