CN108659071A - A kind of extracting method of Pectolinarin - Google Patents
A kind of extracting method of Pectolinarin Download PDFInfo
- Publication number
- CN108659071A CN108659071A CN201710212226.1A CN201710212226A CN108659071A CN 108659071 A CN108659071 A CN 108659071A CN 201710212226 A CN201710212226 A CN 201710212226A CN 108659071 A CN108659071 A CN 108659071A
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- CN
- China
- Prior art keywords
- pectolinarin
- extracting method
- dry
- raw material
- extraction
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a kind of extracting method of Pectolinarin, extracting method includes the following steps：It is placed in dry setose thistle medicinal material in high-speed homogenization machine, 60% ethanol solution of 12 times of raw material is added, 5 ~ 7min is handled under the power of 200W, processed raw material carries out microwave ultrasound 1 ~ 2h of extraction, filtering, and filtrate concentration obtains concentrate；Gained concentrate is extracted through organic solvent, anhydrous sodium sulfate is dry, be concentrated under reduced pressure and etc. to get Pectolinarin.The method of the present invention is simple for process, takes less, high income, and the ingredient of extraction is also more, it is therefore prevented that the oxidation of active ingredient, the quality for being pyrolyzed and improving product.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of extracting method of Pectolinarin.
Background technology
Setose thistle also known as cottonsedge-like thistle herb, big thorn lid, tiger Lei, Chinese medicine name, be composite family (Compositae) tubular flower Asia
The dry aerial parts of cynara scolymus race of section (Cvnareae) Cirsium (Cirsium Mill.) plant C. japonicum DC.
Or root.Perennial herb, it is wild in hillside, roadside etc..It grows wide, originates in national most area, function master
Control haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, metrorrhagia, under band, intestines wind, acute appendicitis setose thistle large carbuncle pyogenic infections, the diseases such as furunculosis.
It is more to the research of setose thistle alkaloid, volatile oil at present but less to the research of Pectolinarin.
Invention content
The purpose of the present invention is to provide a kind of extracting method of Pectolinarin and its antitumor application thereofs.
In order to achieve the above object, the present invention uses following technical scheme：
It is placed in dry setose thistle medicinal material in high-speed homogenization machine, 60% ethanol solution of 1-2 times of raw material is added, handles 5 ~ 7min,
Processed raw material carries out microwave -1 ~ 2h of ultrasonic extraction, filtering, and filtrate concentration obtains concentrate；Gained concentrate is through organic solvent
Extraction, anhydrous sodium sulfate is dry, be concentrated under reduced pressure and etc. to get Pectolinarin.
The power of the high-speed homogenization machine is 200W.
The power of the microwave-ultrasonic extraction is 300W.
The organic solvent is petroleum ether.
It is further illustrated the present invention below in conjunction with specific implementation mode, but the scope of protection of present invention is not limited to
In following embodiments.
Specific implementation mode：
Embodiment 1：
It is placed in dry setose thistle medicinal material in high-speed homogenization machine, 60% ethanol solution of 1 times of raw material is added, under the power of 200W
5min is handled, processed raw material carries out microwave-ultrasonic extraction 1h, power 300W, filtering, and filtrate concentration obtains concentrate；Institute
Concentrate through organic solvent petroleum ether extraction, anhydrous sodium sulfate is dry, be concentrated under reduced pressure and etc. to get Pectolinarin.
Embodiment 2：
It is placed in dry setose thistle medicinal material in high-speed homogenization machine, 60% ethanol solution of 2 times of raw material is added, under the power of 200W
7min is handled, processed raw material carries out microwave-ultrasonic extraction 2h, power 300W, filtering, and filtrate concentration obtains concentrate；Institute
Concentrate through organic solvent petroleum ether extraction, anhydrous sodium sulfate is dry, be concentrated under reduced pressure and etc. to get Pectolinarin.
Embodiment 3：
It is placed in dry setose thistle medicinal material in high-speed homogenization machine, 60% ethanol solution of 1 times of raw material is added, under the power of 200W
6min is handled, processed raw material carries out microwave-ultrasonic extraction 2h, power 300W, filtering, and filtrate concentration obtains concentrate；Institute
Concentrate through organic solvent petroleum ether extraction, anhydrous sodium sulfate is dry, be concentrated under reduced pressure and etc. to get Pectolinarin.
Claims (4)
1. a kind of extracting method of Pectolinarin, it is characterised in that include the following steps：By dry setose thistle medicinal material, it is placed in high speed
In refiner, 60% ethanol solution of 1-2 times of raw material is added, handles 5 ~ 7min, processed raw material carries out microwave-ultrasound and carries
1 ~ 2h is taken, is filtered, filtrate concentration obtains concentrate；Gained concentrate is extracted through organic solvent, anhydrous sodium sulfate is dry, decompression is dense
Contracting and etc. to get Pectolinarin.
2. a kind of extracting method of Pectolinarin according to claim 1, which is characterized in that the high-speed homogenization machine
Power be 200W.
3. a kind of extracting method of Pectolinarin according to claim 1, which is characterized in that the microwave-ultrasound
The power of extraction is 300W.
4. a kind of extracting method of Pectolinarin according to claim 1, which is characterized in that the organic solvent is
Petroleum ether.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710212226.1A CN108659071A (en) | 2017-04-01 | 2017-04-01 | A kind of extracting method of Pectolinarin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710212226.1A CN108659071A (en) | 2017-04-01 | 2017-04-01 | A kind of extracting method of Pectolinarin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108659071A true CN108659071A (en) | 2018-10-16 |
Family
ID=63784706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710212226.1A Pending CN108659071A (en) | 2017-04-01 | 2017-04-01 | A kind of extracting method of Pectolinarin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108659071A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908168A (en) * | 2021-11-30 | 2022-01-11 | 河南省洛阳正骨医院（河南省骨科医院） | Application of pectolinarin in preparing anti-osteosarcoma medicine and anti-osteosarcoma medicinal preparation |
-
2017
- 2017-04-01 CN CN201710212226.1A patent/CN108659071A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113908168A (en) * | 2021-11-30 | 2022-01-11 | 河南省洛阳正骨医院（河南省骨科医院） | Application of pectolinarin in preparing anti-osteosarcoma medicine and anti-osteosarcoma medicinal preparation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181016 |
|
| WD01 | Invention patent application deemed withdrawn after publication |