CN108721696A - A kind of preparation method of artificial blood vessel's high mechanical properties fiber type membrane material - Google Patents
A kind of preparation method of artificial blood vessel's high mechanical properties fiber type membrane material Download PDFInfo
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- CN108721696A CN108721696A CN201810626453.3A CN201810626453A CN108721696A CN 108721696 A CN108721696 A CN 108721696A CN 201810626453 A CN201810626453 A CN 201810626453A CN 108721696 A CN108721696 A CN 108721696A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
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- General Health & Medical Sciences (AREA)
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- Artificial Filaments (AREA)
- Materials For Medical Uses (AREA)
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Abstract
The present invention relates to a kind of artificial blood vessel preparation methods of high mechanical properties fiber type membrane material, belong to technical field of biological materials.Technical solution of the present invention aoxidizes the primary hydroxyl in glucide cellulose macromolecule using nitroxyl radical material selectivity, pass through reacting between oxidized fibre cellulosic material and amino on tropocollagen molecule chain, a degree of crosslinking is carried out to tropocollagen molecule chain, the three-dimensional netted cross-linked structure formed inside tropocollagen molecule by oxidized fibre cellulosic material, it is effectively improved the filming performance and mechanical strength of fiber film material, and the present invention is by containing a large amount of hydroxyl inside tannic acid, with oxidation resistant function, multiple spot Hydrogenbond occurs with protein, so that the connection inside collagem membrane is more closely, structure becomes more fine and close, and tannic acid, which is polyphenols, has flexibility, therefore also there is certain filling effect, so that the degree of packing of collagem membrane gets a promotion, to make to significantly improve by modified collagem membrane tensile strength.
Description
Technical field
The present invention relates to a kind of artificial blood vessel preparation methods of high mechanical properties fiber type membrane material, belong to biomaterial
Technical field.
Background technology
Weave base artificial blood vessel be important one of the substitute of lesion vessels, can pass through it is woven, knitting, braiding and it is non-woven
It is produced and processed etc. a variety of methods, weaving base artificial blood vessel's mechanical mechanics property is preferable, and surface void is more and uniform, favorably
In the growth and adherency of cell, forming technology controllability is high and molding is very fast.Weave base artificial blood vessel's material it is very much, as nylon,
Ao Lun, polyvinyl alcohol, terylene, safe teflon, silk, polytetrafluoroethylene (PTFE) and expanded PTFE etc..But a large amount of animal
Experiment and clinical practice prove the synthetic vascular grafts of the materials such as nylon, Ao Lun, polyvinyl alcohol, safe teflon to after internal,
It can deform, degenerate in short time, fiber strength loss, generating aneurysmal dilatation and rupture, gradually eliminated.It grinds at present
It is mainly terylene, expanded PTFE to study carefully more weaving base artificial blood vessel's material（e PTFE）And silk.
Electrostatic spinning technique is considered as preparing one of polymeric nanofiber most efficient method, and it is a variety of to be that one kind can be applied
Synthetic material（Such as polyurethane, polylactic acid, hydroxyacetic acid, polycaprolactone and a variety of copolymers）And natural material is molded nanofiber
New technique.It is not only able to directly form the tubular structure of required bore, and can be good at simulating extracellular matrix
The Nomenclature Composition and Structure of Complexes, provide good living environment for cell.The intravascular stent that Static Spinning obtains has its unique advantage, mainly
It shows：
（1）Structure is stacked by being orientated different Nano/micron grade fiber, and the combination between fiber is weaker, when cell into
After going in vivo, the fiber around hole can be pushed, the permeability of cell is made to be improved.
Static Spinning minor diameter artificial blood vessel has very high porosity and specific surface area, while simulating cell
Epimatrix topological structure is conducive to the adherency and growth of cell.
Change the parameter of polymer composition and Static Spinning process by control to meet blood vessel in form and machine
Various requirement in tool mechanical property.
Catheter holder prepared by method of electrostatic spinning is formed by holder than common large-diameter fiber to be had more preferably
Mechanical property.
Collagen is the main component of extracellular matrix, is distributed widely in connective tissue, skin, bone, gut cell interstitial
And the positions such as flesh chamber, ligament, sclera.Collagenous fibres not only act as in vivo transmit strength, the energy that dissipates, prevent normal structure by
To the effect of mechanical external force and premature failure, and bio signal can be provided in adjacent iuntercellular to adjust various functions sound
It answers.In numerous collagen-types, type i collagen is most important function and structure albumen, distinctive 3 strands of helical structures,
Make collagen that there is bioactivity, low immunological rejection can promote growth, adherency, differentiation and the proliferation of cell.Pass through electrostatic spinning
Technology can simply and effectively prepare continuous nanoscale or micron order collagenous fibres, can simulate natural extracellular matrix well
The three-dimensional netted topological structure of middle collagen.But the mechanical property of collagen is poor, so it is strong with high machinery to prepare a kind of artificial blood vessel
The preparation method of degree type fiber film material.
Invention content
The technical problems to be solved by the invention：The artificial blood vessel's mechanical property prepared for existing collagen-based materials is poor
Problem provides a kind of preparation method of artificial blood vessel's high mechanical properties fiber type membrane material.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
（1）It counts in parts by weight, weighs 45~50 parts of dissociation fiber slurries, 6~8 parts of tetramethyl piperidines, 1~2 part of NaClO respectively
It is stirred with 1~2 part of sodium bromide, adjusting pH to 5.6, after insulation reaction, adjusts pH to 7.0, standing is cooled to room temperature；
（2）Filter and collect filter cake, vacuum freeze drying is simultaneously collected modified cellulose, is counted in parts by weight, respectively weigh 45~
50 parts of pH are that 4.0 disodium hydrogen phosphates-citrate buffer solution, 3~5 parts of tannic acid and 10~15 parts of modified celluloses are added to beaker
In, it is stirred and collects mixed liquor；
（3）Mixed liquor is set into oscillation treatment, standing is cooled to room temperature, and ultrasonic disperse collects to obtain dispersion liquid, adjusts pH to 3.0,
Dispersion liquid must be modified；
（4）In mass ratio 1:8, collagen powder is added in modified dispersion liquid, is stirred and stands, collect modification liquid simultaneously
It counts in parts by weight, weighs 45~50 parts of acetic acid solutions, 10~15 parts of modification liquids and 6~8 parts of hexafluoroisopropanols respectively and be placed in burning
In cup, it is stirred simultaneously standing and defoaming, collects to obtain spinning solution；
（5）Spinning solution is placed in electrostatic spinning apparatus needle tubing, mass ratio 1:10, polyethylene glycol oxide is added to modified dispersion liquid
In, it is stirred and electrostatic spinning is handled, collect spinning fibre, you can be prepared into artificial blood vessel with high mechanical properties fiber type film
Material.
Step（2）Described is filtered into the strainer filtering for being 0.25 micron with aperture.
Step（5）The electrostatic spinning processing is to be injected by 20# metal needles, adjusts electrostatic spinning voltage
For 10~15kV, solution fltting speed is 0.8~1.2mL/h, and it is 22~25cm to receive distance, in 20~25 DEG C, relative humidity
For 40~45% times electrostatic spinnings.
Compared with other methods, advantageous effects are the present invention：
（1）Technical solution of the present invention is aoxidized using nitroxyl radical material selectivity in glucide cellulose macromolecule
Primary hydroxyl carries out certain journey by reacting between oxidized fibre cellulosic material and amino on tropocollagen molecule chain to tropocollagen molecule chain
The crosslinking of degree, the three-dimensional netted cross-linked structure formed inside tropocollagen molecule by oxidized fibre cellulosic material, is effectively improved fibre
Tie up the filming performance and mechanical strength of membrane material；
（2）In technical solution of the present invention, by tannic acid modified, due to containing a large amount of hydroxyl inside tannic acid, there is antioxygen
The function of change, and multiple spot Hydrogenbond can occur with protein so that more closely, structure becomes the connection inside collagem membrane
Must be more fine and close, and tannic acid has flexibility for polyphenols, therefore also have certain filling effect so that collagem membrane
The degree of packing gets a promotion, to make to significantly improve by modified collagem membrane tensile strength.
Specific implementation mode
Count in parts by weight, respectively weigh 45~50 parts dissociation fiber slurries, 6~8 parts of tetramethyl piperidines, 1~2 part
NaClO and 1~2 part of sodium bromide, which is placed in beaker, to be stirred and with 5% salt acid for adjusting pH of mass fraction to 5.6,45~50
At DEG C after 1~2h of insulation reaction, then with 5% sodium hydroxide solution of mass fraction adjust pH to 7.0, standing is cooled to room temperature, use
Aperture be 0.25 micron strainer filtering and collect filter cake, vacuum freeze drying simultaneously collects modified cellulose；It counts in parts by weight,
It is 4.0 disodium hydrogen phosphates-citrate buffer solution, 3~5 parts of tannic acid and 10~15 parts of modified fibres to weigh 45~50 parts of pH respectively
Element is added in beaker, is stirred and collects mixed liquor, and mixed liquor is placed in 3~5h of oscillation treatment at 25~35 DEG C, is stood
It is cooled to room temperature, then 10~15min of ultrasonic disperse at 200~300W, collects to obtain dispersion liquid；Dispersion liquid is adjusted with acetic acid
PH to 3.0 obtains modified dispersion liquid and in mass ratio 1:8, collagen powder is added in modified dispersion liquid, is stirred and stands
6~8h collects modification liquid and to count in parts by weight, weighs 45~50 parts of 85% acetic acid solutions of mass fraction, 10~15 respectively
Part modification liquid and 6~8 parts of hexafluoroisopropanols are placed in beaker, are stirred simultaneously standing and defoaming, spinning solution are collected to obtain, by spinning solution
It is placed in electrostatic spinning apparatus needle tubing, mass ratio 1:10, polyethylene glycol oxide is added in modified dispersion liquid, is stirred and leads to
20# metal needles to be crossed to be injected, adjusting electrostatic spinning voltage is 10~15kV, and solution fltting speed is 0.8~1.2mL/h,
It is 22~25cm to receive distance, is 40~45% times electrostatic spinnings in 20~25 DEG C, relative humidity and collects spinning fibre, you can
Artificial blood vessel is prepared into high mechanical properties fiber type membrane material.
It counts in parts by weight, weighs 45 parts of dissociation fiber slurries, 6 parts of tetramethyl piperidines, 1 part of NaClO and 1 part of bromination respectively
Sodium, which is placed in beaker, to be stirred and with 5% salt acid for adjusting pH of mass fraction to 5.6, at 45 DEG C after insulation reaction 1h, then is used
5% sodium hydroxide solution of mass fraction adjusts pH to 7.0, and standing is cooled to room temperature, the strainer filtering for being 0.25 micron with aperture
And filter cake is collected, vacuum freeze drying simultaneously collects modified cellulose；It counts in parts by weight, it is 4.0 phosphoric acid to weigh 45 parts of pH respectively
Disodium hydrogen-citrate buffer solution, 3 parts of tannic acid and 10 parts of modified celluloses are added in beaker, are stirred and are collected mixing
Mixed liquor is placed in oscillation treatment 3h at 25 DEG C by liquid, and standing is cooled to room temperature, then the ultrasonic disperse 10min at 200W, is collected
Obtain dispersion liquid；By dispersion liquid vinegar acid for adjusting pH to 3.0, modified dispersion liquid and in mass ratio 1 are obtained:8, collagen powder is added to
In modified dispersion liquid, it is stirred and is stood 6h, collects modification liquid and to count in parts by weight, weighs 45 parts of mass fractions respectively
85% acetic acid solution, 10 parts of modification liquids and 6 parts of hexafluoroisopropanols are placed in beaker, are stirred simultaneously standing and defoaming, are collected to obtain and be spun
Silk liquid, spinning solution is placed in electrostatic spinning apparatus needle tubing, mass ratio 1:10, polyethylene glycol oxide is added to modified dispersion liquid
In, it is stirred and is injected by 20# metal needles, adjusting electrostatic spinning voltage is 10kV, and solution fltting speed is
0.8mL/h, it is 22cm to receive distance, is 40% time electrostatic spinning in 20 DEG C, relative humidity and collects spinning fibre, you can prepares
Obtain artificial blood vessel's high mechanical properties fiber type membrane material.
It counts in parts by weight, weighs 47 parts of dissociation fiber slurries, 7 parts of tetramethyl piperidines, 2 parts of NaClO and 2 part of brominations respectively
Sodium, which is placed in beaker, to be stirred and with 5% salt acid for adjusting pH of mass fraction to 5.6, at 47 DEG C after insulation reaction 2h, then is used
5% sodium hydroxide solution of mass fraction adjusts pH to 7.0, and standing is cooled to room temperature, the strainer filtering for being 0.25 micron with aperture
And filter cake is collected, vacuum freeze drying simultaneously collects modified cellulose；It counts in parts by weight, it is 4.0 phosphoric acid to weigh 47 parts of pH respectively
Disodium hydrogen-citrate buffer solution, 4 parts of tannic acid and 12 parts of modified celluloses are added in beaker, are stirred and are collected mixing
Mixed liquor is placed in oscillation treatment 4h at 27 DEG C by liquid, and standing is cooled to room temperature, then the ultrasonic disperse 12min at 250W, is collected
Obtain dispersion liquid；By dispersion liquid vinegar acid for adjusting pH to 3.0, modified dispersion liquid and in mass ratio 1 are obtained:8, collagen powder is added to
In modified dispersion liquid, it is stirred and is stood 7h, collects modification liquid and to count in parts by weight, weighs 47 parts of mass fractions respectively
85% acetic acid solution, 12 parts of modification liquids and 7 parts of hexafluoroisopropanols are placed in beaker, are stirred simultaneously standing and defoaming, are collected to obtain and be spun
Silk liquid, spinning solution is placed in electrostatic spinning apparatus needle tubing, mass ratio 1:10, polyethylene glycol oxide is added to modified dispersion liquid
In, it is stirred and is injected by 20# metal needles, adjusting electrostatic spinning voltage is 12kV, and solution fltting speed is
0.9mL/h, it is 23cm to receive distance, is 42% time electrostatic spinning in 22 DEG C, relative humidity and collects spinning fibre, you can prepares
Obtain artificial blood vessel's high mechanical properties fiber type membrane material.
It counts in parts by weight, weighs 50 parts of dissociation fiber slurries, 8 parts of tetramethyl piperidines, 2 parts of NaClO and 2 part of brominations respectively
Sodium, which is placed in beaker, to be stirred and with 5% salt acid for adjusting pH of mass fraction to 5.6, at 50 DEG C after insulation reaction 2h, then is used
5% sodium hydroxide solution of mass fraction adjusts pH to 7.0, and standing is cooled to room temperature, the strainer filtering for being 0.25 micron with aperture
And filter cake is collected, vacuum freeze drying simultaneously collects modified cellulose；It counts in parts by weight, it is 4.0 phosphoric acid to weigh 50 parts of pH respectively
Disodium hydrogen-citrate buffer solution, 5 parts of tannic acid and 15 parts of modified celluloses are added in beaker, are stirred and are collected mixing
Mixed liquor is placed in oscillation treatment 5h at 35 DEG C by liquid, and standing is cooled to room temperature, then the ultrasonic disperse 15min at 300W, is collected
Obtain dispersion liquid；By dispersion liquid vinegar acid for adjusting pH to 3.0, modified dispersion liquid and in mass ratio 1 are obtained:8, collagen powder is added to
In modified dispersion liquid, it is stirred and is stood 8h, collects modification liquid and to count in parts by weight, weighs 50 parts of mass fractions respectively
85% acetic acid solution, 15 parts of modification liquids and 8 parts of hexafluoroisopropanols are placed in beaker, are stirred simultaneously standing and defoaming, are collected to obtain and be spun
Silk liquid, spinning solution is placed in electrostatic spinning apparatus needle tubing, mass ratio 1:10, polyethylene glycol oxide is added to modified dispersion liquid
In, it is stirred and is injected by 20# metal needles, adjusting electrostatic spinning voltage is 15kV, and solution fltting speed is
1.2mL/h, it is 25cm to receive distance, is 45% time electrostatic spinning in 25 DEG C, relative humidity and collects spinning fibre, you can prepares
Obtain artificial blood vessel's high mechanical properties fiber type membrane material.
Example 1,2,3 prepared by the present invention is tested for the property, specific test result is as follows shown in table table 1：
1 performance test table of table
As seen from the above table, the fiber film material that prepared by the present invention has excellent mechanical property.
Claims (3)
1. a kind of artificial blood vessel preparation method of high mechanical properties fiber type membrane material, it is characterised in that specific preparation process
For：
（1）It counts in parts by weight, weighs 45~50 parts of dissociation fiber slurries, 6~8 parts of tetramethyl piperidines, 1~2 part of NaClO respectively
It is stirred with 1~2 part of sodium bromide, adjusting pH to 5.6, after insulation reaction, adjusts pH to 7.0, standing is cooled to room temperature；
（2）Filter and collect filter cake, vacuum freeze drying is simultaneously collected modified cellulose, is counted in parts by weight, respectively weigh 45~
50 parts of pH are that 4.0 disodium hydrogen phosphates-citrate buffer solution, 3~5 parts of tannic acid and 10~15 parts of modified celluloses are added to beaker
In, it is stirred and collects mixed liquor；
（3）Mixed liquor is set into oscillation treatment, standing is cooled to room temperature, and ultrasonic disperse collects to obtain dispersion liquid, adjusts pH to 3.0,
Dispersion liquid must be modified；
（4）In mass ratio 1:8, collagen powder is added in modified dispersion liquid, is stirred and stands, collect modification liquid simultaneously
It counts in parts by weight, weighs 45~50 parts of acetic acid solutions, 10~15 parts of modification liquids and 6~8 parts of hexafluoroisopropanols respectively and be placed in burning
In cup, it is stirred simultaneously standing and defoaming, collects to obtain spinning solution；
（5）Spinning solution is placed in electrostatic spinning apparatus needle tubing, mass ratio 1:10, polyethylene glycol oxide is added to modified dispersion liquid
In, it is stirred and electrostatic spinning is handled, collect spinning fibre, you can be prepared into artificial blood vessel with high mechanical properties fiber type film
Material.
2. a kind of preparation method of artificial blood vessel according to claim 1 high mechanical properties fiber type membrane material, special
Sign is：Step（2）Described is filtered into the strainer filtering for being 0.25 micron with aperture.
3. a kind of preparation method of artificial blood vessel according to claim 1 high mechanical properties fiber type membrane material, special
Sign is：Step（5）The electrostatic spinning processing is to be injected by 20# metal needles, adjusts electrostatic spinning voltage and is
10~15kV, solution fltting speed are 0.8~1.2mL/h, and it is 22~25cm to receive distance, is in 20~25 DEG C, relative humidity
40~45% times electrostatic spinnings.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113321936A (en) * | 2021-06-30 | 2021-08-31 | 西南林业大学 | High-strength biomass membrane material and preparation method thereof |
| CN114306728A (en) * | 2022-01-18 | 2022-04-12 | 人福医药集团医疗用品有限公司 | Composite film forming agent, waterproof liquid band-aid and preparation method thereof |
| CN114534527A (en) * | 2022-04-18 | 2022-05-27 | 重庆文理学院 | Membrane filtration assembly |
| CN114558467A (en) * | 2022-04-18 | 2022-05-31 | 重庆文理学院 | Protein-filtering bacterium-inhibiting hollow fiber membrane and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103333356A (en) * | 2013-06-27 | 2013-10-02 | 无锡贝迪生物工程有限公司 | Method for preparing collagen modified regenerated cellulose composite material |
| CN104491934A (en) * | 2014-12-25 | 2015-04-08 | 东莞颠覆产品设计有限公司 | Expansible coronary stent provided with collagen tectorial membrane |
| CN105999410A (en) * | 2016-05-05 | 2016-10-12 | 广州昕生医学材料有限公司 | Acellular tissue matrix composite and preparation method thereof |
-
2018
- 2018-06-19 CN CN201810626453.3A patent/CN108721696A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103333356A (en) * | 2013-06-27 | 2013-10-02 | 无锡贝迪生物工程有限公司 | Method for preparing collagen modified regenerated cellulose composite material |
| CN104491934A (en) * | 2014-12-25 | 2015-04-08 | 东莞颠覆产品设计有限公司 | Expansible coronary stent provided with collagen tectorial membrane |
| CN105999410A (en) * | 2016-05-05 | 2016-10-12 | 广州昕生医学材料有限公司 | Acellular tissue matrix composite and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| JING GAO等: "Water-Stability and Biological Behavior of Electrospun Collagen/PEO Fibers by Environmental Friendly Crosslinking", 《FIBERS AND POLYMERS》 * |
| 邓依等: "天然植物单宁酸交联改性胶原膜", 《皮革科学与工程》 * |
| 陈燕: "胶原基静电纺纤维/真丝复合人工血管材料的制备及性能", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113321936A (en) * | 2021-06-30 | 2021-08-31 | 西南林业大学 | High-strength biomass membrane material and preparation method thereof |
| CN114306728A (en) * | 2022-01-18 | 2022-04-12 | 人福医药集团医疗用品有限公司 | Composite film forming agent, waterproof liquid band-aid and preparation method thereof |
| CN114534527A (en) * | 2022-04-18 | 2022-05-27 | 重庆文理学院 | Membrane filtration assembly |
| CN114558467A (en) * | 2022-04-18 | 2022-05-31 | 重庆文理学院 | Protein-filtering bacterium-inhibiting hollow fiber membrane and preparation method and application thereof |
| CN114534527B (en) * | 2022-04-18 | 2023-07-04 | 重庆文理学院 | Membrane filtration assembly |
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