CN108592986A - The unimpeded verifying attachment of micropore needle tubing and dressing anthemorrhagic performance in-vitro evaluation system and method - Google Patents
The unimpeded verifying attachment of micropore needle tubing and dressing anthemorrhagic performance in-vitro evaluation system and method Download PDFInfo
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- CN108592986A CN108592986A CN201810445846.4A CN201810445846A CN108592986A CN 108592986 A CN108592986 A CN 108592986A CN 201810445846 A CN201810445846 A CN 201810445846A CN 108592986 A CN108592986 A CN 108592986A
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- 238000011156 evaluation Methods 0.000 title claims abstract description 54
- 238000000338 in vitro Methods 0.000 title claims abstract description 46
- 238000000034 method Methods 0.000 title abstract description 8
- 238000012360 testing method Methods 0.000 claims abstract description 45
- 238000007789 sealing Methods 0.000 claims abstract description 19
- 238000001514 detection method Methods 0.000 claims abstract description 16
- 238000002474 experimental method Methods 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 238000003556 assay Methods 0.000 claims description 22
- 230000007246 mechanism Effects 0.000 claims description 21
- 238000012545 processing Methods 0.000 claims description 17
- 239000000523 sample Substances 0.000 claims description 16
- 239000008280 blood Substances 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 230000017531 blood circulation Effects 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 238000002955 isolation Methods 0.000 claims description 7
- 210000004204 blood vessel Anatomy 0.000 claims description 6
- 239000013068 control sample Substances 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 12
- 238000010171 animal model Methods 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000005587 bubbling Effects 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010616 electrical installation Methods 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
- G01D21/00—Measuring or testing not otherwise provided for
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
Abstract
The present invention discloses a kind of unimpeded verifying attachment of micropore needle tubing and dressing anthemorrhagic performance in-vitro evaluation system and method, it is related to medical treatment detection device technical field, the technical issues of to solve how to ensure the normal use of dressing anthemorrhagic performance in-vitro evaluation system, invalid test data is avoided to interfere.The unimpeded verifying attachment of micropore needle tubing of the present invention, including：Number bubbler, and number bubbler is connected with photoelectric counter；The number bubbler includes：Sealing container equipped with liquid, sealing container are communicated with negative tube, and the detection pipe that can be communicated with experiment needle stretches into the liquid of sealing container.
Description
Technical field
The present invention relates to medical treatment detection device technical field, more particularly to the unimpeded verifying attachment of a kind of micropore needle tubing and dressing
Anthemorrhagic performance in-vitro evaluation system and method.
Background technology
Currently, in the prior art, the evaluation detection of dressing anthemorrhagic performance is typically to be operated using animal model.
However, present inventor find, using animal model evaluation detect dressing anthemorrhagic performance when, be easy exist with
Lower defect：
Experimental animal has differences with human body, and evaluation testing result is inaccurate；Experimental animal is consumed, animal guarantor is unfavorable for
Shield；Experimental design is relative complex, as a result not energetic, it is difficult to is compared to the anthemorrhagic performance of dressing；Evaluate testing cost compared with
It is high.
Therefore, how a kind of dressing anthemorrhagic performance in-vitro evaluation system and method are provided, can be realized in vitro to dressing
Anthemorrhagic performance carries out evaluation detection, it has also become the technical issues of those skilled in the art's urgent need to resolve；Also, how to provide one kind
The unimpeded verifying attachment of micropore needle tubing, it can be ensured that the normal use of dressing anthemorrhagic performance in-vitro evaluation system avoids testing in vain
The interference of data, also become those skilled in the art's urgent need to resolve the technical issues of.
Invention content
It is an object of the present invention to provide a kind of unimpeded verifying attachments of micropore needle tubing, to solve how to ensure that dressing stops
It is courageous and upright can in-vitro evaluation system normal use, the technical issues of avoiding invalid test data from interfering.
The present invention provides a kind of unimpeded verifying attachment of micropore needle tubing, including：Number bubbler, several bubblers are connected with photoelectrometer
Number device；Several bubblers include：Sealing container equipped with liquid, the sealing container are communicated with negative tube, can be communicated with experiment
It is stretched into the detection pipe of needle in the liquid of the sealing container.
Compared with the existing technology, the unimpeded verifying attachment of micropore needle tubing of the present invention has the advantage that：
In the unimpeded verifying attachment of micropore needle tubing provided by the invention, including：Number bubbler, and number bubbler is connected with photoelectric counting
Device；The number bubbler includes：Sealing container equipped with liquid, sealing container are communicated with negative tube, can be communicated with the inspection of experiment needle
Test tube stretches into the liquid of sealing container.From this analysis, the unimpeded verifying attachment of micropore needle tubing provided by the invention, is being tested
Before being not inserted into liquid with needle, needle can be made by air is aspirated under -4kPa, even if also negative tube generates negative pressure, photoelectrometer
Number devices observe and record the bubble in " read bubble chamber ", and not bubbling or the excessively slow needle of bubbling are accurately determined as " blocking needle ", cannot
For testing, to realize the interference that can effectively avoid invalid test data, test period is saved.
It is existing to solve another object of the present invention is to provide a kind of dressing anthemorrhagic performance in-vitro evaluation system and method
Animal model evaluation detection dressing anthemorrhagic performance when, it is as a result inaccurate, can not quantify, and the higher technical problem of cost.
The present invention provides a kind of dressing anthemorrhagic performance in-vitro evaluation system, including：Assay balance is set on the assay balance
It is useful for measuring the test model mechanism for the blood flow reduced rate for flowing through dressing, the test model mechanism passes through suction pipeline
Several bubblers are communicated with, and the front end of the suction pipeline is serially connected with biological air-isolation filter；Pneumatic conveyer dryer, the air-flow
Drier becomes one with several bubblers, and drier is housed in the drying chamber of the pneumatic conveyer dryer；Operation touches dress
It sets, the operation touching device is connect with the pneumatic conveyer dryer, and the operation touching device is used for permanent vacuum suction and operates
Execution；Data processing equipment, the data processing equipment are connect with the assay balance and the operation touching device respectively,
And the data processing equipment is used to acquire, handle data, and result is exported.
When practical application, the test model mechanism includes：Disposable sample holding device, the disposable sample holder
Device includes：Blood vessel equipped with human whole blood, and the disposable syringe equipped with test sample or control sample；It is described
Disposable syringe is communicated with injection needle, and the injection needle stretches into the human whole blood in the blood vessel.
Wherein, the test model mechanism further includes：Spring touches ball and is loaded structure, and the spring touches the ball structure that is loaded and is used for
The disposable syringe is clamped.
Specifically, the spring touches the ball structure that is loaded and includes：Be loaded ontology, and the ontology that is loaded is equipped with described for being clamped
The holding tank of disposable syringe is additionally provided with groove that is vertical with the holding tank and being connected to setting on the ontology that is loaded, and
Compressed spring is housed in the groove；One end of the compressed spring is connect with the groove, the other end is connected with steel ball, and institute
It states steel ball and contacts setting with the disposable syringe.
Further, be equipped at intervals with three groups on the ontology that is loaded described in holding tank and the groove, groove described in every group
Inside it is respectively arranged with a pair of compressed spring and the steel ball.
Further, the test model mechanism further includes：Fast lifting device, the fast lifting device are located at institute
State the top of assay balance；The fast lifting device includes：Rack, and with the rack meshed gears；The spring
It touches the ball structure that is loaded to connect with the gear, and can be moved up and down along the rack.
Still further, the fast lifting device further includes：Clamping screw, the clamping screw are used in the spring
It touches ball and is loaded after structure is in proper height and be locked.
Compared with the existing technology, dressing anthemorrhagic performance in-vitro evaluation system of the present invention has the advantage that：
In dressing anthemorrhagic performance in-vitro evaluation system provided by the invention, including：Assay balance, pneumatic conveyer dryer, operation
Touching device and data processing equipment；Wherein, assay balance is equipped with for measuring the blood flow reduced rate for flowing through dressing
Test model mechanism, which is communicated with several bubblers by suction pipeline, and the front end of suction pipeline is serially connected with
Biological air-isolation filter；Specifically, pneumatic conveyer dryer becomes one with number bubbler, and in the drying chamber of pneumatic conveyer dryer
Equipped with drier；Further, operation touching device is connect with pneumatic conveyer dryer, and is operated touching device and be used for permanent vacuum suction
The execution of operation；Data processing equipment is connect with assay balance and operation touching device respectively, and data processing equipment is for adopting
Collection, processing data, and result is exported.From this analysis, dressing anthemorrhagic performance in-vitro evaluation system provided by the invention, energy
It is enough in the anthemorrhagic performance of in-vitro evaluation detection dressing, it is existing all when to solve the existing detection using animal model evaluation
More problems, specially experimental animal have differences with human body, and evaluation testing result is inaccurate；Experimental animal is consumed, is unfavorable for moving
Object is protected；Experimental design is relative complex, as a result not energetic, it is difficult to is compared to the anthemorrhagic performance of dressing；Evaluation detection at
This is higher.
The present invention also provides a kind of dressing anthemorrhagic performance in-vitro evaluation methods, including：Using assay balance and test model
Mechanism perseverance vacuum suction measures the blood flow reduced rate for flowing through dressing, and passes through d=(Vi- VfThe formula manipulation data of)/t；
In formula：D --- flow-reduction, every square of second (μ g/s of microgram2)；Vi--- initial flow, microgram are (μ g/s) per second；Vf--- most
Whole flow, microgram are (μ g/s) per second；T --- the time interval between initial flow and final flow rate is 30s, second (s).
Wherein, the permanent vacuum suction is -4kPa ± 0.1kPa.
The dressing anthemorrhagic performance in-vitro evaluation method is with above-mentioned dressing anthemorrhagic performance in-vitro evaluation system relative to existing
Advantage possessed by technology is identical, and details are not described herein.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, other drawings may also be obtained based on these drawings.
Fig. 1 is the structural schematic diagram of number bubbler in the unimpeded verifying attachment of micropore needle tubing provided in an embodiment of the present invention；
Fig. 2 is the structural schematic diagram of dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention；
Fig. 3 is the disposable of experiment prototype structure in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of sample holding device；
Fig. 4 is that the spring of experiment prototype structure in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention touches
Ball is loaded the structural schematic diagram of structure；
Fig. 5 is the quick liter that prototype structure is tested in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of falling unit；
Fig. 6 is pneumatic conveyer dryer and number bubbler in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
Structural schematic diagram.
In figure：31- sealing containers；32- negative tubes；33- detection pipes；0- experiment needles；1- assay balances；2- is tried
Test model mechanism；3- number bubblers；4- biology air-isolation filters；5- pneumatic conveyer dryers；51- drier；6- operations are touched
Touch device；7- data processing equipments；The disposable sample holding devices of 21-；211- blood vessels；212- is disposably injected
Device；213- injection needles；22- springs touch ball and are loaded structure；221- is loaded ontology；222- compressed springs；223- steel balls；
23- fast lifting devices；231- racks；232- gears；233- clamping screws.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
The every other embodiment that personnel are obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term "center", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for the description present invention and simplify description, do not indicate or imply the indicated device or element must have a particular orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for description purposes only, and is not understood to indicate or imply relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
Can also be electrical connection to be mechanical connection；It can be directly connected, can also indirectly connected through an intermediary, it can be with
It is the connection inside two elements.For the ordinary skill in the art, it can understand that above-mentioned term exists with concrete condition
Concrete meaning in the present invention.
Fig. 1 is the structural schematic diagram of number bubbler in the unimpeded verifying attachment of micropore needle tubing provided in an embodiment of the present invention.
The embodiment of the present invention provides a kind of unimpeded verifying attachment of micropore needle tubing, as shown in Figure 1, including：Number bubbler 3, number bubble
Device 3 is connected with photoelectric counter；Counting bubbler 3 includes：Sealing container 31 equipped with liquid, sealing container 31 are communicated with negative tube
32, the detection pipe 33 that can be communicated with experiment needle 0 stretches into the liquid of sealing container 31.
Compared with the existing technology, the unimpeded verifying attachment of micropore needle tubing described in the embodiment of the present invention has the advantage that：
In the unimpeded verifying attachment of micropore needle tubing provided in an embodiment of the present invention, including：Number bubbler 3, and number bubbler 3 is connected with
Photoelectric counter；The number bubbler 3 includes：Sealing container 31 equipped with liquid, sealing container 31 are communicated with negative tube 32, can be connected to
There is the detection pipe 33 of experiment needle 0 to stretch into the liquid of sealing container 31.From this analysis, provided in an embodiment of the present invention micro-
Needle tubing unimpeded verifying attachment in hole can make needle by aspirating air under -4kPa before experiment needle 0 is not inserted into liquid,
Even if also negative tube 32 generates negative pressure, photoelectric counter observes and records the bubble in " reading bubble chamber ", and not bubbling or bubbling are excessively slow
Needle be accurately determined as " block needle ", it is impossible to be used in experiment, to realize the interference that can effectively avoid invalid test data,
Save test period.
Fig. 2 is the structural schematic diagram of dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention.
As shown in Fig. 2, the embodiment of the present invention provides a kind of dressing anthemorrhagic performance in-vitro evaluation system, including：Assay balance
1, assay balance 1 is equipped with the test model mechanism 2 for measuring the blood flow reduced rate for flowing through dressing, test model mechanism
2 are communicated with several bubblers 3 by suction pipeline, and the front end of suction pipeline is serially connected with biological air-isolation filter 4；Pneumatic conveying drying
Device 5, pneumatic conveyer dryer 5 becomes one with number bubbler 3, and drier 51 is housed in the drying chamber of pneumatic conveyer dryer 5；Operation is touched
Device 6 is touched, operation touching device 6 is connect with pneumatic conveyer dryer 5, and is operated touching device 6 and be used for holding for permanent vacuum suction operation
Row；Data processing equipment 7, data processing equipment 7 is connect with assay balance 1 and operation touching device 6 respectively, and data processing fills
7 are set for acquiring, handling data, and result is exported.
Compared with the existing technology, the dressing anthemorrhagic performance in-vitro evaluation system described in the embodiment of the present invention has following excellent
Gesture：
In dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, including：Assay balance 1, pneumatic conveying drying
Device 5 operates touching device 6 and data processing equipment 7；Wherein, assay balance 1 is equipped with for measuring the blood for flowing through dressing
The test model mechanism 2 of flow quantity reduced rate, the test model mechanism 2 are communicated with several bubblers 3, and suction tube by suction pipeline
The front end on road is serially connected with biological air-isolation filter 4；Specifically, pneumatic conveyer dryer 5 becomes one with number bubbler 3, and gas
Drier 51 is housed in the drying chamber of flash dryer 5；Further, operation touching device 6 is connect with pneumatic conveyer dryer 5, and is grasped
Make touching device 6 for execution that permanent vacuum suction operates；Data processing equipment 7 touches dress with assay balance 1 and operation respectively
6 connections are set, and data processing equipment 7 is used to acquire, handle data, and result is exported.From this analysis, the present invention is implemented
The dressing anthemorrhagic performance in-vitro evaluation system that example provides can be used in the anthemorrhagic performance of in-vitro evaluation detection dressing, to solve
Existing problems, specially experimental animal have differences with human body, evaluate when the existing detection using animal model evaluation
Testing result is inaccurate；Experimental animal is consumed, animal protection is unfavorable for；Experimental design is relative complex, as a result not energetic, it is difficult to
The anthemorrhagic performance of dressing is compared；It is higher to evaluate testing cost.
Wherein, in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, above-mentioned biology air-isolation mistake
Filter 4 is hydrophobic filter；Drier 51 in said flow drier 5 is Bibulous Silica Gel；Above-mentioned perseverance vacuum suction operation
For -4kPa ± 0.1kPa.
Fig. 3 is the disposable of experiment prototype structure in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of sample holding device.
When practical application, as shown in figure 3, above-mentioned test model mechanism 2 may include：Disposable sample holding device 21,
The disposable sample holding device 21 may include：Blood vessel 211 equipped with human whole blood, and test sample or right is housed
The disposable syringe 212 of product in the same old way；The disposable syringe 212 is communicated with injection needle 213, and injection needle 213 stretches into blood
In human whole blood in container 211.
It should be added that, blood is contacted because experiment uses, if the sample holding device in test model herein
It is use repeatly, testing crew can be in biological safety hazards；Therefore, design is considered as high primary of availability
Property use consumptive material, by proving and inquiring into repeatedly, finally determine and use disposable syringe that specification is 1mL as hemostatic material
Expect the clamping device of sample；Also, the injection gauge of connection is 0.2mm-0.3mm.
Fig. 4 is that the spring of experiment prototype structure in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention touches
Ball is loaded the structural schematic diagram of structure.
Wherein, as shown in figure 4, above-mentioned test model mechanism 2 can also include：Spring touches ball and is loaded structure 22, the spring
Touch ball be loaded structure 22 can be used in be clamped disposable syringe 212.It uses spring and touches the design of ball-type clamping, one hand just can be complete
At the handling of sample holding device, right-hand man is operable, while improving the convenience of operation, it is ensured that it tests process
In stability.
Specifically, as shown in figure 4, above-mentioned spring touches the ball structure 22 that is loaded may include：Be loaded ontology 221, this is loaded this
Body 221 is equipped with holding tank for disposable syringe 212 to be clamped, be additionally provided on the ontology 221 that is loaded it is vertical with holding tank and
It is connected to the groove of setting, and compressed spring 222 is housed in groove；One end of the compressed spring 222 is connect with groove, the other end connects
It is connected to steel ball 223, and steel ball 223 contacts setting with disposable syringe 212.
Further, as shown in figure 4, three groups of holding tanks and groove can be equipped at intervals on the above-mentioned ontology 221 that is loaded, and it is every
Group groove in be respectively arranged with a pair of of compressed spring 222 and steel ball 223, to spring touch ball be loaded structure 22 can simultaneously clamping three
Disposable syringe 212, and then effectively improve checkability.
Fig. 5 is the quick liter that prototype structure is tested in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of falling unit.
Further, as shown in figure 5, above-mentioned test model mechanism 2 can also include：Fast lifting device 23, quickly
Lifting gear 23 is located at the top of assay balance 1；The fast lifting device 23 may include：Rack 231, and with rack 231
Meshed gears 232；When specific assembly, spring touches the ball structure 22 that is loaded and is connect with gear 232, and can be along about 231 rack
It is mobile, it is loaded structure 22 and the height of disposable syringe 212 to realize that quick adjustment spring touches ball.
Still further, above-mentioned fast lifting device 23 can also include：Clamping screw 233, the clamping screw 233 are used for
It touches ball in spring and is loaded after structure 22 is in proper height and be locked.
Fig. 6 is pneumatic conveyer dryer and number bubbler in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
Structural schematic diagram.
As shown in fig. 6, in order not to make the moisture of humidifying enter attraction system, the dry bath intracavitary of pneumatic conveyer dryer 5, which is packed into, inhales
Water silicon glue flows through air and is turned round in crooked route above intracavitary silica gel, keeps it fully dry, to effectively prevent in moisture
Moisture is inhaled into attraction system.
It should be added that, in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, it is herein
Make to protect system not by biological pollution, the front end of suction pipeline hydrophobic air filter of connecting can effectively prevent accident
Blood is sucked into attraction system.
In addition, the host panel of operation touching device 6 is equipped with start key (starting suction after shake-up) and timing key is used
It is appended the mouse action of computer, transparent syringe and injection needle needle stand, can realize the wink for observing contacting blood to test specimen
Between hand formula touch mouse-keyboard after make instrument start meter record.
The embodiment of the present invention also provides a kind of dressing anthemorrhagic performance in-vitro evaluation method, including：Using assay balance and examination
It tests the perseverance vacuum suction of model mechanism and measures the blood flow reduced rate for flowing through dressing, and pass through d=(Vi- VfThe formula manipulation of)/t
Data；In formula：D --- flow-reduction, every square of second (μ g/s of microgram2)；Vi--- initial flow, microgram are (μ g/s) per second；
Vf--- final flow rate, microgram are (μ g/s) per second；T --- the time interval between initial flow and final flow rate is 30s, second
(s)。
Wherein, above-mentioned permanent vacuum suction is -4kPa ± 0.1kPa.
Dressing anthemorrhagic performance in-vitro evaluation system and method provided in an embodiment of the present invention, meet claimed below：
One, biological safety requirement：Using human oriented design, sample is easy to loading and unloading, the risk of blood test for contamination system
Within the acceptable range；The risk that injection needle is surprisingly pricked the hand is within the acceptable range；
Two, operation requires：Reliable jacking system；Host panel is equipped with start key (starting suction after shake-up) and meter
Shi Jian (instrument starts timing after the moment for observing contacting blood to test specimen touches)；
Three, automation requires：After timing key is opened, instrument record simultaneously runs autostop behind 90s ± 0.5, records respectively
The mass loss of preceding 30s and rear 30s, automatic display and/or print result (difference of the flow of preceding 30s and rear 30s, then divided by always
Time) simultaneously, with μ g/s2Or μ L/s2(weight counting is converted into volume reading by density of blood) is unit；
Four, vacuum suction source stability requirement：The vacuum suction of output -4kPa ± 0.5kPa；
Five, injection needle screening function requirement：An interface for the screening of injection needle gas is designed on host, can determine that injection
Whether syringe intracavity is unimpeded and/or meets test requirements document；
Six, electrical security requirement：Meet GB in 4793.1《The safety of measurement, control and laboratory's electrical installation is wanted
Seek part 1：General Requirement》.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (10)
1. a kind of unimpeded verifying attachment of micropore needle tubing, which is characterized in that including：Number bubbler, several bubblers are connected with photoelectrometer
Number device；
Several bubblers include：Sealing container equipped with liquid, the sealing container are communicated with negative tube, can be communicated with experiment and use
The detection pipe of needle stretches into the liquid of the sealing container.
2. a kind of dressing anthemorrhagic performance in-vitro evaluation system, which is characterized in that including：Such as above-mentioned micropore described in claim 1
The unimpeded verifying attachment of needle tubing；Further include：
Assay balance, the assay balance are equipped with the test model machine for measuring the blood flow reduced rate for flowing through dressing
Structure, the test model mechanism is communicated with several bubblers by suction pipeline, and the front end of the suction pipeline is serially connected with life
Object air-isolation filter；
Pneumatic conveyer dryer, the pneumatic conveyer dryer becomes one with several bubblers, and the drying chamber of the pneumatic conveyer dryer
It is interior that drier is housed；
Touching device is operated, the operation touching device is connect with the pneumatic conveyer dryer, and the operation touching device is used for
The execution of permanent vacuum suction operation；
Data processing equipment, the data processing equipment are connect with the assay balance and the operation touching device respectively, and
The data processing equipment exports result for acquiring, handling data.
3. dressing anthemorrhagic performance in-vitro evaluation system according to claim 2, which is characterized in that the test model mechanism
Including：Disposable sample holding device, the disposable sample holding device include：Blood vessel equipped with human whole blood, with
And the disposable syringe equipped with test sample or control sample；
The disposable syringe is communicated with injection needle, and the injection needle stretches into the human whole blood in the blood vessel
In.
4. dressing anthemorrhagic performance in-vitro evaluation system according to claim 3, which is characterized in that the test model mechanism
Further include：Spring touches ball and is loaded structure, and the spring touches ball and is loaded structure for the disposable syringe to be clamped.
5. dressing anthemorrhagic performance in-vitro evaluation system according to claim 4, which is characterized in that the spring touches ball and is loaded
Structure includes：Be loaded ontology, and the ontology that is loaded is equipped with the holding tank for the disposable syringe to be clamped, described to be loaded this
It is additionally provided with groove that is vertical with the holding tank and being connected to setting on body, and compressed spring is housed in the groove；
One end of the compressed spring is connect with the groove, the other end is connected with steel ball, and the steel ball with it is described disposable
Syringe contact setting.
6. dressing anthemorrhagic performance in-vitro evaluation system according to claim 5, which is characterized in that between on the ontology that is loaded
Every equipped with holding tank and the groove described in three groups, being respectively arranged with a pair of compressed spring and the steel in groove described in every group
Ball.
7. dressing anthemorrhagic performance in-vitro evaluation system according to claim 4, which is characterized in that the test model mechanism
Further include：Fast lifting device, the fast lifting device are located at the top of the assay balance；
The fast lifting device includes：Rack, and with the rack meshed gears；The spring touch ball be loaded structure with
The gear connection, and can be moved up and down along the rack.
8. dressing anthemorrhagic performance in-vitro evaluation system according to claim 7, which is characterized in that the fast lifting device
Further include：Clamping screw, the clamping screw are used to touch ball in the spring and be loaded after structure is in proper height and be locked
It is fixed.
9. a kind of dressing anthemorrhagic performance in-vitro evaluation method, which is characterized in that negative using assay balance and test model mechanism perseverance
Pressure attracts the blood flow reduced rate for measuring and flowing through dressing, and passes through d=(Vi- VfThe formula manipulation data of)/t；In formula：
D --- flow-reduction, every square of second (μ g/s of microgram2)；
Vi--- initial flow, microgram are (μ g/s) per second；
Vf--- final flow rate, microgram are (μ g/s) per second；
T --- the time interval between initial flow and final flow rate is 30s, second (s).
10. dressing anthemorrhagic performance in-vitro evaluation method according to claim 9, which is characterized in that the perseverance vacuum suction
For -4kPa ± 0.1kPa.
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| CN108896426A (en) * | 2018-05-10 | 2018-11-27 | 山东省医疗器械产品质量检验中心 | Dressing anthemorrhagic performance in-vitro evaluation system and method |
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