CN108671081A - Shield heart protects the compound Chinese medicinal preparation and preparation method that arteries and veins cerebral tonic tranquillizing slows down aging - Google Patents
Shield heart protects the compound Chinese medicinal preparation and preparation method that arteries and veins cerebral tonic tranquillizing slows down aging Download PDFInfo
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- CN108671081A CN108671081A CN201810740961.4A CN201810740961A CN108671081A CN 108671081 A CN108671081 A CN 108671081A CN 201810740961 A CN201810740961 A CN 201810740961A CN 108671081 A CN108671081 A CN 108671081A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of shield heart protects the compound Chinese medicinal preparation and preparation method of arteries and veins cerebral tonic tranquillizing anti-aging.The shield heart of the present invention protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to weight percent, including 35% 50% gynostemma pentaphylla, 10% 30% ganoderma lucidums, and 20% 30% tealeaves, 1% 5% jujubes.The shield heart of the present invention, which protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, has shield heart Bao Mai, cerebral tonic tranquillizing, the effect of function of delaying senility, it is suitble to be used for a long time, reach six punching seven of conditioning vital organs of the human body dredging, liver, kidney, gas, blood balance, purpose of the perverse trend from body.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of shield heart protects the Chinese medicine of arteries and veins cerebral tonic tranquillizing anti-aging
Compound preparation and preparation method.
Background technology
Hyperlipidemia, high lithemia, hypertension be cause the basis of artery sclerosis, and generate cardiovascular and cerebrovascular diseases main causes it
One.Insomnia, depression are to influence quality of life, reduce the important negative factor of immune function.With the improvement of living standards, people
Service life increasingly grow up；How to slow down aging, the internal organs kept fit, function of joint, reduce society and personal life at
Sheet and great social topics；Tea is the generally acknowledged healthy beverage in the whole world.It is how strong using natural medical and edible dual purpose plant
The healthcare function for changing tea, the palatability for improving tea have innovative and practical value.
Tea is the generally acknowledged healthy beverage in the whole world.How the healthcare function of tea is strengthened using natural medical and edible dual purpose plant,
The palatability for improving tea has innovative and practical value.
Invention content
In view of the problems of the existing technology, it is multiple to provide a kind of Chinese medicine that shield heart protects the anti-aging of arteries and veins cerebral tonic tranquillizing by the present invention
Square preparation and preparation method, medicine composite preparation can improve six punching seven of vital organs of the human body dredging in this, and liver, kidney, gas, blood balance,
Perverse trend is suitble to be used for a long time, has shield heart Bao Mai, cerebral tonic tranquillizing, the effect of function of delaying senility from body, medicine-food two-purpose.
The shield heart of the present invention protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to weight percent, including
35%-50% gynostemma pentaphylla, 10%-30% ganoderma lucidums, 20%-30% tealeaves, 1%-5% jujubes.
The shield heart of the present invention protects the preparation method for the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to the following steps
It carries out：
According to weight percent 35%-50% gynostemma pentaphylla, 10%-30% ganoderma lucidums, 20%-30% tealeaves, 1%-5% jujubes
Carry out dispensing；
By gynostemma pentaphylla, ganoderma lucidum, tealeaves, jujube pulverizing medicinal materials are prepared into powder at 5-10mm sizes；Or low temperature ultra micro
Broken wall crushing is prepared into ultramicro powder agent；Or 8 times of weight waters is added to impregnate, and decoction 3 times, 2 hours every time, collecting decoction, degreasing
Cotton filters, and filtrate is directly collected as decoction or filtrate and is prepared into granule or tablet or paste through vacuum spray drying method,
Or pill or vina.
Compared with prior art, the features of the present invention and advantageous effect are：
Gynostemma pentaphylla bitter in the compound Chinese medicinal preparation of the present invention, cold in nature, Return liver, spleen, kidney channel have shield heart Bao Mai, delay
Aging, cerebral tonic tranquillizing, regulating lipid and reducing weight, strengthening the spleen and stomach effect.Modern study shows that it is rich in more than 50 kinds of saponin(e and ginsenoside one
Sample belongs to tetracyclic triterpenes agate saponin(e, glucosides, water-soluble amino acids, flavones, minerals etc., with reducing blood lipid, tune blood pressure, blood
Solidifying, anti-oxidant, antitumor action has prevention thrombus, and anti arteriosclerosis, stomach strengthening and digestion promoting is relieving cough and reducing sputum, clearing heat and detoxicating, resists tired
Labor, function of delaying senility are main ingredients；
There is invigorating qi for tranquilization, qi-regulating stagnation resolvation, nourishing liver and spleen to support lung benefit for ganoderma lucidum, sweet in flavor, mild-natured, the thoughts of returning home, lung, liver and kidney channel
Gas, effect of strengthening the body resistance to consolidate the constitution.Modern study shows that it is rich in germanium, can improve 1.5 times of the ability that red blood cell absorbs oxygen, polysaccharide tool
There are two-way immunoregulation effect, alkaloid to have anti-oxidant, antitumor action, be ministerial drug, can further strengthen the work(of gynostemma pentaphylla
Effect.
Tealeaves, bitter but sweet flavor is cool in nature, the thoughts of returning home, lung, kidney channel, has solution greasy, and along stomach, reducing blood lipid is clearing heat and detoxicating, antioxygen
Change.Anticancer change acts on, and is adjutant, is that most health drink is generally acknowledged in the whole world, can reconcile mouthfeel and consumption habits, and can deepen
The healthcare function of side.
Jujube, sweet in flavor, warm-natured, returns spleen, stomach have invigorating the spleen, promote transporting, and taste is promoted more preferably to absorb the drug substance
Effect, be to make medicine, it can reconcile the mouthfeel of preparation, mitigate the cold of monarch drug in a prescription, promote the absorption of active ingredient, give full play to
The effect of we's conditioning vital organs of the human body, six punching seven of dredging, liver, kidney, gas, blood balance, perverse trend is from body.
Specific implementation mode
The present invention will be further described by the following examples, and but the scope of the present invention is not limited thereto.
Embodiment 1
The shield heart of the present embodiment protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to weight percent, including
40% gynostemma pentaphylla, 30% ganoderma lucidum, 28% tealeaves, 2% jujube.
The shield heart of the present embodiment protects the preparation method for the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to following step
It is rapid to carry out：
According to 40% gynostemma pentaphylla of weight percent, 30% ganoderma lucidum, 28% tealeaves, 2% jujube progress dispensing；
By gynostemma pentaphylla, ganoderma lucidum, tealeaves, jujube pulverizing medicinal materials add 8 times of weight waters to impregnate, decoct 3 times at 5-10mm sizes,
2 hours every time, collecting decoction, absorbent cotton filtered, and filtrate is directly collected as decoction.
Embodiment 2
The shield heart of the present embodiment protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to weight percent, including
45% gynostemma pentaphylla, 25% ganoderma lucidum, 25% tealeaves, 5% jujube.
The shield heart of the present embodiment protects the preparation method for the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to following step
It is rapid to carry out：
According to 45% gynostemma pentaphylla of weight percent, 25% ganoderma lucidum, 25% tealeaves, 5% jujube progress dispensing；
By gynostemma pentaphylla, ganoderma lucidum, tealeaves, jujube pulverizing medicinal materials are prepared into powder at 5-10mm sizes.
Embodiment 3
The shield heart of the present embodiment protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to weight percent, including
50% gynostemma pentaphylla, 25% ganoderma lucidum, 24% tealeaves, 1% jujube.
The shield heart of the present embodiment protects the preparation method for the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, according to following step
It is rapid to carry out：
According to 50% gynostemma pentaphylla of weight percent, 25% ganoderma lucidum, 24% tealeaves, 1% jujube progress dispensing；
By gynostemma pentaphylla, ganoderma lucidum, tealeaves, jujube pulverizing medicinal materials add 8 times of weight waters to impregnate, decoct 3 times at 5-10mm sizes,
2 hours every time, collecting decoction, absorbent cotton filtered, and filtrate is prepared into granule through vacuum spray drying method.
Embodiment 4
The present embodiment uses zoopery, by observing superoxide dismutase (SOD), malonaldehyde (MDA), peroxidating
Lipid (LPO)；Triglycerides (TG), total cholesterol (CHO), low-density lipoprotein (LDL-c)；Partial pressure of oxygen (PO2), blood red egg
Partial pressure of oxygen (P50) when white 50% oxygen saturation；The indexs such as whole blood viscosity, erythrocyte sedimentation rate viscosity are mended to verify shield heart Bao Mai of the present invention
It the effect of compound Chinese medicinal preparation that brain tranquilizing the mind slows down aging, specifically follows the steps below：
(1) experimental design
1. oxygen radical [O2 -] and the hydroxy radical [OH that is generated by it-] there is very strong damaging action to biomolecule.
Under the startup of oxygen radical, free chain reaction occurs for the high price unsaturated fatty acid in biomembrane, generates lipid peroxidation
Matter (LPO) and its derivative propylene glycol (MDA), damage biological film.
2. partial pressure of oxygen [PO2] it is the tension that physical dissolution oxygen molecule generates in arterial blood, it is reflection oxyhemoglobin
[HbO2] key index.Partial pressure of oxygen number when P50 refers to 50% oxygen saturation of hemoglobin, it reflects blood oxygen carrying capacity
And the affinity of hemoglobin.
3. blood fat [triglycerides (TG), total cholesterol (CHO), low-density lipoprotein (LDL-C)] is artery sclerosis, hat
Worry, cerebral infarction, leukodystrophy biochemical basis.
4. hemorheology observes blood by whole blood viscosity and Plasma Viscosity and has the mobility to be formed and aggregation
Changing rule.Whole blood viscosity raising is the Danger Indexes of cardiovascular and cerebrovascular diseases.
(2) drug and reagent
Experimental drug：Compound Chinese medicinal preparation (decoction) prepared by embodiment 1；Control drug：Jujube, matrimony vine, brown sugar water
Decoct decoction.
Instrument and reagent：
The measurement of SOD, MDA, LPO build up the assay kit of Bioengineering Research Institute's production, measurement oxidation with Nanjing
Restore enzyme process.
TG, CHO, LDL-C are detected with Hitachi's full-automatic biochemical analyzer and coordinative experiments.
PO2, P50 blood oxygen analysis instrument detection.
Whole blood viscosity, Plasma Viscosity rheogeniometer.
(3) experimental method
Experimental animal：Healthy new zealand rabbit (Central South University's Experimental Animal Center provides) 24, half male and half female, weight 1.5-
2kg.Rabbit is divided into experimental drug group and each 12 of control group by table of random number.
Medication：Since experimental day, the daily gavage experimental drug 5mL (every milliliter of drug containing 1g) of trial drug group rabbit,
Continuous 4 weeks.The daily gavage control group drug 5mL (every milliliter of drug containing 1g) of control group rabbit, continuous 4 weeks.All experimental rabbits press group
It is required to feed pellet high in fat.
Observation index：After animal feeding 4 weeks, blood 16mL is taken through rabbit heart, is injected separately into 5 anti-freezing heparin tubes for examining
Survey SOD, MDA, LPO；TG、CHO、LDL-C；Whole blood viscosity, Plasma Viscosity；And PO2、P50。
Statistical method：Experimental data is handled using SPSS statistical softwares；Each group of data uses means standard deviationIt indicates, parallel t check analyses.
(4) experimental result
Experimental result is as shown in 1~table of table 4.
Table 1：SOD, MDA, LPO comparision contents after each group animal gavage 4 weeks
Table 2：TG, CHO, LDL-C comparision contents after each group animal gavage 4 weeks
Table 3：PO after each group animal gavage 4 weeks2, P50 comparision contents
Table 4：Whole blood viscosity, Plasma Viscosity comparision contents after each group animal gavage 4 weeks
(5) conclusion
The results show, compound Chinese medicinal preparation of the present invention can significantly remove oxygen radical and mistake in experimental animal blood
Lipid oxide promotes the level of hepatocuprein.It can significantly reduce the lipids contents in blood；Reduce blood viscosity；It carries
The ability of hemoglobin combination oxygen in high red blood cell.So that body is obtained shield heart Bao Mai, reduces or prevent cardiovascular and cerebrovascular diseases and promotion
Health of heart and brain.
The foregoing is merely the preferable specific implementation modes of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and
Its inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (2)
1. a kind of shield heart protects the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging, it is characterised in that according to weight percent, packet
Include 35%-50% gynostemma pentaphylla, 10%-30% ganoderma lucidums, 20%-30% tealeaves, 1%-5% jujubes.
2. a kind of shield heart as claimed in claim 2 protects the preparation method for the compound Chinese medicinal preparation that arteries and veins cerebral tonic tranquillizing slows down aging,
It is characterized in that following the steps below：
1) according to weight percent 35%-50% gynostemma pentaphylla, 10%-30% ganoderma lucidums, 20%-30% tealeaves, 1%-5% jujubes into
Row dispensing；
2) by gynostemma pentaphylla, ganoderma lucidum, tealeaves, jujube pulverizing medicinal materials are prepared into powder at 5-10mm sizes；Or low temperature super-micro wall-broken
Crushing is prepared into ultramicro powder agent；Or 8 times of weight waters is added to impregnate, it decocts 3 times, 2 hours every time, collecting decoction, absorbent cotton was filtered
It crosses, filtrate is directly collected as decoction or filtrate and is prepared into granule or tablet or paste or ball through vacuum spray drying method
Agent or vina.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810740961.4A CN108671081A (en) | 2018-07-08 | 2018-07-08 | Shield heart protects the compound Chinese medicinal preparation and preparation method that arteries and veins cerebral tonic tranquillizing slows down aging |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810740961.4A CN108671081A (en) | 2018-07-08 | 2018-07-08 | Shield heart protects the compound Chinese medicinal preparation and preparation method that arteries and veins cerebral tonic tranquillizing slows down aging |
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| Publication Number | Publication Date |
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| CN108671081A true CN108671081A (en) | 2018-10-19 |
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|---|---|---|---|
| CN201810740961.4A Pending CN108671081A (en) | 2018-07-08 | 2018-07-08 | Shield heart protects the compound Chinese medicinal preparation and preparation method that arteries and veins cerebral tonic tranquillizing slows down aging |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813765A (en) * | 2012-09-05 | 2012-12-12 | 贵州百花医药股份有限公司 | Method for preparing Zhixinkang preparation |
| CN103142876A (en) * | 2013-03-25 | 2013-06-12 | 威海康博尔生物药业有限公司 | Preparation capable of improving functions of heart and cerebral vessels and use of oxygen and capable of delaying senescence |
-
2018
- 2018-07-08 CN CN201810740961.4A patent/CN108671081A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813765A (en) * | 2012-09-05 | 2012-12-12 | 贵州百花医药股份有限公司 | Method for preparing Zhixinkang preparation |
| CN103142876A (en) * | 2013-03-25 | 2013-06-12 | 威海康博尔生物药业有限公司 | Preparation capable of improving functions of heart and cerebral vessels and use of oxygen and capable of delaying senescence |
Non-Patent Citations (3)
| Title |
|---|
| 曾晓虎主编: "《中西汇通中药手册》", 31 May 2006 * |
| 赵玉瑶等: "灵蓝口服液治疗气阴两虚证101例临床观察", 《中国中医药科技》 * |
| 陈明岭，等。: "《皮肤病常用中药药理及临床》", 31 October 2017 * |
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Application publication date: 20181019 |