CN1085776A - Dentrifice composition - Google Patents
Dentrifice composition Download PDFInfo
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- CN1085776A CN1085776A CN 93108906 CN93108906A CN1085776A CN 1085776 A CN1085776 A CN 1085776A CN 93108906 CN93108906 CN 93108906 CN 93108906 A CN93108906 A CN 93108906A CN 1085776 A CN1085776 A CN 1085776A
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- Prior art keywords
- hemodia
- composition
- dentrifice composition
- compositions
- acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses the Dentrifice composition that contains potassium nitrate with improvement effect.The invention also discloses improving one's methods of treatment hemodia.
Description
The present invention relates to eliminate or alleviate the discomfort that cementum and/or dentin by hemodia or exposure cause or the compositions and the method for pain.
The people who is subjected to the hemodia problems affect is more than I expected many, and it is obvious day by day that this problem is just becoming.Suffer from this irritating disorder and can reflect pain heat food or the stimulation of cold drinks and snachs, citric acid or confection or other every days (comprising the toothbrush contact).This problem is general especially in the adult, these people because of corrosion, wearing and tearing, dental caries, enamel is cracked causes the normal protectiveness dentium nitor of dental surface mass shell partial loss, or its gingival atrophy and exposed dentin and/or cementum.
People have done trial aspect the product hypersensitive seeking to alleviate, and the trial of this respect comprises have been examined or check as strontium salt and comprise the materials such as nitrate of potassium nitrate.The latter is disclosed in U.S 3,863,006(1975 January 28) on, this patent is incorporated herein by reference.
The present inventor finds can improve by other components in the level of control surface activating agent and the minimizing compositions effect of potassium nitrate in the toothpaste.
Therefore, an object of the present invention is to provide the improved potassium nitrate tooth paste product that is used for the treatment of hemodia.
Another object of the present invention provides by using improving one's methods of this paper product treatment hemodia.
These and other purpose can easily be found out open from following.
Unless stated otherwise, all percents used herein and ratio all are by weight.In addition, the mentioned test of this paper is also carried out when 25 ℃ of compositionss unless stated otherwise.
In some cases, the present invention includes the dentifrice composition that contains concrete surfactant, potassium nitrate, abrasive and water.
The present invention also comprises the method for using combination treatment hemodia of the present invention.
Term used herein " contains " and means as long as listed material is brought into play its predictive role, various annexing ingredients can combined use in the present composition.
That term used herein " carrier " means is pharmaceutically useful, and can be used for using in the oral cavity proper excipient of this compositions.
The present invention comprises the dentifrice composition that contains potassium nitrate and concrete surfactant in some cases.
Necessity of the present invention and selectable component have been provided below.
Potassium nitrate:
Potassium nitrate is a topmost component of the present invention, is stable commercial product.The content of this material is about 1% to about 20%, is preferably about 2% to about 10%, most preferably is about 5%.
Surfactant:
The surfactant that the present invention uses is sodium lauryl sulfate and synthetic alkyl sodium sulfate, preferred synthetic alkyl sodium sulfate." alkyl " is meant the alkyl chain from about C-8 to about C-14 length.
Surface-active contents in the present composition is about 1.8% to about 3%, is preferably about 2% to about 2.5%.
Also contain water in the present composition.But preparation commercial composite water should optimize ion and not contain the water of organic impurity.Usually water content accounts for about 20% to about 60%, preferred about 35% to about 50% of dentifrice composition weight.This water content comprises that those are combined in other materials such as the Sorbitol and add the Free water of band.
Abrasive:
Include abrasive in the toothpaste as main component.Consider to be used for polishing material of the present invention and can be any can the Dentinal material of excessive wear.These comprise, granule condensation product, and other U.S.3 of for example comprising the sedimentary Silicon stone of silica gel and silicon, calcium carbonate, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, many calcium metaphosphates, insoluble many Polymeric sodium metaphosphate ies, hydrated alumina and resin type abrasives such as carbamide and formaldehyde as people such as Cooley, 070,510(1962 December 25 days) disclosed polishing material, this patent is incorporated herein by reference.Also can use the mixture of abrasive.
Various Silicon stone tooth abrasives have superior cleaning of teeth and burnishing action and can excessive wear enamel and Dentinal distinct advantages.The Silicon stone abrasives can also be compatible admirably with other ion sources with the soluble fluoride source.Because these reasons, this paper preferably uses this class material.
The common particle mean size of the Silicon stone polishing material that this paper is suitable for and other abrasives is about 0.1 to 30 micron, preferred 5 to 15 microns.The Silicon stone abrasive can be the U.S.3 of precipitated silica or silica gel such as Pader etc., 538,230(1970 published March 2) and the U.S.3 of Digiulio, 862,307(1975 published June 21) the middle Silicon stone xerogel of describing, these two pieces of patents all are incorporated herein by reference.W.R.Grace﹠amp preferably; Company, Davison Chemical Division produces, commodity are called the commercially available Silicon stone xerogel of " Syloid ".Preferred precipitated silica material comprises that those are produced by J.M.Huber Corporation, commodity are called the Silicon stones of " Zeodent ", particularly indicate the Silicon stone of " Zeodent119 " trade mark.U.S.4,340,583(1982 July 29) these Silicon stone abrasives have been described, this patent is incorporated herein by reference.
When described dentifrice was toothpaste, the abrasive content in the Dentrifice composition described herein was about 6% to about 70%, preferred about 15 to about 30%.
Optional ingredient in the dentifrice vehicle:
Also can add flavoring agent in the Dentrifice composition of the present invention.Suitable flavoring agent comprises wintergreen oil, Oleum menthae, Oleum Menthae Rotundifoliae, Sassafras oil and cloves oil.Also sweeting agent be can use, aspartame, acesulfame potassium, glucide, glucose, fructose and cyclamate sodium comprised.Be used for the flavoring agent of the present composition and the content of sweeting agent and be generally about 0.005% to about 2%(by weight), and can be as the solvent of the antibacterial of above pointing out.
When preparation toothpaste, must add some thickening agents to reach desirable denseness.Preferred thickening is a carboxy vinyl polymer, the water soluble salt of carrageenin, hydroxyethyl-cellulose and cellulose ether such as sodium carboxymethyl cellulose and carboxymethyl hydroxyethyl cellulose sodium.Also can use natural gum such as Chinese parasol glue, arabic gum, tragakanta and polysaccharide glue such as xanthan gum.Collodial silica magnalium or the thinner Silicon stone of pulverizing can be used as the part of thickening agent with the further structure of improving.The total amount of operable thickening agent is 0.5% to 5.0% of a composition total weight.
It also is ideal containing the wetting agent that prevents its hardening in the toothpaste.Suitable wetting agent comprises glycerol, Sorbitol and other edible polyhydric alcohol, and its content is about 15% to about 70%.
Preferably the present composition contains no more than its exsiccant necessary consumption that prevents of amount of wetting agent, because wetting agent may disturb the effect of product.In addition, some material such as Polyethylene Glycol should be got rid of outside this compositions.
Another kind of optional ingredient is the anion polycarboxylic acid.
Optionally but the anionic polymerisation polycarboxylic acid that this paper preferably uses is well-known, the form of use is its free acid or part or preferred whole neutral water-soluble alkalis (as potassium and preferred sodium) salt or ammonium salt.Preferably [preferable methyl vinyl ethers (methoxy ethylene), molecular weight (M.W.) are about 30,000 to about 1,000,000 for maleic anhydride or acid and another kind of polymerizable alkylene unsaturated monomer.] 1: 4 to 4: 1 copolymer.These copolymers can buy, as Gantrez(AN 139(M.W.500,000), A.N.119(M.W.250,000)) and the S-97 pharmaceutical grade product (M.W.70,000) of preferred GAF Corporation.
Other effective polymeric polycarboxylic acids comprise that [latter is available for 1: 1 copolymer as maleic anhydride and ethyl acrylate, methacrylate hydroxyl ethyl ester, N-vinyl-2-Pyrrolidone or ethylene, as No. 1103 (M.W.10 of Monsanto EMA, 000) and 61 grades of EMA], and 1: 1 copolymer of acrylic acid and methylmethacrylate or methacrylate hydroxyl ethyl ester, acrylic acid methyl ester. or ethyl acrylate, IVE or N-vinyl-2-Pyrrolidone.
Above disclosed other effective polymeric polycarboxylic acids referring to U.S.4,138,477 and 4,183,914, these two pieces of patents are incorporated herein by reference, the copolymer that comprises maleic anhydride and styrene, isobutene. or ethyl vinyl ether, many acrylic acid and many itaconic acids and More Malay acid, and molecular weight is low to moderate 1,000 commercially available sulfo group acrylic acid oligomer, Uniroyal ND-2.
Generally suitable is polymeric olefinic or the alkene unsaturated carboxylic acid that contains the two keys of activated carbon-carbene and at least one carboxyl, promptly contains the acid of the two keys of alkene; The polymerization that the two keys of this alkene make a mistake easily is because it is present in the alpha-beta position of carboxyl in the monomer molecule or as the part of terminal methylene.The example of this class acid is acrylic acid, methacrylate, ethylacrylic acid, α-Lv Daibingxisuan .beta.-methylacrylic acid, β-acryloxy propionic, sorbic acid, alpha-chloro sorbic acid, cinnamic acid, β-styrene acrylic, muconic acid, itaconic acid, citraconic acid, mesaconic acid, glutaconate, equisetic acid, atropic acid, 2 benzyl acrylic acid, 2-cyclohexyl acrylic acid, angelic acid, umbellic acid, Fumaric acid, maleic acid and acid anhydride.Other can comprise vinyl-acetic ester, vinyl chloride and malic acid dimethyl ester etc. with the different olefinic type monomers of this class carboxylic acid monomer copolymerization.Copolymer contains enough makes it become water miscible carboxylate groups.
This paper also is suitable for carboxy vinyl polymer, be referred to as the binding agent that suits above this paper, they are disclosed in the following document as toothpaste component: the U.S.3 of Choun etc., 980, the 767(1976 JIUYUE was published on the 14th), the U.S.3 of Roberts etc., 935,306(1976 published January 27), the U.S.3 of Peria etc., 919,409(1975 published November 11), the U.S 3 of Harrison, 911,904(1975 published October 7), the U.S.3 of Colodney etc., 711,604(1973 published January 16).They are commercial available, Carbopol(trade mark as B.F.Goodrich) 934,940,941 and 956, these products are that the crosslinked polyacrylic acid colloidal state water-soluble polymer of cross-linking agent is formed by polyene propyl group sucrose or polyene propyl group tetramethylolmethane with about 0.75% to about 2.0% basically.
Synthetic anionic polymerization polycarboxylic acid component mainly is to have the hydrocarbon of halogen and oxygen-containing substituents arbitrarily, its connection exists with for example form of ester, ether and OH group, when having this component, its general consumption in said composition is about 0.05%～3%(weight), preferred 0.05～2%, more preferably 0.1～2%.
Another kind of optional ingredient is a fluoride sources.Fluoride sources or the chemical compound of fluorine is provided need be dental caries agent well-known in the art, and also bring into play the effect of dental caries agent in the present invention's practice as essential acid phosphatase and pyrophosphatase inhibitor according to the present invention.This compounds slightly soluble or water-soluble fully.They with the ability of its releasing fluoride ion in water and with oral preparation in other chemical compounds undesirable reaction does not take place is feature.Inorganic fluoride salt such as soluble alkali metal, alkali salt are arranged, for example sodium fluoride, barium fluoride, prodan, ammonium fluosilicate, sodium fluozirconate, sodium monofluorophosphate, list or difluorophosphoric acid ammonium and fluoridize calcium pyrophosphate sodium in this class material.Preferred as alkali and stannum fluoride such as sodium fluoride and stannous fluoride, sodium monofluorophosphate (MFP) and composition thereof.
Amount for fluorine compounds depends on the type of kind, its dissolubility and the oral preparation of compound used therefor, but must be non-toxic, generally accounts for about 0.005 to about 3.0% of preparation.In dentifrice formulation such as tooth glue, toothpaste (comprising emulsifiable paste), when this chemical compound releasing fluoride ion amount reaches approximately 5,000ppm(is in product weight) time, it is satisfied that the consumption of this chemical compound is considered to.Can use this minimum chemical compound that is fit to arbitrarily, but preferred use be enough to discharge about 300 to 2, this chemical compound of 000ppm fluorion, preferred being to use discharges about 800 to about 1, the consumption of 500ppm fluorion.Typically, when using alkali metal fluoride and stannous fluoride, this components contents accounts for about 2%(weight of weight of formulation), preferably about 0.05% to 1%.When using sodium monofluorophosphate, this compounds content is about 0.1～3%, and more representative is about 0.76%.
It is anticalculus agents that this based composition also has a kind of selectable component.This class anticalculus agents comprises for example U.S.4 of any anti-tooth dirt effective substances, 515, and 772(1985 May 7) disclosed pyrophosphate, this patent is incorporated herein by reference.Preferred anticalculus agents is one, two, three and four alkali metal pyrophosphate salts and ammonium salts.
The present composition preferably is placed in the pipe or pump with the said composition component compatibility.This type of container and compositions contact position preferably polyethylene or polyethylene terephthalate.
Non-limiting examples given below has illustrated the present composition.
Embodiment I-IV
Four compositions embodiment that use the inventive method preparation have been provided below.
Composition weight %
I II III IV
Water 36.827 42.257 37.127 35.827
Silicon stone 22.000 22.000 22.000 22.000
Glycerol 13.250 13.250 13.250 13.250
Sorbitol (70%) 10.000 10.000 10.000 10.000
Alkyl sodium sulfate (27.9%) 7.530-7.530 7.530
Potassium nitrate 5.000 5.000 5.000 5.000
Sodium lauryl sulfate-2.100--
Tertiary sodium phosphate 2.100 2.100 2.100 2.100
Thickening Silicon stone---1.000
Carboxymethyl cellulose---1.000
Spice 0.850 0.850 0.850 0.850
Xanthan gum 0.700 0.700 0.700-
Titanium dioxide 0.500 0.500-0.500
Sodium monophosphate 0.350 0.350 0.350 0.350
Glucide 0.350 0.350 0.350 0.350
Carbomer 956 0.300 0.300 0.300 -
Sodium fluoride 0.243 0.243 0.243 0.243
Folc Blue
#1 - - 0.200 -
Amount to 100.000 100.000 100.000 100.000
Preparation method
Provided the method for preparing the present composition below.
1. add liquid (water, sorbitol, glycerol).Be heated to 120-160 °F.
2. with salt (fluoride, potassium nitrate, phosphate-buffered system, glucide) and be mixed to dissolving.
3. add titanium dioxide and be mixed to and be uniformly dispersed.
4. in Silicon stone, disperse binding agent and add other components.Be mixed to homodisperse and do not have block the existence.
5. add spice and mixing.
6. add alkyl sodium sulfate and mixing.When using sodium lauryl sulfate, before adding, be scattered in to make in the glycerol (in the first step, not adding) and be easy to dissolving.
7. mill, outgas, cool off and product is contained in the pipe.
The effect of above-mentioned composition of the present invention is very outstanding because of the consumption of its surfactant.
Claims (14)
1, can alleviate the pain caused Dentrifice composition of hemodia, it is characterized in that it contains:
(a) about 1% to about 20% potassium nitrate;
(b) about 1.8% to about 3.0% surfactant is selected from the group of being made up of sodium lauryl sulfate, alkyl sodium sulfate and composition thereof;
(c) about 6% to about 70% dentifrice abrasive; With
(d) about 20% to about 60% water.
2, according to the Dentrifice composition of claim 1, surfactant wherein is synthetic alkyl sodium sulfate.
3, according to the Dentrifice composition of claim 2, wherein the concentration of potassium nitrate is about 2% to about 10%.
4, according to the Dentrifice composition of claim 3, wherein surfactant concentrations is about 1.8% to about 3%.
5, according to the Dentrifice composition of claim 4, wherein the dentifrice abrasive is selected from the group of being made up of Silicon stone, calcium carbonate and composition thereof.
6, according to the Dentrifice composition of claim 5, wherein said compositions also contains fluoride sources.
7, according to the Dentrifice composition of claim 6, wherein abrasive is that Silicon stone abrasive and fluoride sources are sodium fluoride.
8, according to the Dentrifice composition of claim 7, wherein said compositions also contains anticalculus agents.
9, Dentrifice composition according to Claim 8, wherein said anticalculus agents are the solubility pyrophosphate.
10, according to the Dentrifice composition of claim 9, wherein contain synthetic anionic polymer in addition.
11, alleviate the pain caused method of hemodia by the compositions of using the claim 1 of safe and effective amount to hemodia person's dental surface.
12, alleviate the pain caused method of hemodia by the compositions of using the claim 3 of safe and effective amount to hemodia person's dental surface.
13, alleviate the pain caused method of hemodia by the compositions of using the claim 7 of safe and effective amount to hemodia person's dental surface.
14, alleviate the pain caused method of hemodia by the compositions of using the claim 9 of safe and effective amount to hemodia person's dental surface.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89628692A | 1992-06-10 | 1992-06-10 | |
| US896,286 | 1992-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1085776A true CN1085776A (en) | 1994-04-27 |
Family
ID=25405952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93108906 Pending CN1085776A (en) | 1992-06-10 | 1993-06-10 | Dentrifice composition |
Country Status (4)
| Country | Link |
|---|---|
| CN (1) | CN1085776A (en) |
| AU (1) | AU4398893A (en) |
| MX (1) | MX9303461A (en) |
| WO (1) | WO1993025184A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940037A (en) * | 2008-02-08 | 2015-09-30 | 高露洁-棕榄公司 | Oral care product and method of use and manufacture thereof |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843409A (en) * | 1994-08-08 | 1998-12-01 | Colgate Palmolive Company | Two component dentifrice for the treatment of dentinal hypersensitivity |
| EP0870493A1 (en) * | 1997-04-11 | 1998-10-14 | Carter-Wallace, Inc. | Oral gel composition comprising hydrated silica |
| US5932192A (en) * | 1997-04-23 | 1999-08-03 | Colgate-Palmolive Company | Lower astringent two component stannous and potassium salt containing dentifrice |
| CA2300456C (en) * | 1999-03-12 | 2004-05-11 | Pfizer Products Inc. | Compositions comprising a potassium salt active ingredient, including oral compositions for reducing dental nerve and dentin sensitivity comprising a non-menthol flavoring |
| PL1868689T3 (en) | 2005-03-21 | 2015-10-30 | Glaxo Group Ltd | Alkyl sulfate free and orthophosphate free dentifrice composition comprising a fluoride source and a silica dental abrasive |
| RU2705377C2 (en) | 2015-04-29 | 2019-11-07 | Колгейт-Палмолив Компани | Compositions for oral care |
| US11033096B2 (en) | 2017-12-12 | 2021-06-15 | Colgate-Palmolive Company | Oral care refill head and oral care kit including the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU555971B2 (en) * | 1981-09-03 | 1986-10-16 | Richardson-Vicks Inc. | Stable oral compositions containing zinc and fluoride compounds |
| JPH0629174B2 (en) * | 1987-02-12 | 1994-04-20 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Toothpaste composition for desensitizing pain-sensitive teeth |
| GB8811830D0 (en) * | 1988-05-19 | 1988-06-22 | Unilever Plc | Oral compositions |
-
1993
- 1993-06-01 WO PCT/US1993/005159 patent/WO1993025184A1/en active Application Filing
- 1993-06-01 AU AU43988/93A patent/AU4398893A/en not_active Abandoned
- 1993-06-10 CN CN 93108906 patent/CN1085776A/en active Pending
- 1993-06-10 MX MX9303461A patent/MX9303461A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940037A (en) * | 2008-02-08 | 2015-09-30 | 高露洁-棕榄公司 | Oral care product and method of use and manufacture thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993025184A1 (en) | 1993-12-23 |
| AU4398893A (en) | 1994-01-04 |
| MX9303461A (en) | 1994-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |