CN108653415A - A kind of composition and preparation method thereof with sedative action - Google Patents
A kind of composition and preparation method thereof with sedative action Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention belongs to health foods to research and develop field, and in particular to a kind of composition and preparation method thereof with soporific function.The composition raw material is 50% ~ 60% ganoderma lucidum water extract freeze-dried powder and 40% ~ 50% Chinese medicine freeze-dried powder as mass fraction；The Chinese medicine freeze-dried powder includes following raw material：8 15 parts of ostreae testa pulverata, 58 parts of Poria cocos, 5 12 parts of spina date seed, 38 parts of ginseng, 15 parts of Radix Glycyrrhizae.Product the characteristics of capable of playing each taste Chinese medicine of the present invention, assigns its blood-enriching tranquillizing, the benefits of solidifying gas clears away heart-fire, tranquilizing and allaying excitement by the synergistic effect between Chinese medicine.
Description
Technical field
The invention belongs to health foods to research and develop field, and in particular to a kind of composition and preparation method thereof with soporific function.
Background technology
Sleep disturbance not only all has significant effect the work of people, life and physical and mental health, but also is also diabetes
Therefore it is one of the hot spot of modern medicine study to the treatment of insomnia with the early stage risk factor of the diseases such as angiocarpy.Now,
Modern medical therapy insomnia mostly uses barbiturate, but since there are many adverse reactions for such drug, takes for a long time
It is also easy to produce tolerance and dependence, Liver and kidney function is damaged, so people start to seek to break through in traditional Chinese medicine.Chinese medicine class system
Agent focus on by remove the fire of deficiency type, dispersing stagnated hepatoqi, it is nourishing liver and kidney, take into account and adjust the composite treatment of smooth qi and blood, so that the interior ecology of human body is reached
To harmonious equilibrium state, the purpose of radical cure is realized, and after clinical practice in thousands of years, have to improvement sleep function original
Opinion.
CN 201410329578.1 discloses a kind of health products improving sleep, including spina date seed, Poria cocos, Radix Glycyrrhizae, matrimony vine
Son, lily, campanulaceae and fructus amomi.The active component and its weight proportion of the health food be：8-25 grams of spina date seed, Poria cocos 5-25
Gram, 5-18 grams of Radix Glycyrrhizae, 5-20 grams of the fruit of Chinese wolfberry, 8-25 grams of lily, 5-20 grams of campanulaceae, 2-15 grams of fructus amomi.The present invention uses a variety of medicines
Homologous Chinese herbal medicine effective component extracting is eaten, Chinese traditional herbs characteristic and modern medicine study are combined, keeps various composition reasonable
Prescription, cooperate with shared, through a variety of ways, at many levels come reach improve sleep healthcare function.Three tastes used by the formula
The Chinese medicine fruit of Chinese wolfberry, campanulaceae and fructus amomi, primary efficacy are " clearing and antitussive, nourishing stomach and spleen warm up lung and support kidney ", which is
Based on improvement sleep, or based on tonifying-Yin and nourishing-stomach, it is still not clear.
CN201510257789.3 discloses a kind of health food granule for having and improving sleep function, the health food
It is prepared by following several components：Siberian Ginseng P.E, green-tea extract, Bulbus Lilii extract, Valerian root P.E, west kind
Lotus fruit powder.Health food of the present invention selects a variety of integration of drinking and medicinal herbs Chinese herbal medicine extractions such as wilsonii, green tea, lily, valerian, passionflower
Chinese traditional herbs characteristic and European traditional plant medicine special programs are combined, make various composition reasonable formula, match by active ingredient
Amount to use, have improve sleep, alleviate a variety of effects of anxiety, through a variety of ways, at many levels come reach improve sleep guarantor
Health-care function.Monarch is particular about in drug matching, which selects valerian, the traditional plant in both Europe of passionflower, if energy
The drug effect of enough auxiliary monarchs drug in a prescription is still not clear；And although two kinds of medicine property of medicine are mild, drug effect is fierce, to special population whether
It is suitble to, it is unclear.
The compatibility of drugs principle of " monarch ", prominent ganoderma lucidum, ostreae testa pulverata, Poria cocos, spina date seed four is just utilized in the present invention
The drug effect of taste Chinese medicine " tranquilizing and allaying excitement ", and ginseng is utilized, the characteristics of two taste Chinese medicine " clearing heat and detoxicating " of Radix Glycyrrhizae, the present invention is promoted to improve
The healthcare function of sleep.
Invention content
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of composition with soporific function and its preparation side
Method.It is clear to assign its blood-enriching tranquillizing, solidifying gas by the synergistic effect between Chinese medicine for the characteristics of product of the present invention can play each taste Chinese medicine
The benefits of heart, tranquilizing and allaying excitement.
For achieving the above object, the present invention adopts the following technical scheme that：
A kind of composition with sedative action, raw material be as mass fraction, 50% ~ 60% ganoderma lucidum water extract freeze-dried powder and 40% ~
50% Chinese medicine freeze-dried powder is made；Wherein Chinese medicine freeze-dried powder includes following raw material：8-15 parts of ostreae testa pulverata, 5-8 parts of Poria cocos, acid
5-12 parts of jujube kernel, 3-8 parts of ginseng, 1-5 parts of Radix Glycyrrhizae.
Preferably, the Chinese medicine freeze-dried powder includes following raw material：12 parts of ostreae testa pulverata, 8 parts of Poria cocos, spina date seed 10
Part, 5 parts of ginseng, 3 parts of Radix Glycyrrhizae.
The preparation method of the ganoderma lucidum water extract is：Ganoderma lucidum fruitbody is crushed, 150 ~ 200 mesh sieve is crossed, toward after sieving
Glossy ganoderma powder in 1 ~ 2g of solid-liquid ratio:15 ~ 30mL is added distilled water and is filtered under diminished pressure in 90 ~ 95 DEG C or so 1.5 ~ 2h of heating water bath
Afterwards, first time filtrate and first time filter residue are collected to obtain；First time filter residue is subjected to heating water bath according still further to above-mentioned steps, was depressurized
Filter, collects to obtain second of filtrate and second of filter residue；Second of filter residue is subjected to heating water bath according still further to above-mentioned steps, was depressurized
Third time filtrate and third time filter residue are collected to obtain in filter, after merging filtrate three times, after concentrated, freeze-drying, ganoderma lucidum water are made and carries
Object freeze-dried powder.
The preparation method of the Chinese medicine freeze-dried powder is：Ostreae testa pulverata, Poria cocos, spina date seed, ginseng, Radix Glycyrrhizae are placed in marmite,
By 1 ~ 2g of solid-liquid ratio:Distilled water is added in 10 ~ 20mL, cooks 1 ~ 1.5h, is filtered under diminished pressure, obtains first time filtrate and filter residue；By first
Secondary filter residue presses above-mentioned steps and cooks 0.5 ~ 1h again, is filtered under diminished pressure, obtains second of filtrate and filter residue；Merge filtrate twice, concentration is cold
It is lyophilized and dry freeze-dried powder is made.
It is uniformly mixed in mass ratio by the ratio of 50% ~ 60% ganoderma lucidum water extract freeze-dried powder and 40% ~ 50% Chinese medicine freeze-dried powder, mistake
Sieve, obtains the composition with sedative action.
The beneficial effects of the present invention are：
1）The ingredients such as polysaccharide, nucleoside compound, alkaloid compound are mainly contained in ganoderma lucidum water extract, by itself and Fu
Siberian cocklebur, ostreae testa pulverata, spina date seed, ginseng and Radix Glycyrrhizae mixing composition composition, are allowed to act on target spots different in vivo, form multiple target point
Mechanism can improve the sleep quality of insomniac, and the clinical symptoms of energy relieving insomnia patient；
2）The production of the present invention is simple for process, of low cost, easy to spread, is easy to carry about with one, convenient.
Specific implementation mode
With reference to example, the preparation method and effect of the tranquilizing the mind composition of the present invention are more fully proved.The preparation side of the present invention
Method, it is not limited to which following instance has any type of change to the preparation method of the present invention, falls within the protection of the present invention
Range.
Embodiment 1
A kind of preparation method with sedative action composition, the specific steps are：
1）The preparation method of the ganoderma lucidum water extract is：Ganoderma lucidum fruitbody is crushed, 150 mesh sieve, the ganoderma lucidum toward after sieving are crossed
With solid-liquid ratio 1g in powder:15mL is added distilled water and after being filtered under diminished pressure, collects to obtain first time filtrate in 90 DEG C of heating water bath 1.5h
With first time filter residue；First time filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, second of filtrate is collected to obtain
And filter residue；Second of filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, third time filtrate and filter are collected to obtain
After merging filtrate three times, after concentrated, freeze-drying, ganoderma lucidum water extract freeze-dried powder is made in slag；
2）The preparation method of the Chinese medicine freeze-dried powder is：Ostreae testa pulverata 12g, Poria cocos 8g, spina date seed 10g, ginseng 5g, Radix Glycyrrhizae 3g are set
In marmite, by solid-liquid ratio 1g:Distilled water is added in 10mL, cooks 1.5h, is filtered under diminished pressure, obtains first time filtrate and filter residue；By
Filter residue presses above-mentioned steps and cooks 0.5h again, is filtered under diminished pressure, obtains second of filtrate and filter residue；Merge filtrate twice, concentration is cold
It is lyophilized and dry freeze-dried powder is made；
3）60wt% ganoderma lucidum water extract freeze-dried powders and 40wt% Chinese medicine freeze-dried powders are uniformly mixed, are sieved, obtains and makees with calming the nerves
Composition.
Embodiment 2
A kind of preparation method with sedative action composition, the specific steps are：
1）The preparation method of the ganoderma lucidum water extract is：Ganoderma lucidum fruitbody is crushed, 150 mesh sieve, the ganoderma lucidum toward after sieving are crossed
With solid-liquid ratio 1g in powder:15mL is added distilled water and after being filtered under diminished pressure, collects to obtain first time filtrate in 90 DEG C of heating water bath 1.5h
With first time filter residue；First time filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, second of filtrate is collected to obtain
And filter residue；Second of filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, third time filtrate and filter are collected to obtain
After merging filtrate three times, after concentrated, freeze-drying, ganoderma lucidum water extract freeze-dried powder is made in slag；
2）The preparation method of the Chinese medicine freeze-dried powder is：Ostreae testa pulverata 8g, Poria cocos 5g, spina date seed 5g, ginseng 5g, Radix Glycyrrhizae 2g are placed in
In marmite, by solid-liquid ratio 1g:Distilled water is added in 10mL, cooks 1.5h, is filtered under diminished pressure, obtains first time filtrate and filter residue；By first
Secondary filter residue presses above-mentioned steps and cooks 0.5h again, is filtered under diminished pressure, obtains second of filtrate and filter residue；Merge filtrate twice, concentrates, freezing
Freeze-dried powder is made in drying；
3）60wt% ganoderma lucidum water extract freeze-dried powders and 40wt% Chinese medicine freeze-dried powders are uniformly mixed, are sieved, obtains and makees with calming the nerves
Composition.
Embodiment 3
A kind of preparation method with sedative action composition, the specific steps are：
1）The preparation method of the ganoderma lucidum water extract is：Ganoderma lucidum fruitbody is crushed, 150 mesh sieve, the ganoderma lucidum toward after sieving are crossed
With solid-liquid ratio 1g in powder:15mL is added distilled water and after being filtered under diminished pressure, collects to obtain first time filtrate in 90 DEG C of heating water bath 1.5h
With first time filter residue；First time filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, second of filtrate is collected to obtain
And filter residue；Second of filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, third time filtrate and filter are collected to obtain
After merging filtrate three times, after concentrated, freeze-drying, ganoderma lucidum water extract freeze-dried powder is made in slag；
2）The preparation method of the Chinese medicine freeze-dried powder is：Ostreae testa pulverata 15g, Poria cocos 8g, spina date seed 12g, ginseng 8g, Radix Glycyrrhizae 5g are set
In marmite, by solid-liquid ratio 1g:Distilled water is added in 10mL, cooks 1.5h, is filtered under diminished pressure, obtains first time filtrate and filter residue；By
Filter residue presses above-mentioned steps and cooks 0.5h again, is filtered under diminished pressure, obtains second of filtrate and filter residue；Merge filtrate twice, concentration is cold
It is lyophilized and dry freeze-dried powder is made；
3 are uniformly mixed 60wt% ganoderma lucidum water extract freeze-dried powders and 40wt% Chinese medicine freeze-dried powders, and sieving is made with sedative action
Composition.
Comparative example 1
Ganoderma lucidum fruitbody is crushed, 150 mesh sieve is crossed, into the glossy ganoderma powder after sieving with solid-liquid ratio 1g:Distilled water is added in 15mL,
90 DEG C of heating water bath 1.5h after being filtered under diminished pressure, collect to obtain first time filtrate and first time filter residue；By first time filter residue according still further to upper
It states step to carry out heating water bath, be filtered under diminished pressure, collects to obtain second of filtrate and filter residue；By second of filter residue according still further to above-mentioned steps
It carries out heating water bath, be filtered under diminished pressure, collect to obtain third time filtrate and filter residue, after merging filtrate three times, concentrated, freeze-drying
Afterwards, ganoderma lucidum water extract freeze-dried powder is made, as drug 1.
Comparative example 2
1）Ganoderma lucidum fruitbody is crushed, 150 mesh sieve is crossed, into the glossy ganoderma powder after sieving with solid-liquid ratio 1g:Distilled water is added in 15mL,
In 90 DEG C of heating water bath 1.5h, after being filtered under diminished pressure, first time filtrate and first time filter residue are collected to obtain；By first time filter residue according still further to
Above-mentioned steps carry out heating water bath, are filtered under diminished pressure, and collect to obtain second of filtrate and filter residue；By second of filter residue according still further to above-mentioned step
It is rapid to carry out heating water bath, be filtered under diminished pressure, third time filtrate and filter residue are collected to obtain, after merging filtrate three times, concentrated, freeze-drying
Afterwards, ganoderma lucidum water extract freeze-dried powder is made；
2）Ostreae testa pulverata 10g, Poria cocos 6g, spina date seed 8g are placed in marmite, by solid-liquid ratio 1g:Distilled water is added in 10mL, cooks
1.5h is filtered under diminished pressure, and obtains first time filtrate and filter residue；First time filter residue is pressed to above-mentioned steps again and cooks 0.5h, is filtered under diminished pressure, obtains
Second of filtrate and filter residue；Merge filtrate twice, concentration, freeze-dried powder is made in freeze-drying；
3）60wt% ganoderma lucidum water extract freeze-dried powders and 40wt% Chinese medicine freeze-dried powders are uniformly mixed, are sieved, mixed-powder is as drug
2。
Comparative example 3
1）Ganoderma lucidum fruitbody is crushed, 150 mesh sieve is crossed, into the glossy ganoderma powder after sieving with solid-liquid ratio 1g:Distilled water is added in 15mL,
In 90 DEG C of heating water bath 1.5h, after being filtered under diminished pressure, first time filtrate and first time filter residue are collected to obtain；By first time filter residue according still further to
Above-mentioned steps carry out heating water bath, are filtered under diminished pressure, and collect to obtain second of filtrate and filter residue；By second of filter residue according still further to above-mentioned step
It is rapid to carry out heating water bath, be filtered under diminished pressure, third time filtrate and filter residue are collected to obtain, after merging filtrate three times, concentrated, freeze-drying
Afterwards, ganoderma lucidum water extract freeze-dried powder is made；
2）Ostreae testa pulverata 12g, Poria cocos 8g are placed in marmite, by solid-liquid ratio 1g:Distilled water is added in 10mL, cooks 1.5h, depressurized
Filter, obtains first time filtrate and filter residue；First time filter residue is pressed to above-mentioned steps again and cooks 0.5h, is filtered under diminished pressure, obtains second of filtrate
And filter residue；Merge filtrate twice, concentration, freeze-dried powder is made in freeze-drying；
3）60wt% ganoderma lucidum water extract freeze-dried powders and 40wt% Chinese medicine freeze-dried powders are uniformly mixed, are sieved, mixed-powder is as drug
3。
Comparative example 4
1）Ganoderma lucidum fruitbody is crushed, 150 mesh sieve is crossed, into the glossy ganoderma powder after sieving with solid-liquid ratio 1g:Distilled water is added in 15mL,
In 90 DEG C of heating water bath 1.5h, after being filtered under diminished pressure, first time filtrate and first time filter residue are collected to obtain；By first time filter residue according still further to
Above-mentioned steps carry out heating water bath, are filtered under diminished pressure, and collect to obtain second of filtrate and filter residue；By second of filter residue according still further to above-mentioned step
It is rapid to carry out heating water bath, be filtered under diminished pressure, third time filtrate and filter residue are collected to obtain, after merging filtrate three times, concentrated, freeze-drying
Afterwards, ganoderma lucidum water extract freeze-dried powder is made；
2）Ostreae testa pulverata 15g is placed in marmite, by solid-liquid ratio 1g:Distilled water is added in 10mL, cooks 1.5h, is filtered under diminished pressure, and obtains the
First-time filtrate and filter residue；First time filter residue is pressed to above-mentioned steps again and cooks 0.5h, is filtered under diminished pressure, obtains second of filtrate and filter residue；
Merge filtrate twice, concentration, freeze-dried powder is made in freeze-drying；
3）60wt% ganoderma lucidum water extract freeze-dried powders and 40wt% Chinese medicine freeze-dried powders are uniformly mixed, are sieved, mixed-powder is as drug
4。
Application Example 1
The good effect that the present invention has in terms of improving sleep, is subject to further instruction below by animal experimental data,
Using composition made from embodiment 1 as sample.
1, experimental animal
ICR grades of male mices, weight are provided between 18 ~ 20g by Fuzhou General Hospital of Nanjing Military Command.Mouse is placed in solely
It is raised in vertical ventilated type positive/negative-pressure animal cage, keeps control temperature（20±2℃）And humidity（60 ± 15%）, and holding 12 is small
Time/dark cycle.Food and water can be freely obtained during raising, and are adapted within first 7 days in formal experiment.
2, medication management
Drug made from freeze-dried powder and comparative example 1-4 prepared by embodiment 1.
3, animal is administered
Mouse is randomly divided into 6 groups by weight, respectively：Control group and medicine group.Experimental drug group distinguishes gavage relative medicine, right
Distilled water is given according to a group gavage, gavage volume is 0.2mL/10g weight, once a day, continuous 21 days.
4, experimental method
It is tested using yellow Jackets inducing mouse（Reference《Health food is examined and assessment technique enforcement of regulations handbook（2003
Version）》）：
A. the yellow Jackets sub-threshold dose hypnosis of mouse is tested
1h, every mouse peritoneal inject Nembutal sodium solution to each group after the last administration（30mg/kg）0.1mg/10g weight, with
Righting reflex loss 1min is sleep index, and mouse is placed on warm woollen blanket to slow down its tensity, records small in 30min
The sleep incidence of mouse.
B. extend the experiment of yellow Jackets inducing mouse sleeping time to mouse
1h, every mouse peritoneal inject Nembutal sodium solution to each group after the last administration（50mg/kg）0.1mg/10g weight.With
Righting reflex loss 1min is sleep index, and mouse is placed on warm woollen blanket to slow down its tensity, records each group mouse
Sleeping time, mouse sleep time are calculated more than 120min person with 120min.
C. to the experiment of mouse barbital sodium Sleep latency
1h after the last administration, every mouse peritoneal inject barbital sodium solution（250mg/kg）0.1mg/10g weight.It is anti-to right
It is index to penetrate disappearance, and mouse is placed on warm woollen blanket to slow down its tensity, record each group mouse from be administered into right it is anti-
It penetrates the time of disappearance, mouse sleep time is calculated more than 60min person with 60min.
5, result
A. influence of the medication combined yellow Jackets to mice sleep incidence
Compared with the control group, embodiment 1 combines yellow Jackets with comparative example 2 has extremely significant difference to mice sleep incidence（P
<0.01）, the sleep incidence of 1 mouse of embodiment reaches peak.As shown in table 1.
Influence of the 1 medication combined yellow Jackets of table to mice sleep incidence
Note：Compared with the control group,*P <0.05,**P<0.01.Table 1,2,3 is as above.
B. influence of the drug to yellow Jackets Sleeping Time Prolong Ed
Compared with the control group, embodiment 1 shows extremely significant calm and hypnosis synergistic effect, has to mouse sleep time extremely aobvious
Write difference（P <0.01）, and comparative example 2 can be obviously prolonged the sleeping time of mouse with comparative example 3（P <0.05）, such as 2 institute of table
Show.
Influence of 2 drug of table to yellow Jackets Sleeping Time Prolong Ed
C. drug treats barbital sodium the influence in mice sleep incubation period and sleep time
Compared with the control group, the effect that embodiment 1 combines barbital sodium all has pole remarkable effect to mice sleep incubation period（P
<0.01）, comparative example 2 has remarkable effect（P <0.05）.As shown in table 3.
3 drug of table treats the preclinical influence of mice sleep to barbital sodium
It is proved by zoopery, the Chinese medicine composition of tranquilizing the mind composition can promote the sleep rate of mouse, extend sleeping time, contracting
Short Sleep latency.Illustrating this composition really has the effect for improving and sleeping.
It is mixed composition composition by the present invention with Poria cocos, ostreae testa pulverata, spina date seed, ginseng and Radix Glycyrrhizae, is allowed to act on body
Interior different target spot forms multiple target point mechanism, can improve the sleep quality of insomniac, and the clinic of energy relieving insomnia patient
Symptom, and production is simple for process, of low cost, easy to spread, is easy to carry about with one, it is convenient, for improvement sleep
Health product provides a new selection.
The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with
Modification should all belong to the covering scope of the present invention.
Claims (5)
1. a kind of composition with sedative action, it is characterised in that：Raw material is that 50% ~ 60% ganoderma lucidum water carries as mass fraction
Object freeze-dried powder and 40% ~ 50% Chinese medicine freeze-dried powder；The Chinese medicine freeze-dried powder includes following raw material：8-15 parts of ostreae testa pulverata,
5-8 parts of Poria cocos, 5-12 parts of spina date seed, 3-8 parts of ginseng, 1-5 parts of Radix Glycyrrhizae.
2. the composition according to claim 1 with sedative action, it is characterised in that：The Chinese medicine freeze-dried powder include with
Lower raw material：12 parts of ostreae testa pulverata, 8 parts of Poria cocos, 10 parts of spina date seed, 5 parts of ginseng, 3 parts of Radix Glycyrrhizae.
3. the composition according to claim 1 with sedative action, it is characterised in that：The ganoderma lucidum water extract freeze-dried powder
Preparation method be：Ganoderma lucidum fruitbody is crushed, 150 ~ 200 mesh sieve is crossed, into the glossy ganoderma powder after sieving with 1 ~ 2g of solid-liquid ratio:15
Distilled water is added in ~ 30mL, in 90 ~ 95 DEG C of 1.5 ~ 2h of heating water bath, after being filtered under diminished pressure, collects to obtain first time filtrate and filter for the first time
Slag；First time filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, second of filtrate and second of filter are collected to obtain
Slag；Second of filter residue is subjected to heating water bath according still further to above-mentioned steps, is filtered under diminished pressure, third time filtrate and third time filter are collected to obtain
After merging filtrate three times, after concentrated, freeze-drying, ganoderma lucidum water extract freeze-dried powder is made in slag.
4. the composition according to claim 1 with sedative action, it is characterised in that：The preparation of the Chinese medicine freeze-dried powder
Method is：Ostreae testa pulverata, Poria cocos, spina date seed, ginseng, Radix Glycyrrhizae are placed in marmite, by 1 ~ 2g of solid-liquid ratio:Distillation is added in 10 ~ 20mL
Water cooks 1 ~ 1.5h, is filtered under diminished pressure, obtains first time filtrate and filter residue；First time filter residue is pressed to above-mentioned steps again and cooks 0.5 ~ 1h,
It is filtered under diminished pressure, obtains second of filtrate and filter residue；Merge filtrate twice, concentration, Chinese medicine freeze-dried powder is made in freeze-drying.
5. a kind of method preparing composition according to any one of claims 1-4, it is characterised in that：Ganoderma lucidum water extract is frozen
Dry powder and Chinese medicine freeze-dried powder mix in proportion, and sieving obtains the composition with sedative action.
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| WO2021212700A1 (en) * | 2020-04-20 | 2021-10-28 | 江苏南京农大动物药业有限公司 | Pharmaceutical composition for improving motion sickness of pets, preparation method therefor and use method thereof |
| CN113648352A (en) * | 2021-09-03 | 2021-11-16 | 杨长俊 | A Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases |
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