CN102139007B - Formula of pure traditional Chinese medicine for treating senile osteoporosis and decoction-free granules - Google Patents
Formula of pure traditional Chinese medicine for treating senile osteoporosis and decoction-free granules Download PDFInfo
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- CN102139007B CN102139007B CN201010103204.XA CN201010103204A CN102139007B CN 102139007 B CN102139007 B CN 102139007B CN 201010103204 A CN201010103204 A CN 201010103204A CN 102139007 B CN102139007 B CN 102139007B
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Abstract
The invention relates to a formula of pure traditional Chinese medicine for treating senile osteoporosis. The traditional Chinese medicine of the formula comprises the following medicaments: 6 to 12 grams of rehmanniae vaporata, 6 to 12 grams of epimedium, 6 to 10 grams of Himalayan teasel root, 6 to 10 grams of Chinese taxillus twig, 8 to 12 grams of clematis root, 6 to 8 grams of phellodendron, 6 to 8 grams of common monkshood mother root and 6 to 8 grams of common clubmoss herb, and preferably 10 grams of rehmanniae vaporata, 10 grams of epimedium, 8 grams of Himalayan teasel root, 8 grams of Chinese taxillus twig, 10 grams of clematis root, 7 grams of phellodendron, 7 grams of common monkshood mother root and 7 grams of common clubmoss herb. The invention also provides pure Chinese medicinal decoction-free granules prepared according to the formula of the traditional Chinese medicine for treating the senile osteoporosis. The traditional Chinese medicine for treating the senile osteoporosis can prevent and treat the senile osteoporosis positively, relieve osteodynia (lumbar vertebrae, hips, sacrococcygeal regions, knee joints and the like) of patients, improve joint functions, improve the capacity of daily life action, reduce fracture risks and save hospital cost and human resources, and the decoction-free granules are convenient to take and are suitable for large-scale popularization and application.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly the technical field of Chinese medicines for the treatment of osteoporosis, specifically refers to a kind of pure Chinese medicine formula and single herbal concentrate-granule thereof for the treatment of senile osteoporosis, is particularly useful for treating old primary osteoporosis.
Background technology
The medicine of various treatment osteoporosis comprises Chinese patent medicine in the market, various in style, as XIANLING GUBAO, and LONGMU ZHUANGGU CHONGJI etc., still above-mentioned Chinese patent medicine is cured the symptoms, not the disease mostly, easily recurrence; And before taking, need patient to decoct into soup, and waste time and energy, especially for old people, more inconvenient;
Therefore, need to develop and a kind ofly can effectively treat the pure Chinese medicinal preparation of senile osteoporosis and taking convenience, thereby improve the quality of living, reduce health care expenditures.
Summary of the invention
The object of the invention is to overcome above-mentioned shortcoming of the prior art, a kind of pure Chinese medicine formula and single herbal concentrate-granule thereof for the treatment of senile osteoporosis is provided, this pure Chinese medicine formula carries out active intervention and treatment for senile osteoporosis, reduction of patient osteodynia (lumbar vertebra, hip, sacrococcygeal region, knee joint etc.), improve function of joint, improve daily life behavioral competence, reduce risk of bone fracture, save hospital expenses, save human resources, its single herbal concentrate-granule taking convenience is quick, is suitable for large-scale promotion application.
To achieve these goals, in a first aspect of the present invention, a kind of pure Chinese medicine formula for the treatment of senile osteoporosis is provided, be characterized in, comprise Radix Rehmanniae Preparata 6～12g, Herba Epimedii 6～12g, Radix Dipsaci 6～10g, Herba Taxilli 6～10g, Radix Clematidis 8～12g, Cortex Phellodendri 6～8g, Radix Aconiti 6～8g and Herba Lycopodii 6～8g.
Preferably, described Radix Rehmanniae Preparata 10g, described Herba Epimedii 10g, described Radix Dipsaci 8g, described Herba Taxilli 8g, described Radix Clematidis 10g, described Cortex Phellodendri 7g, described Radix Aconiti 7g, described Herba Lycopodii 7g.
Preferably, described Radix Rehmanniae Preparata 12g, described Herba Epimedii 12g, described Radix Dipsaci 10g, described Herba Taxilli 10g, described Radix Clematidis 10g, described Cortex Phellodendri 8g, described Radix Aconiti 8g, described Herba Lycopodii 8g.
Preferably, described Radix Rehmanniae Preparata 6g, described Herba Epimedii 8g, described Radix Dipsaci 10g, described Herba Taxilli 6g, described Radix Clematidis 8g, described Cortex Phellodendri 6g, described Radix Aconiti 6g, described Herba Lycopodii 6g.
Preferably, described Radix Rehmanniae Preparata 10g, described Herba Epimedii 6g, described Radix Dipsaci 6g, described Herba Taxilli 10g, described Radix Clematidis 12g, described Cortex Phellodendri 6g, described Radix Aconiti 6g, described Herba Lycopodii 7g.
The prescription foundation of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis: Radix Rehmanniae Preparata nourishing the liver and kidney, nourishing YIN benefit essence; The sweet temperature of Herba Epimedii is returned Liver and kidney warp, can kidney invigorating and YANG supporting, removing obstruction in the collateral to relieve pain; Radix Dipsaci, Herba Taxilli coordinate principal agent invigorating the kidney and strengthening the bones, and strong muscle is cured the wound; Cortex Phellodendri bitter cold is also returned kidney channel, consolidating YIN pathogenic fire reducing treatment osteopyrexia and fever; Radix Aconiti coordinates Herba Lycopodii, Radix Clematidis removing obstruction in the collateral to relieve pain, dispelling cold by warming the meridian.Make a general survey of full side, all medicines share, and negative and positive are taken into account, the mutual use of logical benefit, and anxious slow for raising, specimen is controlled altogether.Alleviating pain quickly not only after use, and can improve gradually other symptoms of osteoporosis, improve body resistance against diseases.
In a second aspect of the present invention, a kind of pure free decoction granule for the treatment of senile osteoporosis is provided, be characterized in, each component of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis is processed into respectively to concentrated granule and makes.
In a third aspect of the present invention, a kind of pure free decoction granule for the treatment of senile osteoporosis is provided, be characterized in, each component of the pure Chinese medicine formula of above-mentioned treatment senile osteoporosis is dried after dense decocting respectively and is made for granule.
Because above-mentioned pure Chinese medicine formula is a daily dose.Therefore will add medicine to according to the above ratio, and be processed into respectively after 8 kinds of granules, and generally mixed these 8 kinds of granules being loaded in a sack be sealed, in each like this sack, medicine is the accumulated dose of a day, while taking, takes after mixing it with water with 100～200 milliliters of warm waters.
Beneficial effect of the present invention is specific as follows:
1, the pure Chinese medicine formula for the treatment of senile osteoporosis of the present invention comprises Radix Rehmanniae Preparata 6～12g, Herba Epimedii 6～12g, Radix Dipsaci 6～10g, Herba Taxilli 6～10g, Radix Clematidis 8～12g, Cortex Phellodendri 6～8g, Radix Aconiti 6～8g and Herba Lycopodii 6～8g, by taking this formula, can alleviate osteodynia, improve bone density, reduce risk of bone fracture, reduce medical expense, and improve patient's self care ability, minimizing is accompanied and attended to, and saves social resources;
2, conventional Chinese medicine decoction is twice of decoction on the one and takes twice.And the pure free decoction granule for the treatment of senile osteoporosis provided by the invention after dense decocting is dried the Chinese medicine of a daily dose into granule respectively, more mixed being loaded in a bag.Face the 100～200ml that adds water before taking and dissolve, within 1st, only take once, facilitate patient;
3, the pure free decoction granule taking convenience for the treatment of senile osteoporosis of the present invention, is particularly useful for the old people garment use that self care ability declines, and is suitable for large-scale promotion application.
The specific embodiment
In order more clearly to understand technology contents of the present invention, describe in detail especially exemplified by following examples.
Embodiment 1
Chinese medicine formula is: Radix Rehmanniae Preparata 10g, Herba Epimedii 10g, Radix Dipsaci 8g, Herba Taxilli 8g, Radix Clematidis 10g, Cortex Phellodendri 7g, Radix Aconiti 7g, Herba Lycopodii 7g.
Above-mentioned 8 kinds of Chinese medicinal components being processed into respectively to concentrated granule, then 8 kinds of granules making are put in a sealing bag altogether, is a daily dose in every bag, and take once every day.For ease of describing, the granule of making is called bone in the following text and is dredged clever granule.
The routine Aged Patients with Osteoporosis of clinical observation 59, takes the thin clever granule of bone and treats, and contrasts with Western medicine Alendronate sodium 31 examples.
The March course for the treatment of.Result is as follows:
1, bone is dredged the impact of clever granule on patient's arthralgia subjective scoring
Respectively at by digit score method (Numerical rating scale, NRS), pain Assessment being carried out to (referring to Zhang Chunhua, Zou Birong in patient's topmost pain joint before treatment, when treatment fortnight and three months.Pain Assessment.Chinese Clinical nursing.2009，1(2)：158-162)。" 0 " point represents painless, and " 10 " point represent the most violent insufferable pain.Therapeutic outcome is in table 1.
Table 1 bone is dredged the impact (X ± S) of clever granule on patient's arthralgia subjective scoring
| Group | Number of cases | Before treatment | The 14th day | The 90th day |
| Treatment group | 59 | 5.4±1.2 | 2.3±1.1 **# | 2.0±0.4 **## |
| Matched group | 31 | 5.3±1.1 | 4.2±1.0 | 3.4±0.5 * |
Note: compared with before treatment:
*p < 0.05,
*p < 0.01; Compared with matched group, #P < 0.05, ##P < 0.01.
From table 1, along with the prolongation for the treatment of time, two groups of pain scores all decline gradually, but matched group is respectively organized fall all not as significantly (P < 0.01) of corresponding treatment group.Treatment group declines significantly the 14th day pain scores, there is significant difference (T=6.52 compared with before treatment, P < 0.01), the 90th day time, scoring is decreased significantly and has a significant difference (T=2.24, P < 0.05).
2, bone is dredged the functional evaluation of clever granule to patient's pain joint
Respectively at before treatment, treatment the 14th day and the 90th day carry out functional evaluation (referring to Zhang Chunhua, Zou Birong with function evaluation amount table to the most significant joint of pain.Pain Assessment.Chinese Clinical nursing.2009，1(2)：158-162)。Methods of marking is: 0=is painless, and 1=can stand, and does not also affect any activity; 2=can stand, and affects some activities; 3=cannot stand, but can use phone, sees TV or reading; 4=cannot stand, and can not use phone, see TV or reading; 5=aches the stage that cannot exchange maybe must bed or medication treatment.Two groups the results are shown in Table 2.
Table 2 bone is dredged the functional evaluation (X ± S) of clever granule to patient's pain joint
| Group | Number of cases | Before treatment | The 14th day | The 90th day |
| Treatment group | 59 | 3.2±0.5 | 2.0±0.3 **## | 1.0±0.4 **## |
| Matched group | 31 | 3.3±0.7 | 3.1±0.4 | 2.3±0.4 |
Note: compared with before treatment:
*p < 0.01,
*p < 0.05; Compared with matched group, ##P < 0.01.
From table 2, treatment group patient's pain function of joint after treatment is significantly improved, and has significant difference (P < 0.01) compared with before treatment; And treatment group declined at the 14th day significantly (T=2.53, P < 0.05), and along with extend the course for the treatment of, integration continues decline (T=4.63, P < 0.01).And though matched group scoring declines to some extent, each group of no difference of science of statistics (T=0.26～1.31, P > 0.05) compared with before treatment.Between group, compare, treatment group integration is better than concurrent control group, and has significant difference (P < 0.01).
3, bone is dredged the impact of clever granule on indexs such as blood biochemicals
Respectively at treating front and back to osteoporosis and osteoarthritis index of correlation (parathyroid hormone PTH, serum calcium ion Ca
++, alkali phosphatase BAKP, TNF a) is measured, and the results are shown in Table 3.
Table 3 bone is dredged the impact (X ± S) of clever granule on indexs such as blood biochemicals
Note: compared with before treatment:
*p < 0.05,
*p < 0.01; Compared with matched group, #P < 0.05.
From table 3, treatment group PTH, BAKP and TNFa level after treatment significantly decline, and there are significant difference (T=2.61～32.83 compared with before treatment, P < 0.05～0.01), and after treatment of control group, BAKP and PTH decline to some extent and have significant difference (T=3.94～8.42, P < 0.05～0.01).Between group, compare, after treatment group treatment, BAKP and TNFa value, lower than matched group, and have significant difference (P < 0.01), and Ca
++also there is significant difference (T=2.32～4.73, P < 0.05).
4, bone is dredged the impact of clever granule on lumbar vertebra CT bone density
Respectively at the bone density of measuring lumbar vertebra CT before and after treatment, the results are shown in Table 4.
Table 4 bone is dredged the impact (X ± S) of clever granule on lumbar spine bmd
| Group | Number of cases | Before treatment | After treatment |
| Treatment group | 59 | -3.4±0.6 | -2.1±0.4 **# |
| Matched group | 31 | -3.3±0.6 | -2.8±0.5 |
Note: compared with before treatment:
*p < 0.01; Compared with matched group, #P < 0.05.
From table 4, treatment group patient's bone density after treatment significantly improves, there is significant difference (T=4.62 compared with before treatment, P < 0.01), and after treatment of control group, in bone density, increase but no difference of science of statistics (T=0.66, P > 0.05).Between group, compare, after treatment group treatment, bone density improvement is better than concurrent control group, and has significant difference (T=2.74, P < 0.05).
Embodiment 2
Old XX, man, 78 years old, because of waist and sacrum pain, walking disorder, surveyed ankle bone density T=-3.8, gives Radix Rehmanniae Preparata 12g, Herba Epimedii 12g, Radix Dipsaci 10g, Herba Taxilli 10g, Radix Clematidis 10g, Cortex Phellodendri 8g, Radix Aconiti 8g, Herba Lycopodii 8g.Treat pain after two weeks and significantly alleviate, walking function improves.
Embodiment 3
Old XX, female, 74 years old, because sternocostal part and lumbar vertebra, lower limb successively 8 fragility fractures companion gonalgia come institute, survey lumbar spine bmd T=-3.2, give Radix Rehmanniae Preparata 6g, Herba Epimedii 8g, Radix Dipsaci 10g, Herba Taxilli 6g, Radix Clematidis 8g, Cortex Phellodendri 6g, Radix Aconiti 6g, Herba Lycopodii 6g.Treat pain after two weeks and significantly alleviate, walking function improves, and checks bone density T=-2.7 after March.The gonalgia obviously alleviates.
Embodiment 4
Zhao XX, female, 82 years old, because of knee joint and hip joint, shoulder arthralgia, 3 years companion's walking disorder of moving obstacle come institute, survey lumbar spine bmd T=-2.9, give Radix Rehmanniae Preparata 10g, Herba Epimedii 6g, Radix Dipsaci 6g, Herba Taxilli 10g, Radix Clematidis 12g, Cortex Phellodendri 6g, Radix Aconiti 6g, Herba Lycopodii 7g.Treat pain after two weeks and significantly alleviate, walking function improves, and after two weeks, multi-joint pain obviously alleviates, and function of joint is improved, and checks bone density T=-2.3 after March.
To sum up, the pure Chinese medicine formula for the treatment of senile osteoporosis of the present invention carries out active intervention and treatment for senile osteoporosis, reduction of patient osteodynia (lumbar vertebra, hip, sacrococcygeal region, knee joint etc.), improve function of joint, improve daily life behavioral competence, reduce risk of bone fracture, save hospital expenses, save human resources, its single herbal concentrate-granule taking convenience is quick, is suitable for large-scale promotion application.
In this description, the present invention is described with reference to its specific embodiment.But, still can make various modifications and conversion obviously and not deviate from the spirit and scope of the present invention.Therefore, description is regarded in an illustrative, rather than a restrictive.
Claims (7)
1. treat the Chinese medicine composition of senile osteoporosis for one kind, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Rehmanniae Preparata 6～12g, Herba Epimedii 6～12g, Radix Dipsaci 6～10g, Herba Taxilli 6～10g, Radix Clematidis 8～12g, Cortex Phellodendri 6～8g, Radix Aconiti 6～8g and Herba Lycopodii 6～8g.
2. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Rehmanniae Preparata 10g, Herba Epimedii 10g, Radix Dipsaci 8g, Herba Taxilli 8g, Radix Clematidis 10g, Cortex Phellodendri 7g, Radix Aconiti 7g, Herba Lycopodii 7g.
3. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Rehmanniae Preparata 12g, Herba Epimedii 12g, Radix Dipsaci 10g, Herba Taxilli 10g, Radix Clematidis 10g, Cortex Phellodendri 8g, Radix Aconiti 8g, Herba Lycopodii 8g.
4. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Rehmanniae Preparata 6g, Herba Epimedii 8g, Radix Dipsaci 10g, Herba Taxilli 6g, Radix Clematidis 8g, Cortex Phellodendri 6g, Radix Aconiti 6g, Herba Lycopodii 6g.
5. the Chinese medicine composition for the treatment of senile osteoporosis according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the crude drug of following weight portion: Radix Rehmanniae Preparata 10g, Herba Epimedii 6g, Radix Dipsaci 6g, Herba Taxilli 10g, Radix Clematidis 12g, Cortex Phellodendri 6g, Radix Aconiti 6g, Herba Lycopodii 7g.
6. a pure free decoction granule for the treatment of senile osteoporosis, is characterized in that, makes being processed into respectively granule according to each component of the Chinese medicine composition of arbitrary described treatment senile osteoporosis in claim 1～5.
7. a pure free decoction granule for the treatment of senile osteoporosis, is characterized in that, makes for granule being dried after decocting respectively according to each component of the Chinese medicine composition of arbitrary described treatment senile osteoporosis in claim 1～5.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1706441A (en) * | 2005-04-27 | 2005-12-14 | 杨文锋 | Arthralgia treating plaster |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706441A (en) * | 2005-04-27 | 2005-12-14 | 杨文锋 | Arthralgia treating plaster |
Non-Patent Citations (2)
| Title |
|---|
| "原发性骨质疏松症的中医药研究进展";曾宪铁等;《中国矫形外科杂志》;20080228;第16卷(第3期);191-193 * |
| 曾宪铁等."原发性骨质疏松症的中医药研究进展".《中国矫形外科杂志》.2008,第16卷(第3期),191-193. |
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Application publication date: 20110803 Assignee: Guangdong E.Fong Pharmaceutical Co., Ltd. Assignor: Shanghai Yangpu Central Hospital Contract record no.: 2019310000048 Denomination of invention: Formula of pure traditional Chinese medicine for treating senile osteoporosis and decoction-free granules Granted publication date: 20140618 License type: Exclusive License Record date: 20190719 |
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