CN108732371A - Cross matching and ABO and RhD blood groups and irregular antibody screening sample injector - Google Patents
Cross matching and ABO and RhD blood groups and irregular antibody screening sample injector Download PDFInfo
- Publication number
- CN108732371A CN108732371A CN201810527247.7A CN201810527247A CN108732371A CN 108732371 A CN108732371 A CN 108732371A CN 201810527247 A CN201810527247 A CN 201810527247A CN 108732371 A CN108732371 A CN 108732371A
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- China
- Prior art keywords
- memotron
- abo
- sample injector
- antibody screening
- vomit pipe
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
Abstract
The present invention relates to medical experiment equipment, are cross matching and ABO and RhD blood groups and irregular antibody screening sample injector, and there are one horizontally disposed memotrons for tool, it is characterized in that：At least two measuring cups are equipped in memotron side by side, measuring cup bottom is equipped with vomit pipe, vomit pipe is pierced by downwards memotron, each vomit pipe is equipped with valve A, fixed frame there are one being set outside memotron, vomit pipe lower end is pierced by fixed frame, and the memotron sets that there are one feed liquor hoses and one to go out liquid hose and be communicated with memotron, and feed liquor hose and the other end for going out liquid hose set that there are one reagent bottles；The problem of present invention solves existing blood transfusion cross matching and positive and negative ABO and RhD blood groups and irregular antibody screening experiment there is no special sample injector, extremely complex using common suction pipe or dropper operation, and efficiency is low and easy error.
Description
The application is application No. is 2017106406027, and the applying date is on July 31st, 2017, and entitled " intersection is matched
The divisional application of the application for a patent for invention of blood and ABO and RhD blood groups and irregular antibody screening sample injector ".
Technical field
The present invention relates to medical experiment equipment, specifically cross matching and ABO and RhD blood groups and irregular antibody screening adds
Sample device.
Background technology
Up to the present, situation of all-level hospitals Blood Transfusion Dept. to be that blood transfusion cross match blood test, ABO be positive and negative and RhD bracket for blood grouping with
And in serum when three big experiment of irregular antibody screening be be loaded using common plastics suction pipe or plastic dropper, if by
Blood person needs the donor blood of two person-portions or more, the cross matching done before blood transfusion to test extremely complex, every blood donor
Cross matching experiment will be carried out between receptor and between every blood donor and blood donor, such as the experiment of y-bend one needs six
Branch transparent pipe, each transparent pipe sample-adding blood cell and serum are each primary, need to be loaded altogether 12 times, and the experiment of trident one needs sample-adding 24 times,
And blood cell and serum are pushed the wrong bit pairing mode and are added to supervisor and time pipe, it is seen that only sample-adding process is just very cumbersome, is easy
Error, on the other hand, existing sample-adding process can not retain sample, if sample-adding process error, later stage counter can not look into.
For this purpose, applicant once applied for a kind of multi-purpose disposable blood transfusion cross match blood test combination on 2 13rd, 2015
Device, and patent for invention has been obtained, a kind of special combination tester is provided for cross matching experiment, but there is no at present dedicated
Sample injector, but use and be manually loaded one by one, efficiency is low and easy error.
Invention content
Present invention aim to solve three big experiment of transfusion safety（Blood group cross matching is tested, ABO is positive and negative and RhD
Bracket for blood grouping and irregular antibody screening）Without special sample injector, using common suction pipe or dropper be loaded complicated for operation numerous
It is trivial, be easy error, the later stage can not anti-the problem of looking into, provide cross matching and ABO and RhD blood groups and irregular antibody screening sample-adding
Device.
The present invention concrete scheme be：Cross matching and ABO and RhD blood groups and irregular antibody screening sample injector, have
One horizontally disposed memotron, is equipped at least two measuring cups in memotron side by side, and measuring cup bottom is equipped with vomit pipe, vomit pipe to
Under be pierced by memotron, each vomit pipe is equipped with valve A, is set outside memotron there are one fixed frame, vomit pipe lower end is pierced by solid
Determine frame, the memotron sets that there are one feed liquor hoses and one to go out liquid hose and be communicated with memotron, feed liquor hose and to go out liquid soft
The other end of pipe is set there are one reagent bottle.
In the present invention, the volume of the measuring cup is set according to sample-adding amount needed for experiment.
In the present invention, 1-3 valve B is optionally had additional on the vomit pipe.
In the present invention, described valve A, B are common shut-off valve or solenoid valve.
Working principle of the invention is as follows：Reagent bottle is moved up, its bottom level is made to be higher than memotron import, reagent bottle
Interior sample is flowed into memotron naturally by feed liquor hose, and valve A and valve B are in closed state at this time, wait for each
After measuring cup is filled naturally, then reagent bottle moved down, so that the outlet tube open height of memotron is higher than reagent bottleneck, store at this time
The interior extra sample of pipe is directed at the required experimental group clutch being loaded since difference in height flow back into reagent bottle naturally, then by sample injector
Then sample-adding can be completed according to the opening valve A of actual demand selectivity and valve B in test tube mouth.
The present invention has the following advantages compared with prior art：1, simple in structure, manufacturing cost is low, disposable, safety
Reliably；2, cross matching and positive and negative ABO and RhD blood groups are carried out using the present invention and irregular antibody screening is tested, it is convenient and efficient,
It is not error-prone；3, the scanning of conveniently taking pictures of remaining sample achieves in sample injector after being loaded in experimentation, and the later stage can check.
Description of the drawings
Fig. 1 is the schematic diagram of structure of the invention；
Fig. 2 is one experimental group clutch schematic diagram of y-bend；
In figure：1- memotrons, 2- valves A, 3- valve B, 4- fixed frame, 5- vomit pipes, 6- feed liquor hoses, 7- go out liquid hose, 8-
Reagent bottle.
Specific implementation mode
Referring to Fig. 1, present invention tool is equipped at least two measuring cups there are one horizontally disposed memotron 1 side by side in memotron 1
9,9 bottom of measuring cup is equipped with vomit pipe 5, and vomit pipe 5 is pierced by downwards memotron 1, and each vomit pipe 5 is equipped with valve A2, memotron 1
Outside is set there are one fixed frame 4, and 5 lower end of vomit pipe is pierced by fixed frame 4, and the memotron 1 sets that there are one feed liquor hose 6 and one
Go out liquid hose 7 to communicate with memotron 1, feed liquor hose 6 and the other end for going out liquid hose 7 set that there are one reagent bottles 8.
Increase on vomit pipe 5 in the present embodiment and sets there are two valve B3.
Valve A2, valve B3 are common shut-off valve in the present embodiment.
When the present embodiment is tested for one match of y-bend, operating procedure is as follows：
1, the multi-purpose disposable blood transfusion cross match blood test combiner 9 of Patent No. 201510077271.1 is taken to be combined into such as figure
Then one structural experiment combiner of y-bend shown in 2 takes the sample injector six of the present embodiment, stick respectively white " 0 ", " 1 ",
" 2 " number and red " 0 ", " 1 ", " 2 " number labeling；
2, receptor's serum is added into the sample injector of label white " 0 " number, 1 is added into the sample injector of label white " 1 " number
No. 2 blood donor's serum are added into the sample injector of label white " 2 " number in number blood donor's serum, toward the sample-adding of label red " 0 " number
Receptor's blood cell suspension is added in device, No. 1 blood donor's blood cell suspension is added into the sample injector of label red " 1 " number, toward label
No. 2 blood donor's blood cell suspensions are added in the sample injector of red " 2 " number；
3, first white " 0 " number sample injector alignment combiner is horizontally-arranged, then opens valve and is loaded；
4, second white " 1 " number sample injector alignment combiner is horizontally-arranged, then opens valve and is loaded；
5, the third for white " 2 " number sample injector being directed at combiner is horizontally-arranged, then opens valve and is loaded；
6, red " 0 " number sample injector is directed at the first vertical setting of types of combiner, then opens valve and is loaded；
7, red " 1 " number sample injector is directed at the second vertical setting of types of combiner, then opens valve and is loaded；
8, red " 2 " number sample injector is directed at the third vertical setting of types of combiner, then opens valve and is loaded；
9, low solion is added into combiner with the present embodiment sample injector again（LIM）0.65ml is added after mixing
Amine aqueous solution is agglomerated,（Polybene）Solution two drips, and is uniformly mixed；
10, with special centrifugal machine by each row's small test tube centrifugally operated 10 seconds（3400 turns/min）, then use special drawing liquid pump
Supernatant is taken out, and retains 0.1ml blood cell mixtures；
11, each row's test tube is gently shaken manually, and whether there is or not agglutinations for range estimation red blood cell, must be reformed if without agglutination；
12, Resuspending is added（Suspending agent）Two drops gently shake test tube and mix and observe as a result, being such as aggregated in 60 seconds
It scatters, representative is to cause rejection aggregation match result to be harmonious by Polybene cohesion amine；Then it is red blood cell if agglutination is not scattered
The specific reaction that antigen-antibody combines, match result are not consistent；
13, it as reacted suspicious, is sucked the sample into transparent plastic film capsule with micro- sem observation using sampling viewer.
The present embodiment can be also used for ABO positive definite forms and the experiment of RhD bracket for blood grouping and ABO reverse types and irregular antibody
Screening is tested.
Claims (4)
1. cross matching and ABO and RhD blood groups and irregular antibody screening sample injector have there are one horizontally disposed memotron,
It is characterized in that：At least two measuring cups are equipped in memotron side by side, measuring cup bottom is equipped with vomit pipe, and vomit pipe is pierced by downwards storage
Pipe, each vomit pipe are equipped with valve A, set that there are one fixed frames outside memotron, and vomit pipe lower end is pierced by fixed frame, the storage
It deposits pipe and sets to go out liquid hose there are one feed liquor hose and one and communicate with memotron, feed liquor hose and the other end for going out liquid hose are set
There are one reagent bottles.
2. cross matching according to claim 1 and ABO and RhD blood groups and irregular antibody screening sample injector, feature
It is：The volume of the measuring cup is set according to sample-adding amount needed for experiment.
3. cross matching according to claim 1 and ABO and RhD blood groups and irregular antibody screening sample injector, feature
It is：1-3 valve B is optionally had additional on the vomit pipe.
4. cross matching according to claim 1 or 3 and ABO and RhD blood groups and irregular antibody screening sample injector, special
Sign is：Described valve A, B are common shut-off valve or solenoid valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810527247.7A CN108732371B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood type and irregular antibody screening sample injector |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710640602.7A CN107247154B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood group and irregular antibody screening sample injector |
| CN201810527247.7A CN108732371B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood type and irregular antibody screening sample injector |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710640602.7A Division CN107247154B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood group and irregular antibody screening sample injector |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108732371A true CN108732371A (en) | 2018-11-02 |
| CN108732371B CN108732371B (en) | 2022-02-01 |
Family
ID=60012029
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710640602.7A Active CN107247154B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood group and irregular antibody screening sample injector |
| CN201810527247.7A Active CN108732371B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood type and irregular antibody screening sample injector |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710640602.7A Active CN107247154B (en) | 2017-07-31 | 2017-07-31 | Cross matching and ABO and RhD blood group and irregular antibody screening sample injector |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN107247154B (en) |
| WO (1) | WO2019024624A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107247154B (en) * | 2017-07-31 | 2018-12-18 | 刘大基 | Cross matching and ABO and RhD blood group and irregular antibody screening sample injector |
| CN108931657B (en) * | 2018-04-17 | 2021-02-02 | 杭州电子科技大学 | Cross blood matching instrument |
| CN110187133B (en) * | 2019-04-12 | 2022-04-01 | 杭州电子科技大学 | Test device for cross matching |
| CN111513961B (en) * | 2020-04-26 | 2021-07-02 | 青岛大学附属医院 | Medical dressing bracket |
| CN111481389B (en) * | 2020-04-26 | 2021-07-16 | 青岛市妇女儿童医院 | Medicine changing device comprising medicine changing box |
| CN111505318A (en) * | 2020-05-15 | 2020-08-07 | 刘大基 | Blood transfusion compatibility detection package analyzer |
| CN113341163B (en) * | 2021-06-03 | 2024-01-19 | 上海市血液中心 | -D-rare blood group screening reagent and application thereof |
| CN115820397B (en) * | 2023-02-15 | 2023-09-08 | 季华实验室 | Intermittent superposition sample adding device, system and method |
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| CN105465054A (en) * | 2015-12-21 | 2016-04-06 | 温锡钦 | Device capable of improving fluid pressure intensity or height |
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| CN2415356Y (en) * | 1999-12-16 | 2001-01-17 | 吴昌 | Tube type micro liquid distributor for making biological water |
| CH695544A5 (en) * | 2000-11-17 | 2006-06-30 | Tecan Trading Ag | Apparatus for dispensing or aspirating / dispensing liquid samples. |
| EP1344565A1 (en) * | 2002-03-13 | 2003-09-17 | The Automation Partnership (Cambridge) Limited | Low volume droplet dispensing |
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| CN107247154B (en) * | 2017-07-31 | 2018-12-18 | 刘大基 | Cross matching and ABO and RhD blood group and irregular antibody screening sample injector |
-
2017
- 2017-07-31 CN CN201710640602.7A patent/CN107247154B/en active Active
- 2017-07-31 CN CN201810527247.7A patent/CN108732371B/en active Active
-
2018
- 2018-06-25 WO PCT/CN2018/092535 patent/WO2019024624A1/en active Application Filing
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2074761U (en) * | 1990-07-14 | 1991-04-10 | 北京有色金属研究总院 | Automatic rationing liquid feeder |
| JPH0545365A (en) * | 1991-08-09 | 1993-02-23 | Olympus Optical Co Ltd | Sample separate injection method |
| CN2679227Y (en) * | 2003-12-31 | 2005-02-16 | 宜兴市科达机械有限公司 | Quantitative pulp filling appts. for moulding injection of paper pulp |
| CN201859148U (en) * | 2010-08-26 | 2011-06-08 | 广州阳普医疗科技股份有限公司 | Dropping liquid detection device, reagent addition device comprising same and blood type analyzer |
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| CN105465054A (en) * | 2015-12-21 | 2016-04-06 | 温锡钦 | Device capable of improving fluid pressure intensity or height |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019024624A1 (en) | 2019-02-07 |
| CN108732371B (en) | 2022-02-01 |
| CN107247154A (en) | 2017-10-13 |
| CN107247154B (en) | 2018-12-18 |
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