CN108606945A - 一种消毒湿纸巾及其制备方法 - Google Patents
一种消毒湿纸巾及其制备方法 Download PDFInfo
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- CN108606945A CN108606945A CN201810536549.0A CN201810536549A CN108606945A CN 108606945 A CN108606945 A CN 108606945A CN 201810536549 A CN201810536549 A CN 201810536549A CN 108606945 A CN108606945 A CN 108606945A
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- Biomedical Technology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
本发明公开了一种消毒湿纸巾,包括:基材和负载于该基材上的药液,所述药液组分包括:茶树精油0.1~0.2份、芦荟提取物0.1~0.2份、α‑红没药醇0.01~0.05份、紫草提取物0.1~0.5份、洋甘菊油0.01~0.05份、杀菌剂0.01~0.1份、透明质酸钠0.2~0.4份、烟酰胺0.01~0.05份、甘油0.1~1份、丙二醇0.1~1份、丁二醇0.1~1份和水100份;所述消毒湿纸巾消毒、杀菌消毒、杀菌效果佳,使用感好。
Description
技术领域
本发明涉及生活用品技术领域,具体涉及一种消毒湿纸巾及其制备方法。
背景技术
湿纸巾是选用湿强柔纤高渗透性基材,经折叠、加湿、包装制成一次性清洁卫生用品,因其具有清洁、保湿皮肤的基本功能以及便于携带等特点成为人们日常生活中必不可少的清洁用品。以前多用于如民航、酒店、餐馆、展会等商务及接待场所,近几年来随着人们生活水平的提高,湿纸巾的个人消费量逐渐增多,现有湿巾主要用于消毒,使用后,由于,湿纸巾作用于皮肤表面的水分迅速蒸发,消毒效果不能满足人们的需求。
发明内容
有鉴于此,本申请提供了一种消毒湿纸巾及其制备方法;所述消毒湿纸巾消毒、杀菌消毒、杀菌效果佳,使用感好。
为解决以上技术问题,本发明提供的技术方案是一种消毒湿纸巾,包括:基材和负载于该基材上的药液,所述药液组分包括:茶树精油0.1~0.2份、芦荟提取物0.1~0.2份、α-红没药醇0.01~0.05份、紫草提取物0.1~0.5份、洋甘菊油0.01~0.05份、杀菌剂0.01~0.1份、透明质酸钠0.2~0.4份、烟酰胺0.01~0.05份、甘油0.1~1份、丙二醇0.1~1份、丁二醇0.1~1份和水100份。
优选的,所述药液组分包括:茶树精油0.15~0.2份、芦荟提取物0.15~0.2份、α-红没药醇0.02~0.05份、紫草提取物0.2~0.5份、洋甘菊油0.02~0.05份、杀菌剂0.05~0.1份、透明质酸钠0.3~0.4份、烟酰胺0.02~0.05份、甘油0.5~1份、丙二醇0.5~1份、丁二醇0.5~1份和水100份。
优选的,所述药液组分包括:茶树精油0.2份、芦荟提取物0.2份、α-红没药醇0.05份、紫草提取物0.5份、洋甘菊油0.05份、杀菌剂0.1份、透明质酸钠0.4份、烟酰胺0.05份、甘油0.5份、丙二醇1份、丁二醇1份和水100份。
优选的,所述芦荟提取物由以下方法制得:选用生长周期满三年以上的芦荟叶片,用清水清洗干净,沥干水分后去除表皮,在无菌条件下打制成浆;然后加入纯化水稀释后离心分离、去渣,获得提取液;提取液经冷冻脱水处理后低温烘干喷雾,经60℃低温烘干至含水量为8%时取出,冷却至常温状态,过100~200目筛,即得。
优选的,所述紫草提取物由如下方法制得:紫草经乙醇浸提,过滤,滤液减压浓缩,即得。
优选的,所述杀菌剂为对氯间二甲基苯酚和/或2,4,4'-三氯-2'-羟基二苯醚。
优选的,所述杀菌剂为对氯间二甲基苯酚和2,4,4'-三氯-2'-羟基二苯醚,所述对氯间二甲基苯酚和所述2,4,4'-三氯-2'-羟基二苯醚重量比为1:1。
优选的,所述药液组分还包括:薄荷0.001~0.005份、冰片0.001~0.005份。
优选的,所述基材和所述负载于该基材上的药液的重量比为1:4~5。药液含量充足。
优选的,所述基材为水刺无纺布。
本发明还提供了一种消毒湿纸巾的制备方法,包括以下步骤:
(1)将药液组分混合,升温至50~60℃,搅拌混合均匀,降温至30~40℃,制得药液;所述药液组分包括:茶树精油0.1~0.2份、芦荟提取物0.1~0.2份、α-红没药醇0.01~0.05份、紫草提取物0.1~0.5份、洋甘菊油0.01~0.05份、杀菌剂0.01~0.1份、透明质酸钠0.2~0.4份、烟酰胺0.01~0.05份、甘油0.1~1份、丙二醇0.1~1份、丁二醇0.1~1份、鲸蜡醇乳酸酯0.5~1.5份和水100份;
(2)将基材浸泡在所述药液中2~4小时。
本申请与现有技术相比,其详细说明如下:
本发明提供的药液组分各具有消毒杀菌作用的组分共同发挥消毒杀菌作用,提高了湿纸巾的消毒杀菌效果,且皮肤体验感觉良好。
药液组分包括了茶树精油、芦荟提取物、紫草提取物、α-红没药醇、洋甘菊油、杀菌剂、透明质酸钠。茶树精油为市售的茶树的提取物,具有杀菌消炎、收敛毛孔的功效,最主要的化学成分为对孟乙烯(terpinene)、松油精(pinene)、柠檬油精(limonene)、桉油酚(cineole)、香油脑(terpineol)、茴香素(cumene),适用于油性及粉刺皮肤,治疗化脓伤口及灼伤、晒伤、香港脚及头屑。芦荟提取物具有很好的保湿、消炎、营养和促进损伤皮肤愈合等作用。紫草提取物具有抗炎、抗菌作用。透明质酸钠具有保湿、消炎抑菌、促进组织增生与修复、促进伤口愈合和抗皱防衰老等作用,还能根据环境湿度变化自动调节最佳保水量。α—红没药醇具有抗炎、抗刺激和止痒的作用。洋甘菊油用于治疗粉刺、湿疹、皮疹、创伤、皮炎、干燥和发痒的皮肤,以及一般的过敏状况。能够起到很好的舒缓收敛作用肌肤的作用。而本发明提供的湿纸巾具有消毒、杀菌、消炎、保湿、止痒的功效,使用温和,对皮肤无刺激。药液组分中的烟酰胺在能经一部降低经皮的水分丢失,减少皮脂的分泌,增强皮肤的屏障功能,还能能增加角质层的黏结性和厚度,增加角质层的成熟度,起到保护皮肤的作用,使得保湿湿巾具有良好的提高皮肤水分含量,降低皮肤水分散失的的作用,提升湿纸巾的使用感。在此基础上甘油,丙二醇,丁二醇进行配伍使用,共同提供保湿体系,少量甘油的使用,在利用甘油吸湿性的同时,避免了甘油单独使用带来粘腻的使用感,丙二醇,丁二醇提供了清爽、爽滑的使用感,进一步提升本发明提供的湿纸巾的使用感。
对氯间二甲基苯酚是一种液体酚类消毒剂,相比传统酚类消毒剂的消毒效果更好,气味更轻,化学性质稳定,是一种广谱的防霉抗菌剂,对革兰氏阳性、阴性菌,真菌,霉菌都有杀灭功效;2,4,4'-三氯-2'-羟基二苯醚是一种广谱抗菌剂,能有效抑制大肠杆菌,金黄色葡萄球菌,白色念珠菌,同时能够保护有益细菌。进一步的,本发明采用氯间二甲基苯酚、2,4,4'-三氯-2'-羟基二苯醚作为杀菌剂剂,进一步提高了本发明提供的消毒湿巾的消毒杀菌的功效。
进一步,本发明提供的药液组分中还包括薄荷、冰片,使用于肌肤,给使用者带来清凉的感觉,使保湿湿巾的使用感佳。
具体实施方式
为了使本领域的技术人员更好地理解本发明的技术方案,下面结合具体实施例对本发明作进一步的详细说明。
实施例1
一种消毒湿纸巾,包括:基材和负载于该基材上的药液,所述药液组分包括:茶树精油0.2份、芦荟提取物0.2份、α-红没药醇0.05份、紫草提取物0.5份、洋甘菊油0.05份、杀菌剂0.1份、透明质酸钠0.4份、烟酰胺0.05份、甘油0.5份、丙二醇1份、丁二醇1份和水100份;
其中,
上份以克计;
所述杀菌剂为对氯间二甲基苯酚和2,4,4'-三氯-2'-羟基二苯醚,所述对氯间二甲基苯酚和所述2,4,4'-三氯-2'-羟基二苯醚重量比为1:1;
上述芦荟提取物由以下方法制得:选用生长周期满三年以上的芦荟叶片,用清水清洗干净,沥干水分后去除表皮,在无菌条件下打制成浆;然后加入纯化水稀释后离心分离、去渣,获得提取液;提取液经冷冻脱水处理后低温烘干喷雾,经60℃低温烘干至含水量为8%时取出,冷却至常温状态,过100~200目筛,即得;
上述紫草提取物由如下方法制得:紫草经体积浓度为95%的乙醇在50-70℃的水浴中浸提,过滤,滤液减压浓缩,即得;
所述基材和所述负载于该基材上的药液的重量比为1:4~5;所述基材为水刺无纺布。
上述消毒湿纸巾的制备方法,包括以下步骤:
(1)将上述药液组分混合,升温至50~60℃,搅拌混合均匀,降温至30~40℃,制得药液;
(2)将基材浸泡在所述药液中2~4小时。
实施例2
本实施例与实施例1的区别仅在于:
所述药液组分包括:茶树精油0.15份、芦荟提取物0.15份、紫草提取物0.2~0.5份、α-红没药醇0.02份、洋甘菊油0.02份、杀菌剂0.05份、透明质酸钠0.3份、烟酰胺0.02份、甘油1份、丙二醇0.5份、丁二醇0.5份和水100份。
实施例3
本实施例与实施例1的区别仅在于:
所述药液组分包括:茶树精油0.1份、芦荟提取物0.1份、α-红没药醇0.01份、紫草提取物0.1份、洋甘菊油0.01份、杀菌剂0.01份、透明质酸钠0.2份、烟酰胺0.01份、甘油0.1份、丙二醇0.1份、丁二醇0.1份和水100份。
实施例4
本实施例与实施例1的区别仅在于:
所述杀菌剂为对氯间二甲基苯酚。
实施例5
本实施例与实施例1的区别仅在于:
所述杀菌剂为2,4,4'-三氯-2'-羟基二苯。
实施例6
功效评测
消毒湿纸巾杀菌效果与毒性实验研究
1.1材料
本发明实施例1~5中的药液,依次编号为试验样A~E。
1.2受试菌种
金黄色葡萄球菌
大肠杆菌
1.3供试培养基
TSB固体培养基:蛋白胨10g/L,NaCl10g/L,K2HPO42.5g/L,酵母提取物3g/L,琼脂15g/L,采用蒸馏水溶解,调节pH值为7.2±0.2,在115℃高压灭菌20min;TSB液体培养基:蛋白胨10g/L,NaCl10g/L,K2HPO42.5g/L,酵母提取物3g/L,采用蒸馏水溶解,调节pH值为7.2±0.2,在115℃高压灭菌20min。
2菌悬液制备及接种
取甘油保藏的金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌100μL涂布于TSB固体培养基上,在37℃培养2d,用生理盐水重悬,得到菌悬液,并用平板培养法计数,将测试菌浓度调整为105~106CFU/mL。
3试验过程
3.1取上述菌悬液,分别在上述试验样A~E和清水对照样内滴加100μL,均匀混合,开始计时,作用2、5、10、20min,用无菌镊各取0.5mL样液试验样A~H和清水对照样分别投入含5mL 0.03mol/LPBS的试管内,充分混匀,作适当稀释,然后取其中2~3个稀释度,分别吸取0.5mL,置于两个平皿,用凉至40~45℃的TSB固体培养基15mL作倾注,转动平皿,使其充分均匀,35℃±2℃培养48h,作活菌菌落计数。
3.2检测条件:环境温度20℃-22℃,相对湿度50%-52%,试验重复3次。
3.3按下式计算单次试验抑菌率:
X=(A-B)/A×100%
式中:X——单次试验抑菌率,%;
A——对照样品平均菌落数;
B——被试样液平均菌落数。
4评价标准
抑菌率≥50%~90%,产品有抑菌作用,抑菌率≥90%,产品有较强抑菌作用。5试验结果
表1本发明湿纸巾药液对金黄色葡萄球菌的抑菌试验
清水对照样平均菌量为1.96×104~6.70×104CFU/mL。
表2本发明湿纸巾药液对大肠杆菌的抑菌试验
清水对照样平均菌量为6.70×104~8.60×104CFU/mL。
由上表可知,本发明提供的湿纸巾消毒杀菌效果好,起效快。
以上仅是本发明的优选实施方式,应当指出的是,上述优选实施方式不应视为对本发明的限制,本发明的保护范围应当以权利要求所限定的范围为准。对于本技术领域的普通技术人员来说,在不脱离本发明的精神和范围内,还可以做出若干改进和润饰,这些改进和润饰也应视为本发明的保护范围。
Claims (10)
1.一种消毒湿纸巾,其特征在于,包括:基材和负载于该基材上的药液,所述药液组分包括:茶树精油0.1~0.2份、芦荟提取物0.1~0.2份、α-红没药醇0.01~0.05份、紫草提取物0.1~0.5份、洋甘菊油0.01~0.05份、杀菌剂0.01~0.1份、透明质酸钠0.2~0.4份、烟酰胺0.01~0.05份、甘油0.1~1份、丙二醇0.1~1份、丁二醇0.1~1份和水100份。
2.根据权利要求1所述的消毒湿纸巾,其特征在于,所述药液组分包括:茶树精油0.15~0.2份、芦荟提取物0.15~0.2份、α-红没药醇0.02~0.05份、紫草提取物0.2~0.5份、洋甘菊油0.02~0.05份、杀菌剂0.05~0.1份、透明质酸钠0.3~0.4份、烟酰胺0.02~0.05份、甘油0.5~1份、丙二醇0.5~1份、丁二醇0.5~1份和水100份。
3.根据权利要求1所述的消毒湿纸巾,其特征在于,所述芦荟提取物由以下方法制得:选用生长周期满三年以上的芦荟叶片,用清水清洗干净,沥干水分后去除表皮,在无菌条件下打制成浆;然后加入纯化水稀释后离心分离、去渣,获得提取液;提取液经冷冻脱水处理后低温烘干喷雾,经60℃低温烘干至含水量为8%时取出,冷却至常温状态,过100~200目筛,即得。
4.根据权利要求1所述的消毒湿纸巾,其特征在于,所述紫草提取物由如下方法制得:紫草经乙醇浸提,过滤,滤液减压浓缩,即得。
5.根据权利要求1所述的消毒湿纸巾,其特征在于,所述杀菌剂为对氯间二甲基苯酚和/或2,4,4'-三氯-2'-羟基二苯醚。
6.根据权利要求1所述的消毒湿纸巾,其特征在于,所述杀菌剂为对氯间二甲基苯酚和2,4,4'-三氯-2'-羟基二苯醚,所述对氯间二甲基苯酚和所述2,4,4'-三氯-2'-羟基二苯醚重量比为1:1。
7.根据权利要求1所述的保湿湿纸巾,其特征在于,所述药液组分还包括:薄荷0.001~0.005份、冰片0.001~0.005份。
8.根据权利要求1所述的消毒湿纸巾,其特征在于,所述基材和所述负载于该基材上的药液的重量比为1:4~5。
9.根据权利要求1所述的消毒湿纸巾,其特征在于,所述基材为水刺无纺布。
10.权利要求1~9中任一项所述的消毒湿纸巾的制备方法,其特征在于,包括以下步骤:
(1)将药液组分混合,升温至50~60℃,搅拌混合均匀,降温至30~40℃,制得药液;所述药液组分包括:茶树精油0.1~0.2份、芦荟提取物0.1~0.2份、α-红没药醇0.01~0.05份、紫草提取物0.1~0.5份、洋甘菊油0.01~0.05份、杀菌剂0.01~0.1份、透明质酸钠0.2~0.4份、烟酰胺0.01~0.05份、甘油0.1~1份、丙二醇0.1~1份、丁二醇0.1~1份、鲸蜡醇乳酸酯0.5~1.5份和水100份;
(2)将基材浸泡在所述药液中2~4小时。
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