CN108606856B - Transcranial magnetic stimulation coil fixing device and method for mouse range movement - Google Patents
Transcranial magnetic stimulation coil fixing device and method for mouse range movement Download PDFInfo
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- CN108606856B CN108606856B CN201810525270.2A CN201810525270A CN108606856B CN 108606856 B CN108606856 B CN 108606856B CN 201810525270 A CN201810525270 A CN 201810525270A CN 108606856 B CN108606856 B CN 108606856B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/004—Magnetotherapy specially adapted for a specific therapy
- A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N2/00—Magnetotherapy
- A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
Abstract
A fixing device and method for a transcranial magnetic stimulation coil used for mouse range movement are provided with a fixed front plate arranged at the upper end of a base and used for arranging a coil, a fixed rear plate connected to one side of the fixed front plate and used for limiting the mouse movement range by binding a mouse, and a coil fixing structure is integrally formed on the upper end surface of the fixed front plate. The method comprises the following steps: placing the transcranial magnetic stimulation coil in the coil accommodating groove, inserting one end of the fixing pressing strip into the fixing frame, and pressing the other end of the fixing pressing strip on the inner diameter limiting plate to complete the fixation of the transcranial magnetic stimulation coil; placing the head of a mouse in a base, using 2 binding bands to wrap the abdomen of the mouse, and tying the end parts of the 2 binding bands on 4 binding band grooves on a fixed rear plate; adjusting the angles and the positions of the rotating arm and the supporting arm according to the experiment requirements, and accessing a magnetic stimulator to perform a transcranial magnetic stimulation experiment of the mouse in the moving state. The invention can be used for the transcranial magnetic stimulation experiment task in the mouse range moving state.
Description
Technical Field
The present invention relates to a coil fixing device. In particular to a fixing device and a method of a transcranial magnetic stimulation coil for mouse and mouse range activities.
Background
Transcranial Magnetic Stimulation (TMS) was the first magnetic stimulation technique of the nervous system created in 1985 by Barker et al, who is the university of sheffield, uk. The basic principle is that time-varying current is introduced into a stimulating coil, so that an induction magnetic field is generated in the space around the coil, the magnetic field acts on human craniocerebral tissues to generate corresponding induction current, and when the induction current exceeds a nerve stimulation threshold value of the region, nerve cells can be depolarized to form an evoked potential, thereby influencing intracerebral metabolism and nerve electrical activity.
Compared with nerve stimulation modes such as nerve electrical stimulation and the like, transcranial magnetic stimulation has the advantages of no wound, no pain, simplicity in operation and the like, and is applied to treatment of diseases such as Parkinson's disease, depression, epilepsy and the like.
Animal experiments are important components of transcranial magnetic stimulation research, but the current animal experiments generally carry out transcranial magnetic stimulation with different frequencies after a mouse is fixed, and the transcranial magnetic stimulation experiments cannot be carried out under the condition that the mouse freely moves. The animal figure-of-eight coil commonly used at present generally has the inner diameter of 10mm-20mm, small size and light weight, and the focus area comprises the whole brain area of the mouse. Therefore, the fixation of the small coil in the mouse moving state is feasible. Therefore, the fixing device for the transcranial magnetic stimulation coil for the small-range movement of the mouse is designed, and has important significance for widening the experimental mode of the transcranial magnetic stimulation animal experiment and carrying out the research work of the transcranial magnetic stimulation animal experiment in the moving state.
Disclosure of Invention
The invention aims to solve the technical problem of providing a transcranial magnetic stimulation coil fixing device and method for mouse range movement, which can be used for experimental research of transcranial magnetic stimulation animals in the moving state of a mouse.
The technical scheme adopted by the invention is as follows: a transcranial magnetic stimulation coil fixing device for mouse movement in a small range comprises a base for fixing the head of a mouse, a fixing front plate arranged at the upper end of the base and used for arranging a coil, and a fixing rear plate connected to one side of the fixing front plate and used for limiting the movement range of the mouse by binding the mouse, wherein a coil fixing structure is integrally formed on the upper end face of the fixing front plate.
The fixed front plate is horizontally arranged, and the base is obliquely arranged at an included angle of 20 degrees with the fixed front plate.
The base, the fixed front plate and the fixed rear plate are integrally formed.
The base is of a U-shaped structure, and the fixed front plate is fixed at the opening end of the U-shaped structure base.
The coil fixing structure is used for fixing 8-shaped coils or round coils and comprises an outer convex edge which protrudes upwards and is integrally formed on the upper end surface of the fixed front plate and used for drawing the outer side of the coil, and an inner diameter limiting plate which is arranged on the inner side of the outer convex edge and used for positioning the inner diameter of the coil, wherein a gap between the inner periphery of the outer convex edge and the outer periphery of the inner diameter limiting plate forms a coil accommodating groove used for accommodating the coil.
And the outer convex edge and the inner diameter limiting plate are provided with coil fixing pieces for preventing the coil from overflowing from the coil accommodating groove.
The coil fixing piece comprises a fixing frame fixedly arranged on the upper end face of the outer convex edge, and a fixing pressing strip, wherein one end of the fixing frame is inserted into the fixing frame, and the other end of the fixing frame is pressed on the inner diameter limiting plate.
Four binding belt grooves used for inserting and binding belts of the mouse are formed in the body part, corresponding to the mouse, of the fixed back plate, two binding belt grooves are formed in one side of the fixed back plate in the front-back direction along the length direction, the other two binding belt grooves are formed in the other side of the fixed back plate in the front-back direction along the length direction, and the binding belt grooves in the two sides of the fixed back plate are symmetrically arranged.
Still be provided with coil lead-out wire support frame, coil lead-out wire support frame sets up a side of fixed front bezel, pass through universal joint swing joint including the support arm, the one end that set up perpendicularly and be in the rotor arm on the top of support arm, the fixation clamp of coil lead-out wire can be cliied to the other end fixedly connected with of rotor arm.
A method of using a transcranial magnetic stimulation coil fixation device for mouse-mouse range activities, comprising the steps of:
1) placing the transcranial magnetic stimulation coil in the coil accommodating groove, inserting one end of the fixing pressing strip into the fixing frame, and pressing the other end of the fixing pressing strip on the inner diameter limiting plate to complete the fixation of the transcranial magnetic stimulation coil;
2) placing the head of a mouse in a base, using 2 binding bands to wrap the abdomen of the mouse, tying the end parts of the 2 binding bands on 4 binding band grooves on a fixed rear plate, and enabling the mouse to be located below the fixed rear plate to complete the fixation between the mouse and a coil fixing device;
3) the outgoing line of the coil is fixed on a fixing clamp of a coil outgoing line supporting frame, the angle and the position of the rotating arm and the supporting arm are adjusted according to the experiment requirement, so that the moving range of the mouse is controlled, the fixing task of the whole device is completed, and the magnetic stimulation instrument is connected to perform transcranial magnetic stimulation experiment of the mouse in the moving state.
The fixing device and the method for the transcranial magnetic stimulation coil used for the mouse and mouse range movement can be used for fixing the common animal experiment transcranial magnetic stimulation coil and the mouse. The device is formed by 3D printing of PLA materials, and has no influence on magnetic field distribution. The invention can be used for the experimental task of transcranial magnetic stimulation in the mouse range of activity, widens the task mode for experimental research of transcranial magnetic stimulation animals, and has important significance for experimental research of transcranial magnetic stimulation animals in different states.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a transcranial magnetic stimulation coil fixing device for mouse and mouse range activities according to the invention;
FIG. 2 is a schematic view of the overall structure of the base in the present invention;
FIG. 3 is a schematic structural view of an outer flange of the coil fixing structure according to the present invention;
FIG. 4 is a schematic structural view of an inner diameter limiting plate of the coil fixing structure according to the present invention;
FIG. 5 is a schematic structural view of a fixing frame of the coil fixing member according to the present invention;
FIG. 6 is a schematic structural view of a fixing bead of the coil fixing member of the present invention;
FIG. 7 is a schematic view of the construction of the fixed back plate of the present invention;
fig. 8 is a schematic structural view of the coil lead-out wire support frame of the present invention.
In the drawings
1: base 2: fixed front plate
3: fixing the rear plate 3.1: bandage fixing hole
4: coil fixing structure 4.1: outer convex edge
4.2: inner diameter limiting plate 4.3: coil accommodating groove
4.4: coil fixing member 4.41: fixing frame
4.42: fixing a pressing strip 5: support arm
6: the universal joint 7: rotating arm
8: fixing clamp
Detailed Description
The invention provides a transcranial magnetic stimulation coil fixing device and a method for mouse range movement, which are described in detail in the following with reference to the embodiments and the attached drawings.
As shown in figure 1, the transcranial magnetic stimulation coil fixing device for mouse range activity of the invention comprises a base 1 for fixing the head of a mouse, a fixed front plate 2 arranged at the upper end of the base 1 for bearing a coil, a fixed rear plate 3 connected to one side of the fixed front plate 2 for limiting the mouse range of activity by binding the mouse, and a coil fixing structure 4 integrally formed on the upper end surface of the fixed front plate 2. Fixed front bezel 2 set up for the level, base 1 for the slope setting that is 20 contained angles with fixed front bezel 2, be convenient for set up the mouse. The base 1, the fixed front plate 2 and the fixed rear plate 3 are integrally formed. Can be integrally formed by 3D printing of PLA materials.
As shown in fig. 2, the base 1 is a U-shaped structure, and the fixed front plate 2 is fixed at the open end of the U-shaped structure base 1.
The coil fixing structure 4 is a coil fixing structure for fixing a figure-8 coil or a circular coil. As shown in fig. 1, 3 and 4, the coil fixing device comprises an outer convex edge 4.1 protruding upwards and integrally formed on the upper end surface of the fixed front plate 2 for drawing the outer side of the coil, and an inner diameter limiting plate 4.2 arranged on the inner side of the outer convex edge 4.1 for positioning the inner diameter of the coil, wherein a gap between the inner periphery of the outer convex edge 4.1) and the outer periphery of the inner diameter limiting plate 4.2 forms a coil accommodating groove 4.3 for accommodating the coil. The coil fixation structure 4 and the fixation front plate 2 may be integrally formed by 3D printing of PLA material.
As shown in fig. 1, 5 and 6, the outer flange 4.1 and the inner diameter limiting plate 4.2 are provided with coil fixing members 4.4 for preventing the coil from overflowing from the coil accommodating groove 4.3. Coil mounting 4.4 including fixed setting up fixed frame 4.41 on the chimb 4.1 up end, and one end insert in fixed frame 4.41, the other end is pressed fixed layering 4.42 on the internal diameter limiting plate 4.2.
As shown in fig. 7, four strap grooves 3.1 for inserting and binding straps of the mouse are formed on the fixed back plate 3 corresponding to the body of the mouse, wherein two strap grooves 3.1 are formed on one side of the fixed back plate 3 in the front-back direction along the length direction, the other two strap grooves 3.1 are formed on the other side of the fixed back plate 3 in the front-back direction along the length direction, and the strap grooves 3.1 on the two sides of the fixed back plate 3 are symmetrically arranged.
Still be provided with coil lead-out wire support frame, as shown in fig. 8, coil lead-out wire support frame sets up a side of fixed front bezel 2 is in through 6 swing joint in the rotor arm 7 on the top of support arm 5 including the support arm 5, the one end of perpendicular setting, the other end fixedly connected with of rotor arm 7 can clip the fixation clamp 8 of coil lead-out wire.
The invention discloses a using method of a transcranial magnetic stimulation coil fixing device for mouse and mouse range movement, which comprises the following steps:
1) placing the transcranial magnetic stimulation coil in the coil accommodating groove 4.3, inserting one end of the fixed pressing strip 4.42 into the fixed frame 4.41, and pressing the other end of the fixed pressing strip 4.42 on the inner diameter limiting plate 4.2 to complete the fixation of the transcranial magnetic stimulation coil;
2) placing the head of a mouse in a base 1, using 2 binding bands to wrap the abdomen of the mouse, tying the end parts of the 2 binding bands on 4 binding band grooves 3.1 on a fixed back plate 3, enabling the mouse to be located below the fixed back plate 3, and fixing the binding bands without influencing the normal movement of the mouse, thereby completing the fixation between the mouse and a coil fixing device;
3) the outgoing line of the coil is fixed on a fixing clamp 8 of a coil outgoing line supporting frame, the angles and the positions of a rotating arm 7 and a supporting arm 5 are adjusted according to experiment requirements so as to control the moving range of the mouse, complete the fixing task of the whole device, and the device is connected into a magnetic stimulation instrument to perform transcranial magnetic stimulation experiments under the moving state of the mouse.
Claims (6)
1. A transcranial magnetic stimulation coil fixing device for mouse range movement is characterized by comprising a base (1) for fixing the head of a mouse, a fixing front plate (2) arranged at the upper end of the base (1) and used for arranging a coil, a fixing rear plate (3) connected to one side of the fixing front plate (2) and used for limiting the movement range of the mouse by binding the mouse, and a coil fixing structure (4) is integrally formed on the upper end surface of the fixing front plate (2);
the fixed front plate (2) is horizontally arranged, and the base (1) is obliquely arranged at an included angle of 20 degrees with the fixed front plate (2); the base (1), the fixed front plate (2) and the fixed rear plate (3) are integrally formed, and the fixed front plate (2) connected with the fixed rear plate (3) is positioned on the base (1); the base (1) is of a U-shaped structure, and the fixed front plate (2) is fixed at the opening end of the U-shaped structure base (1);
still be provided with coil lead-out wire support frame, coil lead-out wire support frame sets up a side of fixed front bezel (2), pass through universal joint (6) swing joint including support arm (5), the one end that sets up perpendicularly and be in rotor arm (7) on the top of support arm (5), the fixation clamp (8) of coil lead-out wire can be cliied to the other end fixedly connected with of rotor arm (7).
2. The transcranial magnetic stimulation coil fixing device for mouse and mouse range activities according to claim 1, wherein the coil fixing structure (4) is a coil fixing structure for fixing a figure-8 coil or a circular coil, and comprises an outer convex edge (4.1) protruding upwards and integrally formed on the upper end surface of the fixing front plate (2) and used for drawing the outer side of the coil, and an inner diameter limiting plate (4.2) arranged on the inner side of the outer convex edge (4.1) and used for positioning the inner diameter of the coil, and a gap between the inner periphery of the outer convex edge (4.1) and the outer periphery of the inner diameter limiting plate (4.2) forms a coil accommodating groove (4.3) used for accommodating the coil.
3. The transcranial magnetic stimulation coil fixing device for mouse and mouse range of motion according to claim 2, wherein the outer convex edge (4.1) and the inner diameter limiting plate (4.2) are provided with coil fixing pieces (4.4) for preventing the coil from overflowing from the coil accommodating groove (4.3).
4. The transcranial magnetic stimulation coil fixing device for mouse and mouse range of motion according to claim 3, wherein the coil fixing piece (4.4) comprises a fixing frame (4.41) fixedly arranged on the upper end face of the outer convex edge (4.1), and a fixing pressing strip (4.42) with one end inserted into the fixing frame (4.41) and the other end pressed on the inner diameter limiting plate (4.2).
5. The transcranial magnetic stimulation coil fixing device for mouse and mouse range of motion according to claim 1, wherein four binding belt grooves (3.1) for inserting and binding a binding belt of a mouse are formed on the fixing back plate (3) corresponding to the body part of the mouse, two binding belt grooves (3.1) are formed on one side of the fixing back plate (3) in the length direction in the front-back direction, the other two binding belt grooves (3.1) are formed on the other side of the fixing back plate (3) in the front-back direction in the length direction, and the binding belt grooves (3.1) on the two sides of the fixing back plate (3) are symmetrically arranged.
6. A method of using the transcranial magnetic stimulation coil fixation device for mouse-mouse range of motion as described in claim 1, comprising the steps of:
1) placing the transcranial magnetic stimulation coil in the coil accommodating groove (4.3), inserting one end of the fixed pressing strip (4.42) into the fixed frame (4.41), and pressing the other end of the fixed pressing strip (4.42) on the inner diameter limiting plate (4.2) to complete the fixation of the transcranial magnetic stimulation coil;
2) placing the head of a mouse in a base (1), using 2 binding bands to wrap the abdomen of the mouse, tying the end parts of the 2 binding bands on 4 binding band grooves (3.1) on a fixed rear plate (3), and enabling the mouse to be located below the fixed rear plate (3) to complete the fixation between the mouse and a coil fixing device;
3) the outgoing line of the coil is fixed on a fixing clamp (8) of a coil outgoing line supporting frame, the angle and the position of a rotating arm (7) and a supporting arm (5) are adjusted according to the experiment requirement, so that the moving range of the mouse is controlled, the fixing task of the whole device is completed, and a magnetic stimulation instrument is accessed to perform transcranial magnetic stimulation experiment of the mouse in the moving state.
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| CN201810525270.2A CN108606856B (en) | 2018-05-28 | 2018-05-28 | Transcranial magnetic stimulation coil fixing device and method for mouse range movement |
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| CN201810525270.2A CN108606856B (en) | 2018-05-28 | 2018-05-28 | Transcranial magnetic stimulation coil fixing device and method for mouse range movement |
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| CN108606856B true CN108606856B (en) | 2020-11-27 |
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| CN101518669A (en) * | 2009-01-23 | 2009-09-02 | 梅州康立高科技有限公司 | Magneto therapy apparatus for animal experiments |
| CN201949241U (en) * | 2010-08-16 | 2011-08-31 | 温州医学院附属第二医院 | Magnetic occupational therapy bed |
| CN102302823A (en) * | 2011-05-23 | 2012-01-04 | 天津大学 | Automatic transcranial magnetic stimulation (TMS) regulation and control method based on motion path planning |
| RU2635653C2 (en) * | 2011-08-26 | 2017-11-14 | Эндомагнетикс Лтд | Device for energy field generation for treatment of body cavities cancer and cavity organs cancer |
| CN202961527U (en) * | 2012-12-18 | 2013-06-05 | 深圳英智科技有限公司 | Transcranial magnetic stimulation coil structure |
| ES2768426T3 (en) * | 2013-11-29 | 2020-06-22 | Nexstim Oyj | Device support apparatus |
| AU2016241024B2 (en) * | 2015-04-03 | 2020-05-21 | Osaka University | Coil apparatus for use in transcranial magnetic stimulation apparatus |
| CN205181528U (en) * | 2015-12-10 | 2016-04-27 | 遵义医学院 | Rabbit position fixer |
| CN106110507A (en) * | 2016-07-26 | 2016-11-16 | 沈阳爱锐宝科技有限公司 | The navigation positional device of a kind of transcranial magnetic stimulation device and localization method |
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