CN108735061A - The method for preparing transparent soft human body viscera model based on 3D printing - Google Patents
The method for preparing transparent soft human body viscera model based on 3D printing Download PDFInfo
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- CN108735061A CN108735061A CN201710240789.1A CN201710240789A CN108735061A CN 108735061 A CN108735061 A CN 108735061A CN 201710240789 A CN201710240789 A CN 201710240789A CN 108735061 A CN108735061 A CN 108735061A
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- human body
- transparent soft
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/30—Anatomical models
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
Abstract
The invention discloses a kind of methods preparing transparent soft human body viscera model based on 3D printing, according to the dirty body CT imaging datas of human body, establish dirty body internal pipeline and the threedimensional model by taking out the dirty body case of shell processing, it is sliced using 3D printer, printing shaping, obtains dirty body case and dirty internal portion's pipeline model；After painting to dirty internal portion's pipeline model with dirty body case model assembled formation；It is cast to dirty external shell model using AB types silica gel or AB type epoxy resin embedding adhesives, after curing molding, removes dirty external shell model to get transparent soft human body viscera model；The Visceral models can be applied to surgery planning, operation rehearsal, doctor patient communication, can also be used as teaching mould, has extremely wide market application prospect, and the preparation method environmental pollution of Visceral models is small, technique is easily controllable, is suitable for large-scale industrial production.
Description
Technical field
The present invention relates to a kind of preparation method of human body viscera model, more particularly to one kind is prepared transparent soft based on 3D printing
The method of body human body viscera model；Belong to 3D printing and medical field.
Background technology
In the prior art, most of traditional operation relies on the experience and skilled operation of doctor, the quantity of clinical case mostly
It determines surgical ability, the experience and hand for depending on doctor substantially is cut in the case where lacking three-dimensional stereo model auxiliary judgment, in art
Sense, this so that all kinds of surgical operations have prodigious difficulty and error may.
It is human anatomy, modern image techniques, computerized three-dimensional reconstruction, inverse with the development of 3D printing rapid shaping technique
Be combined to engineering philosophy and 3D printing technique, for how to position, orient in medical surgery, depthkeeping and pre-operative surgical are advised
Draw simulation the problem of, there is a kind of novel computer aided manufacturing individuation model-aided technology, it is virtual with it is real between set up
One bridge block.It accurately performs the operation for medicine and provides a kind of new method.And traditional 3D printing Visceral models, three fraction of blood vessel
Dirty interior numerous conduit types cannot be distinguished in the plastics of branch frangibility, single color, and internal organ shell quality is brittle and opaque, only
Internal structure can be observed by way of model windowing, although helping greatly, to be difficult to face to studying dirty interior conduit anatomical structure
Bed extensive use.The hardness of popular transparent material photosensitive resin is higher currently on the market, can not achieve the emulation feel of soft base,
It is at high price, and for SLA technology, on same profiled part, colored and transparent material cannot be printed simultaneously.
104123752 A of Chinese patent CN disclose a kind of three-dimensional modeling side for the human organ that can carry out 3D printing
Method, the model that can be printed is three-dimensional lively, and surface is smooth, can really reflect the apperance of human organ.But it is mainly beaten
Print solid human organ mold, internal structure None- identified.
Chinese patent CN105243945A discloses a kind of organ shell for preparing hollow out by 3D printing, can be intuitive
Observation tumour again can measure tumour and organ surface layer distance, for operation excision guidance is provided, can be directly from model reader
The space length of tumour or blood vessel apart from the organ surface region of anatomy inside official.But this hollow out organ mold is difficult to really
Reflect human organ pattern, and internal organ shell can only use quality crisp and hard material, can not achieve the emulation feel of soft base, in addition,
Dirty interior numerous conduit types cannot be distinguished in the plastics of its single color.
Invention content
Defect existing for the technology of human organ is prepared for existing 3D printing technique, the purpose of the present invention is be to lead to
3D printing technique is crossed to prepare soft base, transparent have 1:The Visceral models of 1 actual proportions, this method is simple and practicable, is conducive to promote
It is preferably applied as medical operating supplementary means into 3D printing model.
The invention discloses a kind of method preparing transparent soft human body viscera model based on 3D printing, this method include with
Lower step：
1) according to the dirty body CT imaging datas of human body, dirty body internal pipeline and three by taking out the dirty body case of shell processing are established
Dimension module, and generate corresponding threedimensional model file；
2) the input SLS moldings of threedimensional model file or SLA are molded 3D printer, are sliced, printing shaping, are obtained dirty
External shell model and dirty internal portion's pipeline model；
3) after painting to dirty internal portion's pipeline model, assembling is fixed in dirty external shell model；
4) it uses AB types silica gel or AB type epoxy resin embedding adhesives to cast to dirty external shell model, after curing molding, goes
Except dirty external shell model is to get transparent soft human body viscera model.
The thickness of shell of preferred scheme, the dirty external shell model is 0.1mm~3mm.Prepare ultra-thin dirty body case
Model is more advantageous to obtain 1:1 true dirty body Model.
Preferred scheme, to not being same as above different face according to pipeline type during dirty internal portion's pipeline model colouring
Color；The pipeline includes artery, vein and other pipelines.As artery can more than it is red, vein can be with blue.
More preferably scheme, the pigment used of painting is acrylic paints, oily ink or clothes pigment.
Preferred scheme, the AB types silica gel are add-on type AB silica gel or condensed type AB silica gel.AB type silica gel is commercially available normal
Advise product.
More preferably scheme, the mass ratio range of A glue and B glue is 1 in the AB types silica gel:1~15:1；Most preferably
12:1。
More preferably scheme, A glue and B glue is stirred at room temperature 5~after twenty minutes, in casting to dirty external shell model.It stirs
It is preferably 10 minutes to mix the time.
Preferred scheme, the mass ratio range of A glue and B glue is 1 in the AB epoxy resin embedding adhesives:1~5:1；Most
Preferably 2:1.AB epoxy resin embedding adhesives are conventional commercial product.
More preferably scheme, A glue and B glue is stirred at room temperature 5~after twenty minutes, in casting to dirty external shell model.It stirs
It is preferably 10 minutes to mix the time.
More preferably scheme, the cured process are：In 0 DEG C~80 DEG C air environments, stands 12~48 hours and coagulate
Gu；Or de-bubble 5~30 minutes in vacuum environment, then in 0 DEG C~80 DEG C air environments, stand 12~48 hours and solidify.
Most preferably in 30 DEG C of air environments, stands 36 hours and solidify.
The design of the transparent Visceral models of soft base of the present invention includes step in detail below with preparation method：
1) the dirty body CT of people is imaged, generates dicom formatted files, after being placed on Mimics softwares, export stl files, then
Stl files are imported in Magics and is pre-processed and is repaired；The dirty body having good positioning is carried out to take out shell processing, retains outer layer
The shell of 0.1mm~3mm thickness；Merge after processing and detach and export two parts stl files, first part is internal artery and vein vascular
And other pipelines, another part are that dirty body takes out shell treated shell；To after reparation two stl files input SLS types or
SLA types 3D printer carries out slice printing shaping；
2) pigment is dipped in writing brush to printing shaping product and carries out colouring convenient for distinguishing, color principle is：Artery is red, and vein is blue
Color, other pipelines such as bile duct are green；By after drying blood vessel and dirty body case re-assemblied and fixed, in order to avoid dislocation；
3) with the A glue and B glue of add-on type or condensed type silica gel according to mass ratio 1:1~15:1 range proportioning is mixed
It closes, carries out 5~20 minutes magnetic agitations at room temperature and be uniformly mixed；Or the A glue and B glue of AB type epoxy resin electronic pouring sealants are pressed
According to mass ratio 1:1~5:1 range matches, and carries out 5~20 minutes magnetic agitations at room temperature and is uniformly mixed；
4) directly quiet in 0 DEG C~80 DEG C air environments in the solution-cast to dirty body case after being sufficiently stirred synthesis
It sets 12~48 hours and solidifies；Or be first put into vacuum environment 5~30 minutes, the micro bubble that removal stirring generates, then at 0 DEG C
12~48 hours are stood in~80 DEG C of air environments solidifies.
5) the dirty body Model after solidification is removed into shell, cleaning removal spillage solution is prepared and completed.
Compared with the prior art, the advantageous effects that technical scheme of the present invention is brought：
The transparent Visceral models transparency of soft base prepared by the present invention is high, and light transmittance reaches 99% or more, and soft texture connects
Nearly skin pattern, internal various blood vessels and other pipelines are high-visible, and can be distinguished according to color.
The preparation method of the present invention can utilize existing ripe 3D printing equipment, and reaction condition is mild, environmental-friendly, raw
It produces at low cost, is suitable for large-scale industrial production.
Technical scheme of the present invention combines computer 3D reconstruction techniques and visual simulating surgical technic, to human body viscera
Structure carries out accurate three-dimensional reconstruction, can interior internal organs and corresponding diseased region be presented on doctor in the form of " material object " of 1: 1 ratio
In face of raw and patient and family members, doctor can be with preoperative accurate assessment extent of disease and adjacent organ, the three dimensions of important blood vessels
Relationship formulates detailed surgery planning, designs operative approach, greatly improves the accuracy of operation, can reduce hand to greatest extent
Art risk and complication.
The transparent Visceral models of soft base prepared by the present invention are completely the same with sufferer ontology diseased organ, and transparent visible all
Each position such as vascular tumor can carry out detailed surgery planning according to model, and introduce the state of an illness with patient.And Visceral models have
There are the emulation feel of soft base, operating doctor that can carry out surgical cut on model, once be previewed to really performing the operation, maximum journey
Degree reduces operation risk.
The transparent Visceral models of soft base prepared by the present invention, which thoroughly solve traditional 3D printing model, " can not pry through complex space
The problem of conformation ", can be applied not only to surgery planning, operation rehearsal, doctor patient communication, can also be used as teaching mould, there is pole
For wide market application prospect.
Description of the drawings
【Fig. 1】It is dicom formats through the transformed stl livers 3D molding effects of Mimics；True case 1 as seen from the figure:1
Situation before three-dimensional modeling printing.
【Fig. 2】For dicom formats section effect is molded through the transformed stl livers 3D of Mimics；Internal blood as seen from the figure
Pipe tumour situation before printing.
【Fig. 3】,【Fig. 4】【Fig. 5】【Fig. 6】For the liver cancer patient 1 prepared in the embodiment of the present invention 1:1 modeling prints transparent
Software organ.
Specific implementation mode
It is intended to further illustrate the content of present invention with reference to embodiments, the protection model for the claim that is not intended to limit the present invention
It encloses.
Embodiment 1
Certain liver cancer patient affected part liver body CT is imaged, dicom formatted files is generated and is led after being placed on Mimics softwares
Go out stl files, then stl files are imported in Magics and is pre-processed and is repaired.The liver body having good positioning take out at shell
Reason retains the shell of outer layer 1mm thickness.Merge after processing and detach and export two parts stl files, first part is internal arteriovenous
Blood vessel and bile duct, another part are that liver body takes out shell treated shell and tumour body.To two stl files after reparation into
The 3D printer of SLS or SLA carries out slice printing shaping.
Oiliness prepared Chinese ink is dipped in writing brush to printing shaping product and carries out colouring convenient for differentiation：Artery is red, vein blue, and bile duct is
Green.By after drying blood vessel and dirty body case re-assemblied and fixed, in order to avoid dislocation.
With AB organic silicon potting adhesives A and B according to 12:1 proportioning is mixed, and it is mixed to carry out 10 minutes magnetic agitations at room temperature
It closes uniform.
In solution-cast to liver body case after synthesis is sufficiently stirred, it is put into vacuum environment 20 minutes, removal is stirred
The bubble of generation is mixed, rear taking-up, which is sealed in 30 ° of environment, stands solidification in 36 hours.
Liver body Model after solidification is removed into shell, cleaning removal spillage solution is prepared and completed.
The transparent soft organ of preparation is such as【Fig. 3】,【Fig. 4】【Fig. 5】【Fig. 6】It is shown, it can be seen from the figure that organ model
It is sufficiently close to the ratio of actual organ, and transparent especially high (close to 100%) of organ model, it may be clearly seen that in it
The pipeline of portion's a variety of colors, organ are software, have the softness close with human body actual organ.
Embodiment 2
Certain nephrotic affected part liver body CT is imaged, dicom formatted files is generated and is led after being placed on Mimics softwares
Go out stl files, then stl files are imported in Magics and is pre-processed and is repaired.The kidney body having good positioning take out at shell
Reason retains the shell of outer layer 1mm thickness.Merge after processing and detach and export two parts stl files, first part is internal arteriovenous
Blood vessel and ureter, another part are that kidney body takes out shell treated shell.To two stl files after reparation into SLS or
The 3D printer of SLA carries out slice printing shaping.
Oiliness prepared Chinese ink is dipped in writing brush to printing shaping product and carries out colouring convenient for differentiation：Artery is red, vein blue, ureter
For green.By after drying blood vessel and kidney body case re-assemblied and fixed, in order to avoid dislocation.
By AB epoxy resin electronic pouring sealants A and B according to 1：3 proportionings carry out magnetic agitation mixing in 10 minutes at room temperature
Uniformly.
In solution-cast to liver body case after synthesis is sufficiently stirred, it is put into vacuum environment 20 minutes, removal is stirred
The bubble of generation is mixed, rear taking-up, which is sealed in 35 ° of environment, stands solidification in 24 hours.
Kidney body Model after solidification is removed into shell, cleaning removal spillage solution is prepared and completed.
The organ model of preparation and the ratio of actual organ are sufficiently close to, and organ model is transparent especially high (close
100%), it may be clearly seen that the pipeline of its internal a variety of colors, organ are software, are had close with human body actual organ
Softness.
Claims (10)
1. the method for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：Include the following steps：
1) according to the dirty body CT imaging datas of human body, dirty body internal pipeline and the three-dimensional mould by taking out the dirty body case of shell processing are established
Type, and generate corresponding threedimensional model file；
2) the input SLS moldings of threedimensional model file or SL A are molded 3D printer, are sliced, printing shaping, obtain dirty body
Shell model and dirty internal portion's pipeline model；
3) after painting to dirty internal portion's pipeline model, assembling is fixed in dirty external shell model；
4) AB types silica gel or AB type epoxy resin embedding adhesives is used to cast to dirty external shell model, after curing molding, removal is dirty
External shell model is to get transparent soft human body viscera model.
2. the method according to claim 1 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
The thickness of shell of the dirty external shell model is 0.1mm~3mm.
3. the method according to claim 1 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
To not being same as above different colors according to pipeline type during dirty internal portion's pipeline model colouring；The pipeline include artery,
Vein and other pipelines.
4. the method according to claim 3 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
The pigment used of painting is acrylic paints, oily ink or clothes pigment.
5. the method according to claim 1 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
The AB types silica gel is add-on type AB silica gel or condensed type AB silica gel.
6. the method according to claim 5 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
The mass ratio range of A glue and B glue is 1 in the AB types silica gel:1~15:1.
7. the method according to claim 6 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
A glue and B glue is stirred at room temperature 5~after twenty minutes, in casting to dirty external shell model.
8. the method according to claim 1 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
The mass ratio range of A glue and B glue is 1 in the AB epoxy resin embedding adhesives:1~5:1.
9. the method according to claim 8 for preparing transparent soft human body viscera model based on 3D printing, it is characterised in that：
A glue and B glue is stirred at room temperature 5~after twenty minutes, in casting to dirty external shell model.
10. according to the method that claim 1~8 any one of them prepares transparent soft human body viscera model based on 3D printing,
It is characterized in that：The cured process is：In 0 DEG C~80 DEG C air environments, stands 12~48 hours and solidify；Or true
De-bubble 5~30 minutes under Altitude, then in 0 DEG C~80 DEG C air environments, stand 12~48 hours and solidify.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674558A (en) * | 2019-03-08 | 2019-04-26 | 北京工业大学 | A method of high degrees of smoothness and transparent aortic root are prepared based on plasma corona method |
| CN110142796A (en) * | 2019-04-24 | 2019-08-20 | 上海大学 | It is a kind of can compound bending software finger and preparation method thereof |
| CN111531912A (en) * | 2020-04-29 | 2020-08-14 | 西安增材制造国家研究院有限公司 | Manufacturing method of silica gel headrest and silica gel pillow |
| CN113580576A (en) * | 2021-06-23 | 2021-11-02 | 浙江省人民医院 | 3D printing simple liver model for preoperative planning and intraoperative navigation and manufacturing method |
| CN114078354A (en) * | 2020-08-12 | 2022-02-22 | 北京创鑫汇智科技发展有限责任公司 | Application of 3D printing soft organ model in medical operation simulation |
| CN114454393A (en) * | 2022-01-12 | 2022-05-10 | 武汉大学 | Heart valve model and manufacturing method thereof |
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| CN103871305A (en) * | 2014-02-26 | 2014-06-18 | 南方医科大学 | Human anatomy canal model and manufacturing method thereof |
| CN104760288A (en) * | 2015-04-15 | 2015-07-08 | 浙江大学 | 3D printing based complex structure mold manufacturing method and molding method |
| CN105243945A (en) * | 2015-11-19 | 2016-01-13 | 王峻峰 | Tumor grid organ model 3D printing method |
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| CN103153589A (en) * | 2011-03-31 | 2013-06-12 | 国立大学法人神户大学 | Method for manufacturing three-dimensional molded model and support tool for medical treatment, medical training, research, and education |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674558A (en) * | 2019-03-08 | 2019-04-26 | 北京工业大学 | A method of high degrees of smoothness and transparent aortic root are prepared based on plasma corona method |
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| CN111531912A (en) * | 2020-04-29 | 2020-08-14 | 西安增材制造国家研究院有限公司 | Manufacturing method of silica gel headrest and silica gel pillow |
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| CN114078354A (en) * | 2020-08-12 | 2022-02-22 | 北京创鑫汇智科技发展有限责任公司 | Application of 3D printing soft organ model in medical operation simulation |
| CN113580576A (en) * | 2021-06-23 | 2021-11-02 | 浙江省人民医院 | 3D printing simple liver model for preoperative planning and intraoperative navigation and manufacturing method |
| CN114454393A (en) * | 2022-01-12 | 2022-05-10 | 武汉大学 | Heart valve model and manufacturing method thereof |
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Application publication date: 20181102 |