CN108524738A - The clean antibacterial skin formula of liquid of eyelid - Google Patents
The clean antibacterial skin formula of liquid of eyelid Download PDFInfo
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- CN108524738A CN108524738A CN201810658777.5A CN201810658777A CN108524738A CN 108524738 A CN108524738 A CN 108524738A CN 201810658777 A CN201810658777 A CN 201810658777A CN 108524738 A CN108524738 A CN 108524738A
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- eyelid
- skin
- solution
- liquid
- pure water
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Abstract
The invention discloses a kind of clean antibacterial skin formula of liquid of eyelid.The present invention is by following components according to the mass percentage composition：20% polyaminopropyl biguanide 0.20 1.50%, 98% fragrant glycol 68T 0.50 2.00%, aloe extracting solution 0.25 2.00%, 60 rilanit specials 1.00 5.00% of PEG, surplus are EDI pure water.Inventive formulation forms the form for being easy to skin absorption, it is that eye part skin preferably cleans, moisturizing, easy-to-use defends solution, solution acid alkalinity is moderate, can preferably act on the periocualr skins such as the vigorous margo palpebrae of fat secretion, helps the eyelid treatment and nursing of ocular related disorder patients.
Description
Technical field
The present invention relates to eye surface diseases related fields, are to be related to a kind of antibacterial skin liquid for ocular more specifically.
Background technology
Optical arena is regarded in ophthalmology, the eye of China, relevant eye surface diseases include blear-eye, belephroadenitis, dry eyes, acute and chronic
Conjunctivitis etc. advocates the sanitation and hygiene that patient pays attention to keeping itself ocular in the treatment.And reality is only general in the market
Logical paper handkerchief, wet tissue, lack American-European ophthalmology, eye regard the eye-care of optical arena special eye part skin clean, nursing materials,
Including wet tissue, cleaning solution, gel etc., many products are dependent on import at present.Especially lack to blear-eye, dry eyes, belephroadenitis
Etc. diseases eyeware products and solution for lenses and contact lenses.
Blepharitis is the common chronic inflammation of eyelid, and eyelid is often accompanied by the scales of skin that peel off, greasy object.These may be by bacterium
Caused by infection, it is also possible to which property allergy in origin is related with skin and skin seborrhea.It periodically cleans eyelid and keeps appropriate
Eye health can treat and prevent blepharitis.
Bacterium infection usually with blear-eye in relation to or secondary to skin surface, referred to as belephroadenitis.Such case also companion
With pain, red and swollen and margo palpebrae tenderness.Although often recurrence, such case can be reduced by periodically cleaning eyelid.
The glandular secretion grease of eyelid and surrounding can form greasy object on eyelashes and eyelid.The usual companion of accumulation of greasy object
With having cell fragment, dust etc., if this accumulation is excessive, the possibility of bacterium infection can increase.The illness of previous blear-eye
Cleaning-nursing can be carried out by facial cleanser, shampoo for baby etc. " custom setup " solution.This needs patient to be washed with tap water dilution
Then face milk, shampoo for baby use spongarion, certain liquid, finger, cotton swab is coordinated to clean eyelid.And simply skin is clear
Clean dose or antimicrobial fluid are not suitable for using on delicate eyelid.
Invention content
The technical problem to be solved by the present invention is to overcome the deficiencies in the prior art, provide a kind of skin cleaning
Liquid.
The clean antibacterial skin formula of liquid of eyelid of the present invention, by following components according to the mass percentage composition：20% poly- ammonia third
Base biguanides 0.20-1.50%, 98% fragrant glycol 68T0.50-2.00%, aloe extracting solution 0.25-
2.00%, PEG-60 rilanit specials 1.00-5.00%, surplus are EDI pure water.
Further, the clean antibacterial skin formula of liquid of eyelid, by following components according to the mass percentage composition：20% poly- ammonia third
It is base biguanides 0.20%, 98% fragrant glycol 68T 0.50%, extract solution from aloe 0.50%, PEG-60 rilanit specials 1.50%, remaining
Amount is EDI pure water.
Wherein the poly- six subunits biguanides PHMB of primary raw material is a kind of good Fungicidal substance for not stimulating eyeball, is much moistened
Ocular fluid, soft and hard contact lens conditioning liquid use；Fragrant glycol 68T (English：68T), it is Germany's production
Compound cosmetic material, ingredient include：Three kinds of 1.2 hexylene glycols, pungent glycol, tropolone dominant chemical mixing；
PEG-40 castor oil, extract solution from aloe, EDI pure water etc. are the antibacterial skin liquid of auxiliary material.
Compared with prior art, the beneficial effects of the invention are as follows：
The present invention can make the forms such as antibacterial wet tissue, antibacterial skin liquid, gel, before helping various eyeglass wearers to wear mirror
After clean periocualr skin, help, to the soak of eye circumference, moistening, cleaning, helps cleaning-nursing eyelid gland to hold with asthenopia person
Secretion, greasy object caused by outer margo palpebrae problem are cleaned in susceptible to plugging problem, help.
Inventive formulation forms the form for being easy to skin absorption, is that eye part skin preferably cleans, moisturizing, easy-to-use defends eye
Solution, solution acid alkalinity is moderate, can preferably act on the periocualr skins such as the vigorous margo palpebrae of fat secretion, helps ocular related
The eyelid treatment and nursing of Disease.
This product foundation has simultaneously implemented GB27954-2011《Mucosa disinfectant General Requirement》, former People's Republic of China (PRC) defends
Life portion version in 2009《Sterile products manufacturing enterprise hygienic practice》With national health State Family Planning Commission version in 2014《Sterile products health is pacified
Full evaluation regulation》Requirement；Former Ministry of Public Health version in 2002《Disinfection technology standard》, 2003 years versions《Sterile products inspection provision》.
By inventive formulation liquid inspection, have passed through liquid microbe detection, kill strain test, skin and mucous membrane irritation experimental test,
The tests such as stability test, acute ophthalmic irritant test, test result show it with good killing anti-microbial effect, but
It is non-stimulated to eyes, nonirritant performance is tried to skin and mucous membrane irritation, solution formula is stablized.
Compared with existing eyelid cleaner is with articles for use of washing one's face, composition of the invention is by using polyaminopropyl biguanide
(PHMB), novel fragrant glycol 68TModified Cremophor RH40 solubilizer is a kind of excellent
There is wider pH value stability, low foam can be used as pharmaceutical grade solubilizer, Ke Yibang for non-ionic solubilizer and emulsifier
It helps and retains mixture pH stabilizations, avoid stimulation caused by traditional preservative.
Fragrant glycol 68TIt is novel moisturizer and antioxidant with anti-corrosion function.Itself tool
There are good skin moisture-keeping performance and antioxygenic property, excellent broad spectrum antibiotic activity, can quickly kill saccharomycete and mould, it can
To substitute traditional preservative completely, the eye care solution without preservative is prepared.Have between fragrant glycol 68T and common preservatives
Good synergistic effect can substantially reduce the dosage of preservative, increase the anti-corrosion function of product, reduce the stimulation of product, high
Purity, low smell, high security are particularly suitable for that eye circumference is sensitive and delicate skin care.
A kind of polyaminopropyl biguanide (PHMB) and Novel sterilizing, sterilization and preservative, can use what skin degerming and stealth
Glasses cleaning (bacterium and microorganism effectively on cleaning eyeglass；Proteolysin and solion effectively remove the egg on eyeglass
In vain, and on eyeglass protective film is formed, albumen precipitation is prevented), it may also act as deodorant.It is under the concentration of 10mg/l to very much
Xi Jun are He Mildew bacterium can play certain sterilization, bacteriostasis.
The composition of the present invention includes humidizer.The mainly nutritious moisturizing of aloe extracting solution, anti-sunlight function.Aloe liquid
Fibrous polymer albumen drop can be promoted at NMF with natural moisturizing and water lock, effect mechanism, to increase natural moisture preserving because
Son increases water content immediately, reduces percutaneous water loss by slight filming function, aloe liquid energy forms one layer in skin surface
Smooth hygroscopic mem-brane promotes the beautiful feeling and flexibility of formula in the case where not increasing viscosity, has easypro because being rich in polysaccharide
Slow effect.There is aloe anti-inflammatory and healing of wound effect, embedded biometric enzyme to play anti-inflammation and sterilization by slowly being hydrolyzed with skin
Effect, and under amino acid effect, acted on collagen in cuticula, healing of wound.
Specific implementation mode
Invention is further described in detail for knot specific embodiment below.It should be appreciated that specific reality described herein
It applies example to be only used to explain the present invention, be not intended to limit the present invention.
Embodiment 1：
Prepare the present invention：20% polyaminopropyl biguanide 0.20g, 98% fragrant glycol 68T0.50g, reed
Luxuriant growth extracting solution 0.25g, PEG-60 rilanit special 1.0g, EDI pure water 48.25g.
Sketch the preparation process to antibacterial skin liquid：Example weighs 20% polyaminopropyl biguanide 0.20g, 98% fragrant in mass ratio
Glycol 68T0.50g, extract solution from aloe 0.25g, PEG-60 rilanit special 1.0g, 3.50%CAB35
Foaming agent is heated to 40-50 DEG C, is sufficiently stirred dissolving, is then added in the EDI pure water of 40-50 DEG C of 8.25g and completes solution A
Configuration (solution A).By solution A and EDI pure water mixed liquor (B solution), addition surfactant (foaming agent) is added, fully stirs
It mixes, being configured to 50ml solution can (solution C).
Embodiment 2：
Prepare the present invention：20% polyaminopropyl biguanide 1.20g, 98% fragrant glycol 68T1.50g, reed
Luxuriant growth extracting solution 1.0g, PEG-60 rilanit special 3.0g, EDI pure water 48.25g.
Summary prepares the process of the wet tissue containing the present invention：Example weighs 20% polyaminopropyl biguanide 0.20g, 98% in mass ratio
Fragrant glycol 68T0.50g, extract solution from aloe 0.25g, PEG-60 rilanit special 1.0g, are heated to 40-
50 DEG C, it is sufficiently stirred dissolving, is then added in the EDI pure water of 40-50 DEG C of 8.25g and completes the configuration (solution A) of solution A.Most
Additional EDI pure water (B solution) is added afterwards, is sufficiently stirred, being configured to 50ml solution can (solution C).The skin that will have been configured
Antimicrobial fluid (C solution) is directly added into clean monolithic wet tissue packaging, is not added with additional liquid, is packed.The production of wet tissue
Follow strictly GB27728-2011《Wet tissue》Standard, GG15979-2002《Disposable Sanitary Accessory sanitary standard》、
WS575-2017《Wet sanitary napkins hygienic requirements》Etc. standard as defined in national legislations.
Embodiment 3：
Prepare the present invention：20% polyaminopropyl biguanide 1.20g, 98% fragrant glycol 68T1.50g, reed
Luxuriant growth extracting solution 1.0g, PEG-60 rilanit special 3.0g, EDI pure water 8.25g.
Summary prepares the process of the medical gel containing the present invention：20% polyaminopropyl biguanide 0.20g of example weighing in mass ratio,
98% fragrant glycol 68T 0.50g, extract solution from aloe 0.25g, PEG-60 rilanit special 1.0g, are heated to 40-50 DEG C, fully stir
Dissolving is mixed, is then added in the EDI pure water of 40-50 DEG C of 8.25g and completes the configuration (solution A) of solution A.It is eventually adding additional
EDI pure water (B solution), is sufficiently stirred, and is configured in sol preparation host material, forms antibacterial skin gel (C gels).It will match
The antibacterial skin liquid (C gels) set is directly added into aseptic packaging, is packed.The production of gel follows strictly national legislation
The production standard of defined medical gel.
One of the product form of inventive formulation liquid is the form of eye wet tissue, and eye wet tissue is disposably wrapped using monolithic
The nonwoven cloth pad of dress, wet tissue pre-wetted is easy to use convenient for cleaning to the eyelid and periocualr skin for needing to clean or handle
Person is rinsed with water eyelid using front and back, abandons used fabric pad.On the one hand dry and astringent eyelid skin tired out can be made to obtain wet
Moisten, releive, clearly, while wet tissue there can also be common objects surface cleaning bacteriostasis, convenient for objects such as clean operation table tops
Manage environment.
The present invention primary efficacy include：Shield is cleaned in secretion, greasy object caused by the outer margo palpebrae problem of daily cleaning, help
The problem of eyelid gland is easy blocking person is managed, before and after helping contact lens wearers to wear mirror the effects that cleaning periocualr skin.
Fragrant glycol 68TIt is novel moisturizer and antioxidant with anti-corrosion function.Itself tool
There are good skin moisture-keeping performance and antioxygenic property, excellent broad spectrum antibiotic activity, can quickly kill saccharomycete and mould, it can
To substitute traditional preservative completely, the eye care solution without preservative is prepared.Have between fragrant glycol 68T and common preservatives
Good synergistic effect can substantially reduce the dosage of preservative, increase the anti-corrosion function of product, reduce the stimulation of product, high
Purity, low smell, high security are particularly suitable for that eye circumference is sensitive and delicate skin care.
Polyaminopropyl biguanide (PHMB) is a kind of Novel sterilizing, sterilization and preservative, does not stimulate eyeball, can be disappeared with what skin
Poison and washing contact glasses (bacterium and microorganism effectively on cleaning eyeglass；Proteolysin and solion, effectively remove mirror
The albumen of on piece, and protective film is formed on eyeglass, prevent albumen precipitation), it may also act as deodorant.Its concentration in 10mg/L
Under certain sterilization, bacteriostasis can be played to many bacteriums and fungi.
The mainly nutritious moisturizing of aloe extracting solution, anti-sunlight function.Aloe liquid has natural moisturizing and water lock, effect
Mechanism can promote fibrous polymer albumen drop to increase water content immediately, by slight at NMF to increase natural moisturizing factor
Filming function reduces percutaneous water loss, and aloe liquid energy forms one layer of smooth hygroscopic mem-brane in skin surface, do not increasing viscosity
In the case of promote the beautiful feeling and flexibility of formula, because being rich in polysaccharide and the effect of releiving.Aloe has anti-inflammatory and healing
Wound acts on, and embedded biometric enzyme plays the role of anti-inflammation and sterilization, and under amino acid, with angle by slowly being hydrolyzed with skin
Collagen acts in matter layer, healing of wound.
The above is only a preferred embodiment of the present invention, it is noted that for the common skill of the art
For art personnel, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (2)
1. a kind of clean antibacterial skin formula of liquid of eyelid, characterized in that by following components according to the mass percentage composition：20% is poly-
Aminopropyl biguanides 0.20-1.50%, 98% fragrant glycol 68T 0.50-2.00%, extract solution from aloe 0.25-2.00%, PEG-60
Rilanit special 1.00-5.00%, surplus are EDI pure water.
2. the clean antibacterial skin formula of liquid of eyelid according to claim 1, characterized in that by following components according to the quality hundred
Divide than composition：20% polyaminopropyl biguanide 0.20%, 98% fragrant glycol 68T 0.50%, extract solution from aloe 0.50%, PEG-60
Rilanit special 1.50%, surplus are EDI pure water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810658777.5A CN108524738A (en) | 2018-06-25 | 2018-06-25 | The clean antibacterial skin formula of liquid of eyelid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810658777.5A CN108524738A (en) | 2018-06-25 | 2018-06-25 | The clean antibacterial skin formula of liquid of eyelid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108524738A true CN108524738A (en) | 2018-09-14 |
Family
ID=63487146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810658777.5A Pending CN108524738A (en) | 2018-06-25 | 2018-06-25 | The clean antibacterial skin formula of liquid of eyelid |
Country Status (1)
| Country | Link |
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| CN (1) | CN108524738A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101391111A (en) * | 2008-10-31 | 2009-03-25 | 广州科甫眼镜有限公司 | Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil |
| JP2013043873A (en) * | 2011-08-25 | 2013-03-04 | Kao Corp | Agent for preventing or improving deterioration in regulation function of eye |
| CN106512062A (en) * | 2016-12-14 | 2017-03-22 | 成都锦汇科技有限公司 | Multifunctional contact lenses care solution and preparation method thereof |
-
2018
- 2018-06-25 CN CN201810658777.5A patent/CN108524738A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101391111A (en) * | 2008-10-31 | 2009-03-25 | 广州科甫眼镜有限公司 | Contact lens nursing liquid or moisture retention eye drop containing polyethylene glycol hydrogenated castor oil |
| JP2013043873A (en) * | 2011-08-25 | 2013-03-04 | Kao Corp | Agent for preventing or improving deterioration in regulation function of eye |
| CN106512062A (en) * | 2016-12-14 | 2017-03-22 | 成都锦汇科技有限公司 | Multifunctional contact lenses care solution and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 唐建红等: "芦荟的药理作用及临床应用", 《华夏医学》 * |
| 李传秋等: "双胍类消毒防腐剂的应用", 《食品与药品》 * |
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Application publication date: 20180914 |