CN104922784A - Drug balloon catheter - Google Patents
Drug balloon catheter Download PDFInfo
- Publication number
- CN104922784A CN104922784A CN201510378938.1A CN201510378938A CN104922784A CN 104922784 A CN104922784 A CN 104922784A CN 201510378938 A CN201510378938 A CN 201510378938A CN 104922784 A CN104922784 A CN 104922784A
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- cavity
- coating
- balloon
- sacculus
- catheter body
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Abstract
The embodiment of the present invention discloses a drug balloon catheter, and belong to the technical field of medical equipment. The problem that blood flow is blocked when balloon dilatation happens is solved, and complications are prevented. The drug balloon catheter provided by the embodiment of the present invention comprises a drug balloon and a catheter body connected with the drug balloon; an external surface of the drug balloon is provided with a drug coating layer; an inner cavity of the catheter body is provided with a first cavity body and a second cavity body; the first cavity body allows a guide wire to pass through; and the second cavity body allows blood to pass through. The second cavity body is disposed in the catheter body to allow the blood to pass through, when the balloon dilatation happens, the blood can pass through the second cavity body and flow, the blood cannot be blocked, and the complications are prevented.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly relate to a kind of medicinal balloon catheter.
Background technology
Angiostenosis easily causes vascular flow smooth, and even artery-clogging causes life danger, and the primary treatments at present for angiostenosis is comprised arrangement intravascular stent and treated by medicinal balloon delivering medicament.
Intravascular stent refers to that inserting inner support in pathological changes section supports stenosis occlusion section blood vessel to reach, reduce blood vessel elasticity retraction and moulding again, keep tube chamber blood flow unobstructed, but owing to accepting PCI (percutaneouscoronary intervention, percutaneous coronary intervention (pci)) patient populations rise year by year, the quantity of patient that stent restenosis occurs also increases gradually.
Through external a large amount of clinical verification, medicinal balloon delivering medicament treatment Ink vessel transfusing is narrow has significant advantage with in-stent restenosis, compared with the multiple treatment means used at present, its blood vessel and stent restenosis rate lower, not there is DES (Drug-Eluting sten, bracket for eluting medicament) drug release use polymer, the reaction that causes inflammation can be avoided, reduce the potential risk of antiplatelet aggregation treatment, there is ideal effectiveness or safety, become the emphasis of medical domain research both at home and abroad at present.
Summary of the invention
Inventor finds through research, on medicinal balloon is narrow in the pathological changes and support for the treatment of vascular occlusion, there is significant advantage, and be considered to effective treatment means for the treatment of vascular occlusion pathological changes and in-stent restenosis, but the blood flow at existing medicinal balloon meeting blocking lesion position when expanding, easily causes complication.
Further, the problem that the utilization rate of the medicine that the medicine that the present invention can also solve existing medicinal balloon surface-coated easily causes by washing away of blood flow is low.
The embodiment of the present invention provides a kind of medicinal balloon catheter, comprising:
Catheter body, is arranged on the sacculus on catheter body;
The outer surface of described sacculus is provided with medication coat;
Be axially arranged with the first cavity and the second cavity along catheter body in the inner chamber of described catheter body, the first cavity and the second cavity run through the catheter body arranging balloon portion;
Wherein, described first cavity passes through for seal wire; Second cavity passes through for blood.
Preferably, described second cavity is provided with opening at catheter body near-end, and blood supply liquid stream goes out.
Preferably, the outer surface of described sacculus is through Cement Composite Treated by Plasma.
Preferably, described medication coat comprises the first coating and the second coating;
Wherein, the first coating, in balloon surface, is lipophilic drugs, or the mixture of lipophilic drugs and hydrophilic aids;
Second coating, above the first coating, is hydrophilic auxiliary agent.
Preferably, lipophilic drugs comprises: the derivant of paclitaxel, rapamycin or rapamycin.
Preferably, hydrophilic auxiliary agent comprises: carbamide, Iopromide, alcohols material or aminoacid.
Preferably, also comprise: be arranged on the 3rd coating between medication coat and balloon surface, described 3rd coating is ehter bond layer.
Preferably, the catheter body running through balloon portion is provided with metal platinum loop, locates for sacculus.
Compared with prior art, technical scheme provided by the invention has the following advantages:
Medicinal balloon catheter provided by the invention, in the inner chamber of catheter body, be also provided with the first cavity and the second cavity, described first cavity passes through for seal wire, guides sacculus to arrive diseased region by seal wire, second cavity passes through for blood, when balloon expandable, the blood vessel of diseased region can be strutted, now, blood flow to opposite side by the second cavity from the side of sacculus, avoid the situation of balloon expandable blocking blood flow in prior art, further, avoid because blood flow is blocked the generation of the complication caused.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of a kind of medicinal balloon catheter provided by the invention;
Fig. 2 is the structural representation of sacculus coating in a kind of medicinal balloon catheter provided by the invention.
Detailed description of the invention
The embodiment of the present invention provides a kind of medicinal balloon catheter, its core concept is: have mutually independent and distribute side by side the second cavity that blood supply flows through and the first cavity guiding silk guide passage in catheter body, when balloon expandable blocking blood flow, blood flow enters downstream by the second cavity from upstream, can not block completely, avoid leading to complications.In addition, the medication coat of balloon surface adopts the mode of two-double spray coating, and in course of conveying, outermost hydrophilic protective layer can be washed, and in time arriving pathological changes, just exposes medicine layer, balloon expandable, medicine is fully contacted with blood vessel wall.
The present invention program is understood better in order to make those skilled in the art person, below in conjunction with the accompanying drawing in the embodiment of the present invention, technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the embodiment of a part of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, should belong to the scope of protection of the invention.
Below in conjunction with drawings and Examples, disclosed in detail further description is done to the specific embodiment of the present invention.
Shown in figure 1, be the structural representation of a kind of medicinal balloon catheter provided by the invention, the foley's tube that the present embodiment provides specifically can comprise: sacculus 3, the catheter body 7 be connected with sacculus 3, and sacculus is arranged on catheter body 7; The outer surface of described sacculus is provided with medication coat 6; Be provided with the first cavity 1 and the second cavity 2, first cavity and the second cavity in the inner chamber of described catheter body axially to arrange along catheter body in catheter body, and the first cavity and the second cavity run through the catheter body arranging balloon portion; Wherein, described first cavity passes through for seal wire; Second cavity passes through for blood.
The outer surface of medicinal balloon scribbles medicine, this medicine can for suppressing the medicine of vascular restenosis, before medicinal balloon arrives diseased region, sacculus is in the state of tightening up, guided by seal wire and deliver to diseased region, now blood flow flows through balloon surface in the blood vessel, and because sacculus tightens up, blood flow can not pass through from the second cavity.When sacculus arrives diseased region, sacculus is expanded by pressurizeing gradually, prop up the blood vessel of diseased region, sacculus and vessel wall contact, the medicine on sacculus external surface coating can intravasation wall, now, blood flows through sacculus by the second cavity, namely, when balloon expandable, blood flow can not be caused to be blocked completely, to avoid the generation of complication.
Medicinal balloon catheter provided by the invention, the first cavity and the second cavity is also provided with in the inner chamber of catheter body, described first cavity passes through for seal wire, sacculus is guided to reach diseased region accurately by seal wire, second cavity passes through for blood, when balloon expandable, the blood vessel of diseased region can be strutted, now, blood flow to opposite side by the second cavity from the side of sacculus, avoid the situation of balloon expandable blocking blood flow in prior art, further, avoid because blood flow is blocked the generation of the complication caused.
Preferably, in certain embodiments, the second cavity in catheter body is provided with opening (shown in figure 1) at the near-end that catheter body is connected with sacculus, and blood can be made to flow through sacculus intravasation as early as possible.In order to locate sacculus accurately, make sacculus can arrive diseased region accurately, metal platinum loop (shown in figure 1, for 4 metal platinum loops in Fig. 1) can be set on the catheter body running through balloon portion, for labelling and the location of sacculus.
Above embodiments enable the not current limliting of balloon expandable to blood, but ensureing that balloon expandable can not cause blood flow to block completely and then on the basis that leads to complications, how to ensure that medicine is in the process being delivered to diseased region, can not be washed away by blood flow as far as possible, the utilization rate improving medicine is the technical problem that the present invention will solve further.
Therefore, in order to solve the problem, further, the outer surface of medicinal balloon can be carried out Cement Composite Treated by Plasma to increase the roughness of balloon surface, sacculus can be reduced like this in the process arriving diseased region, blood flow washes away balloon surface medication coat, reduces the loss of medicine as far as possible.
Further, the medication coat of balloon surface adopts double-deck medicine coating, resist blood flow washing away medicine, with reference to the balloon surface medication coat schematic diagram shown in figure 2, preferably, described double-deck medicine coating comprises the first coating and the second coating, and wherein the first coating is in balloon surface, for lipophilic drugs, or the mixture of lipophilic drugs and hydrophilic aids; Second coating, above the first coating, is hydrophilic auxiliary agent.The hydrophilic aids of the second coating can protect the medicine of the first coating not washed away by blood flow when being delivered to diseased region.When practical operation, the spraying process of double-deck medicine coating is: the first step is sprayed on balloon surface by after lipophilic medicine and the mixing of hydrophilic auxiliary agent, forms the first coating, after solvent volatilization, pure hydrophilic aids is sprayed in the first coating, as the second coating.
Preferably, described lipophilic drugs can comprise: the derivant of paclitaxel, rapamycin and/or rapamycin.Described hydrophilic auxiliary agent can comprise: carbamide, Iopromide, alcohols material or aminoacid.
When practical operation, the 3rd coating of a band ehter bond can also be applied between balloon surface and the first coating, increase the adhesion of medicine and balloon surface.
To sum up, the invention provides a kind of medicinal balloon catheter, be used for the treatment of in vascular occlusion pathological changes or support narrow, can pass through by guarantee section blood flow in use, while balloon expandable, be unlikely to cause blood flow ceases completely, avoid the generation of bad complication.Conduit is transported in the process of diseased region along seal wire, and protectiveness hydrophilic coating can be washed away by blood flow, when arriving diseased region, just exposes nexine medication coat.By pressurization, make balloon expandable, fit tightly with blood vessel wall, lipophilic medicine, under the effect of external force, enters into blood vessel wall.Lipophilic medicine can suppress the hypertrophy of endo cell, reduces angiostenosis rate.
Above embodiment only in order to technical scheme of the present invention to be described, is not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (8)
1. a medicinal balloon catheter, is characterized in that, comprising:
Catheter body, is arranged on the sacculus on catheter body;
The outer surface of described sacculus is provided with medication coat;
Be axially arranged with the first cavity and the second cavity along catheter body in the inner chamber of described catheter body, the first cavity and the second cavity run through the catheter body arranging balloon portion;
Wherein, described first cavity passes through for seal wire; Second cavity passes through for blood.
2. medicinal balloon catheter according to claim 1, is characterized in that, the near-end that described second cavity is connected with sacculus at catheter body is provided with opening, and blood supply liquid stream goes out.
3. medicinal balloon catheter according to claim 1, is characterized in that, the outer surface of described sacculus is through Cement Composite Treated by Plasma.
4. medicinal balloon catheter according to claim 1, is characterized in that, described medication coat comprises the first coating and the second coating;
Wherein, the first coating, in balloon surface, is lipophilic drugs, or the mixture of lipophilic drugs and hydrophilic aids;
Second coating, above the first coating, is hydrophilic auxiliary agent.
5. medicinal balloon catheter according to claim 4, is characterized in that, lipophilic drugs comprises: the derivant of paclitaxel, rapamycin or rapamycin.
6. medicinal balloon catheter according to claim 4, is characterized in that, hydrophilic auxiliary agent comprises: carbamide, Iopromide, alcohols material or aminoacid.
7. the medicinal balloon catheter according to claim 1 or 4, is characterized in that, also comprises: be arranged on the 3rd coating between medication coat and balloon surface, and described 3rd coating is ehter bond layer.
8. medicinal balloon catheter according to claim 1, is characterized in that, the catheter body running through balloon portion is provided with metal platinum loop, locates for sacculus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510378938.1A CN104922784A (en) | 2015-07-01 | 2015-07-01 | Drug balloon catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510378938.1A CN104922784A (en) | 2015-07-01 | 2015-07-01 | Drug balloon catheter |
Publications (1)
| Publication Number | Publication Date |
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| CN104922784A true CN104922784A (en) | 2015-09-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201510378938.1A Pending CN104922784A (en) | 2015-07-01 | 2015-07-01 | Drug balloon catheter |
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| CN (1) | CN104922784A (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288823A (en) * | 2015-11-27 | 2016-02-03 | 王显 | Drug eluting balloon system |
| CN105749407A (en) * | 2016-04-20 | 2016-07-13 | 周广如 | Balloon dilatation catheter for blood vessels or valves |
| CN106310495A (en) * | 2016-08-22 | 2017-01-11 | 苗立夫 | Perfusion and dilation balloon system |
| CN106621001A (en) * | 2015-10-27 | 2017-05-10 | 先健科技(深圳)有限公司 | Recyclable drug balloon catheter |
| CN107376028A (en) * | 2017-07-07 | 2017-11-24 | 辽宁垠艺生物科技股份有限公司 | A kind of medicine for covering air bag plastics pipe surface |
| CN107440764A (en) * | 2017-08-16 | 2017-12-08 | 北京赛铂医药科技有限公司 | A kind of conveying device of intravascular distal protector |
| CN108295360A (en) * | 2017-01-13 | 2018-07-20 | 翎秀生物科技（上海）有限公司 | A kind of medicine-coated balloon bracket component |
| CN108325050A (en) * | 2018-03-28 | 2018-07-27 | 周胜华 | A kind of novel cyclic sacculus and its application method |
| CN108742959A (en) * | 2018-04-21 | 2018-11-06 | 李皇德 | A kind of blood saccule, balloon-stent drug release device and its medicine release method |
| CN109481826A (en) * | 2018-11-05 | 2019-03-19 | 南京友德邦医疗科技有限公司 | A kind of drug coated balloon catheter and preparation method thereof |
| CN109938893A (en) * | 2017-12-18 | 2019-06-28 | 上海微创医疗器械（集团）有限公司 | Sacculus dilating catheter and its medicinal balloon |
| CN111658956A (en) * | 2020-06-29 | 2020-09-15 | 东莞科威医疗器械有限公司 | Improved arteriovenous cannula |
| CN111658955A (en) * | 2020-06-29 | 2020-09-15 | 东莞科威医疗器械有限公司 | Improved medical cannula |
| CN112336966A (en) * | 2020-05-27 | 2021-02-09 | 深圳北芯生命科技有限公司 | Microcatheter with dual lumen |
| CN112439122A (en) * | 2019-09-05 | 2021-03-05 | 尤东侠 | Balloon dilatation catheter |
| CN113262381A (en) * | 2021-07-02 | 2021-08-17 | 深圳麦普奇医疗科技有限公司 | Balloon dilatation catheter |
| CN113368371A (en) * | 2021-06-03 | 2021-09-10 | 复旦大学附属中山医院 | Medicine carrying balloon for preventing and treating benign stricture of esophagus |
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Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106621001A (en) * | 2015-10-27 | 2017-05-10 | 先健科技(深圳)有限公司 | Recyclable drug balloon catheter |
| CN106621001B (en) * | 2015-10-27 | 2020-03-13 | 先健科技(深圳)有限公司 | Medicine-recoverable balloon catheter |
| CN105288823A (en) * | 2015-11-27 | 2016-02-03 | 王显 | Drug eluting balloon system |
| CN105749407A (en) * | 2016-04-20 | 2016-07-13 | 周广如 | Balloon dilatation catheter for blood vessels or valves |
| CN106310495A (en) * | 2016-08-22 | 2017-01-11 | 苗立夫 | Perfusion and dilation balloon system |
| CN108295360A (en) * | 2017-01-13 | 2018-07-20 | 翎秀生物科技（上海）有限公司 | A kind of medicine-coated balloon bracket component |
| CN107376028A (en) * | 2017-07-07 | 2017-11-24 | 辽宁垠艺生物科技股份有限公司 | A kind of medicine for covering air bag plastics pipe surface |
| CN107440764A (en) * | 2017-08-16 | 2017-12-08 | 北京赛铂医药科技有限公司 | A kind of conveying device of intravascular distal protector |
| CN107440764B (en) * | 2017-08-16 | 2023-10-27 | 北京赛铂医药科技有限公司 | Conveying device of intravascular distal protector |
| CN109938893A (en) * | 2017-12-18 | 2019-06-28 | 上海微创医疗器械（集团）有限公司 | Sacculus dilating catheter and its medicinal balloon |
| CN108325050A (en) * | 2018-03-28 | 2018-07-27 | 周胜华 | A kind of novel cyclic sacculus and its application method |
| CN108742959A (en) * | 2018-04-21 | 2018-11-06 | 李皇德 | A kind of blood saccule, balloon-stent drug release device and its medicine release method |
| CN109481826A (en) * | 2018-11-05 | 2019-03-19 | 南京友德邦医疗科技有限公司 | A kind of drug coated balloon catheter and preparation method thereof |
| CN112439122A (en) * | 2019-09-05 | 2021-03-05 | 尤东侠 | Balloon dilatation catheter |
| CN112336966A (en) * | 2020-05-27 | 2021-02-09 | 深圳北芯生命科技有限公司 | Microcatheter with dual lumen |
| CN112336966B (en) * | 2020-05-27 | 2021-04-23 | 深圳北芯生命科技有限公司 | Microcatheter with dual lumen |
| CN111658956A (en) * | 2020-06-29 | 2020-09-15 | 东莞科威医疗器械有限公司 | Improved arteriovenous cannula |
| CN111658955A (en) * | 2020-06-29 | 2020-09-15 | 东莞科威医疗器械有限公司 | Improved medical cannula |
| CN111658955B (en) * | 2020-06-29 | 2022-06-14 | 东莞科威医疗器械有限公司 | Improved medical cannula |
| CN111658956B (en) * | 2020-06-29 | 2022-06-14 | 东莞科威医疗器械有限公司 | Improved arteriovenous cannula |
| CN113368371A (en) * | 2021-06-03 | 2021-09-10 | 复旦大学附属中山医院 | Medicine carrying balloon for preventing and treating benign stricture of esophagus |
| CN113262381A (en) * | 2021-07-02 | 2021-08-17 | 深圳麦普奇医疗科技有限公司 | Balloon dilatation catheter |
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Application publication date: 20150923 |