CN108670996A - 人参鲜提冷冻干燥粉末饮片 - Google Patents

人参鲜提冷冻干燥粉末饮片 Download PDF

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CN108670996A
CN108670996A CN201810733206.3A CN201810733206A CN108670996A CN 108670996 A CN108670996 A CN 108670996A CN 201810733206 A CN201810733206 A CN 201810733206A CN 108670996 A CN108670996 A CN 108670996A
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ginseng
decoction
fresh
medicine materical
materical crude
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徐璐
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Wuhu Tiancheng Puyang Traditional Chinese Medicine Technology Co Ltd
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Wuhu Tiancheng Puyang Traditional Chinese Medicine Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
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Abstract

本发明公布了一种“人参鲜提冷冻干燥粉末饮片”，其主要特征在于：人参药材采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩后，冻结、真空冷冻干燥，再经粉碎、过筛后真空包装。冷冻粉末饮片的含水量少于12%，含人参皂苷Rg1（C42H72O14）和人参皂苷Re（C48H82O18）的总量不得低于0.40%。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入丸剂、散剂、片剂、膏滋，利于携带，临床使用方便。

Description

人参鲜提冷冻干燥粉末饮片
技术领域
本发明属于中药饮片技术领域，尤其属于中药人参饮片的加工领域。
背景技术
中药人参为五加科植物人参Panaxginseng C.A.Mey.的干燥根和根茎。常在秋季采挖，洗净后晒干或烘干。传统生晒人参饮片的加工方法为，将在产地晒干或者烘干的人参药材，去芦头，分档，加水润软，或者烘软后切片，干燥，包装。这样的饮片体积大，卫生学标准差，易于受潮、长霉，带有虫卵，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型人参饮片，势在必行。目前市场有人参超微粉饮片和人参浓缩颗粒饮片，但两者都是以传统人参饮片为原料，其质量决定于人参饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“人参鲜提喷雾干燥粉末饮片”，其主要特征在于：人参药材采收后，净选，除去杂质，在6小时内趁鲜洗净泥沙，并于24小时内切成2~5mm厚的片，压榨取汁。所得药渣中加1~5倍重量的水，搅拌5~30分钟，过滤，药渣再压榨取汁。第二次所得药渣中再加入5~10倍重量的水，煮沸10~30分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度设定为50~70℃，浓缩至相对密度为1.05~1.20的清膏。将此清膏置于-20~-80℃冰箱内冻结12~24小时，取出后于-20~-40℃真空冷冻干燥，收集冻干物，再于60℃真空干燥箱内干燥至干燥物含水量少于12%，粉碎，过60目筛，真空包装，即得成品。饮片成品含人参皂苷Rg1（C42H72O14）和人参皂苷Re（C48H82O18）的总量不得低于0.40%。 本饮片临床一般使用量为1~3g。此饮片既可入汤剂煎服或冲服，也可直接入丸剂、散剂、胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
具体实施例
将人参药材采收后，净选，除去杂质和芦头，在6小时内趁鲜洗净泥沙，并于24小时内切成3mm厚的片，压榨取汁。所得药渣中加5倍重量的水，搅拌30分钟，过滤，药渣再压榨取汁。第二次所得药渣中再加入8倍重量的水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.20清膏。将所得的清膏于-80℃冰箱冻结24小时，再于-40℃真空冷冻干燥。收集冻干物，于60℃真空干燥至干燥物含水量低于12%，取出，粉碎，过60目筛，真空包装，即得成品。饮片成品含人参皂苷Rg1（C42H72O14）和人参皂苷Re（C48H82O18）的总量不得低于0.40%。

Claims (2)

1.一种人参鲜提冷冻干燥粉末饮片，其主要特征在于：人参药材采收后，净选，6小时内趁鲜洗净泥沙，24小时内切成2~5mm厚的片；压榨取汁，药渣中加1~5倍重量的水，搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再榨汁，收集药汁；合并上述药汁，减压浓缩，温度为50~70℃，浓缩至相对密度为1.05~1.20的清膏；将此清膏冻结后真空冷冻干燥，收集冻干物，控制干燥物含水量为10%以内，粉碎，过60目筛，真空包装，即得成品；成品含人参皂苷Rg1（C42H72O14）和人参皂苷Re（C48H82O18）的总量不得低于0.40%。
2.根据权利要求1所述的人参鲜提冷冻干燥粉末饮片，其主要特征在于：临床一般使用量为1~3g，此饮片既可入汤剂煎服，也可直接入丸剂、散剂、胶囊剂及片剂中。
CN201810733206.3A 2018-07-06 2018-07-06 人参鲜提冷冻干燥粉末饮片 Withdrawn CN108670996A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109999072A (zh) * 2019-05-16 2019-07-12 康美（北京）药物研究院有限公司 一种鲜人参活性物质的制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109999072A (zh) * 2019-05-16 2019-07-12 康美（北京）药物研究院有限公司 一种鲜人参活性物质的制备方法

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