CN108653587A - A kind of Chinese medicinal granule and preparation method thereof for treating hypertension - Google Patents

A kind of Chinese medicinal granule and preparation method thereof for treating hypertension Download PDF

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Publication number
CN108653587A
CN108653587A CN201810723800.4A CN201810723800A CN108653587A CN 108653587 A CN108653587 A CN 108653587A CN 201810723800 A CN201810723800 A CN 201810723800A CN 108653587 A CN108653587 A CN 108653587A
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parts
raw material
chinese medicinal
treating hypertension
medicinal granule
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付用海
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Bozhou Jingxing Network Technology Co Ltd
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Bozhou Jingxing Network Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/536—Prunella or Brunella (selfheal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A61K36/855—Clerodendrum, e.g. glorybower
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8988—Gastrodia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

In order to solve the deficiencies in the prior art, the present invention provides a kind of Chinese medicinal granules for treating hypertension, include the raw material of following parts by weight：15 25 parts of Ramulus Taxilli, 18 23 parts of pueraria lobata, 35 38 parts of Rhizoma Chuanxiong, 8 13 parts of wild chrysanthemum, 9 16 parts of Prunella vulgaris, 13 27 parts of Folium Apocyni Veneti, 10 15 parts of uncaria, 12 18 parts of Rhizoma Gastrodiae, 8 12 parts of ganoderma lucidum, 22 26 parts of radix scutellariae, 8 10 parts of clerodendron trichotomum.The present invention also provides a kind of preparation methods of Chinese medicinal granule that treating hypertension, include the following steps：Feedstock capture, refrigeration sterilizing, impurity elimination, sterilizing-drying, drying and granulating.The present invention keeps the nutritional ingredient and medicinal ingredient of medicinal material to the maximum extent, and drinking in facilitating people's life and working can effectively reduce blood pressure, be suitble to promote.

Description

A kind of Chinese medicinal granule and preparation method thereof for treating hypertension
Technical field
The invention belongs to processing technique of Chinese herbs fields, and in particular to a kind of Chinese medicinal granule that treating hypertension and its preparation side Method.
Background technology
With the increase of live and work pressure, much people are suffering from hypertension at present, and Chinese medicine is pure plant medicine, and pair is made With small, therefore it is widely noticed；Many Chinese medicines all have the effect of it is more, such as：
(1) pueraria lobata is the dry root of legume pueraria lobata, practises and claim elegant jessamine.Autumn, the excavation of two season of winter, take advantage of fresh-cut at sheet or Fritter；It is dry.It is sweet, pungent, it is cool.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.It is usually used in exterior syndrome fever, person's back Strong pain, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea；
(2) ganoderma lucidum, also known as Lin Zhongling, fine jade are precious, are the fructifications of On Polyporaceae ganoderma lucidum.With invigorating qi for tranquilization, cough-relieving The effect of relievining asthma, promoting longevity.For dizziness egersis, palpitation, neurasthenia, consumptive disease cough and asthma；
(3) Folium Apocyni Veneti, alias：Bluish dogbane, wartwort fiber crops, wild tealeaves, sage, wild flax；Matter is crisp, gas is micro-, lightly seasoned, has It is depressured the effect of cardiac stimulant.
The effect of drugs of traditional blood pressure lowering is poor, cannot meet allegro life requirement now, therefore, is badly in need of a kind of The Chinese medicinal granule of the blood pressure lowering of conveniently edible.
Invention content
In order to solve the deficiencies in the prior art, the purpose of the present invention is to provide a kind of Chinese medicinal granules for treating hypertension.
To achieve the goals above, the technical solution adopted by the present invention is：
A kind of Chinese medicinal granule for treating hypertension, includes the raw material of following parts by weight：15-25 parts of Ramulus Taxilli, pueraria lobata 18-23 Part, 35-38 parts of Rhizoma Chuanxiong, 8-13 parts of wild chrysanthemum, 9-16 parts of Prunella vulgaris, 13-27 parts of Folium Apocyni Veneti, 10-15 parts of uncaria, Rhizoma Gastrodiae 12- 18 parts, 8-12 parts of ganoderma lucidum, 22-26 parts of radix scutellariae, 8-10 parts of clerodendron trichotomum.
Further, the pueraria lobata be roll rub it is broken after it is powdered.
Further, 23 parts of Ramulus Taxilli, 19 parts of pueraria lobata, 36 parts of Rhizoma Chuanxiong, 11 parts of wild chrysanthemum, 13 parts of Prunella vulgaris, Folium Apocyni Veneti 20 parts, 13 parts of uncaria, 16 parts of Rhizoma Gastrodiae, 10 parts of ganoderma lucidum, 23 parts of radix scutellariae, 9 parts of clerodendron trichotomum.
The present invention also provides a kind of preparation methods of Chinese medicinal granule that treating hypertension, specifically include following operation step Suddenly：
Step 1：In source area collection raw material-pretreatment, the raw material after acquisition is cleaned, is dried 3 days or more after cleaning, by Natural-wind dry, it is spare；
Step 2：Raw material in step 1 is placed in refrigerating chamber, subzero 25 DEG C, refrigerate 2 days or more, after taking-up, rise to room Temperature is placed 12 hours；
Step 3：Raw material in step 2 is led into screen filtration screening, and manually picks out the raw material of damage；
Step 4：The damaged location of artificial excision damage raw material, the raw material after excision is put into sterilization tank sterilized, It is dry.
Step 5：By treated in step 4, damage raw material is put into togerther in sterilization tank with intact raw material and sterilizes, and sterilizes three Secondary, every minor tick 20 minutes is placed 12 hours or more after sterilizing；
Step 6：After raw material is ground, dry adhesives are added, pressurizes into pelletiod in a mold, is put into drying box It is dried to Chinese medicinal granule.
Further, raw material cleans in three times in step 1, cleans duration interval every time and is no less than 20 minutes.
Further, in steps of 5, a concentration of 12-15mg/m is added in sterilization tank3Ozone sterilizes, when sterilizing It is 20-30 minutes a length of；The temperature of sterilization tank is controlled at 55-65 DEG C.
Further, at pelletiod, concrete technology is that raw material and dry adhesives are put into togerther pressure for pressurization described in step 6 It in mould, suppresses in three times, 15-25 minutes a length of when compacting every time, the interval pressing time is 30-45 seconds.
Beneficial effects of the present invention：
The present invention is direct-edible, by refrigeration, drying and sterilizing, reduces and is contacted with oxygen, bacterium etc. in air, It effectively avoids aoxidizing, goes mouldy, damages by worms, germ contamination, and using repeatedly sterilizing, repeatedly extrusion forming, not destroying the effective of medicinal material Ingredient remains the activity of medicinal material, edible in facilitating people's life and working, can effectively reduce blood pressure, be suitble to promote.
Specific implementation mode
For ease of to the present invention technological means and operation have further understanding and understanding, with reference to specific Embodiment is elaborated as follows.
A kind of Chinese medicinal granule for treating hypertension, includes the raw material of following parts by weight：23 parts of Ramulus Taxilli, 19 parts of pueraria lobata, river 36 parts of rhizome of chuanxiong, 11 parts of wild chrysanthemum, 13 parts of Prunella vulgaris, 20 parts of Folium Apocyni Veneti, 13 parts of uncaria, 16 parts of Rhizoma Gastrodiae, 10 parts of ganoderma lucidum, radix scutellariae 23 Part, 9 parts of clerodendron trichotomum.
Further, the pueraria lobata be roll rub it is broken after it is powdered.
The present invention also provides a kind of preparation methods of Chinese medicinal granule that treating hypertension, specifically include following operation step Suddenly：
Step 1：In source area collection raw material-pretreatment, the raw material after acquisition is cleaned, is dried 3 days or more after cleaning, by Natural-wind dry, it is spare；
Step 2：Raw material in step 1 is placed in refrigerating chamber, subzero 25 DEG C, refrigerates 2 days, after taking-up, be warmed to room temperature and put It sets 12 hours；
Step 3：Raw material in step 2 is led into screen filtration screening, and manually picks out the raw material of damage；
Step 4：The damaged location of artificial excision damage raw material, the raw material after excision is put into sterilization tank sterilized, It is dry.
Step 5：By treated in step 4, damage raw material is put into togerther in sterilization tank with intact raw material and sterilizes, and sterilizes three Secondary, every minor tick 20 minutes is placed 12 hours after sterilizing；
Step 6：After raw material is ground, dry adhesives are added, pressurizes into pelletiod in a mold, is put into drying box It is dried to Chinese medicinal granule.
Further, raw material cleans in three times in step 1, cleans duration interval every time 20 minutes.
Further, in steps of 5, a concentration of 13mg/m is added in sterilization tank3Ozone sterilizes, and when sterilizing is a length of 20-30 minutes；The temperature of sterilization tank is controlled at 62 DEG C.
Further, at pelletiod, concrete technology is that raw material and dry adhesives are put into togerther pressure for pressurization described in step 6 It in mould, suppresses in three times, 18 minutes a length of when compacting every time, the interval pressing time is 42 seconds.
The present invention is direct-edible, by refrigeration, drying and sterilizing, reduces and is contacted with oxygen, bacterium etc. in air, It effectively avoids aoxidizing, goes mouldy, damages by worms, germ contamination, and using repeatedly sterilizing, repeatedly extrusion forming, not destroying the effective of medicinal material Ingredient remains the activity of medicinal material, edible in facilitating people's life and working, can effectively reduce blood pressure, be suitble to promote.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace And modification, the scope of the present invention is defined by the appended.

Claims (7)

1. a kind of Chinese medicinal granule for treating hypertension, which is characterized in that include the raw material of following parts by weight：15-25 parts of Ramulus Taxilli, 18-23 parts of pueraria lobata, 35-38 parts of Rhizoma Chuanxiong, 8-13 parts of wild chrysanthemum, 9-16 parts of Prunella vulgaris, 13-27 parts of Folium Apocyni Veneti, uncaria 10-15 Part, 12-18 parts of Rhizoma Gastrodiae, 8-12 parts of ganoderma lucidum, 22-26 parts of radix scutellariae, 8-10 parts of clerodendron trichotomum.
2. a kind of Chinese medicinal granule for treating hypertension according to claim 1, which is characterized in that the pueraria lobata is to roll to rub It is powdered after broken.
3. a kind of Chinese medicinal granule for treating hypertension according to claim 1, which is characterized in that 23 parts of Ramulus Taxilli, pueraria lobata 19 parts, 36 parts of Rhizoma Chuanxiong, 11 parts of wild chrysanthemum, 13 parts of Prunella vulgaris, 20 parts of Folium Apocyni Veneti, 13 parts of uncaria, 16 parts of Rhizoma Gastrodiae, 10 parts of ganoderma lucidum, 23 parts of radix scutellariae, 9 parts of clerodendron trichotomum.
4. a kind of preparation method of Chinese medicinal granule for treating hypertension according to claim 1, which is characterized in that including with Lower step：
Step 1：In source area collection raw material-pretreatment, the raw material after acquisition is cleaned, is dried 3 days or more after cleaning, by nature It is air-dried dry, it is spare；
Step 2：Raw material in step 1 is placed in refrigerating chamber, subzero 25 DEG C, refrigerate 2 days or more, after taking-up, it is warmed to room temperature and puts It sets 12 hours；
Step 3：Raw material in step 2 is led into screen filtration screening, and manually picks out the raw material of damage；
Step 4：The damaged location of artificial excision damage raw material, the raw material after excision is put into sterilization tank and sterilized, dried.
Step 5：By treated in step 4, damage raw material is put into togerther in sterilization tank with intact raw material and sterilizes, and sterilizes three times, often Minor tick 20 minutes is placed 12 hours or more after sterilizing；
Step 6：After raw material is ground, dry adhesives are added, pressurize into pelletiod in a mold, is put into drying box dry At Chinese medicinal granule.
5. a kind of preparation method of Chinese medicinal granule for treating hypertension according to claim 4, which is characterized in that step 1 Middle raw material cleans in three times, cleans duration interval every time and is no less than 20 minutes.
6. a kind of preparation method of Chinese medicinal granule for treating hypertension according to claim 4, which is characterized in that in step In 5, a concentration of 12-15mg/m is added in sterilization tank3Ozone sterilizes, and when sterilizing is 20-30 minutes a length of；The temperature of sterilization tank Degree control is at 55-65 DEG C.
7. a kind of preparation method of Chinese medicinal granule for treating hypertension according to claim 4, which is characterized in that step 6 At pelletiod, concrete technology is that raw material and dry adhesives are put into togerther in pressing mold, suppressed in three times, is pressed every time for the pressurization 15-25 minutes a length of when processed, the interval pressing time is 30-45 seconds.
CN201810723800.4A 2018-07-04 2018-07-04 A kind of Chinese medicinal granule and preparation method thereof for treating hypertension Withdrawn CN108653587A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113663031A (en) * 2021-09-15 2021-11-19 荔波荔泉民族医药有限公司 Formula of blood pressure lowering medicine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113663031A (en) * 2021-09-15 2021-11-19 荔波荔泉民族医药有限公司 Formula of blood pressure lowering medicine

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