CN213312823U - Controlled release type medicine sacculus - Google Patents
Controlled release type medicine sacculus Download PDFInfo
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- CN213312823U CN213312823U CN202020778221.2U CN202020778221U CN213312823U CN 213312823 U CN213312823 U CN 213312823U CN 202020778221 U CN202020778221 U CN 202020778221U CN 213312823 U CN213312823 U CN 213312823U
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Abstract
The utility model discloses a controlled release type drug balloon, which comprises a drug-carrying balloon body and a delivery catheter, wherein the drug-carrying balloon body is detachably connected with the delivery catheter; the drug-loaded balloon body comprises a first end part and a second end part, the first end part is a free end, the second end part is arranged opposite to the first end part, and the second end part is provided with an installation part; the medicine carrying balloon body is internally provided with an accommodating space for accommodating medicine; a through hole is formed in the wall surface of the drug-carrying balloon body and is communicated with the accommodating space; a film is laid on the outer surface of the drug-carrying balloon body and covers the through hole; the catheter comprises a connecting part and a catheter seat, wherein the connecting part is arranged opposite to the catheter seat. The user can directly lead in the medicine to the medicine carrying sacculus body through the external interface on the catheter, thereby greatly avoiding the loss of medicine carrying amount of the medicine carrying sacculus in the processes of pushing, expanding, withdrawing, scouring by blood and the like of the blood vessel, effectively improving the effectiveness of the medicine carrying sacculus, and further improving the treatment effect.
Description
Technical Field
The utility model relates to the technical field of medical equipment, concretely relates to controlled release type medicine sacculus.
Background
With the aging population and the change of dietary structure, arterial occlusive diseases (heart, brain, viscera and peripheral blood vessels) caused by Atherosclerosis (AS) become the leading cause of human death. Currently, percutaneous transluminal vascular balloon angioplasty (PTA) and endovascular stent placement have become the primary means for treating vascular stenosis. Compared with the traditional surgical operation treatment, the interventional method for opening the angiostenosis has the advantages of small injury, higher technical success rate, short hospitalization time, less complications, excellent curative effect, repeated application, no influence on other treatment methods and the like, thereby having wide application prospect. The coronary intervention field is the most actively developing and rapidly branching of all vascular interventions. Since 1990, with the widespread clinical use of angioplasty and subsequent coronary stenting, interventional therapy has undoubtedly opened a new era in coronary revascularization therapy, and in-stent restenosis (ISR) has become one of the major challenges it faces. Although the use of drug-eluting stents (DES) significantly reduces the incidence of ISR, ISR remains of value as the number of patients undergoing Percutaneous Coronary Intervention (PCI) increases year by year. ISR is an independent predictor of target vascular revascularization. Although ISR does not occur widely after implantation of DES, it still affects a significant proportion of patients. ISR is currently considered to be difficult to treat and has a high recurrence rate. It was found in several small randomized registration studies that there was no significant difference between paclitaxel and sirolimus stents in the more posterior aspect of restenosis treatment. For example, 450 ISR patients were selected from ISAR-DESIRE-2 experiments and randomly divided into paclitaxel stent group and sirolimus stent group, and the results showed that the target revascularization rate of postoperative patients was similar to 16.1% vs 14.6%, and the restenosis rate was also similar to 20.6% vs 19%. Lee et al found that treatment with DES followed by drug eluting ISR was relatively poor and the incidence of major cardiac events was higher compared to treatment of restenosis following bare stents, indicating that a technique similar to "sandwich" stent-in-stent has a high clinical risk for treating ISR and that new therapeutic approaches need to be sought.
The medicine saccule is one new kind of medicine releasing saccule technology developed on the basis of saccule expanding operation, saccule forming operation and other intervention technology, and is one technology of coating antiproliferative medicine, such as taxol, onto the surface of saccule, expanding and contacting with the inner membrane of blood vessel wall to release and transfer medicine fast.
The main difficulties restricting the large-scale application of the Drug Eluting Balloon (DEB) at present are as follows: 1. the drug delivery efficiency is low, and data shows that drug-loaded capacity loss of drug balloons in the current market in processes of pushing, expanding, withdrawing, flushing by blood and the like is 85-90%, wherein the loss in the delivery process is 47.42 +/-4.72%, the loss in the expansion process is 24.27 +/-4.45%, the loss in the withdrawal process is 7.61 +/-4.65%, the drug residues on the surface of the balloon after the balloon is withdrawn from a catheter are 10.81 +/-3.55%, and the drug capable of directly entering target vascular tissues to play a therapeutic role only accounts for 12.29 +/-3.44% of the total drug content (see the journal of Chinese medical instruments, volume 41, No. 2 of 2017, and the in vitro assessment method for drug release from drug-coated balloons and particle shedding); 2. in order to ensure that the drug which can reach the target blood vessel can fully enter a blood vessel of a diseased tissue, a Drug Eluting Balloon (DEB) is always attached to the blood vessel wall under high pressure and is expanded for a long time, so that blood flow is necessarily blocked for a long time, far-end tissue ischemia is possibly caused, and new complications are generated.
In addition, the balloon and the connecting piece thereof are of an integrated structure at present, so that the storage space occupation is large, and more materials are wasted.
SUMMERY OF THE UTILITY MODEL
Aiming at the defect of poor dosage in the prior art, the utility model provides a controlled release type drug balloon.
A controlled release type drug balloon comprises a drug-carrying balloon body and a catheter, wherein the drug-carrying balloon body is detachably connected with the catheter; the drug-loaded balloon body comprises a first end part and a second end part, the first end part is a free end, the second end part is arranged opposite to the first end part, and the second end part is provided with an installation part; the medicine carrying balloon body is internally provided with an accommodating space which is used for accommodating medicines; a through hole is formed in the wall surface of the drug-carrying balloon body and is communicated with the accommodating space; a film is laid on the outer surface of the drug-carrying balloon body and covers the through hole; the catheter comprises a connecting part and a catheter seat, wherein the connecting part and the catheter seat are arranged oppositely; the transmission conduit is internally provided with a transmission channel, an external interface is arranged close to the conduit seat, and the external interface is communicated with the transmission channel.
Preferably, the surface of the drug-loaded balloon body is corrugated.
Preferably, the two ends of the medicine carrying balloon body are respectively provided with a mark block.
Preferably, the installation department includes protective layer and rubber membrane, the rubber membrane with protective layer parallel arrangement, just the rubber membrane with be an installation passageway between the protective layer, the annular is provided with the internal thread on the inner wall of installation passageway.
Preferably, the connection portion includes a piercing head having a medication injection channel in communication with the delivery channel.
Preferably, the outer wall surface of the connecting part is annularly provided with an external thread, and the external thread is in fit connection with the internal thread.
Preferably, the connecting part further comprises a tapered projection, and the tapered projection is arranged in the transmission channel to enable the transmission channel and the medicine injection channel to have a tapered transition.
Preferably, the controlled release drug balloon further comprises a connection hose, the connection hose comprises a first interface and a second interface, the first interface and the second interface are oppositely arranged, and the first interface is connected with the external interface.
The beneficial effects of the utility model are embodied in: the user can directly introduce the medicine into the medicine carrying balloon body through the external interface on the catheter, so that the loss of medicine carrying amount of the medicine carrying balloon in the processes of pushing, expanding, withdrawing, scouring by blood and the like of the blood vessel is greatly avoided, the use effectiveness of the medicine carrying balloon is effectively improved, and the treatment effect is further improved; and medicine carrying sacculus body and defeated pipe adopt split type detachable design, can make medicine carrying sacculus body and defeated pipe separately pack the storage, and defeated pipe can the secondary use after disinfecting simultaneously, environmental protection more.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below. Throughout the drawings, like elements or portions are generally identified by like reference numerals. In the drawings, elements or portions are not necessarily drawn to scale.
Fig. 1 is a schematic structural view of a controlled release drug balloon according to an embodiment of the present invention;
fig. 2 is a schematic structural view of a drug-loaded balloon body according to an embodiment of the present invention;
fig. 3 is a schematic view of a conduit structure according to an embodiment of the present invention;
fig. 4 is a schematic view of a connection structure of a drug-loaded balloon body and a catheter according to an embodiment of the present invention;
fig. 5 is a schematic cross-sectional view illustrating a controlled release drug balloon according to an embodiment of the present invention;
fig. 6 is a schematic view of a connection structure of a connection hose and a delivery tube according to an embodiment of the present invention.
In the attached drawing, 10-a medicine carrying balloon body, 101-a first end, 102-a second end, 103-a mark block, 100-an installation channel, 105-a through hole, 106-a film, 107-a rubber film, 108-a protective layer, 109-an internal thread, 110-a containing space, 20-a transmission pipe, 201-an external interface, 200-a transmission channel, 202-a connecting part, 203-a puncture head, 2021-an external thread, 2022-a conical bump, 30-a connecting hose, 301-a first interface and 302-a second interface.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to the accompanying drawings. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the present invention belongs.
As shown in fig. 1, the utility model provides a controlled release drug balloon, which comprises a drug-carrying balloon body 10 and a catheter 20, wherein the drug-carrying balloon body 10 is detachably connected with the catheter 20; specifically, the drug-loaded balloon body 10 comprises a first end part 101 and a second end part 102, wherein the first end part 101 is a free end, the second end part 102 is arranged opposite to the first end part 101, and the second end part 102 is provided with an installation part; as shown in fig. 2, the mounting portion includes a protective layer 108 and a rubber film 107, the rubber film 107 and the protective layer 108 are arranged in parallel, a mounting channel 100 is arranged between the rubber film 107 and the protective layer 108, and an inner thread 109 is annularly arranged on the inner wall of the mounting channel 100. Further, as shown in fig. 3, the catheter 20 includes a connecting portion 202 and a catheter hub, wherein the connecting portion 202 is disposed opposite to the catheter hub; the transmission conduit 20 has a transmission channel 200 therein, and an external interface 201 is disposed near the conduit seat, wherein the external interface 201 is communicated with the transmission channel 200. The connection part 202 comprises a piercing head 203, and the piercing head 203 is provided with a medicine injection channel which is communicated with the transmission channel 200. The outer wall surface of the connecting portion 202 is annularly provided with an external thread 2021, and the external thread 2021 is connected with the internal thread 109 in a matching manner.
As shown in fig. 2, the medicine carrying balloon body 10 has an accommodating space 110 therein, and the accommodating space 110 is used for accommodating medicine; a through hole 105 is formed in the wall surface of the drug-carrying balloon body 10, and the through hole 105 is communicated with the accommodating space 110; a film 106 is laid on the outer surface of the drug-carrying balloon body 10, and the film 106 covers the through hole 105.
Before the drug-carrying balloon body 10 and the catheter 20 are attached, the protective layer 108 on the attachment portion is first peeled off, and the purpose of the protective layer 108 is to seal the attachment portion before use, thereby preventing invasion of microorganisms such as bacteria. Then the puncture head 203 pierces the rubber membrane 107, and the external thread 2021 is matched with the internal thread 109, so that the drug-loaded balloon body 10 and the catheter 20 are integrally installed by screwing, as shown in fig. 4.
Further, as shown in fig. 5, the surface of the drug-carrying balloon body 10 is corrugated.
The two ends of the medicine carrying balloon body 10 are respectively provided with a mark block 103. The operator can be helped to identify the specific position of the drug-loaded balloon body 10 in the tubular vessel.
Preferably, the connecting portion 202 further comprises a tapered protrusion 2022, and the tapered protrusion 2022 is disposed in the delivery channel 200 to provide a tapered transition between the delivery channel 200 and the injection channel. The medicine flow can flow more smoothly.
Further, as shown in fig. 6, the controlled-release drug balloon further includes a connection hose 30, the connection hose 30 includes a first interface 301 and a second interface 302, the first interface 301 and the second interface 302 are oppositely disposed, and the first interface 301 is connected to the outer interface 201. The adoption of the connecting hose 30 can effectively improve the convenience of the operation of the injection operator.
In the utility model, the user can directly lead the medicine into the medicine carrying sacculus body through the external interface on the catheter, thereby greatly avoiding the loss of the medicine carrying sacculus in the processes of pushing, expanding, withdrawing, being washed by blood and the like of the blood vessel, effectively improving the effectiveness of the medicine carrying sacculus, and further improving the treatment effect; and medicine carrying sacculus body and defeated pipe adopt split type detachable design, can make medicine carrying sacculus body and defeated pipe separately pack the storage, and defeated pipe can the secondary use after disinfecting simultaneously, environmental protection more.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the scope of the embodiments of the present invention, and are intended to be covered by the claims and the specification.
Claims (8)
1. A controlled release drug balloon, characterized in that: the drug-carrying balloon comprises a drug-carrying balloon body and a catheter, wherein the drug-carrying balloon body is detachably connected with the catheter; the drug-loaded balloon body comprises a first end part and a second end part, the first end part is a free end, the second end part is arranged opposite to the first end part, and the second end part is provided with an installation part; the medicine carrying balloon body is internally provided with an accommodating space which is used for accommodating medicines; a through hole is formed in the wall surface of the drug-carrying balloon body and is communicated with the accommodating space; a film is laid on the outer surface of the drug-carrying balloon body and covers the through hole; the catheter comprises a connecting part and a catheter seat, wherein the connecting part and the catheter seat are arranged oppositely; the transmission conduit is internally provided with a transmission channel, an external interface is arranged close to the conduit seat, and the external interface is communicated with the transmission channel.
2. The controlled release drug balloon of claim 1, wherein: the surface of the medicine carrying balloon body is in a fold shape.
3. The controlled release drug balloon of claim 1, wherein: the two ends of the medicine carrying balloon body are respectively provided with a mark block.
4. The controlled release drug balloon of claim 1, wherein: the installation department includes protective layer and rubber membrane, the rubber membrane with protective layer parallel arrangement, just the rubber membrane with be an installation passageway between the protective layer, the annular is provided with the internal thread on the inner wall of installation passageway.
5. The controlled release drug balloon of claim 1, wherein: the connecting part comprises a puncture head, the puncture head is provided with a medicine injection channel, and the medicine injection channel is communicated with the transmission channel.
6. The controlled release drug balloon of claim 4, wherein: the outer wall surface of the connecting part is annularly provided with an external thread, and the external thread is matched and connected with the internal thread.
7. The controlled release drug balloon of claim 5, wherein: the connecting part further comprises a conical lug which is arranged in the transmission channel, so that the transmission channel and the medicine injection channel are in conical transition.
8. The controlled release drug balloon of claim 1, wherein: the controlled release type drug balloon further comprises a connecting hose, the connecting hose comprises a first interface and a second interface, the first interface and the second interface are oppositely arranged, and the first interface is connected with the outer interface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020778221.2U CN213312823U (en) | 2020-05-12 | 2020-05-12 | Controlled release type medicine sacculus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020778221.2U CN213312823U (en) | 2020-05-12 | 2020-05-12 | Controlled release type medicine sacculus |
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| CN213312823U true CN213312823U (en) | 2021-06-01 |
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| CN202020778221.2U Active CN213312823U (en) | 2020-05-12 | 2020-05-12 | Controlled release type medicine sacculus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350648A (en) * | 2021-07-18 | 2021-09-07 | 温州医科大学附属第一医院 | Tracheal catheter capable of accurately local anesthesia |
| CN114098899A (en) * | 2021-11-04 | 2022-03-01 | 杭州天路医疗器械有限公司 | Non-closed balloon shock waveguide tube, preparation process thereof and directional drug delivery method |
-
2020
- 2020-05-12 CN CN202020778221.2U patent/CN213312823U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113350648A (en) * | 2021-07-18 | 2021-09-07 | 温州医科大学附属第一医院 | Tracheal catheter capable of accurately local anesthesia |
| CN114098899A (en) * | 2021-11-04 | 2022-03-01 | 杭州天路医疗器械有限公司 | Non-closed balloon shock waveguide tube, preparation process thereof and directional drug delivery method |
| CN114098899B (en) * | 2021-11-04 | 2023-11-03 | 杭州天路医疗器械有限公司 | Impact waveguide tube of non-closed balloon, preparation process thereof and directional drug delivery method |
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