CN108635402A - 甘草鲜提喷雾干燥颗粒饮片 - Google Patents

甘草鲜提喷雾干燥颗粒饮片 Download PDF

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CN108635402A
CN108635402A CN201810733182.1A CN201810733182A CN108635402A CN 108635402 A CN108635402 A CN 108635402A CN 201810733182 A CN201810733182 A CN 201810733182A CN 108635402 A CN108635402 A CN 108635402A
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materical crude
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徐自升
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/484—Glycyrrhiza (licorice)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

本发明公布了“一种甘草鲜提喷雾干燥颗粒饮片”，其主要特征在于：在甘草采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩后喷雾干燥，制粒、整粒、真空包装。颗粒饮片的含水量少于10%。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入胶囊、片剂中，利于携带，临床使用方便。

Description

甘草鲜提喷雾干燥颗粒饮片
技术领域
本发明属于中药饮片技术领域，尤其属于甘草饮片的加工领域。
背景技术
中药甘草为豆科植物甘草、胀果甘草或光果甘草的干燥根和根茎。甘草具有补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药的功效，是中医临床中使用频率最高的中药。传统甘草的加工方法为：将药材采挖后，直接晒干/晾干，捆扎打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。由此得到的甘草饮片体积大，卫生学标准差，易于受潮、长霉、生虫，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型甘草饮片，势在必行。目前市场甘草饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成份。
发明内容
本发明公布了“一种甘草鲜提喷雾干燥颗粒饮片”，其主要特征在于：在甘草采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10的浓缩液。所得浓缩液留取1%~3%备用，其余喷雾干燥。将收集的喷干粉与备用的浓缩液混合制粒，干燥至含水量低于10%，整粒，真空包装，即得成品。成品饮片含甘草苷(C21H22O9)不少于0.70％。甘草颗粒饮片质量稳定，流动性好，临床一般使用量为1~5g。此类饮片既可入汤剂煎服、冲服，也可直接入胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统甘草饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将甘草药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.05。将所得的浓缩液留取3%备用，其余的喷雾干燥。收集喷干粉，与备用的浓缩液混合制颗粒，80℃真空干燥至含水量为10%，整粒，真空包装，即得成品。成品饮片含甘草苷(C21H22O9)不得少于0.75％。

Claims (2)

1.一种甘草鲜提喷雾干燥颗粒饮片，其主要特征在于：在甘草采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10；所得浓缩液留取1%~3%备用，其余喷雾干燥；将收集的喷干粉与备用的浓缩液混合制粒，干燥至含水量低于10%，整粒，真空包装，即得成品；成品饮片含甘草苷(C21H22O9)不得少于0.70％。
2.根据权利要求1所述的甘草鲜提喷雾干燥颗粒饮片，其主要特征在于：临床一般使用量为1~5g，本饮片既可入汤剂煎服、冲服，也可直接入胶囊剂及片剂中。
CN201810733182.1A 2018-07-06 2018-07-06 甘草鲜提喷雾干燥颗粒饮片 Withdrawn CN108635402A (zh)

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