CN108697673A - 用于治疗莫顿神经瘤疼痛的辣椒碱依次给予方法 - Google Patents

用于治疗莫顿神经瘤疼痛的辣椒碱依次给予方法 Download PDF

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Publication number
CN108697673A
CN108697673A CN201780013961.8A CN201780013961A CN108697673A CN 108697673 A CN108697673 A CN 108697673A CN 201780013961 A CN201780013961 A CN 201780013961A CN 108697673 A CN108697673 A CN 108697673A
Authority
CN
China
Prior art keywords
capsaicine
neuroma
dosage
patient
metatarsal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780013961.8A
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English (en)
Chinese (zh)
Inventor
J·N·卡姆普贝尔
P·D·汉森
R·史蒂文
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Central Therapy Co
Original Assignee
Central Therapy Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Therapy Co filed Critical Central Therapy Co
Publication of CN108697673A publication Critical patent/CN108697673A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201780013961.8A 2016-01-22 2017-01-20 用于治疗莫顿神经瘤疼痛的辣椒碱依次给予方法 Pending CN108697673A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662281877P 2016-01-22 2016-01-22
US62/281,877 2016-01-22
PCT/US2017/014257 WO2017127628A1 (en) 2016-01-22 2017-01-20 Capsaicn sequential dosing method for treatment of morton's neuroma pain

Publications (1)

Publication Number Publication Date
CN108697673A true CN108697673A (zh) 2018-10-23

Family

ID=59362242

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780013961.8A Pending CN108697673A (zh) 2016-01-22 2017-01-20 用于治疗莫顿神经瘤疼痛的辣椒碱依次给予方法

Country Status (7)

Country Link
US (2) US20190022036A1 (cg-RX-API-DMAC7.html)
EP (1) EP3405187A4 (cg-RX-API-DMAC7.html)
JP (1) JP2019506397A (cg-RX-API-DMAC7.html)
CN (1) CN108697673A (cg-RX-API-DMAC7.html)
AU (1) AU2017210315A1 (cg-RX-API-DMAC7.html)
CA (1) CA3011647A1 (cg-RX-API-DMAC7.html)
WO (1) WO2017127628A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102657458B1 (ko) 2016-11-02 2024-04-12 센트렉시온 테라퓨틱스 코포레이션 안정한 수성의 캡사이신 주사 가능한 제형 및 이의 의학적 용도
IL272036B2 (en) 2017-07-20 2025-01-01 Centrexion Therapeutics Corp Methods and compositions for treating pain using capsaicin
WO2020041658A1 (en) * 2018-08-24 2020-02-27 Centrexion Therapeutics Corporation Capsaicin sequential dosing method for treatment of knee joint pain
US11447444B1 (en) 2019-01-18 2022-09-20 Centrexion Therapeutics Corporation Capsaicinoid prodrug compounds and their use in treating medical conditions
US11254659B1 (en) 2019-01-18 2022-02-22 Centrexion Therapeutics Corporation Capsaicinoid prodrug compounds and their use in treating medical conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1750839A (zh) * 2002-12-18 2006-03-22 阿尔高克斯制药公司 类辣椒素的给药
US20140142073A1 (en) * 2012-11-12 2014-05-22 Api Genesis, Llc Aqueous based capsaicinoid formulations and methods of manufacture and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040186182A1 (en) * 2002-12-18 2004-09-23 Algorx Administration of capsaicinoids
CN104010635A (zh) * 2011-09-09 2014-08-27 Api起源有限责任公司 包含trpv1选择性激动剂的止痛组合物及其制备和应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1750839A (zh) * 2002-12-18 2006-03-22 阿尔高克斯制药公司 类辣椒素的给药
US20140142073A1 (en) * 2012-11-12 2014-05-22 Api Genesis, Llc Aqueous based capsaicinoid formulations and methods of manufacture and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
朱洁平等: ""辣椒素与疼痛研究综述"", 《卫生职业教育》 *

Also Published As

Publication number Publication date
CA3011647A1 (en) 2017-07-27
EP3405187A1 (en) 2018-11-28
US20190022036A1 (en) 2019-01-24
AU2017210315A1 (en) 2018-08-16
US20200297670A1 (en) 2020-09-24
JP2019506397A (ja) 2019-03-07
WO2017127628A1 (en) 2017-07-27
EP3405187A4 (en) 2019-07-31

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SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20181023