CN108578563A - A kind of Chinese medicine for treating diabetic nephropathy - Google Patents
A kind of Chinese medicine for treating diabetic nephropathy Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/481—Astragalus (milkvetch)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The invention discloses a kind of Chinese medicines for treating diabetic nephropathy, belong to technical field of traditional Chinese medicines.The present invention is used to treat the Chinese medicine of diabetic nephropathy, is made of the raw material components of following parts by weight：20 60 parts of prepared rehmannia root, 20 55 parts of Radix Astragali, 12 24 parts of Radix Salviae Miltiorrhizae, 15 26 parts of Radix Ophiopogonis, 25 35 parts of pueraria lobata, 20 30 parts of Poria cocos, 10 18 parts of moxibustion Radix Glycyrrhizae.The present invention is used to treat in the Chinese medicine preparation of diabetic nephropathy, prepared rehmannia root invigorating heart blood kidney water, Radix Astragali tonifying lung invigorating the spleen, and the two is monarch drug in a prescription altogether；Radix Salviae Miltiorrhizae is reposed sedate, tonneau Guan pulse, Radix Ophiopogonis Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire, and the two is ministerial drug altogether；Pueraria lobata relieving superficies by cooling, Shengyang Zhixie, Poria cocos invigorating spleen to remove dampness, the two are adjutant altogether；Moxibustion Radix Glycyrrhizae is to make medicine, coordinating the drug actions of a prescription.All formulas are matched, plays tonifying lung tonifying speen and tonifying kidney altogether, qi-supplementing, blood-engendering, quench one's thirst sharp water the effect of.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine for treating diabetic nephropathy.
Background technology
Diabetic nephropathy is a kind of serious and larger chronic complicating diseases of harmfulness caused by diabetes, by diabetes
Glomerulosclerosis caused by caused microangiopathies belongs to Chinese medicine " quenching one's thirst ", and the scope of " oedema ", patient once occurs micro-
Albuminuria is measured, if without timely and effectively treating, renal function is faded until failure.Western medical treatment is mostly from diet control at present
System is strengthened glycemic control, decompression, adjustment lipid metaboli etc. and is set about, or uses dialysis, the treatment means such as kidney transplant, although
There is certain curative effect, but brings heavy financial burden to patient.Theory of traditional Chinese medical science thinks that the interpretation of the cause, onset and process of an illness of diabetic nephropathy is with gas the moon
It is deficient for this, with extravasated blood, water is wet, phlegm is turbid for mark, sick position in spleen, lung, kidney, quench one's thirst with the passing of time, hinder Tianjin gas consumption, it is yin-yang deficiency be glycosuria
The basic cause of disease of sick nephrosis.Traditional Chinese medicine shows unique advantage in terms of preventing diabetic nephropathy, delay disease progression and
The deterioration aspect for controlling disease is better.
Invention content
The purpose of the invention is to overcome the problems of the prior art, provide a kind of for treating in diabetic nephropathy
Medicine.
The present invention provides a kind of Chinese medicines for treating diabetic nephropathy, are made of the raw material components of following parts by weight：
20-60 parts of prepared rehmannia root, 20-55 parts of Radix Astragali, 12-24 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 15-26 part, 25-35 parts of pueraria lobata, 20-30 parts of Poria cocos, moxibustion
10-18 parts of Radix Glycyrrhizae.
Preferably, being made of the raw material components of following parts by weight：49 parts of prepared rehmannia root, 48 parts of Radix Astragali, 21 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 17
Part, 26 parts of pueraria lobata, 22 parts of Poria cocos, 11 parts of moxibustion Radix Glycyrrhizae.
Preferably, being made of the raw material components of following parts by weight：56 parts of prepared rehmannia root, 36 parts of Radix Astragali, 21 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 23
Part, 25 parts of pueraria lobata, 24 parts of Poria cocos, 15 parts of moxibustion Radix Glycyrrhizae.
Preferably, being made of the raw material components of following parts by weight：37 parts of prepared rehmannia root, 46 parts of Radix Astragali, 17 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 25
Part, 31 parts of pueraria lobata, 28 parts of Poria cocos, 16 parts of moxibustion Radix Glycyrrhizae.
Preferably, the above-mentioned dosage form for treating the Chinese medicine of diabetic nephropathy is solution, tablet, pill, granule, punching
Agent or capsule.
Compared with prior art, the beneficial effects of the invention are as follows：The present invention is used to treat the Chinese medicine of diabetic nephropathy, Fang Zhong
Prepared rehmannia root invigorating heart blood kidney water, Radix Astragali tonifying lung invigorating the spleen, the two are monarch drug in a prescription altogether；Radix Salviae Miltiorrhizae is reposed sedate, tonneau Guan pulse, Radix Ophiopogonis yin-nourishing profit
Lung, reinforcing stomach reg fluid, relieving restlessness that clears away heart-fire, the two are ministerial drug altogether；Pueraria lobata relieving superficies by cooling, Shengyang Zhixie, Poria cocos invigorating spleen to remove dampness, the two are altogether
Adjutant；Moxibustion Radix Glycyrrhizae is to make medicine, coordinating the drug actions of a prescription.All formulas are matched, play tonifying lung tonifying speen and tonifying kidney, qi-supplementing, blood-engendering altogether, quench one's thirst sharp water the effect of.
The raw material components of the present invention are respectively provided with following effect and effect：
Prepared rehmannia root：《Drugization justice》Described in, radix rehmanniae preparata is cooked by wine, and bitterization is sweet, alternating temperature cool in nature, is specially entered liver and is enriched blood.
Because liver is bitter anxious, delay it with sweet, and main temperature courage, energy invigorating heart blood, more kidney tonifying water.《This is through meeting original》Described in, prepared rehmannia root, false firepower steams
Solarization, it is sweet to turn hardship, is the yang aspect of yin, therefore vigour in energy kidney tonifying.
Radix Astragali：《Collected statements on the herbal foundation》Described in, " Radix Astragali, tonifying lung invigorating the spleen, defend arrest sweating in fact, and wind dispelling transports the medicine of poison.Therefore the deficiency of yang it
People, spontaneous perspiration frequency, is exterior deficiency and interspaces of skin and muscles being loose, Radix Astragali can be defended and arrest sweating in fact；The card of typhoid fever, row is delivered and evil sweat does not go out,
It is interior deficiency and weary in healthy tendency, Radix Astragali can help Tianjin to help sweat；The disease of harmful wind, not with person, Radix Astragali can be with by inclined invasion of vessels and brothers
Flourish muscles and bones ".《Book on Chinese herbal medicine is just read》Described in, Radix Astragali Starch 1500 table benefit is defended, and warm boundary between muscles, fertile space between skin and muscles makes yang-energy and profit, full of prevalence, certainly
So promote the production of body fluid green blood, therefore is surgery person's panacea, with ying, wei, qi, xue Taihe county, from the stagnant ear of no stasis of blood.”
Radix Salviae Miltiorrhizae：《Book on Chinese herbal medicine is just》Described in, Radix Salviae Miltiorrhizae, the heart, spleen, liver, kidney blood system medicine.《Japan hanako materia medica》Described in, Radix Salviae Miltiorrhizae,
It reposes sedate, tonneau Guan pulse controls cold and hot labor, arthralgia, and four limbs are unsuccessful；Apocenosis pain relieving, myogenic are put on flesh；Broken place blood is mended newborn
Blood.
Radix Ophiopogonis：《Records of Tradition Chinese and Western Medicine in Combination》Yan Qi：" stomach can be entered with nourishing the stomach liquid, stimulating appetite can more enter spleen to help spleen to dissipate essence
In lung, Dingchuan relieving coughing." Chinese medicine thinks, Radix Ophiopogonis is sweet in flavor, slight bitter, and cold nature returns stomach, lung, the heart channel of Hang-Shaoyin, there is Yin nourishing and lung moistening, beneficial stomach life
The effect of Tianjin, relieving restlessness that clears away heart-fire, for dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia,
The diseases such as dry constipation of intestines.《Herbal lease making》Claim Radix Ophiopogonis " moistening lung clears away heart-fire purges heat and promotes the production of body fluid, resolving sputum preventing or arresting vomiting, controls row water of coughing ".
Pueraria lobata：《Haigoushen》Described in, " gas on day row is controlled, is vomitted inverse, whetting the appetite, principal solution wine poison, only polydipsia.Bits are endured to control
Metal-inflicted wound, disease is antipyretic when controlling.”《This warp》Described in, " master quenches one's thirst, and body is too warm, vomiting, all numbness, plays cloudy gas, solves all poison.”.
Poria cocos：For diseases such as difficult urination, oedema.Poria cocos clearing damp and promoting diuresis and mild in medicine property and, Li Shui is without hindering healthy tendency
Clearing damp and promoting diuresis key medicine.
Moxibustion Radix Glycyrrhizae：Tonifying spleen and stomach, Yiqi and vein recovery.
Specific implementation mode
The specific implementation mode of the present invention is described in detail below, it is to be understood that protection scope of the present invention is not
It is restricted by specific implementation.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creativeness
The every other embodiment obtained under the premise of labour, shall fall within the protection scope of the present invention.
Embodiment 1：
A kind of Chinese medicine for treating diabetic nephropathy provided by the invention, is made of the raw material components of following parts by weight：
49 parts of prepared rehmannia root, 48 parts of Radix Astragali, 21 parts of Radix Salviae Miltiorrhizae, 17 parts of Radix Ophiopogonis, 26 parts of pueraria lobata, 22 parts of Poria cocos, 11 parts of moxibustion Radix Glycyrrhizae.
Conventionally, traditional Chinese herbal decoction is made, daily 1 dose, a point morning and evening takes twice, decocts every time in above-mentioned raw materials
150ml, 2 weeks as a treatment course, continuously treats 3 courses for the treatment of.
Embodiment 2：
A kind of Chinese medicine for treating diabetic nephropathy provided by the invention, is made of the raw material components of following parts by weight：
37 parts of prepared rehmannia root, 46 parts of Radix Astragali, 17 parts of Radix Salviae Miltiorrhizae, 25 parts of Radix Ophiopogonis, 31 parts of pueraria lobata, 28 parts of Poria cocos, 16 parts of moxibustion Radix Glycyrrhizae.
Conventionally, traditional Chinese herbal decoction is made, daily 1 dose, a point morning and evening takes twice, decocts every time in above-mentioned raw materials
150ml, 2 weeks as a treatment course, continuously treats 3 courses for the treatment of.
Embodiment 3：
A kind of Chinese medicine for treating diabetic nephropathy provided by the invention, is made of the raw material components of following parts by weight：
56 parts of prepared rehmannia root, 36 parts of Radix Astragali, 21 parts of Radix Salviae Miltiorrhizae, 23 parts of Radix Ophiopogonis, 25 parts of pueraria lobata, 24 parts of Poria cocos, 15 parts of moxibustion Radix Glycyrrhizae.
Conventionally, traditional Chinese herbal decoction is made, daily 1 dose, a point morning and evening takes twice, decocts every time in above-mentioned raw materials
150ml, 2 weeks as a treatment course, continuously treats 3 courses for the treatment of.
Clinical test：
1,160 progress clinical observations of selection Diabetic Nephropathy patients, wherein man 80, female 80, age 37-75 Sui,
Average age 58.34 years old, course of disease 6-25 is 17.46 average, and it is (every that 160 Diabetic Nephropathy patients are divided into experimental group 1-3
Group 40) and control group 40.Difference equilibrium (the P at 4 groups such as patient age size, sex composition and diabetic duration>0.05),
It is comparable.
2, diabetic nephropathy diagnostic criteria
2.1 Western medicine diagnostic criterias refer to《Diabetes mellitus in China guideline of prevention and treatment》：There are diabetes medical history, microdose urine protein quantitative
30-300mg/24h or the qualitative positive of Urine proteins, exclude gestation, tumour, calculus, infection, rheumatic disease, heart disease, hepatopathy and
Albuminuria caused by primary renal disease.
2.2, tcm diagnosis standard：Early stage show as the deficiency of vital energy, have a dizzy spell, enuresis nocturna frequency, tongue nature are light red, stringy and hesitant pulse；In
Phase visible become thin weak, soreness and weakness of waist and knees, dizziness and tinnitus, frequent urination, tongue be red, thready rapid pulse, and Late manifestations are shortness of breath lazyness speech, chilly
Limb is cold, loose stool, edema of lower extremity, tongue is thin white or lacks tongue, deep thready pulse.
3, experimental method：The corresponding 1-3 of the embodiment of the present invention that takes is used to treat in diabetic nephropathy experimental group 1-3 respectively
Medicine decoction, daily 1 dose of above-mentioned Chinese medicine, a point morning and evening take twice, decoct 150ml every time, and 2 weeks as a treatment course, continuous treatment 3
The course for the treatment of.Control group gives diabetic diet, movement, psychotherapy according to standard, and with take orally acarbose antidiabetic drug or
(and) insulin controls blood glucose, an experimental group 1-3 and control group patient clinical symptom, sign are observed every 2 weeks in therapeutic process
With every clinical biochemistry indications.
4, efficacy determination：
It is effective：Urinary albumin excretion ratio<20ug/min, S＆S disappear；
Effectively：More than urinary albumin excretion ratio drop by half, S＆S is substantially reduced；
In vain：It is unchanged that urinary albumin excretion ratio does not decline or decline not up to half, S＆S.Total effective rate packet
It includes effective and effective.
Using X2It examines, p<0.05 difference is statistically significant.
Clinical test results：
Table 1：Effect statistical form after treating 2 weeks
| Grouping | Total number of persons | It is effective | Effectively | In vain | Total effective rate |
| Experimental group 1 | 40 | 2 | 7 | 31 | 29% |
| Experimental group 2 | 40 | 2 | 10 | 28 | 30% |
| Experimental group 3 | 40 | 3 | 9 | 28 | 30% |
| Control group | 40 | 3 | 11 | 26 | 35% |
Table 2：Effect statistical form after treating 4 weeks
| Grouping | Total number of persons | It is effective | Effectively | In vain | Total effective rate |
| Experimental group 1 | 40 | 15 | 17 | 8 | 80% |
| Experimental group 2 | 40 | 17 | 19 | 4 | 90% |
| Experimental group 3 | 40 | 14 | 21 | 5 | 87.5% |
| Control group | 40 | 9 | 20 | 11 | 72.5% |
Table 3：Effect statistical form after treating 6 weeks
| Grouping | Total number of persons | It is effective | Effectively | In vain | Total effective rate |
| Experimental group 1 | 40 | 20 | 17 | 3 | 92.25% |
| Experimental group 2 | 40 | 25 | 14 | 1 | 97.5% |
| Experimental group 3 | 40 | 23 | 15 | 2 | 95% |
| Control group | 40 | 14 | 21 | 5 | 87.5% |
By table 1-3 it is found that after experimental group 1-3 and control group treat 2 weeks respectively, the therapeutic effect of control group is better than experimental group
1-3；But with the extension for the treatment of time, after treating 4 weeks, the total effective rate of experimental group 2 is promoted to 90%, experimental group 1-3's
Curative effect is superior to control group；After treating 6 weeks, the effect of total effective rate of experimental group 2 is up to 97.5%, experimental group 1-3, is obviously excellent
In control group.Therefore, the Chinese medicine preparation of 1-3 of the embodiment of the present invention all has apparent therapeutic effect to Diabetic Nephropathy patients,
The therapeutic effect for the Chinese medicine preparation that wherein embodiment of the present invention 2 is prepared is best.Over the course for the treatment of, experimental group 1-3 and right
Do not occur obvious adverse reaction according to group, pretherapy and post-treatment blood routine, liver function test are showed no obvious abnormalities.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. a kind of Chinese medicine for treating diabetic nephropathy, which is characterized in that be made of the raw material components of following parts by weight：Radix rehmanniae preparata
20-60 parts yellow, 20-55 parts of Radix Astragali, 12-24 parts of Radix Salviae Miltiorrhizae, Radix Ophiopogonis 15-26 part, 25-35 parts of pueraria lobata, 20-30 parts of Poria cocos, moxibustion Radix Glycyrrhizae
10-18 parts.
2. the Chinese medicine as described in claim 1 for treating diabetic nephropathy, which is characterized in that by the raw material of following parts by weight
Component is made：49 parts of prepared rehmannia root, 48 parts of Radix Astragali, 21 parts of Radix Salviae Miltiorrhizae, 17 parts of Radix Ophiopogonis, 26 parts of pueraria lobata, 22 parts of Poria cocos, 11 parts of moxibustion Radix Glycyrrhizae.
3. the Chinese medicine as described in claim 1 for treating diabetic nephropathy, which is characterized in that by the raw material of following parts by weight
Component is made：56 parts of prepared rehmannia root, 36 parts of Radix Astragali, 21 parts of Radix Salviae Miltiorrhizae, 23 parts of Radix Ophiopogonis, 25 parts of pueraria lobata, 24 parts of Poria cocos, 15 parts of moxibustion Radix Glycyrrhizae.
4. the Chinese medicine as described in claim 1 for treating diabetic nephropathy, which is characterized in that by the raw material of following parts by weight
Component is made：37 parts of prepared rehmannia root, 46 parts of Radix Astragali, 17 parts of Radix Salviae Miltiorrhizae, 25 parts of Radix Ophiopogonis, 31 parts of pueraria lobata, 28 parts of Poria cocos, 16 parts of moxibustion Radix Glycyrrhizae.
5. the Chinese medicine for treating diabetic nephropathy as described in claim 1-4 any one, it is characterised in that：The Chinese medicine
Dosage form be solution, tablet, pill, granule, electuary or capsule.
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| CN113144070A (en) * | 2021-04-25 | 2021-07-23 | 河南中医药大学 | A Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof |
| CN113995823A (en) * | 2021-10-29 | 2022-02-01 | 瑞纳康(北京)生物科技有限公司 | Blood sugar-reducing and pancreas-strengthening formula and preparation method thereof |
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| CN112274592A (en) * | 2020-12-09 | 2021-01-29 | 丽江糖去宁生物科技有限公司 | Medicinal and edible tea substitute for treating and recovering diabetes |
| CN113144070A (en) * | 2021-04-25 | 2021-07-23 | 河南中医药大学 | A Chinese medicinal composition for treating diabetic nephropathy and preparation method thereof |
| CN113995823A (en) * | 2021-10-29 | 2022-02-01 | 瑞纳康(北京)生物科技有限公司 | Blood sugar-reducing and pancreas-strengthening formula and preparation method thereof |
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