CN108543052A - A kind of drug for the treatment of of arthritis and preparation method thereof - Google Patents

A kind of drug for the treatment of of arthritis and preparation method thereof Download PDF

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Publication number
CN108543052A
CN108543052A CN201810805155.0A CN201810805155A CN108543052A CN 108543052 A CN108543052 A CN 108543052A CN 201810805155 A CN201810805155 A CN 201810805155A CN 108543052 A CN108543052 A CN 108543052A
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parts
radix
drug
pharmaceutical chemicals
bulk pharmaceutical
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朱德胜
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/583—Snakes; Lizards, e.g. chameleons
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    • A61K35/56—Materials from animals other than mammals
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Abstract

The invention discloses a kind of drugs for the treatment of of arthritis and preparation method thereof, include the raw material of following weight parts：25 35 parts of capsicum, 25 35 parts of black snake, windproof 13 17 parts, 13 17 parts of the root of Dahurain angelica, 8 12 parts of scorpio, 13 17 parts of Rhizoma Et Radix Notopterygii, 13 17 parts of tripterygium wilfordii, 13 17 parts of Radix Astragali, 8 12 parts of dragon's blood, 8 12 parts of peppermint, 18 22 parts of ginger, 13 17 parts of Radix Angelicae Sinensis, 13 17 parts of Rhizoma Atractylodis Macrocephalae, 8 12 parts of monkshood, 8 12 parts of radix aconiti agrestis, 46 parts of Moschus, 25 35 parts of radix scrophulariae, 25 35 parts of asparagus fern, 25 35 parts of Radix Ophiopogonis, 25 35 parts of glutinous rehmannia, 25 35 parts of Radix Isatidis, 25 35 parts of moutan bark, 25 35 parts of the tuber of stemona, 25 35 parts of tussilago.Preparation method is that bulk pharmaceutical chemicals crushed 10 50 mesh sieve, is added in the rice wine of 2.5 3.5 times 52 55 degree of gross mass, impregnates 8 12 days, obtain medicine for oral administration；Or bulk pharmaceutical chemicals be crushed into 10 50 mesh sieve, it is added in the alcohol of 1.5 2.5 times of gross mass, impregnates 8 12 days, obtain externally applied drug.The drug of the present invention can effective treatment of arthritis.Its rapid-action, good effect, has no toxic side effect, and medication is convenient and efficient.Clinical treatment case 60, total effective rate 96.6%.

Description

A kind of drug for the treatment of of arthritis and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, relate in particular to a kind of drug for the treatment of of arthritis, also relate to it Preparation method.
Background technology
Arthritis（arthritis）Refer to and be happened at human synovial and its surrounding tissue, by inflammation, infection, degeneration, wound Or inflammatory disease caused by other factors, tens of kinds can be divided into.The arthritic in China has 100,000,000 or more, and number is continuous Increase.Clinical manifestation is the red, swollen, hot of joint, pain, dysfunction and joint deformity, and severe patient leads to joint deformity, influences to suffer from Person's quality of life.Half suffers from osteoarthritis in China 50 years old or more crowd according to statistics, 90% women and 80% in over-65s crowd Male suffers from osteoarthritis.The illness rate in China is 0.34%~0.36%, and severe patient's service life about shortens 10~15 years.Arthritic disease It is mainly related with the factors such as inflammation, autoimmune response, infection, metabolic disorder, wound, retrogression pathological changes because of complexity.According to disease Because arthritis can be divided into rheumatic, rheumatoid, traumatic, bone and suppurative.
Western medical treatment arthritis at present, mainly with anti-inflammation analgesia medicine and non-steroid medicine etc. based on symptomatic treatment, But side effect is big, and there are many contraindication, patient is difficult to take for a long time and be resistant to.Also type is numerous for used Chinese medicine currently on the market It is more, but effect is irregular, and I is unequal to ideal.
Invention content
The purpose of the present invention is to provide the drugs of a kind of rapid-action, good effect, the treatment of arthritis having no toxic side effect.
Another object of the present invention is to provide the preparation methods of the drug.
A kind of drug for the treatment of of arthritis of the present invention, includes the raw material of following weight parts：
25-35 parts of capsicum, black 25-35 parts of snake, 13-17 parts windproof, 13-17 parts of the root of Dahurain angelica, 8-12 parts of scorpio, 13-17 parts of Rhizoma Et Radix Notopterygii, thunder Public rattan 13-17 parts, 13-17 parts of Radix Astragali, 8-12 parts of dragon's blood, 8-12 parts of peppermint, 18-22 parts of ginger, 13-17 parts of Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae 13- 17 parts, 8-12 parts of monkshood, 8-12 parts of radix aconiti agrestis, 4-6 parts of Moschus, 25-35 parts of radix scrophulariae, 25-35 parts of asparagus fern, Radix Ophiopogonis 25-35 part, glutinous rehmannia 25-35 parts, 25-35 parts of Radix Isatidis, 25-35 parts of moutan bark, 25-35 parts of the tuber of stemona, 25-35 parts of tussilago.
A kind of drug of above-mentioned treatment of arthritis, preferably each parts by weight of raw materials are as follows：
30 parts of capsicum, black 30 parts of snake, 15 parts windproof, 15 parts of the root of Dahurain angelica, 10 parts of scorpio, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of tripterygium wilfordii, Radix Astragali 15 It is part, 10 parts of dragon's blood, 10 parts of peppermint, 20 parts of ginger, 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of monkshood, 10 parts of radix aconiti agrestis, 5 parts of Moschus, profound 30 parts of ginseng, 30 parts of asparagus fern, 30 parts of Radix Ophiopogonis, 30 parts of glutinous rehmannia, 30 parts of Radix Isatidis, 30 parts of moutan bark, 30 parts of the tuber of stemona, 30 parts of tussilago.
A kind of drug of above-mentioned treatment of arthritis, preparation method include the following steps：
（（1）Bulk pharmaceutical chemicals are screened, are sampled by weight；
（2）Each bulk pharmaceutical chemicals are crushed, 10-50 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the rice wine of 2.5-3.5 times of 52-55 degree of gross mass, impregnate 8-12 days to get for oral administration Medicine.
A kind of drug of above-mentioned treatment of arthritis, preparation method include the following steps：
（1）Bulk pharmaceutical chemicals are screened, are sampled by weight；
（2）Each bulk pharmaceutical chemicals are crushed, 10-50 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the alcohol of 1.5-2.5 times of gross mass, impregnate 8-12 days to get externally applied drug.
The drug of the present invention compared with prior art, has clear advantage and effect, from above technical scheme：This Capsicum, black snake, the windproof, root of Dahurain angelica, scorpio, Rhizoma Et Radix Notopterygii, tripterygium wilfordii, Radix Astragali, dragon's blood, peppermint, ginger, Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae, river are selected in invention Crow, radix aconiti agrestis, Moschus, radix scrophulariae, asparagus fern, Radix Ophiopogonis, glutinous rehmannia, Radix Isatidis, moutan bark, the tuber of stemona, tussilago are raw material, pass through each drug Synergistic effect is played and is strengthened muscles and bones, promoting blood circulation and removing blood stasis, anti-inflammation detumescence, the effect of removing obstruction in channels to relieve pain.It can effective treatment of arthritis.It works Soon, good effect has no toxic side effect, and medication is convenient and efficient.Clinical treatment case 60, total effective rate 96.6%.
Specific implementation mode
Carry out the advantageous effect of the present invention is further explained the drug below by way of test example.
Test example：The clinical observation of drug of the present invention
1, case selection
Case 60 is treated, wherein：Age 40-80 Sui, man 30, female 30.
2, Disease Diagnosis Standard
《Disease of tcm Standardization of diagnosis and curative effect》.
3, therapy：
The drug prepared by the embodiment of the present invention is taken, oral medicinal liquor three times a day, take exercise more by each 25-50g, one after each meal；It takes Externally applied drug is spilt soaks husky cloth external application affected part in right amount；1 month is 1 course for the treatment of, the 1-2 course for the treatment of.
4, curative effect determinate standard
It is effective：Symptomatology substantially eliminates or cardinal symptom is eliminated.
Effectively：Cardinal symptom is substantially eliminated or is obviously improved.
In vain：Various symptoms and sign are without change.
5, treatment results：
All 60 patients use drug of the present invention, wherein effective 51, effective 7, invalid 2, total effective rate 96.6%.
The preparation method of this drug is illustrated by following embodiment.
Embodiment 1
A kind of preparation method of the drug for the treatment of of arthritis, includes the following steps：
（1）Bulk pharmaceutical chemicals are screened, capsicum 25g, black snake 35g, windproof 13g, root of Dahurain angelica 17g, scorpio 8g, Rhizoma Et Radix Notopterygii 17g, tripterygium wilfordii are weighed 13g, Radix Astragali 17g, dragon's blood 8g, peppermint 12g, ginger 18g, Radix Angelicae Sinensis 17g, Rhizoma Atractylodis Macrocephalae 13g, monkshood 12g, radix aconiti agrestis 8g, Moschus 6g, radix scrophulariae 25g, asparagus fern 35g, Radix Ophiopogonis 25g, glutinous rehmannia 35g, Radix Isatidis 25g, moutan bark 35g, the tuber of stemona（It fries）25g, tussilago（It fries）35g；
（2）Each bulk pharmaceutical chemicals are crushed, 10 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the rice wine of 2.5 times 55 degree of gross mass, impregnate 8 days to get oral medicinal liquor.
Embodiment 2
A kind of preparation method of the drug for the treatment of of arthritis, includes the following steps：
（1）Bulk pharmaceutical chemicals are screened, capsicum capsicum 30g, black snake 30g, windproof 15g, root of Dahurain angelica 15g, scorpio 10g, Rhizoma Et Radix Notopterygii 15g, thunder are weighed Public rattan 15g, Radix Astragali 15g, dragon's blood 10g, peppermint 10g, ginger 20g, Radix Angelicae Sinensis 15g, Rhizoma Atractylodis Macrocephalae 15g, monkshood 10g, radix aconiti agrestis 10g, Moschus 5g, radix scrophulariae 30g, asparagus fern 30g, Radix Ophiopogonis 30g, glutinous rehmannia 30g, Radix Isatidis 30g, moutan bark 30g, the tuber of stemona（It fries）30g, tussilago（It fries） 30g；
（2）Each bulk pharmaceutical chemicals are crushed, 24 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the rice wine of 3 times 52 degree of gross mass, impregnate 10 days to get oral medicinal liquor.
Embodiment 3
A kind of preparation method of the drug for the treatment of of arthritis, includes the following steps：
（1）Bulk pharmaceutical chemicals are screened, capsicum 35g, black snake 25g, windproof 17g, root of Dahurain angelica 13g, scorpio 12g, Rhizoma Et Radix Notopterygii 13g, tripterygium wilfordii are weighed 17g, Radix Astragali 13g, dragon's blood 12g, peppermint 8g, ginger 22g, Radix Angelicae Sinensis 13g, Rhizoma Atractylodis Macrocephalae 17g, monkshood 8g, radix aconiti agrestis 12g, Moschus 4g, radix scrophulariae 35g, asparagus fern 25g, Radix Ophiopogonis 35g, glutinous rehmannia 25g, Radix Isatidis 35g, moutan bark 25g, the tuber of stemona（It fries）35g, tussilago（It fries）25g；
（2）Each bulk pharmaceutical chemicals are crushed, 50 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the rice wine of 3.5 times 53 degree of gross mass, impregnate 12 days to get oral medicinal liquor.
Embodiment 4
A kind of preparation method of the drug for the treatment of of arthritis, includes the following steps：
（1）Bulk pharmaceutical chemicals are screened, capsicum 25g, black snake 35g, windproof 13g, root of Dahurain angelica 17g, scorpio 8g, Rhizoma Et Radix Notopterygii 17g, tripterygium wilfordii are weighed 13g, Radix Astragali 17g, dragon's blood 8g, peppermint 12g, ginger 18g, Radix Angelicae Sinensis 17g, Rhizoma Atractylodis Macrocephalae 13g, monkshood 12g, radix aconiti agrestis 8g, Moschus 6g, radix scrophulariae 25g, asparagus fern 35g, Radix Ophiopogonis 25g, glutinous rehmannia 35g, Radix Isatidis 25g, moutan bark 35g, the tuber of stemona（It fries）25g, tussilago（It fries）35g；
（2）Each bulk pharmaceutical chemicals are crushed, 10 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the alcohol of 1.5 times of gross mass, impregnate 12 days to get exterior-applied medical wine.
Embodiment 5
A kind of preparation method of the drug for the treatment of of arthritis, includes the following steps：
（1）Bulk pharmaceutical chemicals are screened, capsicum capsicum 30g, black snake 30g, windproof 15g, root of Dahurain angelica 15g, scorpio 10g, Rhizoma Et Radix Notopterygii 15g, thunder are weighed Public rattan 15g, Radix Astragali 15g, dragon's blood 10g, peppermint 10g, ginger 20g, Radix Angelicae Sinensis 15g, Rhizoma Atractylodis Macrocephalae 15g, monkshood 10g, radix aconiti agrestis 10g, Moschus 5g, radix scrophulariae 30g, asparagus fern 30g, Radix Ophiopogonis 30g, glutinous rehmannia 30g, Radix Isatidis 30g, moutan bark 30g, the tuber of stemona（It fries）30g, tussilago（It fries） 30g；
（2）Each bulk pharmaceutical chemicals are crushed, 24 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the alcohol of 2 times of gross mass, impregnate 10 days to get exterior-applied medical wine.
Embodiment 6
A kind of preparation method of the drug for the treatment of of arthritis, includes the following steps：
（1）Bulk pharmaceutical chemicals are screened, capsicum 35g, black snake 25g, windproof 17g, root of Dahurain angelica 13g, scorpio 12g, Rhizoma Et Radix Notopterygii 13g, tripterygium wilfordii are weighed 17g, Radix Astragali 13g, dragon's blood 12g, peppermint 8g, ginger 22g, Radix Angelicae Sinensis 13g, Rhizoma Atractylodis Macrocephalae 17g, monkshood 8g, radix aconiti agrestis 12g, Moschus 4g, radix scrophulariae 35g, asparagus fern 25g, Radix Ophiopogonis 35g, glutinous rehmannia 25g, Radix Isatidis 35g, moutan bark 25g, the tuber of stemona（It fries）35g, tussilago（It fries）25g；
（2）Each bulk pharmaceutical chemicals are crushed, 50 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the alcohol of 2.5 times of gross mass, impregnate 8 days to get exterior-applied medical wine.
The above described is only a preferred embodiment of the present invention, being not intended to limit the present invention in any form, appoint What is simply repaiied to any made by above example according to the technical essence of the invention without departing from technical solution of the present invention content Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.

Claims (4)

1. a kind of drug for the treatment of of arthritis, includes the raw material of following weight parts：
25-35 parts of capsicum, black 25-35 parts of snake, 13-17 parts windproof, 13-17 parts of the root of Dahurain angelica, 8-12 parts of scorpio, 13-17 parts of Rhizoma Et Radix Notopterygii, thunder Public rattan 13-17 parts, 13-17 parts of Radix Astragali, 8-12 parts of dragon's blood, 8-12 parts of peppermint, 18-22 parts of ginger, 13-17 parts of Radix Angelicae Sinensis, Rhizoma Atractylodis Macrocephalae 13- 17 parts, 8-12 parts of monkshood, 8-12 parts of radix aconiti agrestis, 4-6 parts of Moschus, 25-35 parts of radix scrophulariae, 25-35 parts of asparagus fern, Radix Ophiopogonis 25-35 part, glutinous rehmannia 25-35 parts, 25-35 parts of Radix Isatidis, 25-35 parts of moutan bark, 25-35 parts of the tuber of stemona, 25-35 parts of tussilago.
2. a kind of drug for the treatment of of arthritis as described in claim 1, includes the raw material of following weight parts：
30 parts of capsicum, black 30 parts of snake, 15 parts windproof, 15 parts of the root of Dahurain angelica, 10 parts of scorpio, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of tripterygium wilfordii, Radix Astragali 15 It is part, 10 parts of dragon's blood, 10 parts of peppermint, 20 parts of ginger, 15 parts of Radix Angelicae Sinensis, 15 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of monkshood, 10 parts of radix aconiti agrestis, 5 parts of Moschus, profound 30 parts of ginseng, 30 parts of asparagus fern, 30 parts of Radix Ophiopogonis, 30 parts of glutinous rehmannia, 30 parts of Radix Isatidis, 30 parts of moutan bark, 30 parts of the tuber of stemona, 30 parts of tussilago.
3. a kind of drug for the treatment of of arthritis as claimed in claim 1 or 2, preparation method include the following steps：
（1）Bulk pharmaceutical chemicals are screened, are sampled by weight；
（2）Each bulk pharmaceutical chemicals are crushed, 10-50 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the rice wine of 2.5-3.5 times of 52-55 degree of gross mass, impregnate 8-12 days to get for oral administration Medicine.
4. a kind of drug for the treatment of of arthritis as claimed in claim 1 or 2, preparation method include the following steps：
（1）Bulk pharmaceutical chemicals are screened, are sampled by weight；
（2）Each bulk pharmaceutical chemicals are crushed, 10-50 mesh sieve, mixing are crossed；
（3）Bulk pharmaceutical chemicals after crushing are added in the alcohol of 1.5-2.5 times of gross mass, impregnate 8-12 days to get externally applied drug.
CN201810805155.0A 2018-07-20 2018-07-20 A kind of drug for the treatment of of arthritis and preparation method thereof Pending CN108543052A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103705894A (en) * 2013-12-24 2014-04-09 李媛春 Traditional Chinese medicine decoction for treating rheumatoid arthritis
CN106310105A (en) * 2015-06-16 2017-01-11 王新钢 Medicine for treating joint diseases and preparation method of medicine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103705894A (en) * 2013-12-24 2014-04-09 李媛春 Traditional Chinese medicine decoction for treating rheumatoid arthritis
CN106310105A (en) * 2015-06-16 2017-01-11 王新钢 Medicine for treating joint diseases and preparation method of medicine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
沈红新: "药酒治疗类风湿性关节炎70例", 《江苏中医》 *
王代明等: "三联法治疗类风湿关节炎阴虚络热证40例", 《光明中医》 *

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