CN108635276A - A kind of skin care compositions of anti-wrinkle and its application - Google Patents
A kind of skin care compositions of anti-wrinkle and its application Download PDFInfo
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- CN108635276A CN108635276A CN201810860612.6A CN201810860612A CN108635276A CN 108635276 A CN108635276 A CN 108635276A CN 201810860612 A CN201810860612 A CN 201810860612A CN 108635276 A CN108635276 A CN 108635276A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention discloses a kind of anti-wrinkle composition, contain active constituent in the composition, on the basis of the total weight of the composition and by weight percentage, the active constituent includes Morinda（MORINDA CITRIFOLIA）Berry extract 0.1 5%, Herba Epimedii（EPIMEDIUM BREVICORNUM）Extract 0.1 5%, dipeptides diaminobutyryl benzyl amide diacetin 0.001 0.1%.The present invention can effectively inhibit the non-glycosylation of protein, promote the activity of Skin Cell, accelerate the metabolism of Skin Cell, and the generation of collagen and elastin is promoted to increase the effect of skin elasticity to reach anti-wrinkle.
Description
Technical field
The present invention relates to cosmetic field, the skin care compositions more particularly to a kind of anti-wrinkle and its application.
Background technology
Non-enzymatic glycation refers to the aldehyde radical or ketone group and egg of reducing sugar under conditions of no enzymatic in organism
Free amine group reaction in the macromoleculars such as white matter generates reversible or Irreversible binding object-advanced glycosylation end product
The process of (Advanced glycation end-products, AGEs).Dyer et al. has found skin aging and non-enzymatic glycosyl
Change related, collagen and elastin laminin be rich in the skin corium of skin, the amino acid in protein molecule be easy with it is extracellular
Non-enzymatic glycation occurs for the aldehyde radical of glucose or ketone group in liquid, and with advancing age, and AGEs progressive increases, and makes
Collagen forms intermolecular cross-linking, not only reduces the elasticity and permeability of skin, the diffusion of nutriment and waste is made to subtract
It is weak, and the solubility for reducing collagen makes it be difficult to, by collagen enzyme hydrolysis, skin elasticity be caused to decline, wrinkle be not easy to calm down and
Constantly deepen.
Sun Min et al. observes the influence that Chinese medicine Radix picrorrhizae and hypericum perforatum react external protein non-enzyme glycosylation, comments
The relationship of valence its antioxidation and non-enzymatic glycation.As a result show various concentration Radix picrorrhizae and hypericum perforatum with dosage
Dependence mode obviously inhibits the formation of AGEs.Conclusion obtains：Radix picrorrhizae and hypericum perforatum can inhibit the non-enzymatic glycosyl of protein
Change, it may be related with its antioxidation.
Invention content
The technical problem to be solved in the present invention is to provide a kind of non-glycosylations that can effectively inhibit protein, promote skin
The activity of skin cell accelerates the anti-wrinkle composition of the metabolism of Skin Cell.The present inventor verifies by long-term experiment, in many ways
Screening, selects Morinda（MORINDA CITRIFOLIA）Berry extract, Herba Epimedii（EPIMEDIUM BREVICORNUM）Extraction
Skin care item are made in object, dipeptides diaminobutyryl benzyl amide diacetin prescription compounding, effectively inhibit the non-enzymatic glycosyl of protein
Change, promote the activity of Skin Cell, accelerate the metabolism of Skin Cell, promotes collagen（Tension is provided）And elastin
（Elasticity is provided）Generation increase the effect of skin elasticity to reach anti-wrinkle.
The second object of the present invention is to provide purposes of the above-mentioned anti-wrinkle composition in preparing anti-wrinkle skin care item.
For this purpose, technical solution provided by the invention is such：
A kind of anti-wrinkle composition contains active constituent in the composition, on the basis of the total weight of the composition and with weight
Percentages are measured, the active constituent includes：
Morinda（MORINDA CITRIFOLIA）Berry extract 0.1-5%；
Herba Epimedii（EPIMEDIUM BREVICORNUM）Extract 0.1-5%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.001-0.1%.
Further, above-mentioned anti-wrinkle composition contains active constituent in the composition, with the gross weight of the composition
On the basis of amount and by weight percentage, the active constituent further includes：
African Lee（PRUNUS AFRICANA）Bark extract 0.1-5%；
Chinese torreyanut（TORREYA GRANDIS）Extract 0.1-5%；
Balsamine（IMPATIENS BALSAMINA）Flower extract 0.1-5%.
Further, above-mentioned anti-wrinkle composition contains active constituent in the composition, with the gross weight of the composition
On the basis of amount and by weight percentage, the active constituent further includes：
1 ‰ aqueous solution 0.1-5% of palmityl tripeptides -5；
1 ‰ aqueous solution 0.1-1% of oligopeptides -1.
Further, above-mentioned anti-wrinkle composition contains active constituent in the composition, with the gross weight of the composition
On the basis of amount and by weight percentage, the active constituent is grouped as by following groups：
Morinda（MORINDA CITRIFOLIA）Berry extract 0.1-5%；
Herba Epimedii（EPIMEDIUM BREVICORNUM）Extract 0.1-5%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.001-0.1%；
African Lee（PRUNUS AFRICANA）Bark extract 0.1-5%；
Chinese torreyanut（TORREYA GRANDIS）Extract 0.1-5%；
Balsamine（IMPATIENS BALSAMINA）Flower extract 0.1-5%；
1 ‰ aqueous solution 0.1-5% of palmityl tripeptides -5；
1 ‰ aqueous solution 0.1-1% of oligopeptides -1.
Further, the purposes the present invention also provides above-mentioned anti-wrinkle composition in preparing anti-wrinkle skin care item.
Further, the skin care item are anti-wrinkle frost.
Further, anti-wrinkle frost includes the component of following mass percentage, as shown in table 1：
Table 1
The present invention has the advantages that：
1, anti-wrinkle composition provided by the invention is by Morinda（MORINDA CITRIFOLIA）Berry extract, Herba Epimedii
（EPIMEDIUM BREVICORNUM）Extract, dipeptides diaminobutyryl benzyl amide diacetin are rationally compounded, effectively
Inhibit the non-glycosylation of protein, moreover it is possible to promote the generation of collagen and elastin, there is anti-wrinkle, increase skin elasticity
The effect of.
2, African Lee is compounded（PRUNUS AFRICANA）Bark extract, Chinese torreyanut（TORREYA GRANDIS）Extract,
Balsamine（IMPATIENS BALSAMINA）Flower extract can further suppress the non-glycosylation of protein, and it is thin to promote skin
The activity of born of the same parents accelerates the metabolism of Skin Cell, and skin surface is made to be continuously available update, promotes skin to remain soft and moist, thin
Greasy and high resilience.
3,1 ‰ aqueous solutions of palmityl tripeptides -5,1 ‰ aqueous solutions of oligopeptides -1 are further compounded, can be skin addition battalion
Substance is supported, nourishes rough skin slows down aging.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
It is worth noting that, unless otherwise indicated, various components used in the present invention are this field current material, can
It is bought by commercial channel and obtains or be made by existing method.
Anti-wrinkle frost 1-9 includes the component of following mass percentage, as shown in Table 2-4：
Table 2
Table 3
Table 4
Comparative example 1-8 includes the component of following mass percentage, as illustrated in tables 5-7：
Table 5
Table 6
Table 7
Prepared anti-wrinkle frost and its number are along in following experiment in the above various embodiments.
In order to better illustrate advantages of the present invention, effect experiment of the present invention is given below：
1, the inhibiting effect that test anti-wrinkle frost 1-9 and comparative example 1-8 reacts protein non-enzyme glycosylation
Experimental method is as follows：
1）The foundation of protein glycosylation reaction system
With reference to the methods of Fari and Vinson, by D-Glucose, D-Fructose and BSA are mixed in a certain ratio, and are dissolved in 0.1mol/L
PBS (PH7.4) in, it is BSA14mg/mL to make its whole mass concentration, and filtration sterilization seals black out, protein glycosylation is made
Reaction solution.Sample uses water respectively, and 1%Tween80 or DMSO are configured to certain mass concentration, spare.
2）Method repeatability is investigated
The a certain amount of reaction solution containing BSA14mg/mL is taken, sets 12 parallel pipes altogether, whole mass concentration is added into test tube respectively is
The aminoguanidine hydrochloride solution of 40mg/mL, and set control group (adding same volume PBS) and blank group (being free of glucose/fructose).It sets
It is incubated 7d in 37 DEG C of incubators.After glycation product is incubated, the fluorescence intensity at 430nm.3）Sample is to AGEs shapes
At effect
Ibid, the reaction solution of a certain amount of mg/mL containing BSA14 is taken, every group sets 2 parallel pipes, is added respectively into each dosage group
Whole mass concentration is the sample solution of 0.005 mg/mL, and sets control group (adding same volume PBS) and blank group (without grape
Sugar/fructose).It sets in 37 DEG C of incubators and is incubated 7d.After glycation product is incubated, the fluorescence intensity at 430nm.Root
Inhibiting rate is calculated according to institute's measured data:Inhibiting rate (%)=(1-FExtract/FControl group)×100%
Blank group fluorescence intensity is adjusted to 0;
FExtract =FSample measured value- FSample blank
Experimental result is as shown in table 8：
The influence (x, n=2) that table 8 anti-wrinkle frost 1-9 and comparative example 1-8 forms AGEs
Experimental result:Anti-wrinkle frost 1-9 is formed with apparent inhibiting effect to incubated in vitro AGEs, in 100 mg of sample concentration
mL- 1When left and right, inhibiting rate 40-85%.
By embodiment 1-3 and comparative example 1-3 comparisons it is found that Morinda（MORINDA CITRIFOLIA）It is berry extract, excessive
The sheep leaves of pulse plants（EPIMEDIUM BREVICORNUM）When extract, dipeptides diaminobutyryl benzyl amide diacetin share, to external
It is just apparent to be incubated the inhibiting effect that AGEs is formed（Embodiment 1-3 inhibiting rates are 40.2-41.8%, and comparative example 1-3 inhibiting rates are
8.7-12.4%）.
Wherein, by embodiment 4-6 and embodiment 1-3 comparisons it is found that African Lee（PRUNUS AFRICANA）Bark extracts
Object, Chinese torreyanut（TORREYA GRANDIS）Extract, balsamine（IMPATIENS BALSAMINA）The addition of flower extract, to body
The outer inhibiting effect for being incubated AGEs formation improves 10% or more（Embodiment 1-3 inhibiting rates are 40.2-41.8%, embodiment 4-6 suppressions
Rate processed is 54.3-57.6%）.
By embodiment 4-6 and comparative example 4-6 comparisons it is found that African Lee（PRUNUS AFRICANA）Bark extract, Chinese torreyanut
（TORREYA GRANDIS）Extract, balsamine（IMPATIENS BALSAMINA）When flower extract shares, to incubated in vitro
It is just apparent that AGEs forms inhibiting effect effect（Comparative example 4-6 inhibiting rates are 41.2-41.9%, and embodiment 4-6 inhibiting rates are 54.3-
57.6%）.
By embodiment 7-9 and embodiment 4-6 comparisons it is found that 1 ‰ water of 1 ‰ aqueous solutions of palmityl tripeptides -5, oligopeptides -1
The addition of solution improves 20% or more to the incubated in vitro AGEs inhibiting effect formed（Embodiment 4-6 inhibiting rates are 54.3-
57.6%, embodiment 7-9 inhibiting rates are 82.1-85.2%）.
By embodiment 7-9 and comparative example 7-8 comparisons it is found that 1 ‰ water of 1 ‰ aqueous solutions of palmityl tripeptides -5, oligopeptides -1
When solution shares, it is just apparent that inhibiting effect effect is formed to incubated in vitro AGEs（Comparative example 7-8 inhibiting rates are 55.3-56.6%,
Embodiment 7-9 inhibiting rates are 82.1-85.2%）.
2, crowd's test on probation
The effect of in order to assess anti-wrinkle of the present invention, carries out product made from embodiment 1-9 and comparative example 1-8 with volunteer
Test, participates in experiment 680 people of volunteer, wherein 366 people of male, 314 people of women, the age one's mid-40s to 50s, at random
Be divided into 17 groups, every group of 40 people, using sample obtained, select on the inside of volunteer's left and right arm totally 2 pieces of regions 5cm × 5cm and
Right and left eyes edge position is used as Test sites；Above-mentioned sample is smeared, is smeared sooner or later daily twice, 1 gram every time.During experiment, aspiration
Person cannot smear any other cosmetics in Test sites；Volunteer test position be used continuously 2 months and 3 months after, with
Photo before smearing is control, evaluates the effect of cosmetics anti-wrinkle.Inquire that volunteer feels and has using after sample simultaneously
It without allergic phenomena etc., and records, using the results are shown in Table 9.
The front and back efficacy standard of record：
It is effective：Skin smooth high resilience, wrinkle obviously desalinate or disappear, and small microgroove disappears；
Effectively：Skin is relatively smooth, and skin becomes flexible, and small microgroove is obviously desalinated, and wrinkle is desalinated but still remained；
In vain：Small microgroove, wrinkle still remain, or even have the tendency that intensification.
Table 9
Observation using result can be seen that the anti-wrinkle frost that 1-9 of the embodiment of the present invention is provided have significantly smooth away wrinkles, smooth muscle
The effect of skin, permanence operation more preferably, can allow skin smooth to compact, rich in gloss, and without finding that product produces trier
Raw stimulation allergic phenomena, reacts according to volunteer, can also remove color spot, have preferable whitening effect, use skin temperature-sensitive and nothing
Stimulation.
To use the data comparison of product after two months made from embodiment 1-9 and comparative example 1-8, it is analyzed as follows：
Embodiment 1-3 is with comparative example 1-3 comparisons as it can be seen that Morinda（MORINDA CITRIFOLIA）Berry extract, Herba Epimedii
（EPIMEDIUM BREVICORNUM）Extract, dipeptides diaminobutyryl benzyl amide diacetin are the key that anti-wrinkle effects
Ingredient, effect is just apparent when sharing, and embodiment 1-3 effective is 12-16 people, the people of effective numbers of comparative example 1-3≤2；
Wherein, by embodiment 4-6 and embodiment 1-3 comparisons it is found that African Lee（PRUNUS AFRICANA）Bark extract, Chinese torreya
Son（TORREYA GRANDIS）Extract, balsamine（IMPATIENS BALSAMINA）Anti-wrinkle is made in the addition of flower extract
With improving 30% or more（The effective numbers of embodiment 4-6 are 21-24 people, and embodiment 1-3 effective is 12-16 people）；
By embodiment 4-6 and comparative example 4-6 comparisons it is found that African Lee（PRUNUS AFRICANA）Bark extract, Chinese torreyanut
（TORREYA GRANDIS）Extract, balsamine（IMPATIENS BALSAMINA）When flower extract shares, anti-wrinkle is carried
It is just apparent to rise effect（The effective numbers of comparative example 4-6 are 13-17 people, and the effective numbers of embodiment 4-6 are 21-24 people）；
By embodiment 7-9 and embodiment 4-6 comparisons it is found that 1 ‰ aqueous solutions of 1 ‰ aqueous solutions of palmityl tripeptides -5, oligopeptides -1
Addition, to anti-wrinkle effect improve 30% or more（The effective numbers of embodiment 4-6 are 21-24 people, and the effective numbers of embodiment 7-9 are
33-36 people）；
By embodiment 7-9 and comparative example 7-8 comparisons it is found that 1 ‰ aqueous solutions of 1 ‰ aqueous solutions of palmityl tripeptides -5, oligopeptides -1
When sharing, it is just apparent that promotion effect is acted on to anti-wrinkle（The effective numbers of comparative example 7-8 are 25-26 people, the effective numbers of embodiment 7-9
For 33-36 people）.
In conclusion anti-wrinkle composition provided by the invention, each component rationally compound, effectively inhibit the non-enzymatic sugar of protein
Base promotes the activity of Skin Cell, accelerates the metabolism of Skin Cell, promotes collagen（Tension is provided）With elastic force egg
In vain（Elasticity is provided）Generation increase the effect of skin elasticity to reach anti-wrinkle.
Embodiment described above is only that the preferred embodiment of the present invention is described, not to the model of the present invention
It encloses and is defined, under the premise of not departing from design spirit of the present invention, technical side of the those of ordinary skill in the art to the present invention
The various modifications and improvement that case is made should all be fallen into the protection domain of claims of the present invention determination.
Claims (7)
1. a kind of anti-wrinkle composition, which is characterized in that contain active constituent in the composition, with the total weight of the composition
On the basis of and by weight percentage, the active constituent includes：
Morinda（MORINDA CITRIFOLIA）Berry extract 0.1-5%；
Herba Epimedii（EPIMEDIUM BREVICORNUM）Extract 0.1-5%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.001-0.1%.
2. anti-wrinkle composition according to claim 1, which is characterized in that contain active constituent in the composition, with institute
It states on the basis of the total weight of composition and by weight percentage, the active constituent further includes：
African Lee（PRUNUS AFRICANA）Bark extract 0.1-5%；
Chinese torreyanut（TORREYA GRANDIS）Extract 0.1-5%；
Balsamine（IMPATIENS BALSAMINA）Flower extract 0.1-5%.
3. anti-wrinkle composition according to claim 2, which is characterized in that contain active constituent in the composition, with institute
It states on the basis of the total weight of composition and by weight percentage, the active constituent further includes：
1 ‰ aqueous solution 0.1-5% of palmityl tripeptides -5；
1 ‰ aqueous solution 0.1-1% of oligopeptides -1.
4. anti-wrinkle composition according to claim 1, which is characterized in that contain active constituent in the composition, with institute
It states on the basis of the total weight of composition and by weight percentage, the active constituent is grouped as by following groups：
Morinda（MORINDA CITRIFOLIA）Berry extract 0.1-5%；
Herba Epimedii（EPIMEDIUM BREVICORNUM）Extract 0.1-5%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.001-0.1%；
African Lee（PRUNUS AFRICANA）Bark extract 0.1-5%；
Chinese torreyanut（TORREYA GRANDIS）Extract 0.1-5%；
Balsamine（IMPATIENS BALSAMINA）Flower extract 0.1-5%；
1 ‰ aqueous solution 0.1-5% of palmityl tripeptides -5；
1 ‰ aqueous solution 0.1-1% of oligopeptides -1.
5. according to purposes of the claim 1-4 any one of them anti-wrinkle compositions in preparing Wrinkle removing cosmetic.
6. purposes according to claim 5, which is characterized in that the Wrinkle removing cosmetic is anti-wrinkle frost.
7. purposes according to claim 6, which is characterized in that the anti-wrinkle frost includes the group of following mass percentage
Point：
Carbonic acid dioctyl ester 1-5%；
Glycerine three（Thylhexoic acid）Ester 1-3%；
Dimethyl silicone polymer 1-3%；
PEG-60 rilanit specials 0.01-0.2%；
Ring five dimethyl silicone polymer 1-3%；
Dimethicone Crosspolymer 0.1-2%；
Docosyl alcohol 0.1-1%；
- 6 0.5-1.5% of ceteareth；
Stearyl alcohol 1-2%；
Bisabolol 0.1-0.3%；
Glycerine 1-6%；
Carbohydrate isomer 0.1-1%；
Butanediol 1-3%；
Carbomer 0.1-0.3%；
Aminomethyl propanol 0.2-0.5%；
Maize gluten amino acids 0.1-1%；
Acrylamide/acryloyl dimethyl tauric acid sodium copolymer 0.1-0.3%；
Parahydroxyacet-ophenone 0.2-0.5%；
Hexylene glycol 1-3%；
Tocopherol acetate 0.1-1%；
Acrylic acid（Ester）Class/C10-30 alkylol acrylamide acid esters cross-linked polymers 0.1-0.3%；
Sodium Hyaluronate 0.01-0.05%；
Morinda（MORINDA CITRIFOLIA）Berry extract 0.1-5%；
Herba Epimedii（EPIMEDIUM BREVICORNUM）Extract 0.1-5%；
Dipeptides diaminobutyryl benzyl amide diacetin 0.001-0.1%；
African Lee（PRUNUS AFRICANA）Bark extract 0.1-5%；
Chinese torreyanut（TORREYA GRANDIS）Extract 0.1-5%；
Balsamine（IMPATIENS BALSAMINA）Flower extract 0.1-5%；
1 ‰ aqueous solution 0.1-5% of palmityl tripeptides -5；
1 ‰ aqueous solution 0.1-1% of oligopeptides -1；
Water surplus.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810860612.6A CN108635276A (en) | 2018-07-29 | 2018-07-29 | A kind of skin care compositions of anti-wrinkle and its application |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810860612.6A CN108635276A (en) | 2018-07-29 | 2018-07-29 | A kind of skin care compositions of anti-wrinkle and its application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394552A (en) * | 2018-11-06 | 2019-03-01 | 广州宝莱生物科技有限公司 | A kind of shining face youth freeze-drying facial mask |
| CN112022769A (en) * | 2020-09-22 | 2020-12-04 | 鲁南制药集团股份有限公司 | Composition containing epimedium extract and phellodendron amurense extract and application thereof |
-
2018
- 2018-07-29 CN CN201810860612.6A patent/CN108635276A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394552A (en) * | 2018-11-06 | 2019-03-01 | 广州宝莱生物科技有限公司 | A kind of shining face youth freeze-drying facial mask |
| CN109394552B (en) * | 2018-11-06 | 2021-09-14 | 广州宝莱生物科技有限公司 | Revitalizing youth freeze-dried mask |
| CN112022769A (en) * | 2020-09-22 | 2020-12-04 | 鲁南制药集团股份有限公司 | Composition containing epimedium extract and phellodendron amurense extract and application thereof |
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