CN108671017A - 根和根茎类药材鲜提冷冻干燥粉末饮片 - Google Patents
根和根茎类药材鲜提冷冻干燥粉末饮片 Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 26
- 239000000463 material Substances 0.000 title claims abstract description 15
- 239000000843 powder Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000006071 cream Substances 0.000 claims abstract description 10
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 10
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000008399 tap water Substances 0.000 claims description 5
- 235000020679 tap water Nutrition 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 239000003826 tablet Substances 0.000 abstract description 2
- 238000003860 storage Methods 0.000 description 3
- 239000000284 extract Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 235000016811 Biondella Nutrition 0.000 description 1
- 241000723369 Cocculus trilobus Species 0.000 description 1
- 241001530209 Swertia Species 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/51—Gentianaceae (Gentian family)
- A61K36/515—Gentiana
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
本发明公布了一种“根和根茎类药材鲜提冷冻干燥粉末饮片”，其主要特征在于：在根和根茎类药材采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩成清膏后冷冻干燥，再经粉碎、过筛后真空包装。粉末饮片的含水量少于12%。此类饮片质量稳定，既可以入汤剂煎煮，也可以直接入丸剂、散剂、片剂、膏滋，利于携带，临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域，尤其属于根和根茎类中药饮片的加工领域。
背景技术
根和根茎类中药材，是中药的重要组成部分。传统根和根茎类药材的加工方法为：将药材采挖后，直接晒干/晾干，捆扎打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。此类饮片体积大，卫生学标准差，易于受潮、长霉、生虫，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型根及根茎类饮片，势在必行。目前市场根及根茎类饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“根和根茎类药材鲜提冷冻干燥粉末饮片”，其主要特征在于：在根和根茎类药材采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏。将所得清膏在-20~-80℃冰箱中冻结12~24小时后，在-20~-40℃真空冷冻干燥。冻干物再在60~80℃真空干燥至含水量低于12%，粉碎，过60目筛，真空包装，即得成品。此类饮片临床一般使用量为1~5g。此类饮片既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统根和根茎类饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
实施例1
将龙胆草药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.20的清膏。将所得的清膏于-80℃冻结12小时后，在-40℃真空冷冻干燥。干燥物再用60℃真空干燥至含水量低于12%，粉碎，过60目筛，真空包装，即得成品。
实施例2
将木防己药材采收后，净选，除去泥沙等杂质和非药用部位，在12小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的60℃的自来水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中加入8倍重量的自来水，煮沸30分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为60℃，浓缩至相对密度为1.20的清膏。将所得的清膏于-80℃冻结12小时后，在-40℃真空冷冻干燥。干燥物再用60℃真空干燥至含水量低于12%，粉碎，过60目筛，真空包装，即得成品。
Claims (2)
1.一种根和根茎类药材鲜提冷冻干燥粉末饮片，其主要特征在于：在根和根茎茎类药材采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏；所得清膏在-20~-80℃冰箱中冻结12~24小时后，在-20~-40℃真空冷冻干燥；冻干物再在60~80℃真空干燥至含水量低于12%，粉碎，过60目筛，真空包装，即得成品。
2.根据权利要求1所述的根和根茎类药材鲜提冷冻干燥粉末饮片，其主要特征在于：临床一般使用量为1~5g，此类饮片既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中。
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| CN201810733225.6A CN108671017A (zh) | 2018-07-06 | 2018-07-06 | 根和根茎类药材鲜提冷冻干燥粉末饮片 |
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| CN201810733225.6A CN108671017A (zh) | 2018-07-06 | 2018-07-06 | 根和根茎类药材鲜提冷冻干燥粉末饮片 |
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| CN108671017A true CN108671017A (zh) | 2018-10-19 |
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| CN201810733225.6A Withdrawn CN108671017A (zh) | 2018-07-06 | 2018-07-06 | 根和根茎类药材鲜提冷冻干燥粉末饮片 |
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- 2018-07-06 CN CN201810733225.6A patent/CN108671017A/zh not_active Withdrawn
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