CN108653463A - Treat the pure Chinese medicine formula and its single herbal concentrate-granule of senile osteoporosis - Google Patents
Treat the pure Chinese medicine formula and its single herbal concentrate-granule of senile osteoporosis Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/716—Clematis (leather flower)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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Abstract
The present invention relates to a kind of pure Chinese medicine formulas for treating senile osteoporosis, including 6~12g of radix rehmanniae preparata, 6~12g of Herba Epimedii, 6~10g of teasel root, 6~10g of Ramulus Taxilli, 8~12g of the root of Chinese clematis, 6~8g of 6~8g of Cortex Phellodendri, 6~8g of monkshood and lycopodium calvatum, preferably, radix rehmanniae preparata 10g, Herba Epimedii 10g, teasel root 8g, Ramulus Taxilli 8g, root of Chinese clematis 10g, Cortex Phellodendri 7g, monkshood 7g, lycopodium calvatum 7g；Additionally provide pure Chinese medicine single herbal concentrate-granule made of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis, the pure Chinese medicine formula of the treatment senile osteoporosis of the present invention carries out active intervention and treatment for senile osteoporosis, reduction of patient ostalgia (lumbar vertebrae, hip, sacrococcygeal region, knee joint etc.), improve function of joint, improve daily life capacity, risk of bone fracture is reduced, hospital expenses are saved, saves human resources, its single herbal concentrate-granule is convenient to take quick, is suitable for large-scale promotion application.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to treat osteoporosis technical field of traditional Chinese medicines, in particular to
A kind of pure Chinese medicine formula and its single herbal concentrate-granule for treating senile osteoporosis is particularly suitable for treating old primary sclerotin
Osteoporosis.
Background technology
The drug of various treatment osteoporosis includes Chinese patent drug currently on the market, various in style, and such as Xianlinggubao, dragon is male
Zhuanggu electuary etc., but above-mentioned Chinese patent drug is mostly palliative, is easy recurrence；And need patient to decoct into soup before taking,
It is time-consuming and laborious, it is more inconvenient for the elderly；
Therefore, it is necessary to develop it is a kind of can effectively treat senile osteoporosis and pure Chinese medicinal preparation convenient to take, to
It improves the quality of living, reduces health care expenditures.
Invention content
The purpose of the present invention is overcoming the disadvantages of the prior art mentioned above, provides and a kind for the treatment of the pure of senile osteoporosis
Chinese medicine preparation and its single herbal concentrate-granule, the pure Chinese medicine formula carry out active intervention and treatment for senile osteoporosis, alleviate
Patient's ostalgia (lumbar vertebrae, hip, sacrococcygeal region, knee joint etc.) improves function of joint, improves daily life capacity, reduces bone
Risk is rolled over, hospital expenses are saved, saves human resources, single herbal concentrate-granule is convenient to take quick, is suitable for large-scale promotion application.
To achieve the goals above, it in the first aspect of the present invention, provides and a kind for the treatment of the pure of senile osteoporosis
Chinese medicine preparation, its main feature is that, including 6~12g of radix rehmanniae preparata, 6~12g of Herba Epimedii, 6~10g of teasel root, 6~10g of Ramulus Taxilli, the root of Chinese clematis 8
~12g, 6~8g of 6~8g of Cortex Phellodendri, 6~8g of monkshood and lycopodium calvatum.
Preferably, the radix rehmanniae preparata 10g, the Herba Epimedii 10g, the teasel root 8g, the Ramulus Taxilli 8g, the root of Chinese clematis
10g, the Cortex Phellodendri 7g, the monkshood 7g, the lycopodium calvatum 7g.
Preferably, the radix rehmanniae preparata 12g, the Herba Epimedii 12g, the teasel root 10g, the Ramulus Taxilli 10g, the root of Chinese clematis
10g, the Cortex Phellodendri 8g, the monkshood 8g, the lycopodium calvatum 8g.
Preferably, the radix rehmanniae preparata 6g, the Herba Epimedii 8g, the teasel root 10g, the Ramulus Taxilli 6g, the root of Chinese clematis 8g,
The Cortex Phellodendri 6g, the monkshood 6g, the lycopodium calvatum 6g.
Preferably, the radix rehmanniae preparata 10g, the Herba Epimedii 6g, the teasel root 6g, the Ramulus Taxilli 10g, the root of Chinese clematis
12g, the Cortex Phellodendri 6g, the monkshood 6g, the lycopodium calvatum 7g.
The prescription foundation of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis：Radix rehmanniae preparata is nourishing liver and kidney, tonifying yin strengthening the essence；It is excessive
The sweet temperature Return liver kidney channel of the sheep leaves of pulse plants, can tonifying kidney and strengthening yang, remove obstruction in channels to relieve pain；Teasel root, Ramulus Taxilli coordinate main ingredient nourishing disney and strengthening bone, strengthening tendons to cure the wound；It is yellow
Cypress bitter cold also returns kidney channel, consolidating the yin fall fire to treat osteopyrexia and fever；Monkshood coordinates lycopodium calvatum, the root of Chinese clematis remove obstruction in channels to relieve pain, is warming channel and expelling cold.It is vertical
Full side is seen, all medicines share, negative and positive are taken into account, and lead to mend and mutually use, and anxious slow with raising, sample is controlled altogether.Pain can not only be alleviated after use quickly
Bitterly, it and can gradually improve the other symptoms of osteoporosis, improve body resistance against diseases.
In the second aspect of the present invention, a kind of pure Chinese medicine single herbal concentrate-granule for treating senile osteoporosis is provided,
Feature is that each component of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis is processed into the particle of concentration respectively and is made
At.
In the third aspect of the present invention, a kind of pure Chinese medicine single herbal concentrate-granule for treating senile osteoporosis is provided,
Feature is dried as particle system after each component of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis is distinguished dense decoct
At.
Since above-mentioned pure Chinese medicine formula is a daily dose.Therefore it will add medicine to according to the above ratio, and be processed into 8 kinds of granules respectively
Afterwards, generally this 8 kinds of granules are mixed and is loaded on a sack interior sealing, the accumulated dose that drug is one in sack each in this way,
When taking with warm water 100~200 milliliters take after mixing it with water.
Beneficial effects of the present invention are specific as follows：
1, the pure Chinese medicine formula for the treatment of senile osteoporosis of the invention include 6~12g of radix rehmanniae preparata, 6~12g of Herba Epimedii,
6~10g of teasel root, 6~10g of Ramulus Taxilli, 8~12g of the root of Chinese clematis, 6~8g of 6~8g of Cortex Phellodendri, 6~8g of monkshood and lycopodium calvatum, pass through clothes
With the formula, ostalgia can be mitigated, improve bone density, reduce risk of bone fracture, reduce medical expense, and improve minimal invasive treatment's self-care
Ability, reduction are accompanied and attended to, and social resources are saved；
2, traditional Chinese herbal decoction is to decoct twice and take twice for 1st.And the old sclerotin for the treatment of provided by the invention is dredged
Drying is granule after the Chinese medicine of one daily dose is distinguished dense decoct by the pure Chinese medicine single herbal concentrate-granule of loose disease, then is mixed loaded on a bag
It is interior.Face before taking plus 100~200ml of water dissolves, only takes within 1st once, facilitate patient；
3, the pure Chinese medicine single herbal concentrate-granule for the treatment of senile osteoporosis of the invention is convenient to take, is particularly suitable for living
The old man that self-care ability declines takes, and is suitable for large-scale promotion application.
Specific implementation mode
In order to be more clearly understood that the technology contents of the present invention, spy are lifted following embodiment and are described in detail.
Embodiment 1
Chinese medicine preparation is：Radix rehmanniae preparata 10g, Herba Epimedii 10g, teasel root 8g, Ramulus Taxilli 8g, root of Chinese clematis 10g, Cortex Phellodendri 7g, monkshood 7g,
Lycopodium calvatum 7g.
Above-mentioned 8 kinds of traditional Chinese medicinal components are processed into the particle of concentration respectively, then manufactured 8 kinds of particles are set into a hermetic bag altogether
It is interior, it is a daily dose in every bag, daily once.For ease of description, manufactured granule, which calls bone in the following text, dredges clever particle.
59 Aged Patients with Osteoporosis of clinical observation take bone and dredge clever particle and treated, and with Western medicine A Lun phosphines
31 comparisons of sour sodium.
Course for the treatment of March.As a result as follows：
1, bone dredges influence of the clever particle to patient articular's pain subjective scoring
Before treatment, treatment fortnight and at three months with digit score method (Numerical rating
Scale, NRS) to the most important tender joint of patient carry out pain Assessment (referring to：Zhang Chunhua, Zou Birong.Pain Assessment.In
State's clinical care.2009,1 (2)：158-162)." 0 " point indicates painless, and " 10 " point represent insufferable most violent pain.
Treatment results are shown in Table 1.
1 bone of table dredges influence (X ± S) of the clever particle to patient articular's pain subjective scoring
Note：Compared with pre-treatment：* P ＜ 0.05, * * P ＜ 0.01；Compared with the control group, #P ＜ 0.05, ##P ＜ 0.01.
By table 1 as it can be seen that with treatment time extension, two groups of pain scores are gradually reduced, but control group each group declines
Amplitude is not so good as corresponding treatment group significantly (P ＜ 0.01).Treatment group declines in the 14th day pain scores significantly, with phase before treatment
Than significant difference (T=6.52, P ＜ 0.01), at the 90th day scoring be decreased significantly and have significant difference (T=2.24,
P ＜ 0.05).
2, bone dredges functional evaluation of the clever particle to patient pain joint
Before treatment, treatment work(is carried out to the most significant joint of pain with function evaluation charter within the 14th day and the 90th day
Can evaluate (referring to：Zhang Chunhua, Zou Birong.Pain Assessment.Chinese Clinical is nursed.2009,1 (2)：158-162).Methods of marking
For：0=is painless, and 1=can be endured, and nor affects on any activity；2=can be endured, and influence some activities；3=cannot bear
By, but phone can be used, see TV or reading；4=cannot be endured, and can not be used phone, be seen TV or reading；
5=pains are to the stage that can not be exchanged or must lie in bed or medication treatment.Two groups the results are shown in Table 2.
2 bone of table dredges functional evaluation (X ± S) of the clever particle to patient pain joint
Note：Compared with pre-treatment：* P ＜ 0.01, * P ＜ 0.05；Compared with the control group, ##P ＜ 0.01.
As can be seen from Table 2, treatment group's patient's tender joint function after treatment significantly improves, it is significant compared with pre-treatment
Difference (P ＜ 0.01)；And treatment group at the 14th day i.e. decline significantly (T=2.53, P ＜ 0.05), as the course for the treatment of extends, integral after
It is continuous to decline (T=4.63, P ＜ 0.01).Though and control group scoring is declined, each group no difference of science of statistics compared with pre-treatment
(T=0.26~1.31, P ＞ 0.05).It is compared between group, treatment group's integral is better than concurrent control group, and significant difference (P ＜
0.01)。
3, bone dredges influence of the clever particle to indexs such as blood biochemicals
Respectively at before and after treatment to osteoporosis and osteoarthritis index of correlation (parathyroid hormone PTH, serum calcium from
Sub- Ca++, alkaline phosphatase BAKP, Tumor necrosis factor TNF a) are measured, and the results are shown in Table 3.
3 bone of table dredges influence (X ± S) of the clever particle to indexs such as blood biochemicals
Note：Compared with pre-treatment：* P ＜ 0.05, * * P ＜ 0.01；Compared with the control group, #P ＜ 0.05.
By table 3 as it can be seen that treatment group's PTH, BAKP and TNFa level after treatment is remarkably decreased, and have compared with pre-treatment aobvious
Sex differernce (T=2.61~32.83, P ＜ 0.05~0.01) is write, and BAKP and PTH is declined and has system after control group treatment
Meter learns difference (T=3.94~8.42, P ＜ 0.05~0.01).Compared between group, treatment group treatment after BAKP and TNFa values less than pair
According to group, and significant difference (P ＜ 0.01), and Ca++ also has significant difference (T=2.32~4.73, P ＜ 0.05).
4, bone dredges influence of the clever particle to lumbar vertebrae CT bone densities
Respectively at the bone density for measuring lumbar vertebrae CT before and after treatment, 4 are the results are shown in Table.
4 bone of table dredges influence (X ± S) of the clever particle to lumbar spine bmd
Note：Compared with pre-treatment：* P ＜ 0.01；Compared with the control group, #P ＜ 0.05.
By table 4 as it can be seen that treatment group's patient's bone density after treatment significantly improves, significant difference (T compared with pre-treatment
=4.62, P ＜ 0.01), and increase in bone density after control group treatment but no difference of science of statistics (T=0.66, P ＞
0.05).It is compared between group, bone density, which improves, after treatment group's treatment is better than concurrent control group, and significant difference (T=2.74, P
＜ 0.05).
Embodiment 2
Old XX, man, 78 years old, because of waist and sacrum pain, inconvenient walking surveyed ankle bone density T=-3.8, gave radix rehmanniae preparata 12g, excessive
Sheep leaves of pulse plants 12g, teasel root 10g, Ramulus Taxilli 10g, root of Chinese clematis 10g, Cortex Phellodendri 8g, monkshood 8g, lycopodium calvatum 8g.Pain is notable after treating two weeks
Alleviate, walking function improves.
Embodiment 3
Old XX, female 74 years old, because sternocostal part and lumbar vertebrae, lower limb 8 fragility fractures of priority come institute with gonalgias, survey waist
Vertebra density T=- 3.2, give radix rehmanniae preparata 6g, Herba Epimedii 8g, teasel root 10g, Ramulus Taxilli 6g, root of Chinese clematis 8g, Cortex Phellodendri 6g, monkshood 6g,
Lycopodium calvatum 6g.Pain is significantly alleviated after treating two weeks, and walking function improves, check bone density T=-2.7 after March.Knee joint aches
It is bitterly substantially reduced.
Embodiment 4
Zhao XX, female, 82 years old, because of knee joint and hip joint, shoulder arthralgia, moving obstacle came institute in 3 years with inconvenient walking, surveys
Lumbar spine bmd T=-2.9 gives radix rehmanniae preparata 10g, Herba Epimedii 6g, teasel root 6g, Ramulus Taxilli 10g, root of Chinese clematis 12g, Cortex Phellodendri 6g, monkshood
6g, lycopodium calvatum 7g.Pain is significantly alleviated after treating two weeks, and walking function improves, and multi-joint pain is substantially reduced after two weeks, joint
Function improves, check bone density T=-2.3 after March.
To sum up, the pure Chinese medicine formula for the treatment of senile osteoporosis of the invention carries out senile osteoporosis positive
Intervene and treatment, reduction of patient ostalgia (lumbar vertebrae, hip, sacrococcygeal region, knee joint etc.) improve function of joint, improves daily life
Capacity reduces risk of bone fracture, saves hospital expenses, saves human resources, single herbal concentrate-granule is convenient to take quick, is suitable for
Large-scale promotion application.
In this description, the present invention is described with reference to its specific embodiment.But it is clear that can still make
Various modifications and alterations are without departing from the spirit and scope of the invention.Therefore, specification should be considered as illustrative rather than limit
Property processed.
Claims (7)
1. a kind of Chinese medicine composition for treating senile osteoporosis, which is characterized in that the Chinese medicine composition is by following parts by weight
Bulk pharmaceutical chemicals composition：6~12g of radix rehmanniae preparata, 6~12g of Herba Epimedii, 6~10g of teasel root, 6~10g of Ramulus Taxilli, 8~12g of the root of Chinese clematis, Huang
6~8g of 6~8g of cypress, 6~8g of monkshood and lycopodium calvatum.
2. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object is made of the bulk pharmaceutical chemicals of following parts by weight：Radix rehmanniae preparata 10g, Herba Epimedii 10g, teasel root 8g, Ramulus Taxilli 8g, root of Chinese clematis 10g, Cortex Phellodendri
7g, monkshood 7g, lycopodium calvatum 7g.
3. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object is made of the bulk pharmaceutical chemicals of following parts by weight：Radix rehmanniae preparata 12g, Herba Epimedii 12g, teasel root 10g, Ramulus Taxilli 10g, root of Chinese clematis 10g, Cortex Phellodendri
8g, monkshood 8g, lycopodium calvatum 8g.
4. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object is made of the bulk pharmaceutical chemicals of following parts by weight：Radix rehmanniae preparata 6g, Herba Epimedii 8g, teasel root 10g, Ramulus Taxilli 6g, root of Chinese clematis 8g, Cortex Phellodendri 6g,
Monkshood 6g, lycopodium calvatum 6g.
5. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, which is characterized in that the Chinese traditional medicine composition
Object is made of the bulk pharmaceutical chemicals of following parts by weight：Radix rehmanniae preparata 10g, Herba Epimedii 6g, teasel root 6g, Ramulus Taxilli 10g, root of Chinese clematis 12g, Cortex Phellodendri
6g, monkshood 6g, lycopodium calvatum 7g.
6. a kind of pure Chinese medicine single herbal concentrate-granule for treating senile osteoporosis, which is characterized in that will be according to Claims 1 to 5
In each component of Chinese medicine composition of any treatment senile osteoporosis be processed into particle respectively and be made.
7. a kind of pure Chinese medicine single herbal concentrate-granule for treating senile osteoporosis, which is characterized in that will be according to Claims 1 to 5
In any treatment senile osteoporosis Chinese medicine composition each component decoct respectively after dry and be made for particle.
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| Application Number | Priority Date | Filing Date | Title |
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Application publication date: 20181016 |