CN104688557A - Single-tube nonaqueous teeth-cleaning agent whitening composition and use and preparation methods of composition - Google Patents
Single-tube nonaqueous teeth-cleaning agent whitening composition and use and preparation methods of composition Download PDFInfo
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Abstract
The invention relates to a single-tube nonaqueous teeth-cleaning agent whitening composition and use and preparation methods of the composition. The invention relates to an oral care composition as well as use and preparation methods of the composition. The composition comprises the single-tube nonaqueous teeth-cleaning agent whitening composition comprising at least enzymes and primers.
Description
The application's to be the applying date be December in 2009 4 days, application number is 200980162735.1 (international application no is PCT/US2009/066737), and denomination of invention is the divisional application of the application for a patent for invention of " single tube non-water dentifrice Lightening compositions and use and preparation method " thereof.
Background of invention
By using dentifrice, especially comprising toothpaste, gel and the powder of active oxygen or hydrogen peroxide release composition (as peroxide, peroxocarbonate and perborate), can remove from dental surface painted.But these methods do not meet the individual demand wishing quick teeth whitening.
Some common method of whitening of being in utilize the dish comprising the bleach be placed on patient teeth, and allow to bleach.This processing method has multiple defect, comprises hemodia, and this may be demineralization due to oral cavity tissue and stimulation.
It is that these products tend to after the production the interior decomposition of relatively short time that domestic comprise one of defect of the bleaching product of oxygen evolution bleaching compounds, and with all or the loss of quite a large amount of available oxygen, thus limit these products effect as dental whitening compositions.Per-compound, as hydrogen peroxide, just keeps instability with regard to peroxide level, and has found to be difficult to be mixed with the abundant pot-life and easily discharged aqueous gel or the cream of oxygen when being applied to oral cavity.Some preparation for the oxygen evolution compositions of teeth whitening utilizes anhydrous powder or anhydrous cream or gel, and these cream or gel must be protected and not pollute and chemical action.The defect of these anhydrous products is used to be that owing to there is not water, apply oral cavity composition and tend to oral cavity tissue is become dry, this may cause stimulating and tissue injury.
Summary of the invention
The present invention relates to oral care product and use product effectively make whitening of dental surfaces and removal or reduce tartar buildup and the method for prevention of gingivitis.
In one embodiment, the invention provides the oral care product of stable, non-water Dentrifice composition form, described compositions comprises at least one enzyme, at least one substrate and applicable carrier.
Another embodiment of the invention provides a kind of stable, non-water Dentrifice composition that tooth and/or oral cavity can be made to brighten and clean, and described compositions comprises at least one enzyme, at least one substrate and applicable carrier.
Another embodiment of the invention provides a kind of can make tooth and/or oral cavity brighten or clean stable, non-water Dentrifice composition, and described compositions comprises at least one enzyme, at least one substrate, at least one abrasive material, at least one surfactant and at least one carrier.
Another embodiment of the invention provides a kind of method making whitening of dental surfaces or reduce or remove tartar from oral cavity.
Another embodiment of the invention provides a kind of test kit, and described test kit comprises stable, the non-water Dentrifice composition comprising at least one enzyme, at least one substrate and applicable carrier.Test kit of the present invention also can comprise at least one abrasive material, at least one surfactant, at least one fluoride source and at least one polymer or copolymer.
Detailed Description Of The Invention
In the text, scope is as describing within the scope of this each simple expression with each value.Any value within the scope of this can be selected as the terminal of scope.The all reference as cite herein quoted in this article is incorporated herein by reference.When definition conflict in definition in the disclosure and institute's incorporated by reference, should be as the criterion with the disclosure.
In one embodiment, the invention provides a kind of stable, non-water Dentrifice composition comprising at least one enzyme, at least one substrate and applicable carrier.As used herein, and unless otherwise specified, term " is applicable to carrier " and refers to that formation allows enzyme and substrate to keep any dose of nonaqueous system close or the combination of these agent with stationary mode, includes but not limited to surfactant, polymer and copolymer.As used herein, and unless otherwise specified, term " substrate " refers to any dose of the generation hydrogen peroxide when contacting with enzyme.The generation enzyme of hydrogen peroxide and the example of substrate are glucose oxidase and glucose.
In certain embodiments of the invention, compositions also can comprise one or more other agent.In other embodiments, compositions comprises at least one abrasive material further.In another embodiment, compositions comprises at least one fluoride source further.In another embodiment, compositions comprises at least one polymer or copolymer further.In another embodiment, compositions comprises at least one surfactant further.In another embodiment, compositions comprises at least one vitamin further.In another embodiment, compositions comprises at least one flavoring agent further.In another embodiment, compositions comprises at least one enzyme further.In another embodiment, compositions comprises at least one wetting agent further.In another embodiment, compositions comprises at least one antiseptic further.
In certain embodiments of the invention, non-water Dentrifice composition is contained in single container, as single tube.
In certain embodiments of the invention, abrasive material includes but not limited to abrasive silica, Polymeric sodium metaphosphate., potassium metaphosphate, tricalcium phosphate, Tri-Compress, aluminium silicate, calcined alumina, bentonite or other material or its combination.
In another embodiment of the invention, fluoride source includes but not limited to sodium fluoride, potassium fluoride, prodan, sodium monofluorophosphate (MFP), ammonium fluosilicate, stannous fluoride and stannous chloride.
In another embodiment of the invention, polymer or copolymer include but not limited to Polyethylene Glycol, PEG/PPG copolymer, PVP and/or polyethylene.
In another embodiment of the invention, flavoring agent includes but not limited to wintergreen oil, Oleum menthae, oleum menthae viridis, Sassafras oil, cloves oil, aspartame, acesulfame, glucide, glucose, fructose and sodium cyclamate and combination thereof.
The present invention also comprises the method making whitening of dental surfaces and/or reduce or remove tartar from oral cavity, described method comprises makes that dental surface or oral cavity are stable with of the present invention, non-water Dentrifice composition contacts, and described compositions comprises at least one enzyme, at least one substrate and applicable carrier.
Compositions of the present invention comprises one or more enzymes.Enzyme of the present invention is used for and substrate-function, to produce hydrogen peroxide.Useful enzyme is included in and produces any of hydrogen peroxide and utilize oxidase with acting on during substrate contact.
In certain embodiments, enzyme is glucose oxidase, monoamine oxidase, MAO, xanthine oxidase, gluconolactone oxidase, laccase, lysyloxidase or its combination.
The mixture of enzyme or several compatibility enzymes is with 0.002% weight to 2% weight in the present invention, 0.05% weight to 1.5% weight, or the amount of 0.1% weight to 0.5% weight exists, and these amounts represent with the % weight of composition weight meter.
Substrate of the present invention is included in and any material discharging hydrogen peroxide during suitable synthase contacts.The example of substrate comprises glucose, and glucose produces hydrogen peroxide when contacting with glucose oxidase.
Compositions can optionally comprise one or more abrasive materials, includes but not limited to abrasive silica, as having the precipitated silica of maximum 20 microns of mean diameters, as the Zeodent that J.M.Huber sells
available abrasive material also comprises Polymeric sodium metaphosphate., potassium metaphosphate, tricalcium phosphate, Tri-Compress, aluminium silicate, calcined alumina, bentonite or other material or its combination.Abrasive silica polishing material used herein and other abrasive material generally have the mean diameter of 0.1 to 30 micron or 5 to 15 microns.Abrasive silica can from precipitated silica or silica gel, and such as authorize the United States Patent (USP) 3,538,230 of Pader etc. and authorize the United States Patent (USP) 3,862 of Digiulio, the silica xerogel described in 307, two full patent texts are incorporated herein by reference.Concrete silica xerogel by W.R.Grace & Co., Davison Chemical Division with trade name
sell.Precipitated silica material comprises J.M.Huber Corp. with trade name
those materials sold, comprise and have title
the silicon dioxide of 115 and 119.These abrasive silica are described in the United States Patent (USP) 4,340,583 authorizing Wason, and described patent is incorporated herein by reference.
In certain embodiments, abrasive material comprises having and is less than 100cc/100g silicon dioxide, scope at 45cc/100g to 70cc/100g silicon dioxide, the silica gel of the oil factor of 45cc/100g to 65cc/100g silicon dioxide or 45cc/100g to 60cc/100g silicon dioxide and precipitation amorphous silica.Oil factor ASTA Rub-Out Method (method of rubbing out) D281 measures.In other embodiments, silicon dioxide is the colloidal particles of the mean diameter with 3 microns to 12 microns and 5 to 10 microns.
Be used in particular for implementing low oil absorption silica abrasive of the present invention by Davison Chemical Division of W.R.Grace & Co., Baltimore, Md.21203 are with trade mark Sylodent
sell.Sylodent 650
the silica hydrogel be made up of with the colloidal silica particle being less than 70cc/100g silicon dioxide oil absorption average 7 to 10 micron diameters with 29% weight water content is the example for implementing low oil absorption silica abrasive of the present invention.Abrasive material is present in oral care strip of the present invention or band compositions with composition weight meter 1 to 40% weight concentration, in other embodiments, and 5 to 30% weight, in another embodiment, 10 to 20% weight.Independent bar or the abrasive material dosage (that is, single dose) in being with are with composition weight meter 0.01 to 0.4% weight, 0.05 to 0.3% weight, in another embodiment, and 0.1 to 0.2% weight.
Compositions also can comprise one or more fluoride ion source.Material can be produced as soluble fluoride source in the compositions of the present invention with multiple fluoride ion.The fluoride ion be applicable to produce the example of material be found in authorize Briner etc. United States Patent (USP) 3,535,421, authorize Parran, Jr. the United States Patent (USP) 4,885,155 waited and the United States Patent (USP) 3 authorizing Widder etc., 678,154, described patent is incorporated herein by reference.
Representative fluoride ion source includes but not limited to stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, prodan, sodium monofluorophosphate (MFP), ammonium fluosilicate and stannum fluoride (such as, stannous fluoride and stannous chloride) and combination thereof.Some specific embodiments comprises stannous fluoride or sodium fluoride and composition thereof.
In certain embodiments, compositions of the present invention also can comprise and be enough to provide 25ppm to 5, and fluoride ion source or the fluorine of the amount of 000ppm fluoride ion provide composition.
In one embodiment, fluoride ion source the amount of 0.01% weight to 3% weight of composition weight can join compositions of the present invention, in another embodiment, with composition weight meter 0.03% weight to 1% weight.The dosage (that is, single dose) of independent bar or band can be with composition weight meter 0.0001 to 0.003% weight, 0.0005 to 0.003% weight, in another embodiment, and 0.001 to 0.02% weight.
The another kind of agent comprised in the present compositions is the mixture of surfactant or compatible surfactants.The surfactant be applicable to is those surfactants at whole wide pH scope reasonably stability, such as anion, cation, nonionic or zwitterionic surfactant.
The surfactant be applicable to more fully is described in the United States Patent (USP) 3,959,458 such as authorizing Agricola etc., the United States Patent (USP) 3 authorizing Haefele, 937,807 and authorize the United States Patent (USP) 4,051 of Gieske etc., 234, described patent is incorporated herein by reference.
In certain embodiments, anion surfactant used herein is included in the water soluble salt of the alkyl sodium sulfate ester in a heatable brick bed base with 10 to 18 carbon atoms and has the water soluble salt of sulfonate monoglycerides of fatty acid of 10 to 18 atoms.The example of sodium lauryl sulfate, sodium lauroyl sarcosine and coconut oil coconut monoglyceride anionic surfactant types for this reason.Also the mixture of anion surfactant can be used.
In another embodiment, the present invention's cationic surfactant used extensively can be defined as the derivant of the fatty quaternary ammonium compounds with the long alkyl chain comprising 8 to 18 carbon atoms, such as Trimethyllaurylammonium chloride, cetylpyridinium chloride, Cetyl trimethyl ammonium, chlorination diisobutyl Phenoxyethyl dimethyl benzyl ammonium, nitrous acid Cocoalkyl trimethyl ammonium, cetyl pyridinium fluoride and composition thereof.
Illustrative cationic surfactant is be described in the United States Patent (USP) 3,535 authorizing Briner etc., and the quaternary ammonium fluoride of 421, described patent is incorporated herein by reference.Some cationic surfactant also can in the composition as antibacterial.
The illustrative non-ionic surface active agent of compositions used in the present invention extensively can be defined through the compound that oxyalkylene group (hydrophilic nmature) produces with the organic hydrophobic compound condensation that can be aliphatic series or alkyl aromatic character.Be applicable to the mixture that the example of non-ionic surface active agent includes but not limited to the ethylene oxide condensation substance of the polyethylene oxide condensates of Pluronics, alkyl phenol, the product derived by the product condensation of ethylene oxide and propylene oxide and ethylenediamine, aliphatic alcohol, long chain tertiary amine oxides, long chain tertiary phosphine oxide, long chain dialkyl sulfoxides and these materials.
In certain embodiments, the present invention's amphion synthetic surfactant used extensively can be described as the derivant of aliphatic quaternary ammonium, p and s compound, wherein aliphatic group can be straight or branched, wherein an aliphatic substituent substituent group comprises 8 to 18 carbon atoms, one comprises anionic water solubilizing group, such as, carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.The illustrative example being applicable to the surfactant covering compositions includes but not limited to alkyl sodium sulfate, sodium lauroyl sarcosine, cocoamidopropyl and polysorbate 20 and combination thereof.
The mixture of surfactant or compatible surfactants can composition total weight 0.1% weight to 5% weight be present in compositions of the present invention, 0.3% weight to 3% weight in another embodiment, in another embodiment 0.5% weight to 2% weight.The dosage (that is, single dose) of independent bar or the surfactant in being with is with composition weight meter 0.001 to 0.05% weight, 0.003 to 0.03% weight, in another embodiment, and 0.005 to 0.02% weight.
Compositions of the present invention also can comprise flavoring agent.Quintessence oil and various seasoning aldehyde, ester, alcohol and similar substance is included but not limited to for implementing flavoring agent of the present invention.The example of quintessence oil comprises the oil of Mentha viridis L, Herba Menthae, Ilicis Purpureae, Cinnamomum porrectum (Roxb.) Kosterm., clove tree, Salvia japonica Thunb., eucalyptus globulus, sweet Adeps Bovis seu Bubali, Cortex Cinnamomi, Fructus Citri Limoniae, limette, grapefruit and orange.These chemicals are also useful, as menthol, carvone and anethole.Some embodiment utilizes the oil of Herba Menthae and Mentha viridis L.
Flavoring agent is present in oral cavity composition with the concentration of composition weight meter 0.1 to 5% weight, or 0.5 to 1.5% weight.The dosage (that is, single dose) of independent bar or the flavoring agent in being with is with composition weight meter 0.001 to 0.05% weight, in another embodiment, and 0.005 to 0.015% weight.
Compositions of the present invention also optionally can comprise one or more can the chelating agen of calcium set up in the cell wall of antibacterial of complexation.In conjunction with this calcium, bacteria cell wall is weakened, and increase the molten born of the same parents of antibacterial.
Another group agent being suitable for use in the present invention as chelating agen is soluble pyrophosphates.The pyrophosphate used in the compositions of the present invention can be any alkali metal pyrophosphate.In certain embodiments, salt comprises four alkali metal pyrophosphates, two alkali metal two acid pyrophosphates, three alkali metal one acid pyrophosphates and composition thereof, and wherein alkali metal is sodium or potassium.Salt can the form of its hydration and non-both hydrations use.The effective dose pyrophosphate used in the compositions of the present invention is generally enough to provide with composition weight meter at least 1.0% weight, 5 to 6% weight, the pyrophosphate ion of 3.5% to 6% weight.The dosage (that is, single dose) of independent bar or the chelating agen in being with is with composition weight meter 0.01 to 0.6% weight, in another embodiment, and 0.035 to 0.06% weight.
Compositions of the present invention also optionally comprises one or more polymer.These materials, well known, use with the form of its free acid or the water-soluble alkali (such as potassium and sodium) partially or completely neutralized or ammonium salt.Some embodiment comprises and has 30,000 to 1,1: 4 to 4: 1 maleic anhydride of molecular weight (M.W.) of 000,000 or the copolymer of acid and another kind of polymerizable ethylenically unsaturated monomers (such as, methyl vinyl ether (methoxy-ethylene)).These copolymers are as obtained as Gantrez AN 139 (M.W.500,000), the AN 119 (M.W.250,000) of GAFChemicals Corporation and S-97 pharmaceutical grade (M.W.70,000).
Other operation polymer comprises 1: 1 copolymer as maleic anhydride and ethyl acrylate, hydroxyethyl methylacrylate, NVP or ethylene, latter case as Monsanto EMA No.1103, M.W.10,000 and EMAGrade 61 obtain; With 1: 1 copolymer of acrylic acid and methyl methacrylate or hydroxyl ethyl ester, acrylic acid methyl ester. or ethyl ester, IVE or NVP.
General polymerization olefinic or the ethylenic unsaturated carboxylic acid being applicable to use and comprising activated carbonto-carbon double bond and at least one carboxyl, namely, be included in the acid of the alkene double bond easily worked in polymerization, because it exists in alpha-beta position or as the part of terminal methylene relative to carboxyl in monomer molecule.The example of these acid is acrylic acid, methacrylic acid, ethylacrylic acid, α-chloroacrylic acid .beta.-methylacrylic acid, β-acryloxy propionic, sorbic acid, α-chlorine sorbic acid, cinnamic acid, β-styrene acrylic, muconic acid, itaconic acid, citraconic acid, mesaconic acid, glutaconate, equisetic acid, atropic acid, 2 benzyl acrylic acid, 2-cyclohexylacrylic, angelic acid, umbellic acid, fumaric acid, maleic acid and acid anhydride.Vinyl acetate, vinyl chloride, dimethyl maleate etc. can be comprised from other different olefinic monomer of these carboxylic acid monomer's copolymerization.Copolymer comprises the enough carboxylate groups about water solubility.
Another kind of polymerizer comprises the compositions of the homopolymer of homopolymer and/or unsaturated sulfonic acid and the salt thereof comprising and be substituted acrylamide, specifically, at this polymer-matrix in the unsaturated sulfonic acid being selected from acrylamido alkyl sulfonic acid, such as, there is 1,000-2,000, the 2-acrylamide-2-methyl propane sulfonic of the molecular weight of 000, is described in the United States Patent (USP) 4,842 that on June 27th, 1989 authorizes Zahid, 847, described patent is incorporated herein by reference.
Another kind of useful polymerizer comprises polyamino acid, particularly comprises ratio anion surface active those polyamino acid amino acid whose, such as aspartic acid, glutamic acid and phosphoserine, as the United States Patent (USP) 4 of Sikes etc., 866, disclosed in 161, described patent is incorporated herein by reference.
In preparation compositions, be sometimes necessary to add some thickening materials, to provide desirable denseness.In certain embodiments, thickening agent is the water soluble salt (as sodium carboxymethyl cellulose and carboxymethyl hydroxyethyl cellulose sodium) of CVP Carbopol ETD2050, carrageenin, hydroxyethyl-cellulose and cellulose ether.Also natural gum can be added, as karayagum, Radix Acaciae senegalis and gum tragacanth.The silicon dioxide of available veegum or fine dispersion as the component of thickener composition, to improve the texture of compositions further.Can use in the thickening agent of composition total weight 0.5% weight to 5.0% weight.
In oral cavity composition, also desirably can adding wetting agent, hardening when being exposed to air to prevent compositions.Some wetting agent also can give the desirable sugariness of Dentrifice composition or taste.Based on pure wetting agent, in one embodiment, wetting agent generally accounts for Dentrifice composition weight 15% weight to 70% weight, in another embodiment 30% weight to 65% weight.
The wetting agent be applicable to comprises edible polyhydric alcohol, as the mixture of glycerol, Sorbitol, xylitol, propylene glycol and other polyhydric alcohol and these wetting agents.In certain embodiments, the mixture of glycerol and Sorbitol can be used as the wetting agent component of dentifrice composition.
In addition to the components described above, embodiment of the present invention also can comprise multiple optional dentifrice ingredients, describe below some of them.Optional composition comprises such as but not limited to adhesive agent, foaming agent, flavoring agent, sweeting agent, additional preventing dental plaque agent, abrasive material and coloring agent.These and other optional component is further described in the United States Patent (USP) 5,004,597 authorizing Majeti, the United States Patent (USP) 3 authorizing Agricola etc., 959,458 and authorize the United States Patent (USP) 3,937 of Haefele, 807, all these patents are incorporated herein by reference.
Compositions of the present invention can be used on the common method preparation in dental products field.
In one illustrative embodiment, non-water oral care composition is prepared by mixing Pluracare L-1220, L-4370 and PEG 600, and they are mixed 15 minutes under perfect vacuum in Mini Ross bucket.Add glucide and sodium fluoride, and mixture is mixed 5 minutes under perfect vacuum.Then add abrasive silicon dioxide and pyrogenic silica, and mixture is mixed other 15 minutes.Then add flavoring agent, glucose oxidase and glucose, and mixture is mixed 15 minutes.
Following examples further describe and demonstrate illustrative embodiment within the scope of the present invention.Embodiment only provides to illustrate, these embodiments should be interpreted as restriction of the present invention, without departing from the spirit and scope of the invention, can have a lot of modification.
EXPERIMENTAL EXAMPLESThe
Embodiment 1
Embodiment 1 illustrates the illustrative embodiment of the compositions of single tube non-water Dentrifice composition different range, and wherein each composition can be included in illustrative embodiment.
| Composition | %, in dentifrice |
| Pluracare L-1220 | 0.1-99 |
| Enzyme | 0.01-30 |
| Substrate, glucose | 0.01-20 |
| Abrasive material | 0-40 |
| Pluracare L-4370 | 0-80 |
| Phosphate | 0-20 |
| Fluoride | 0-2 |
| DC siloxanes liquid-350CST | 0-50 |
| Plastigel 5 | 0-50 |
| Thickening agent (such as, XPVP powder) | 0.01-50 |
| Pyrogenic silica | 0.1-10 |
| Viscosity | 10,000-700.000cps |
Embodiment 2
Embodiment 2 illustrates single tube prototype, two-tube to this and routine layout is compared, and measures the amount of the peroxide of release.
| Prototype | The amount of enzyme | The amount of substrate | The mmol of peroxide |
| Single tube (non-water) | 0.25％GOX | 1.5% glucose | 46 |
| Two-tube (moisture) | 0.32％GOX | 1.5% glucose | 27 |
The amount of the peroxide produced by working sample, analysis package is containing the peroxide utilization rate of the single tube product (preparation 1) of GOX/ glucose.Product is compared with the moisture two-tube product that wherein GOX and glucose are separated from each other.Below show result.Data unexpectedly show single tube product than the more peroxide of the two-tube layout generation of routine.
Embodiment 3
Embodiment 3 illustrates the different illustrative embodiment stablizing non-water single tube compositions of the present invention.Find, use the interaction that non-water Dentrifice composition prevents in the product between incompatible component GOX and glucose.In certain embodiments, in PEG, glycerol and PG, use solid or the non-aqueous composition of GOX.Also the pluronics with ethylidene and propylidene of different molecular weight can be used.In addition, the not bitter liquid copolymer of oxirane and expoxy propane can be used, as BASFPluracare L4370 and L1220.
Refer to some lists of references in this article, their whole disclosures are incorporated herein by reference.
Claims (7)
1. stable, single tube, a non-water Dentrifice composition, described Dentrifice composition comprises
(i) at least one enzyme;
(ii) at least one substrate of described at least one enzyme;
(iii) abrasive silica;
(iv) at least one fluoride source;
(v) at least one surfactant; With
Be applicable to carrier, wherein said at least one substrate produces hydrogen peroxide in aqueous conditions reaction under described at least one enzyme exists, and wherein said compositions comprises at least one polymer or copolymer further, wherein said polymer or copolymer are Polyethylene Glycol, PEG/PPG copolymer, PVP, polyethylene, described enzyme is glucose oxidase, and described substrate is glucose.
2. the compositions of claim 1, wherein said non-water Dentrifice composition is contained in single container.
3. the compositions of claim 1 or 2, described compositions comprises at least one vitamin, other polymer of at least one, at least one flavoring agent, other enzyme of at least one, at least one wetting agent and/or at least one antiseptic and combination thereof further.
4. the compositions of claim 1, wherein fluoride source is the member that one is selected from sodium fluoride, potassium fluoride, prodan, sodium monofluorophosphate (MFP), ammonium fluosilicate, stannous fluoride and stannous chloride.
5. the compositions of claim 3, wherein flavoring agent is a kind of member being selected from wintergreen oil, Oleum menthae, oleum menthae viridis, Sassafras oil, cloves oil, aspartame, acesulfame, glucide, glucose, fructose and sodium cyclamate and combination thereof.
6. make a method for whitening of dental surfaces, described method comprises makes dental surface contact with stable, single tube, the non-water Dentrifice composition any one of aforementioned claim.
7. stable, single tube, non-water Dentrifice composition any one of claim 1 to 5, described compositions is for the treatment of oral cavity tartar buildup.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997041215A1 (en) * | 1996-04-29 | 1997-11-06 | Novo Nordisk A/S | Non-aqueous, liquid, enzyme-containing compositions |
| CN101005879A (en) * | 2004-08-27 | 2007-07-25 | 高露洁-棕榄公司 | Oral care composition with cross-linked polymer peroxide |
-
2009
- 2009-12-04 CN CN201510089955.3A patent/CN104688557A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997041215A1 (en) * | 1996-04-29 | 1997-11-06 | Novo Nordisk A/S | Non-aqueous, liquid, enzyme-containing compositions |
| CN101005879A (en) * | 2004-08-27 | 2007-07-25 | 高露洁-棕榄公司 | Oral care composition with cross-linked polymer peroxide |
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