CN108686165A - A kind of patch and its preparation method and application for pain therapy - Google Patents
A kind of patch and its preparation method and application for pain therapy Download PDFInfo
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- CN108686165A CN108686165A CN201810751756.8A CN201810751756A CN108686165A CN 108686165 A CN108686165 A CN 108686165A CN 201810751756 A CN201810751756 A CN 201810751756A CN 108686165 A CN108686165 A CN 108686165A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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Abstract
The patch and its preparation method and application that the present invention provides a kind of for pain therapy.The effective component raw material of patch of the present invention includes:Radix Angelicae Pubescentis, toddalia, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh, mustard seed and borneol;Auxiliary material includes:Rubber, lanolin, yellow petroleum jelly, rosin and zinc oxide.In the present invention, by by Radix Angelicae Pubescentis, the flying dragon blood palm, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh and mustard seed compatible use, so as to play dispelling wind and eliminating dampness, warming channel and expelling cold, promoting blood circulation dissolving phlegm, the effect of removing obstruction in channels to relieve pain;Have to the local pain discomfort situation caused by the blockage of main and collateral channels such as arthralgia, DOMS and traumatic injury and alleviate, promotes the health-care efficacy of rehabilitation.Meanwhile preparation method processing step of the present invention is easy, is not necessarily to rubber solution, thus the pollution for environment and patch caused by solvent use is avoided, so that preparation method of the present invention is more environmentally friendly, product patch is safe to use.
Description
Technical field
The present invention relates to medicine patch fields, in particular to a kind of patch for pain therapy and its preparation side
Method and application.
Background technology
With the quickening pace of modern life, the self health consciousness of people constantly enhances people, to health product in recent years
Demand increasingly increases.And because blockage of main and collateral channels disease causes the pain symptom in joint more and more, this is serious to affect people just
Normal work and quality of life.The unexpected injury that pain generates in mid-aged population, working clan crowd and sport people is more
See, doctor trained in Western medicine there is no preferable therapy for the pain symptom caused by all kinds of damages at present, clinically also without specific medicament,
Drug used is mostly non-steroid anti-inflammatory drug, hormone, immunosuppressor etc., and since medication time is long, toxic side effect is big, patient is past
It is past to be difficult to receive.Therefore, patient expects that the health treatment auxiliary of safer stabilization alleviates symptom.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of patch for pain therapy, patch of the present invention have it is quick,
Good effect, the advantages that having no toxic side effect.
The second object of the present invention is to provide a kind of preparation method of the patch for pain therapy, the present invention
Preparation method is easy to operate, is suitable for large-scale promotion and produces.
The third object of the present invention is to provide a kind of application of the patch for pain therapy.
In order to realize that the above-mentioned purpose of the present invention, spy use following technical scheme:
The effective component raw material of a kind of patch for pain therapy, the patch includes:Radix Angelicae Pubescentis, toddalia, Chinese cassia tree,
Turmeric, Rhizoma Chuanxiong, frankincense, myrrh, mustard seed and borneol.
Preferably, the raw material of patch of the present invention further includes auxiliary material;Wherein, the auxiliary material includes:Rubber, lanolin,
Yellow petroleum jelly, rosin and zinc oxide.
Preferably, in parts by weight, the effective component raw material of patch of the present invention includes:80~120 parts of Radix Angelicae Pubescentis,
80~120 parts of toddalia, 80~120 parts of Chinese cassia tree, 80~120 parts of turmeric, 80~120 parts of Rhizoma Chuanxiong, 30~60 parts of frankincense, myrrh
40~70 parts, 10~30 parts of 20~50 parts of mustard seed and borneol;It is furthermore preferred that in parts by weight, the drug effect of the patch
Component materials include:90~100 parts of Radix Angelicae Pubescentis, 100~110 parts of toddalia, 90~100 parts of Chinese cassia tree, 100~110 parts of turmeric, river
15~20 parts of 90~100 parts of rhizome of chuanxiong, 40~50 parts of frankincense, 50~60 parts of myrrh, 30~40 parts of mustard seed and borneol;It is further excellent
Choosing, in parts by weight, the effective component raw material of the patch includes:100 parts of Radix Angelicae Pubescentis, 100 parts of toddalia, Chinese cassia tree
100 parts, 100 parts of turmeric, 100 parts of Rhizoma Chuanxiong, 50 parts of frankincense, 50 parts of myrrh, 15 parts of 30 parts of mustard seed and borneol.
Preferably, in parts by weight, the raw material of patch of the present invention includes:80~120 parts of Radix Angelicae Pubescentis, toddalia
80~120 parts, 80~120 parts of Chinese cassia tree, 80~120 parts of turmeric, 80~120 parts of Rhizoma Chuanxiong, 30~60 parts of frankincense, myrrh 40~70
Part, 10~30 parts of 20~50 parts of mustard seed and borneol;And 350~500 parts of rubber, 10~30 parts of lanolin, yellow petroleum jelly
20~50 parts, 500~700 parts of 150~250 parts of rosin and zinc oxide.
Meanwhile the present invention also provides the preparation methods of the patch for pain therapy, including:By Radix Angelicae Pubescentis, fly
The dragon's blood palm, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh and mustard seed extract after crushing, and are concentrated to give medicinal extract;By rubber be soaked in by
In borneol and grinding acquired solution;By the rubber mix after rosin, yellow petroleum jelly, lanolin, zinc oxide, medicinal extract, and immersion, obtain
To semi-finished product lotion;Heating and filtering after semi-finished product lotion is refined, obtains finished product lotion;Finished product lotion applies slice packaging after cream,
Obtain the patch for pain therapy.
Preferably, in preparation method of the present invention, the extraction includes:After raw material after crushing is mixed, with second
Alcohol reflux extracts, recycling gained extracting solution;And/or the concentration includes:Gained extracting solution, which is concentrated to give relative density, is
1.15~1.20 thick paste.
Preferably, preparation method of the present invention includes:Rubber after shearing is pressed to refining in rubber mixing machine, obtains millimeter
The netted or sheet rubber block of grade grain size, is then soaked in again by borneol and grinding acquired solution.
Preferably, in preparation method of the present invention, the preparation of semi-finished product lotion includes:By material in rubber kneading machine
In mixed, mixed temperature control at 50~60 DEG C;Wherein, in mixed process, every 10 minutes rubber kneading machines are opened anti-
Transport 2~5min of row.
Preferably, in preparation method of the present invention, heating and filtering includes after the refining of semi-finished product lotion:It will refine later half
Finished product lotion heats 15~60min under the conditions of 80~100 DEG C;Then it is that 50~120 mesh screens are filtered with aperture.
Meanwhile the present invention also provides the answering in preparing pain therapy drug of the patch for pain therapy
With.
Compared with prior art, beneficial effects of the present invention are:
(1) in the present invention, by by Radix Angelicae Pubescentis, the flying dragon blood palm, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh and mustard seed compatibility
It uses, so as to play dispelling wind and eliminating dampness, warming channel and expelling cold, promoting blood circulation dissolving phlegm, the effect of removing obstruction in channels to relieve pain;To arthralgia, muscle acid
Local pain discomfort situation bitterly and caused by the blockage of main and collateral channels such as traumatic injury, which has, to be alleviated, and the health-care efficacy of rehabilitation is promoted.
(2) preparation method processing step of the present invention is easy, is not necessarily to rubber solution, thus avoids caused by solvent use
Environment and pollution for patch, and this is but also preparation method of the present invention is more environmentally friendly, and product patch is safe to use.
Description of the drawings
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described.
The patch preparation process flow schematic diagram that Fig. 1 is provided by the embodiment of the present invention.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
Patch provided by the present invention for pain therapy, be with traditional Chinese medicine Radix Angelicae Pubescentis, toddalia, Chinese cassia tree, turmeric,
Rhizoma Chuanxiong, frankincense, myrrh, mustard seed and borneol cooperation can using auxiliary material as external use plaster made by carrier as pharmacodynamic raw materials
Good alleviation and rush are played for the local pain caused by the blockage of main and collateral channels such as arthralgia, DOMS, bruises and sprains
Into the effect of rehabilitation.
Specifically, in the present invention, each effective substance effect is as follows:
The pungent scattered hardship of Radix Angelicae Pubescentis is dry, and the fragrant temperature of gas is logical, is apt to energy dispelling wind and eliminating dampness, numbness relieving and pain relieving."Mingyi Bielu"Call its " control all wind, hundred
Section gout is without asking new long person ".All wet miscellaneous to caused numbness pains of chill, no matter course of disease length is suddenly slow, can all apply, oral administration and externally all has
Good effect.
Toddalia is pungent, slight bitter, temperature, has a wind-expelling pain-stopping, dissipate stasis of blood hemostasis, subdhing swelling and detoxicating effect, and Guizhou national folk is used
This medicine treats arthralgia pain due to rheumatism, has a stomachache, injury from falling down, knife wound bleeding, and a variety of pain diseases such as dysmenorrhoea often mash and dress affected part, really
There is effect.
Chinese cassia tree is pungent, sweet, big heat.Kidney,spleen,liver is returned to pass through and can manage it between bones muscle, energy eliminating cold to stop pain, invigorate blood circulation.It is kind
Control waist and knee crymodynia and cold blood coagulation and caused irregular menstruation, dysmenorrhoea, amenorrhoea and postpartum stasis of the cold-dampness visitor caused by bones muscle
Abdominal pain etc..
Turmeric:It is pungent, bitter, temperature.Returns spleen, Liver Channel;With blood-breaking, it is inducing meastruation to relieve menalgia the effect of;For chest side of body shouting pain, the obstruction of qi in the chest
It is pained, dysmenorrhoea Amenorrhea , Disorder lumps in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.
Rhizoma Chuanxiong:It is acrid in flavour and warm in nature.Return liver, courage, pericardium channel;With blood-activating and qi-promoting, the effect of wind-expelling pain-stopping;For chest impediment and cardialgia, chest
Coerce shouting pain, tumbling and swelling, irregular menstruation, closed dysmenorrhea , Disorder lump in the abdomen is suffered from abdominal pain, headache, arthralgia pain due to rheumatism.
Frankincense:It is pungent, bitter, temperature.The thoughts of returning home, liver, the spleen channel;With promoting blood circulation analgesic therapy, the effect of detumescence and promoting granulation;For chest impediment and cardialgia,
Gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, muscle arteries and veins contraction, traumatic injury, carbuncle swells sore.
Myrrh:It is pungent, it is bitter, flat.The thoughts of returning home, liver, the spleen channel;With scattered stasis pain, the effect of detumescence and promoting granulation;For chest impediment and cardialgia,
Gastral cavity pain, dysmenorrhoea Amenorrhea, postpartum stasis , Disorder lump in the abdomen is suffered from abdominal pain, arthralgia pain due to rheumatism, traumatic injury, carbuncle swells sore.
Mustard seed:It is acrid in flavour and warm in nature.It is distributed in lung channel;With the effect of warm lung slit phlegm profit gas, dissipating bind is removed obstruction in channels to relieve pain;For trembling with fear, productive cough is coughed, chest
Coerce distending pain, the stagnant channels and collaterals of phlegm, joint numbness, pain, phlegm-damp oozing in the body, cloudy subcutaneous ulcer pyogenic infections.
Borneol:It is pungent, bitter, it is slightly cold.The thoughts of returning home, spleen, lung channel;With inducing resuscitation of having one's ideas straightened out, the effect of clearing away heat to and alleviating pain;With pyreticosis coma,
Convulsions, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, chest impediment and cardialgia, hot eyes, aphtha, abscess of throat, duct are suppurated.
In pharmaceutical formulation as above, toddalia and Radix Angelicae Pubescentis phase 5 can enhance the work(and dissipate that Radix Angelicae Pubescentis dispels wind and dampness and relieve pain
The benefits of stagnation resolvation is swollen with evident coronary circulation-promoting pain-relieving, is altogether monarch drug in a prescription.Mustard seed, Chinese cassia tree, turmeric, four medicine compatibility of Rhizoma Chuanxiong, can enhance monarch drug in a prescription wind-dispelling
Dehumidifying, promoting blood circulation and stopping pain power, and can temperature through eliminating the phlegm, blood-activating and qi-promoting with remove train of thought phlegm wet qi and blood silts hinder with reinforce relieve pain the benefits of,
It is used altogether for ministerial drug.Assistant reaches channels and collaterals thoroughly with frankincense, the sensible qi and blood of myrrh, and with analgesic therapy, two medicine phases must be to use, and have for eliminating stasis to subdue swelling
The key medicine of traumatology " outer, " appellation, external application health product makes its fragrance walk to alter, analgesic therapy of invigorate blood circulation, detumescence and promoting granulation the benefits of show further, enhancing is deposited
Paste the power of sensible analgesic.Borneol is to make medicine, and one assists the work(that full side sticks analgesic with the work(of borneol swelling and pain relieving, and the two is with it
The full side of the benefits of cool scattered stagnated fire assistant system warms the disadvantage for helping fire to be unfavorable for affected part red and swollen heat pain dissipation;It can be walked to alter power with the pungent perfume (or spice) of borneol again strong
Feature, external application draws all medicines and works thoroughly up to affected part skin up to having one's ideas straightened out thoroughly, to make medicine be used.
Further, there is good compatibility effect, for the chill for being led to pain between present invention pharmacodynamic raw materials as above
The causes of disease such as damp evil, phlegm stagnation, qi depression to blood stasis, swollen knot, play dispelling wind and eliminating dampness altogether, warming channel and expelling cold, dissolving phlegm of invigorating blood circulation, work of removing obstruction in channels to relieve pain
With, it is made of suitable technique and sticks preparation, choose muscles along the regular meridians or point-application appropriate, the gas turbid or foul to rheumatism, phlegm
Neck, shoulder, waist caused by numbness resistance channels and collaterals blood vessels and qi depression to blood stasis, leg joint pain, the muscle muscles along the regular meridians pain caused by ecchymoma of injury from falling down
(no wound bleeding person), can play the role of lenitive.
Further, in parts by weight, in patch pharmacodynamic raw materials of the present invention, each raw material proportioning is as follows:Radix Angelicae Pubescentis 80~
120 parts, such as can be, but it is not limited to 90,100 or 110 parts etc.;80~120 parts of toddalia, such as can be, but not
It is limited to 90,100 or 110 parts etc.;
80~120 parts of Chinese cassia tree, such as can be, but it is not limited to 90,100 or 110 parts etc.;80~120 parts of turmeric, example
It such as can be, but be not limited to 90,100 or 110 parts etc.;80~120 parts of Rhizoma Chuanxiong, such as can be, but 90,100 are not limited to,
Or 110 parts etc.;30~60 parts of frankincense, such as can be, but it is not limited to 40 or 50 parts etc.;40~70 parts of myrrh, such as can
Think, but is not limited to 40,50 or 60 parts etc.;20~50 parts of mustard seed, such as can be, but it is not limited to 30 or 40 parts etc.;
And 10~30 parts of borneol, such as can be, but it is not limited to 15,20 or 25 parts etc..
Preferably, in parts by weight, in patch pharmacodynamic raw materials of the present invention, each raw material proportioning is as follows:Radix Angelicae Pubescentis 90~100
Part, 100~110 parts of toddalia, 90~100 parts of Chinese cassia tree, 100~110 parts of turmeric, 90~100 parts of Rhizoma Chuanxiong, frankincense 40~50
15~20 parts of part, 50~60 parts of myrrh, 30~40 parts of mustard seed and borneol;
It is furthermore preferred that in parts by weight, in patch pharmacodynamic raw materials of the present invention, each raw material proportioning is as follows:Radix Angelicae Pubescentis 100
Part, 100 parts of toddalia, 100 parts of Chinese cassia tree, 100 parts of turmeric, 100 parts of Rhizoma Chuanxiong, 50 parts of frankincense, 50 parts of myrrh, 30 parts of mustard seed, with
And 15 parts of borneol.
Meanwhile as the auxiliary material of patch carrier of the present invention, raw material group becomes:Rubber, lanolin, yellow petroleum jelly, rosin,
And zinc oxide;
Further, in parts by weight, each raw material proportioning is as follows in patch auxiliary material of the present invention:Rubber 350~500
Part, such as can be, but it is not limited to 375,400,425,450 or 475 parts etc.;10~30 parts of lanolin, such as can be,
But it is not limited to 15,20 or 25 parts etc.;20~50 parts of yellow petroleum jelly, such as can be, but 25,30,35,40 are not limited to, or
45 parts etc.;150~250 parts of rosin, such as can be, but it is not limited to 175,200 or 225 parts etc.;And zinc oxide 500~
700 parts, such as can be, but it is not limited to 525,550,575,600,625,650 or 675 parts etc..
Preferably, in parts by weight, each raw material proportioning is as follows in patch auxiliary material of the present invention:415 parts of rubber, lanolin
20 parts, 30 parts of yellow petroleum jelly, 580 parts of 214 parts of rosin and zinc oxide.
Preparation method technique of the present invention for pain therapy patch is also relatively simple, and specific steps can refer to as follows:
(a) 8 kinds of raw materials such as Radix Angelicae Pubescentis, toddalia, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh and mustard seed are crushed;It will
Crushed material is put into extraction tank, and is extracted 2 times, every time 1.5 hours with 90% alcohol reflux;
Then, it is 1.15~1.20 (60 DEG C) extraction gained liquid to be concentrated into relative density, and it is spare to obtain thick paste.
(b) weighing borneol agitation grinding by prescription makes it dissolve, and gained borneol liquid is spare.
(c) weigh rubber, cut into 2 to 3kg fritters, then opening rubber mixing machine pressure be smelt 1 to 2mm it is thick netted or
Sheet rubber block;
Rubber block is added in borneol liquid and is impregnated, and is impregnated 16 hours or more, make the full and uniform exhaustion liquid of rubber block.
(d) by rosin, yellow petroleum jelly, lanolin, zinc oxide and thick paste (step (a) obtains), and the rubber soaked (walks
Suddenly (c) is obtained) it puts into rubber kneading machine, it is sufficiently mixed, mixes 30 minutes ON cycle water coolings;
Wherein, it during material as above is sufficiently mixed, needs to control the temperature of material at 50 to 60 DEG C, avoids height
Temperature leads to the inactivation of effective substance;Meanwhile reversion operation 3min is opened per 10min rubber kneading machines, so that its material is sufficiently mixed
Uniformly, hash total 60min obtains semi-finished product lotion;
Then, rubber kneading machine self-emptying is opened, semi-finished product lotion is stood into storage 16h or more.
(e) gained semi-finished product lotion is refined with opening rubber mixing machine, rubber mixing machine roll spacing control is pressed 1 to 1.5mm
Refining 3 to 4 times so that the flexible toughness of lotion gloss.
(f) lotion after refining is placed in 90 DEG C of constant temperature ovens to heat 30 minutes, then 80 mesh screens is crossed with rubber strainer and are filtered off
Impurity obtains finished product lotion.
(g) gained finished product lotion is subjected to painting cream in base fabric (can be non-woven fabrics etc.) while hot, it is cooling, it cuts, winding;
It is while winding, cream cloth is compound with separate paper, it is then sliced, obtains finished patch;
Further, for the ease of storage, transport and sale, finished patch can also be wrapped with medicinal aluminum foil bag
Dress, and case after sealing.
Detailed process is as shown in Figure 1.
Although in the prior art, also disclosing that some similar to Chinese herbs paste product, in existing method, be only by effect more
Raw material is simply mixed with the auxiliary material comprising rubber, or after rubber is dissolved with solvent, then is mixed with pharmacodynamic raw materials
It closes.Since General Physics mixing used can not make material uniformly mix fully, so product can be caused to paste in these methods
The composition of agent is uneven, and product quality is difficult to control;Meanwhile in existing certain methods solvent use, can not only increase cost, and
And the use of organic solvent all has potentially hazardous property, but also there is organic solvents for environment and operator
The problem of processing, it is both uneconomical, also not environmentally.
And the processing steps such as above-mentioned kneading of the present invention, refining, it can not only ensure being sufficiently mixed for raw material,
Enable each ingredient evenly dispersed, while also avoiding cost, health and environmental problem caused by solvent use.
Embodiment 1
According to:Radix Angelicae Pubescentis 100g, toddalia 100g, Chinese cassia tree 100g, turmeric 100g, Rhizoma Chuanxiong 100g, frankincense 50g, myrrh
50g, mustard seed 30g and borneol 15g, weigh each major ingredient respectively;
Rubber 415g, lanolin 20g, yellow petroleum jelly 30g, rosin 214g and zinc oxide 580g are weighed each auxiliary respectively
Material.
Then, in accordance with the following steps, the patch of embodiment 1 is prepared:
(1) Radix Angelicae Pubescentis, toddalia, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh and mustard seed are crushed;Crushed material is put into
In extractor, extracted 2 times, every time 1.5 hours with 90% alcohol reflux;Then, extraction gained liquid is concentrated into relative density
For 1.20 (60 DEG C), thick paste is obtained;
(2) weighing borneol agitation grinding by prescription makes it dissolve, gained borneol liquid;
(3) weigh rubber, cut into 2 to 3kg fritters, then opening rubber mixing machine pressure be smelt 1 to 2mm it is thick netted or
Sheet rubber block;
Rubber block is added in borneol liquid and impregnates 16h or more, makes the full and uniform exhaustion liquid of rubber block;
(4) by rosin, yellow petroleum jelly, lanolin, zinc oxide and thick paste, and the rubber soaked puts into rubber kneading machine
In, it is sufficiently mixed, mixes 30 minutes ON cycle water coolings;
The temperature of control material is at 50 to 60 DEG C during mixing,;Meanwhile opening reversion per 10min rubber kneading machines
3min is run, so that its material is sufficiently mixed uniformly, hash total 60min obtains semi-finished product lotion;
Then, rubber kneading machine self-emptying is opened, semi-finished product lotion is stood into storage 16h or more.
(5) gained semi-finished product lotion is refined with opening rubber mixing machine, rubber mixing machine roll spacing control is pressed 1 to 1.5mm
Refining 3 to 4 times.
(6) lotion after refining is placed in 90 DEG C of constant temperature ovens to heat 30 minutes, then 80 mesh screens is crossed with rubber strainer and are filtered off
Impurity obtains finished product lotion.
(7) gained finished product lotion is subjected to painting cream in base fabric (can be non-woven fabrics etc.) while hot, it is cooling, it cuts, winding;
Winding while, cream cloth is compound with separate paper, be then sliced, obtain 1000 patch specification 7cm × 10cm at
Product patch.
Embodiment 2
According to:Radix Angelicae Pubescentis 80g, toddalia 120g, Chinese cassia tree 120g, turmeric 80g, Rhizoma Chuanxiong 120g, frankincense 30g, myrrh 40g,
Mustard seed 40g and borneol 15g, weighs each major ingredient respectively;
Rubber 415g, lanolin 20g, yellow petroleum jelly 30g, rosin 214g and zinc oxide 580g are weighed each auxiliary respectively
Material.
Then, with reference to the method for embodiment 1, the patch of embodiment 2 is prepared.
Comparative example 1
According to:Radix Angelicae Pubescentis 200g, Chinese cassia tree 100g, turmeric 100g, Rhizoma Chuanxiong 100g, frankincense 50g, myrrh 50g, mustard seed 30g, and
Borneol 15g weighs each major ingredient respectively;
Rubber 415g, lanolin 20g, yellow petroleum jelly 30g, rosin 214g and zinc oxide 580g are weighed each auxiliary respectively
Material.
Then, with reference to the method for embodiment 1, the patch of comparative example 1 is prepared.
Comparative example 2
According to:Radix Angelicae Pubescentis 130g, toddalia 100g, Chinese cassia tree 100g, turmeric 100g, Rhizoma Chuanxiong 100g, frankincense 50g, myrrh
50g and borneol 15g, weighs each major ingredient respectively;
Rubber 415g, lanolin 20g, yellow petroleum jelly 30g, rosin 214g and zinc oxide 580g are weighed each auxiliary respectively
Material.
Then, with reference to the method for embodiment 1, the patch of comparative example 2 is prepared.
Comparative example 3
According to:Radix Angelicae Pubescentis 150g, toddalia 150g, Chinese cassia tree 100g, Rhizoma Chuanxiong 100g, frankincense 50g, myrrh 50g, mustard seed 30g,
And borneol 15g, each major ingredient is weighed respectively;
Rubber 415g, lanolin 20g, yellow petroleum jelly 30g, rosin 214g and zinc oxide 580g are weighed each auxiliary respectively
Material.
Then, with reference to the method for embodiment 1, the patch of comparative example 3 is prepared.
Comparative example 4
According to:Radix Angelicae Pubescentis 100g, toddalia 100g, Chinese cassia tree 100g, turmeric 100g, Rhizoma Chuanxiong 100g, frankincense 50g, myrrh
50g, mustard seed 30g and borneol 15g, weigh each major ingredient respectively;
Rubber 415g, lanolin 20g, yellow petroleum jelly 30g, rosin 214g and zinc oxide 580g are weighed each auxiliary respectively
Material.
Then, as follows, the patch of comparative example 4 is prepared:
According to 1 step of embodiment (1) method, Radix Angelicae Pubescentis, toddalia, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh are obtained, with
And Semen Brassicae Junceae extract thick paste;
Rubber is impregnated into 12h or more with the ethyl acetate of 5 times of quality, obtains rubber colloid;
After rubber colloid and extract thick paste, borneol and remaining auxiliary material are mixed, according to the side of 1 step of embodiment (7)
Method obtains finished patch.
Experimental example 1
In May, 2016 to the soft tissue bruise gone to a doctor to certain hospital outpatient between in May, 2017 leads to patient in great pain,
The Patients with 300 Cases for agreeing to be treated using external use plaster is chosen, is equally divided into 6 groups, every group of 50 patients;Patient age is 25
Between~55 years old, each group patient is statistically analyzed in terms of gender, age, the state of an illness and the course of disease, no significant difference,
It is comparable;
Wherein, 1-2 groups patient uses the patch of embodiment 1,2,3-6 groups patient to use comparative example 1-4 respectively respectively
Patch;After patient cleans affected part, corresponding patch is attached, a daily patch cleans up affected part during replacement;
Curative effect counts:
It cures:Affected part is painless;It is effective:Affected part feeling of pain is substantially reduced;Effectively:Affected part feeling of pain is mitigated;Nothing
Effect:Affected part feeling of pain is or even serious substantially without improvement.
After a week, each group patient is paid a return visit, counts treatment, it is as a result as follows:
| Experimental group | It cures | It is effective | Effectively | In vain | Efficient (%) |
| Embodiment 1 | 16 | 19 | 13 | 3 | 94 |
| Embodiment 2 | 12 | 16 | 18 | 4 | 92 |
| Comparative example 1 | 3 | 14 | 21 | 12 | 76 |
| Comparative example 2 | 9 | 10 | 23 | 8 | 84 |
| Comparative example 3 | 10 | 12 | 19 | 9 | 82 |
| Comparative example 4 | 13 | 9 | 23 | 5 | 90 |
By therapeutic test as above it is found that patch of the present invention for the pain caused by soft tissue bruise have it is good
Alleviation and therapeutic effect;
And by embodiment and comparative example therapeutic effect data comparison it is found that either monarch drug in a prescription or ministerial drug collocation use,
The therapeutic effect of patch of the present invention is all had a significant impact;
Meanwhile it is more excellent by the apparent wholistic therapy effect of patch prepared by the method for the present invention, it cures and effective patient populations
It is significantly more.It can be seen that the method for the present invention enables to effective substance dispersion to be more uniformly distributed, product patch quality is more excellent.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of patch for pain therapy, which is characterized in that the effective component raw material of the patch includes:
Radix Angelicae Pubescentis, toddalia, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh, mustard seed and borneol.
2. patch according to claim 1, which is characterized in that the raw material of the patch further includes auxiliary material;
Wherein, the auxiliary material includes:Rubber, lanolin, yellow petroleum jelly, rosin and zinc oxide.
3. patch according to claim 1 or 2, which is characterized in that in parts by weight, the effective component of the patch
Raw material includes:
80~120 parts of Radix Angelicae Pubescentis, 80~120 parts of toddalia, 80~120 parts of Chinese cassia tree, 80~120 parts of turmeric, Rhizoma Chuanxiong 80~120
10~30 parts of part, 30~60 parts of frankincense, 40~70 parts of myrrh, 20~50g of mustard seed and borneol;
Preferably, in parts by weight, the effective component raw material of the patch includes:
90~100 parts of Radix Angelicae Pubescentis, 100~110 parts of toddalia, 90~100 parts of Chinese cassia tree, 100~110 parts of turmeric, Rhizoma Chuanxiong 90~100
15~20 parts of part, 40~50 parts of frankincense, 50~60 parts of myrrh, 30~4 parts of mustard seed and borneol;
It is furthermore preferred that in parts by weight, the effective component raw material of the patch includes:
100 parts of Radix Angelicae Pubescentis, 100 parts of toddalia, 100 parts of Chinese cassia tree, 100 parts of turmeric, 100 parts of Rhizoma Chuanxiong, 50 parts of frankincense, 50 parts of myrrh,
15 parts of 30 parts of mustard seed and borneol.
4. patch according to claim 3, which is characterized in that in parts by weight, the raw material of the patch includes:
80~120 parts of Radix Angelicae Pubescentis, 80~120 parts of toddalia, 80~120 parts of Chinese cassia tree, 80~120 parts of turmeric, Rhizoma Chuanxiong 80~120
10~30 parts of part, 30~60 parts of frankincense, 40~70 parts of myrrh, 20~50 parts of mustard seed and borneol;
And 350~500 parts of rubber, 10~30 parts of lanolin, 20~50 parts of yellow petroleum jelly, 150~250 parts of rosin and oxygen
Change 500~700 parts of zinc.
5. the preparation method of the patch for pain therapy described in any one of claim 1-4, which is characterized in that including:
It is extracted after Radix Angelicae Pubescentis, the flying dragon blood palm, Chinese cassia tree, turmeric, Rhizoma Chuanxiong, frankincense, myrrh and mustard seed are crushed, is concentrated to give medicinal extract;
Rubber is soaked in by borneol and grinding acquired solution;
By the rubber mix after rosin, yellow petroleum jelly, lanolin, zinc oxide, medicinal extract, and immersion, semi-finished product lotion is obtained;
Heating and filtering after semi-finished product lotion is refined, obtains finished product lotion;
Finished product lotion applies slice packaging after cream, obtains the patch for pain therapy.
6. preparation method according to claim 5, which is characterized in that the extraction includes:Raw material after crushing is mixed
Afterwards, it is extracted with alcohol reflux, recycling gained extracting solution;
And/or the concentration includes:Gained extracting solution is concentrated to give the thick paste that relative density is 1.15~1.20.
7. preparation method according to claim 5, which is characterized in that the method includes:
Rubber after shearing is pressed to refining in rubber mixing machine, the netted or sheet rubber block of grade grain size is obtained, then again by it
It is soaked in by borneol and grinding acquired solution.
8. preparation method according to claim 5, which is characterized in that the preparation of semi-finished product lotion includes:
Material is mixed in rubber kneading machine, mixed temperature is controlled at 50~60 DEG C;
Wherein, in mixed process, every 10 minutes rubber kneading machines open reversion 2~5mi of operation n.
9. preparation method according to claim 5, which is characterized in that heating and filtering includes after the refining of semi-finished product lotion:
Semi-finished product lotion heats 15~60mi n under the conditions of 80~100 DEG C after refining;Then it is sieved for 50~120 mesh with aperture
Net is filtered.
10. application of the patch for pain therapy in preparing pain therapy drug described in any one of claim 1-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810751756.8A CN108686165A (en) | 2018-07-10 | 2018-07-10 | A kind of patch and its preparation method and application for pain therapy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810751756.8A CN108686165A (en) | 2018-07-10 | 2018-07-10 | A kind of patch and its preparation method and application for pain therapy |
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| Publication Number | Publication Date |
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| CN108686165A true CN108686165A (en) | 2018-10-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810751756.8A Pending CN108686165A (en) | 2018-07-10 | 2018-07-10 | A kind of patch and its preparation method and application for pain therapy |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318071A (en) * | 2021-06-17 | 2021-08-31 | 广州泰柯碧缇科技有限公司 | Gel for treating foot and knee pain and preparation method thereof |
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| CN1623568A (en) * | 2003-12-03 | 2005-06-08 | 李宗悟 | Traditional Chinese medicine for treating hyperosteogeny and protrusion of interverteral disc |
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| CN1623568A (en) * | 2003-12-03 | 2005-06-08 | 李宗悟 | Traditional Chinese medicine for treating hyperosteogeny and protrusion of interverteral disc |
| CN101559098A (en) * | 2008-04-14 | 2009-10-21 | 北京汉潮联创中药科技有限公司 | Chinese patent medicine for treating scapulohumeral periarthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113318071A (en) * | 2021-06-17 | 2021-08-31 | 广州泰柯碧缇科技有限公司 | Gel for treating foot and knee pain and preparation method thereof |
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