CN108653425A

CN108653425A - It is a kind of to have the surface of a wound antibacterial and the Chinese medicine composition of healing effect

Info

Publication number: CN108653425A
Application number: CN201810975383.2A
Authority: CN
Inventors: 李在文
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-08-24
Filing date: 2018-08-24
Publication date: 2018-10-16

Abstract

The invention discloses a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, and the composition includes following raw material：Borneol, borax, menthol, garden burnet and giant knotweed.The present invention dissipates the stasis of blood with stronger heat-clearing, cool blood, anti-inflammatory, removing toxic substances, and analgesic, disappear furuncle, lump of dispelling, sterilization, antibacterial effect, energy rapid healing wound caused by burn, scald, scratch, knife wound etc., and eliminates scar.

Description

It is a kind of to have the surface of a wound antibacterial and the Chinese medicine composition of healing effect

Technical field

The present invention relates to the field of Chinese medicines, more particularly to a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound.

Background technology

It is exactly the cutin that skin infection is rotted that the treatment processing of the infection of skin and mucous membrane, which needs cleaning, coating, cleaning, Layer and the tissue of subcutaneous layer of fat necrosis part are cleaned, some antibacterial or antibacterial drugs are then applied.

Currently on the market there are mainly two types of the antibacterial medicines of most common treatment burn etc., one is antibacterial by chemistry External medicine preparation made of drug, is clinically used for wound external application antibacterial medicines at present, such as clinically controls burning at present and scalds Hinder external used medicine with calm antipruritic, skin care as principle, as usual to select lincomycin lidocaine, skin can be made for a long time by using Atrophy, telangiectasis, and generate dependence it requires that medication is appropriate or discontinuity medication；For another example chlorhexidine acetate is Anti-bacterial drug, but it is mixed to killing, preventing and treating skin, mucosal bacteria or fungal infection or both bacterium and fungi Infectious effect is undesirable, often when antibacterial or antimicrobial concentration is higher, just plays bacteriostasis antibiosis effect, bactericidal effect is slower, 3 points Zhong Hou could preferably play bactericidal effect, and it is shorter to retain effective time in skin and mucous membrane, low concentration bacteriostasis also compared with Difference, chemicals Mlc relatively up to wound therapeutic effect while have obvious irritation, as tingling sensation, The adverse reactions such as sensation of dryness, some even will produce dependence.Another kind is the external preparation made of Chinese medicine, with people couple Health, the increasingly raising of health, safety requirements, more and more consumers are in the antibacterial system of the combinations such as various Chinese herbal medicines Agent, but existing Chinese medicine composition bacteriostasis antibiosis effect is poor, and responding time and healing time are still undesirable, particularly with The wound of burn needs further to be improved and improve.

Invention content

The technical problem to be solved by the present invention is to be used to the medicament of Wound treating in the prior art usually only have antibacterial effect Fruit does not have the effect of promoting skin repair, quick healing of cut, while the performance of its fungistatic effect needs higher medicament dense Degree, on the one hand can cause some patientss allergic reaction occur skin irritant, on the other hand after drug concentration decline Be difficult to it is persistently antibacterial, thus can make patient to these bacteriostatic agents generate dependence.

The present invention also technical problems to be solved are that the Chinese medicine composition as Wound treating is usually antibacterial in the prior art Effect unobvious, treatment cycle are long.

In order to solve the above technical problems, one aspect of the present invention is：A kind of bacteria inhibiting composition is provided, the suppression Bacteria composition raw material includes：Borneol, borax, menthol, garden burnet and giant knotweed.

Borneol is water white transparency or the crisp crystallization of white translucent in the raw material of the present invention, and gas faint scent, acrid flavour is cool, bitter, Cold, thoughts of returning home warp, lung channel, faint scent honey dissipates.

Borax is colourless semi-permeable membrane crystal or white crystalline body, and odorless, taste is salty, has bactericidal effect, is alkalescent, this hair The dosage of bright 0.5~1.5g of borax is to Escherichia coli, Pseudomonas aeruginosa, bacillus anthracis, a variety of bacillus such as shigella flexneri There is good inhibiting effect.

Menthol is usually used in pruitus, and cool pain-alleviating promotes blood circulation, and mitigates edema etc., and other drugs compatibility, There is unique effect under 0.1~1g of menthol dosages of the present invention.

Garden burnet bitter, cold nature is nontoxic, there is cool blood, and hemostasis, the effect of removing toxic substances sore can also be treated and be had blood in stool, hemorrhoid blood, Subcutaneous ulcer swells sore, while to tubercle bacillus, typhoid bacillus, staphylococcus aureus, and Pseudomonas aeruginosa has inhibiting effect.

Clearing heat and detoxicating, the astringing to arrest bleeding of giant knotweed energy, dissipates the stasis of blood, cures mainly wound caused by burn, scald, scratch, knife wound etc., this product Rhizome contains anthra-glucoside, predominantly rheum emodin, rheum-emodin, formic acid, the effect of letting out under having, and has to staphylococcus aureus stronger Inhibiting effect

Inventor has found borneol, borax, menthol, after garden burnet and giant knotweed combination, can rapid healing made by many reasons At wound, and prevent trauma surface infestation, expansion, make its Fast Convergent, can finally substantially eliminate the scar after wound healing, have Not the effect of not having when each component is used alone.

The present invention a kind of specific implementation mode in, in the composition contain 0.5~1.5g of borneol, borax 0.5~ 1.5g, 0.1~1g of menthol, 0.5~1.5g of garden burnet, 0.5~1.5g of giant knotweed.

In the specific embodiment of the present invention, borneol 1.1g, borax 1.1g, menthol are contained in the composition 0.6g, garden burnet 1.2g, giant knotweed 1.2g.

A kind of preferred embodiment of the present invention is that the composition further includes one or more in following raw material：Sophora flower, Cortex Phellodendri, cow-bezoar, Sculellaria barbata, rheum officinale.

In the preferred embodiment, if applying to cow-bezoar, it is preferable to use calculus bovis factitius.

Calculus bovis factitius mainly contain cholic acid, deoxycholic aicd, cholesterine, bilirubin, ergosterol, lecithin, vitamin D calcium, Iron, copper etc..Function：Clearing away heart-fire and eliminating phlegm is had one's ideas straightened out, and is cleared liver, polyp, removing toxic substances, abscess of throat, aphthae, carbuncle swells disease etc..

Inventor find in raw material components and preferred embodiment in the base case of the present invention will newly to increase at Point combination when, can make the present invention it is quick, continue it is antibacterial, promote healing and other effects be greatly improved.

In the preferred embodiment,

The sophora flower bitter, it is mild-natured, it is nontoxic, have effects that heat-clearing, cool blood, hemostasis, decompression.To haematemesis, hematuria, hemorrhoid Bleeding, wind-heat hot eyes, high blood pressure, hyperlipidemia, the tuberculosis of cervical lymph nodes, vascular sclerosis, stool band blood, etc. have significant curative effect.

The Cortex Phellodendri is used for damp-heat dysentery, and jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is preesed, and hectic fever due to yin labor heat is stolen Sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire.For fire excess from yin deficiency, night sweat hectic fever due to yin.

The Sculellaria barbata have it is clearing heat and detoxicating, it is promoting blood circulation and removing blood stasis, the effect of swelling and pain relieving, anticancer；Appendicitis curing, hepatitis, stomachache, Early liver cancer, lung cancer, cervix cancer, mastitis etc.；The treatment of pain furuncle, the diseases such as swelling and pain are controlled in external application.

In the specific implementation mode of the present invention, in the composition containing 0.5~1.5g of sophora flower and/or Cortex Phellodendri 0.9~ 1.3g and/or 0.1~1g of cow-bezoar and/or 0.2~0.9g of Sculellaria barbata and/or rheum officinale 1.5~2.5.

It is understood that basic proportioning feelings of the composition when playing its effect that above-mentioned specific implementation mode refers to Condition, in actual production, technical staff can disposably be enlarged metaplasia production in proportion completely, such as use 5~15kg of borneol, It is prepared by 5~15kg of borax, 1~10kg of menthol, 5~15kg of garden burnet and 5~15kg of giant knotweed, and prepare after the completion of again into Row packing, technical spirit are consistent with the method.

In one embodiment of the invention, the composition contains sophora flower 0.7g and/or Cortex Phellodendri 1.1g and/or ox 0.6~0.9g of Huang and/or Sculellaria barbata 0.6g.

In the concrete mode of the present invention, the composition contains borneol 1.1g, borax 1.1g, menthol 0.6g, garden burnet 1.2g, giant knotweed 1.2g and/or sophora flower 0.7g and/or Cortex Phellodendri 1.1g and/or 0.6~0.9g of cow-bezoar and/or Sculellaria barbata 0.6g, And/or rheum officinale 0.7g.

In the specific implementation mode of the present invention, the bacteria inhibiting composition is the powder of the raw material.

The present invention specific implementation mode in, the raw material giant knotweed, garden burnet powder granularity be 250~300 mesh.

Inventor has found that the therapeutic effect of the product obtained under this grain size is best, relative to other grain sizes, or will be former Material component, which extracts the product being concentrated to give, has better clinical therapeutic efficacy.

In the present invention, the composition is the water extract and/or alcohol extract and/or solvent mixture of the raw material, institute It states solvent and is selected from one or both of water or alcohol..

What solvent mixture described in the embodiment referred to directly carries out the raw material in composition with solvent

The mixture obtained after mixing.

In the present invention, the composition is solvent mixture, and the solvent is sterile water, and quantity of solvent is

200~300mL.

When quantity of solvent is 200~300mL, the material quality is the matter containing raw material in Chinese medicine composition of the present invention Amount.

In the specific implementation mode of the present invention, clinically-acceptable external preparation is made in the bacteria inhibiting composition, such as sprays Agent.

In the specific implementation mode of the present invention, spray is made in the bacteria inhibiting composition.

In the specific implementation mode of the present invention, by the bacteria inhibiting composition for burning, scalding, abrading, knife wound etc. draws The wound risen, and eliminate scar.

In the specific implementation mode of the present invention, the bacteria inhibiting composition is removed into evening sack time and is sprayed every 75min One is inferior to wound surface.

In actual use, Chinese medicine composition of the invention can also use method used below to the present invention：

1. burn and scald skin is not broken, Chinese medicine composition of the present invention is directly imposed on into affected part.Rigid burn and scald, can continuously spray or Affected part is spread on after hospital gauze is squirted, up to no Burning Pain sense, the time is about 20~30 minutes.

2. burn and scald skin has been broken, Chinese medicine composition of the present invention is reused after cleaning the surface of a wound.

3. large area severe burn and scald, can be with cooperation infusion treatment.

4. being used for knife wound, first stops blooding and apply the Chinese medicine composition of the present invention afterwards and bound up a wound with hospital gauze number layer, one Day is replaced primary.

The invention has the advantages that：

(1) present invention has stronger heat-clearing, and cool blood, anti-inflammatory, removing toxic substances, the scattered stasis of blood, analgesic, disappear furuncle, lump of dispelling, and sterilizes, suppression The effect of bacterium, energy rapid healing wound caused by burn, scald, scratch, knife wound etc., and eliminate scar.

(2) externally applied spray can be made in the present invention, to influencing the pyococcus such as staphylococcus aureus of skin health；Greatly Enterobacteria；The pathogenic bacteria such as fungi such as Candida albicans have stronger antibacterial and bacteriostasis, for burning, scalding, abrade, knife wound Equal wounds or post-operative wound.

(3) present invention can be additionally used in treat acne, women Celiotomy Wean scar etc., when for treating or eliminating Cesarean esction When rear wound, relative to the scar drug of existing Celiotomy Wean, such as antipruritic scar softening cream, wound can be made to shift to an earlier date 5~7 Its healing.

(4) present invention has stronger heat-clearing, and cool blood, anti-inflammatory, removing toxic substances, the scattered stasis of blood, analgesic, disappear furuncle, lump of dispelling, and sterilization is made With, while having the function of promoting wound healing, it is remained substantially without apparent scar after wound healing.

(5) antibacterial and promoting healing good effect of the invention, it is cheap, the pain of sufferer is not only alleviated in effect, and And economically reduce the puzzlement of broad masses of the people.

Specific implementation mode

Embodiment 1

Following raw material is prepared into powder：0.5~1.5g of borneol, 0.5~1.5g of borax, 0.1~1g of menthol, garden burnet 0.5~1.5g, 0.5~1.5g of giant knotweed are added sterile wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh Water, the right amount of auxiliary materials for spray to be made are prepared into 250ml sprays.

Embodiment 2

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for being made in 0.5~1.5g of sophora flower The right amount of auxiliary materials of spray is prepared into 250ml sprays.

Embodiment 3

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for being made in 0.9~2.0g of Cortex Phellodendri The right amount of auxiliary materials of spray is prepared into 250ml sprays.

Embodiment 4

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Sterile water is added wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh in 0.1~1g of cow-bezoar, for spray to be made The right amount of auxiliary materials of agent is prepared into 250ml sprays.

Embodiment 5

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for being made in 0.6~0.9g of cow-bezoar The right amount of auxiliary materials of spray is prepared into 250ml sprays.

Embodiment 6

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for making in 0.2~0.9g of Sculellaria barbata At the right amount of auxiliary materials of spray, it is prepared into 250ml sprays.

Embodiment 7

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for being made in 0.3~1.2g of rheum officinale The right amount of auxiliary materials of spray is prepared into 250ml sprays.

Embodiment 8

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, The wherein described raw material giant knotweed of sophora flower 0.7g, Cortex Phellodendri 1.1g, garden burnet powder granularity be 250~300 mesh, be added sterile water, be used for The right amount of auxiliary materials of spray is made, is prepared into 250ml sprays.

Embodiment 9

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, The wherein described raw material giant knotweed of Sculellaria barbata 0.6g, Cortex Phellodendri 1.1g, rheum officinale 0.7g, garden burnet powder granularity be 250~300 mesh, be added Sterile water, the right amount of auxiliary materials for spray to be made are prepared into 250ml sprays.

Embodiment 10

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for spray to be made in sophora flower 0.7g Right amount of auxiliary materials, be prepared into 250ml sprays.

Embodiment 11

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for spray to be made in Cortex Phellodendri 1.1g Right amount of auxiliary materials, be prepared into 250ml sprays.

Embodiment 12

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Sterile water is added wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh in Sculellaria barbata 0.6g, for spray to be made The right amount of auxiliary materials of agent is prepared into 250ml sprays.

Embodiment 13

Following raw material is prepared into powder：Borneol 0.5g, borax 0.5g, menthol 0.1g, garden burnet 0.5g, giant knotweed 0.5g, Wherein the granularity of the raw material giant knotweed, garden burnet powder is 250~300 mesh sterile water is added, for spray to be made in rheum officinale 0.7g Right amount of auxiliary materials, be prepared into 250ml sprays.

Embodiment 14

Patient Liu, 9 years old, female lived Liangshan Mountain autonomous prefecture, accidentally overturns the pig feed pot boiled, leads to abdomen, both legs And both feet scald is serious, whole body scalding area is up to 30~40%, and situations such as excoriation, bubbling also occurs in scald part, in county Hospitalize more than 20 days, has not yet to see any improvement, and the spray for using the embodiment of the present invention 4 to prepare thereafter continues to use about two Wound is not completely cured after week, does not leave apparent scar, and skin heals completely, organizational vitality back to normal, and normally not The skin being burned is identical.

Embodiment 15

Inventor on the way, met the scald accident to happen suddenly together by chance in tourism in 2017, and boiling water is in short supply on train at that time, Tourist's number to be fetched water is numerous, in the case of crowded chaotic, boiling water switch is not turned off after certain passenger's water receiving, makes opening for high temperature Water overflows, and scalds another passenger, causes the passenger front, neck tight to occur down toward 70~80% areas of navel above section It scalds again, entire wound is in the scarlet shape that festers, and is accompanied by serious bubbling, and inventor is by portable reality through the invention Applying the spray that example 5 is prepared is supplied to the patient to use, primary every about 75min sprays, after just having sprayed 10min, visually may be used It observes that its wound has apparent improvement sign, uses the spray about after two weeks lasting, wound heals completely, without apparent scar Trace, vigor of skin tissue back to normal is identical as the skin not being burned normally, and in use, wound is without any expansion It opens and infection occurs, without the appearance recurred repeatedly.

Embodiment 16

Patient Lee, 70 years old, female was scalded in the process for mixing boiling water by the boiling water that overfill is overflowed accidentally when doing housework labour Hinder instep, be at that time summer, patient wears sandals, causes scald serious, and injury is blistered, swelling and pain, and because scald is tired on foot Difficulty seriously affects normal life, and the spray for using the embodiment of the present invention 5 to prepare thereafter continues to control completely behind day using about two weeks More, no recurrence, does not leave apparent scar after the skin healing being burned, vigor of skin tissue back to normal, with normally not by The skin of scald is identical.

Embodiment 17

Thousands of ages, between 9~84 years old, the patient of apparent wound was generated by situations such as burn, scald, scratch, knife wounds Receive the treatment of the Chinese medicine composition (paste that such as embodiment 4 or 5 is prepared) of the present invention, which part patient's scald face Product reaches 40% or more, treats a wheat harvesting period in hospital and does not cure, these patients are cured, and in the treatment may be used To observe, patient wound shrinks quickly, can complete to close up within 10 days, is quickly formed do scar thereafter, generates the left sides 1~2cm Right scar mouth, skin does not leave apparent scar after healing, and organizational vitality back to normal is no different with the skin not being burned.

Embodiment 18

Spray prepared by embodiment 1,2,3,6,7,8,9,10,11,12,13, it is corresponding with embodiment, hereinafter referred to as in fact It applies example 1,2,3,6,7,8,9,10,11,12,13 and carries out following tests：

One, by embodiment 1,2,3,6,7,8,9,10,11,12,13, lincomycin lidocaine spray, chlorhexidine acetate Spray is individually used for the same type of burn wound of different people, with the respective attainable effect of institute of more above-mentioned three kinds of sprays Fruit.

It surveys its onset time, while after 15 days, surveys its cure rate, it is as a result as follows：

Two, by a certain amount of embodiment 1,2,3,6,7,8,9,10,11,12,13, lincomycin lidocaine spray, vinegar Sour Chlorhexidine spray, (process is in sterile item on the surface of the agar medium of the tested strain bacteria suspension of three kinds of even spread respectively Operated under part), culture dish inversion is incubated at 37 DEG C of constant temperature incubations for 24 hours, observes film surface thalli growth phenomenon, and record antibacterial The diameter of circle.

Example the above is only the implementation of the present invention is not intended to limit the scope of the invention, every to utilize this hair Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks Domain is included within the scope of the present invention.

Claims

1. a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that the composition includes following raw material Component：Borneol, borax, menthol, garden burnet and giant knotweed.

2. according to claim 1 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It states and contains 0.5 ~ 1.5g of borneol, 0.5 ~ 1.5g of borax, 0.1 ~ 1g of menthol in composition, 0.5 ~ 1.5 g of garden burnet, giant knotweed 0.5 ~ 1.5g。

3. according to claim 2 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It states and contains borneol 1.1g, borax 1.1g, menthol 0.6g, garden burnet 1.2 g, giant knotweed 1.2g in composition.

4. according to claim 1 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It further includes one or more in following raw material components to state composition：Sophora flower, Cortex Phellodendri, cow-bezoar, Sculellaria barbata, rheum officinale.

5. according to claim 4 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It states and contains 0.5 ~ 1.5 g of sophora flower and/or Cortex Phellodendri 0.9 ~ 1.3 g and/or 0.1 ~ 1g of cow-bezoar and/or Sculellaria barbata in composition 0.3 ~ 1.2g of 0.2 ~ 0.9g and/or rheum officinale.

6. according to claim 5 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It states composition and contains 0.7 g of sophora flower and/or Cortex Phellodendri 1.1 g and/or 0.6 ~ 0.9g of cow-bezoar and/or Sculellaria barbata 0.6g, and/or 0.7 g of rheum officinale.

7. according to claim 6 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It states composition and contains borneol 1.1g, borax 1.1g, menthol 0.6g, garden burnet 1.2 g, giant knotweed 1.2g and/or 0.7 g of sophora flower, And/or 0.7 g of Cortex Phellodendri 1.1 g and/or 0.6 ~ 0.9g of cow-bezoar and/or Sculellaria barbata 0.6g and/or rheum officinale.

8. according to claim 1 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that institute It is 250 ~ 300 mesh powders that state raw material giant knotweed, garden burnet in composition, which be granularity,.

9. according to a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound described in claim 1 ~ 8, which is characterized in that The composition is the water extract and/or alcohol extract and/or solvent mixture of the raw material, and the solvent is in water or alcohol One or two.

10. according to claim 9 a kind of with the antibacterial Chinese medicine composition with healing effect of the surface of a wound, which is characterized in that The composition is solvent mixture, and the solvent is sterile water, and quantity of solvent is 200 ~ 300mL.