CN108699129A - 单链light受体激动剂蛋白 - Google Patents

单链light受体激动剂蛋白 Download PDF

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Publication number
CN108699129A
CN108699129A CN201680073585.7A CN201680073585A CN108699129A CN 108699129 A CN108699129 A CN 108699129A CN 201680073585 A CN201680073585 A CN 201680073585A CN 108699129 A CN108699129 A CN 108699129A
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China
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leu
gly
ser
val
thr
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201680073585.7A
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English (en)
Chinese (zh)
Inventor
克里斯汀·吉费斯
奥利弗·希尔
迈诺尔夫·蒂曼
蒂姆·施尼德
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Apogenix AG
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Apogenix AG
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Publication of CN108699129A publication Critical patent/CN108699129A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201680073585.7A 2015-10-23 2016-10-24 单链light受体激动剂蛋白 Pending CN108699129A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562245943P 2015-10-23 2015-10-23
US62/245,943 2015-10-23
PCT/EP2016/075536 WO2017068180A1 (en) 2015-10-23 2016-10-24 Single-chain light receptor agonist proteins

Publications (1)

Publication Number Publication Date
CN108699129A true CN108699129A (zh) 2018-10-23

Family

ID=57206257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073585.7A Pending CN108699129A (zh) 2015-10-23 2016-10-24 单链light受体激动剂蛋白

Country Status (7)

Country Link
US (2) US10683332B2 (cg-RX-API-DMAC10.html)
EP (1) EP3365361A1 (cg-RX-API-DMAC10.html)
JP (1) JP6873119B2 (cg-RX-API-DMAC10.html)
CN (1) CN108699129A (cg-RX-API-DMAC10.html)
AU (1) AU2016342420B2 (cg-RX-API-DMAC10.html)
CA (1) CA3002587A1 (cg-RX-API-DMAC10.html)
WO (1) WO2017068180A1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114632156A (zh) * 2022-05-17 2022-06-17 中国人民解放军军事科学院军事医学研究院 Tim-3在预防、治疗或减轻疼痛中的应用
WO2023237051A1 (en) * 2022-06-08 2023-12-14 Analytical Biosciences Shanghai Limited Light muteins and uses thereof

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3002588C (en) * 2015-10-23 2021-11-23 Apogenix Ag Single-chain cd137-receptor agonist proteins
JP2022512747A (ja) * 2018-10-17 2022-02-07 アルベルト・アインシュタイン・カレッジ・オブ・メディシン 抗体依存性細胞傷害（ａｄｃｃ）を増強する方法
WO2021229103A2 (en) 2020-05-15 2021-11-18 Apogenix Ag Multi-specific immune modulators
AU2021390545A1 (en) * 2020-12-03 2023-07-06 Shattuck Labs, Inc. Methods of treating cancer using tigit-and light-based chimeric proteins
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160322A (zh) * 2005-01-28 2008-04-09 阿波罗生命科学有限公司 分子及其嵌合分子
WO2010010051A1 (en) * 2008-07-21 2010-01-28 Apogenix Gmbh Tnfsf single chain molecules
WO2016146818A1 (en) * 2015-03-18 2016-09-22 Universität Stuttgart Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR025984A1 (es) 1999-10-07 2002-12-26 Maxygen Aps Polipeptidos oligomericos de cadena simple
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
WO2004085479A2 (en) 2003-03-26 2004-10-07 Apogenix Gmbh Treatment of viral infections
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
EP1844069A4 (en) 2005-01-28 2009-05-20 Apollo Life Sciences Ltd MOLECULES AND CHIMESE MOLECULES THEREOF
JP2008537941A (ja) * 2005-03-31 2008-10-02 ゼンコー・インコーポレイテッド 最適化特性を有するＦｃ変異体
WO2014202773A1 (en) * 2013-06-20 2014-12-24 Innate Pharma Enzymatic conjugation of polypeptides
NO2776305T3 (cg-RX-API-DMAC10.html) * 2014-04-23 2018-01-27

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160322A (zh) * 2005-01-28 2008-04-09 阿波罗生命科学有限公司 分子及其嵌合分子
WO2010010051A1 (en) * 2008-07-21 2010-01-28 Apogenix Gmbh Tnfsf single chain molecules
WO2016146818A1 (en) * 2015-03-18 2016-09-22 Universität Stuttgart Single-chain tnf ligand family molecules and fusion proteins and derivatives thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JUNG-HWAN LEE等: "Biochemical characterization of a new recombinant TNF receptor-hyFc fusion protein expressed in CHO cells", 《PROTEIN EXPRESSION AND PURIFICATION》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114632156A (zh) * 2022-05-17 2022-06-17 中国人民解放军军事科学院军事医学研究院 Tim-3在预防、治疗或减轻疼痛中的应用
WO2023237051A1 (en) * 2022-06-08 2023-12-14 Analytical Biosciences Shanghai Limited Light muteins and uses thereof

Also Published As

Publication number Publication date
CA3002587A1 (en) 2017-04-27
JP6873119B2 (ja) 2021-05-19
JP2018533948A (ja) 2018-11-22
US20180251509A1 (en) 2018-09-06
AU2016342420B2 (en) 2020-10-01
AU2016342420A1 (en) 2018-04-26
US20200331979A1 (en) 2020-10-22
WO2017068180A1 (en) 2017-04-27
EP3365361A1 (en) 2018-08-29
US10683332B2 (en) 2020-06-16

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Application publication date: 20181023